Sildenafil inhibits the up-regulation of phosphodiesterase type 5 elicited with nicotine and tumour necrosis factor-α in cavernosal vascular smooth muscle cells: Mediation by superoxide

BJU International

Volumn 99, Issue 3, 2007, Pages 612-618

  Hotston, Matthew R ^a   Jeremy, Jamie Y ^a   Bloor, Jonathan ^a   Koupparis, Anthony ^a   Persad, Raj ^a   Shukla, Nilima ^a  

^a BRISTOL ROYAL INFIRMARY   (United Kingdom)

Author keywords

Erectile dysfunction; PDE 5; Sildenafil; Superoxide

Indexed keywords

APOCYNIN; CATALASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; NICOTINE; NITRIC OXIDE; OXYGEN; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SILDENAFIL; SUPEROXIDE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ERECTILE DYSFUNCTION; INCUBATION TIME; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; SMOOTH MUSCLE FIBER; SPECTROPHOTOMETRY; STATISTICAL SIGNIFICANCE; UPREGULATION; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; IMPOTENCE, VASCULOGENIC; MALE; MUSCLE, SMOOTH, VASCULAR; NADPH OXIDASE; NICOTINE; PENIS; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PURINES; RABBITS; SULFONES; SUPEROXIDES; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 33846938807     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2006.06618.x     Document Type: Article

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