Effect of long-term passive smoking on erectile function and penile nitric oxide synthase in the rat

Journal of Urology

Volumn 157, Issue 3, 1997, Pages 1121-1126

  Xie, Yining ^a   Garban, Hermes ^a   Ng, Chris ^a   Rajfer, Jacob ^a   Gonzalez Cadavid, Nestor F ^a  

^a HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

hypertension; impotence; nitric oxide; penile erection

Indexed keywords

CIGARETTE SMOKE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DENSITOMETRY; ELECTRIC FIELD; ENZYME ACTIVITY; HYPERTENSION; IMMUNOBLOTTING; IMPOTENCE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PASSIVE SMOKING; PENIS ERECTION; PRIORITY JOURNAL; RAT; VASOCONSTRICTION;

EID: 0031021827     PISSN: 00225347     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-5347(01)65153-X     Document Type: Article

References (39)

1. Feldman, H. A., Goldstein, I., Hatzichristou, D. G., Krane, R. J. and McKinlay, J. B.: Impotence and its medical and psychosocial correlates: results of the Massachusetts male aging study. J. Urol., 151: 54, 1994.
2. Mannino, D. M., Kievens, R. M. and Flanders, W. D.: Cigarette smoking: an independent risk factor for impotence? Amer. J. Epidemiol., 140: 1003, 1994.
3. Rosen, M. P., Greenfield, A. J., Walker, T. G., Grant, P., Dubrow, J., Bettman, M. A., Fried, L. E. and Goldstein, L: Cigarette smoking: an independent risk factor for atherosclerosis in the hypogastric-cavernous arterial bed of men with arteriogenic impotence. J. Urol., 145: 759, 1991.
4. Shabsigh, R., Fishman, I. J., Schum, C. and Dunn, J. K.: Cigarette smoking and other vascular risk factors in vasculogenic impotence. Urology, 38: 227, 1991.
5. Hirshkowitz, M., Karakan, I., Howell, J. W., Arcasoy, M. O. and Williams, R. L.: Nocturnal penile tumescence in cigarette smokers with erectile dysfunction. Urology, 34: 101, 1992.
6. Pittilo, R. M.: Cigarette smoking and endothelial injury: a review. In: Tobacco Smoking and Atherosclerosis. J. N. Dana, editor, Plenum Press, New York, pp. 61-78, 1990.
7. Chung, S. M., Gay, C. A. and McCrary, J. A.: Nonarteric ischemic optic neuropathy. The impact of tobacco use. Ophthalmology, 101: 779, 1994.
8. Ishii, D. N.: Implication of insulin-like growth factors in the pathogenesis of diabetic neuropathy. Brain Res. Rev., 20: 47, 1995.
9. Russell, M. A. H., Wilson, C., Patel, U. A., Feyerabend, C. and Cole, P. V.: Plasma nicotine levels after smoking cigarettes with high, medium, and low nicotine yields. Br. Med. J., 2: 414, 1975.
10. Saenz de Tejada, L: Commentary on mechanisms tor the regulation of the penile smooth muscle contractility. J. Urol., 153: 1762, 1995.
11. Jacobs, M. C., Lenders, J. W., Kapma, J. A., Smits, P. and Thien, T.: Effect of chronic smoking on endothelium-dependent vascular relaxation in humans. Clin. Sci., 85: 51, 1993.
12. Levine, L. A. and Gerber, G. S.: Acute vasospasm of penile arteries in response to cigarette smoking: letter. Urology, 36: 99, 1990.
13. Mersdorf, A., Golsmith, P. C., Diederichs, W., Padula, C. A., Lue, T., Fishman, I. J. and Tanagho, E.: Ultrastructural changes in impotent penile tissue: a comparison of 65 patients. J. Urol., 145: 749, 1991.
14. Juenemann, K. P., Lue, T. F., Luo, J. A., Benowitz, N. L., Abozeid, M. and Tanagho, E. A.: The effect of cigarette smoking on penile erection. J. Urol., 138: 438, 1987.
15. Saenz de Tejada, I.: Mechanisms for the regulation of penile smooth muscle contractility. In: World Book of Impotence. T. Lue, editor. Smith Gordon/Nishimura, London, pp. 264-292, 1992.
16. Lugg, J., Gonzalez-Cadavid, N. F. and Rajfer, J.: The role of nitric oxide in erectile function. J. Androl., 16: 2, 1995.
17. Garban, H., Vernet, D., Freedman, A., Rajfer, J. and Gonzalez-Cadavid, N. F.: Effect of aging on nitric oxide-mediated penile erection in the rat. Am. J. Physiol., 268: H467, 1995.
18. dp (Type II) rats with erectile dysfunction. Endocrinology, 136: 5709, 1995.
19. Lugg, J., Rajfer, J. and Gonzalez-Cadavid, N. F.: Dihydrotestosterone is the active androgen in the maintenance of nitric oxide mediated penile erection in the rat. Endocrinology, 136: 1495, 1995.
20. Garban, H., Marquez, D., Cai, L., Rajfer, J. and Gonzalez-Cadavid, N. F.: Restoration of normal penile erectile response in aged rats by long-term treatment with androgens. Biol. Reprod., 53: 1365, 1995.
21. Lugg, J., Ng, C., Rajfer, J. and Gonzalez-Cadavid, N. F.: Cavernosal nerve stimulation in the rat reverses the castration-induced decrease in penile nitric oxide synthase activity. Am. J. Physiol., 271: 354, 1996.
22. Penson, D. F., Ng, C., Cai, L., Rajfer, J. and Gonzalez-Cadavid, N. F.: Androgen dependence of neuronal nitric oxide synthase content and erectile function in the rat penis. In: The Biology of Nitric Oxide. J. Stamler, S. Gross, S. Moncada and A. E. Higgs editors. Portland Press, London, in press, 1996.
23. Berkan, T., Ustunes, L., Kerry, Z., Karol, M., Tosun, M., Yalcinkaya, C. and Ozer, A.: The effect of a single treatment with cigarette smoke on the blood levels and hemodynamic effects of propanolol in rats. Eur. J. Drug Metabol. Pharmacokin., 14: 221, 1989.
24. Turner, J., McLennan, P. L., Abeywardena, M. Y. and Charnock, J. S.: Absence of coronary or aortic atherosclerosis in rats having dietary lipid modified vulnerability to cardiac arrhytmias. Atherosclerosis, 82: 105, 1990.
25. Rajfer, J., Aronson, W. J., Bush, P., Dorey, F. J. and Ignarro, L. J.: Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N. Engl. J. Med., 326: 90, 1992.
26. Burnett, A. L., Lowenstein, C. J., Bredt, D., Chang, T. S. K. and Snyder, S. H.: Nitric oxide: a physiologic mediator of penile erection. Science, 257: 401, 1992.
27. Forsterman, U., Closs, E. I., Pollock, J. S., Nakane, M., Schwarz, P., Gath, I. and Kleinert, H.: Nitric oxide isozymes. Characterization, purification, molecular cloning and functions. Hypertension, 23: 1121, 1994.
28. Burnett, A. L., Tillman, S. L., Chang, T. S. K., Epstein, J. I., Lowenstein, C. J., Bredt, D. S., Snyder, S. H. and Walsh, P. C.: Immunohistochemical localization of nitric oxide synthase in the autonomic innervation of the human penis. J. Urol., 150: 73, 1993.
29. Kiowski, W., Linder, L., Stoschitzky, K., Pfisterer, M., Burckhardt, D., Burkart, F. and Buhler, F. R.: Diminished vascular response to inhibition of endothelium-derived nitric oxide and enhanced vasoconstriction to exogenously administered endothelin-1 in clinically healthy smokers. Circulation, 90: 27, 1994.
30. Bodis, S. and Haregewoin, A.: Significantly reduced salivary nitric oxide levels in smokers. Ann. Oncol., 5: 371, 1994.
31. Kharitonov, S. A., Robbins, R. A., Yates, D., Keatings, V. and Barnes, P. J.: Acute and chronic effects of cigarette smoking on exhaled nitric oxide. Am. J. Resp. Crit. Care Med., 152: 609, 1995.
32. Hung, A., Vernet, D., Xie, Y., Rajavashisth, T., Rodriguez, J. A., Rajfer, J. and Gonzalez-Cadavid, N. F.: Expression of the inducible nitric oxide synthase in smooth muscle cells from the rat penile corpora cavernosa. J. Androl., 16: 469, 1995.
33. Forstermann, U., Pollock, J. S., Schmidt, H. H. H. W., Heller, M. and Murad, F.: Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells. Proc. Natl. Acad. Sci. US, 88: 1788, 1991.
34. Sleight, P.: Smoking and hypertension. Clin. Exptl. Hypert., 15: 1181, 1993.
35. Berry, B. and Wright, J. L.: Long-term pulmonary hypertension produced by cigarette smoking is associated with subendocardial fibrosis and inflammation of the right ventricle: a morphometric analysis in the guinea pig model. Exptl. Pathol., 43: 163, 1991.
36. Cadwgan, T. M. and Benjamin, N.: Evidence for altered platelet nitric oxide synthesis in essential hypertension. J. Hypertens., 11: 417, 1993.
37. Giaid, A. and Saleh, D.: Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N. Engl. J. Med., 333: 214, 1995.
38. Schaad, N. C., Vanacek, J. and Schulz, P. E.: Photoneural regulation of rat pineal nitric oxide synthase. J. Neurochem., 62: 2496, 1994.
39. Muller, S. C., el-Damanhoury, H., Ruth, J. and Lue, T. F.: Hypertension and impotence. Eur. Urol., 19: 29, 1991.