One patient out of four with newly diagnosed erectile dysfunction is a young man-worrisome picture from the everyday clinical practice

Journal of Sexual Medicine

Volumn 10, Issue 7, 2013, Pages 1833-1841

  Capogrosso, Paolo ^a   Colicchia, Michele ^a   Ventimiglia, Eugenio ^a   Castagna, Giulia ^a   Clementi, Maria Chiara ^a   Suardi, Nazareno ^a   Castiglione, Fabio ^a   Briganti, Alberto ^a   Cantiello, Francesco ^b   Damiano, Rocco ^b   Montorsi, Francesco ^a   Salonia, Andrea ^a,b  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

Age; Clinical Practice; Comorbidities; Elderly; Erectile Dysfunction; Health Status; International Index of Erectile Function; Risk Factors; Young

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIDIABETIC AGENT; ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; ILLICIT DRUG; PROTON PUMP INHIBITOR; TESTOSTERONE; THIAZIDE DIURETIC AGENT; URICOSURIC AGENT;

ADULT; ARTICLE; BODY MASS; CHARLSON COMORBIDITY INDEX; CLINICAL FEATURE; CLINICAL PRACTICE; CLINICAL STUDY; COMORBIDITY; DEMOGRAPHY; DISEASE SEVERITY; DRUG USE; ERECTILE DYSFUNCTION; HUMAN; INTERNATIONAL INDEX OF ERECTILE FUNCTION; LOWER URINARY TRACT SYMPTOM; MAJOR CLINICAL STUDY; MALE; PEYRONIE DISEASE; PREMATURE EJACULATION; PRIORITY JOURNAL; SMOKING HABIT; SOCIAL ASPECT; TESTOSTERONE BLOOD LEVEL;

EID: 84879838100     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/jsm.12179     Document Type: Article

References (44)

1. Glina S, Sharlip ID, Hellstrom WJ. Modifying risk factors to prevent and treat erectile dysfunction. J Sex Med 2013;10:115-119.
2. Corona G, Lee DM, Forti G, O'Connor DB, Maggi M, O'Neill TW, Pendleton N, Bartfai G, Boonen S, Casanueva FF, Finn JD, Giwercman A, Han TS, Huhtaniemi IT, Kula K, Lean ME, Punab M, Silman AJ, Vanderschueren D, Wu FC, EMAS Study Group. Age-related changes in general and sexual health in middle-aged and older men: Results from the European Male Ageing Study (EMAS). J Sex Med 2010;7:1362-1380.
3. Salonia A, Castagna G, Saccà A, Ferrari M, Capitanio U, Castiglione F, Rocchini L, Briganti A, Rigatti P, Montorsi F. Is erectile dysfunction a reliable proxy of general male health status? The case for the International Index of Erectile Function-Erectile Function domain. J Sex Med 2012;9:2708-2715.
4. Montorsi F, Briganti A, Salonia A, Rigatti P, Margonato A, Macchi A, Galli S, Ravagnani PM, Montorsi P. Erectile dysfunction prevalence, time of onset and association with risk factors in 300 consecutive patients with acute chest pain and angiographically documented coronary artery disease. Eur Urol 2003;44:360-364.
5. Guo W, Liao C, Zou Y, Li F, Li T, Zhou Q, Cao Y, Mao X. Erectile dysfunction and risk of clinical cardiovascular events: A meta-analysis of seven cohort studies. J Sex Med 2010;7:2805-2816.
6. Dong JY, Zhang YH, Qin LQ. Erectile dysfunction and risk of cardiovascular disease: Meta-analysis of prospective cohort studies. J Am Coll Cardiol 2011;58:1378-1385.
7. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. J Urol 1994;151:54-61.
8. Laumann EO, Paik A, Rosen RC. Sexual dysfunction in the United States: Prevalence and predictors. JAMA 1999;281:537-544.
9. Prins J, Blanker MH, Bohnen AM, Thomas S, Bosch JL. Prevalence of erectile dysfunction: A systematic review of population-based studies. Int J Impot Res 2002;14:422-432.
10. Roth A, Kalter-Leibovici O, Kerbis Y, Tenenbaum-Koren E, Chen J, Sobol T, Raz I. Prevalence and risk factors for erectile dysfunction in men with diabetes, hypertension, or both diseases: A community survey among 1, 412 Israeli men. Clin Cardiol 2003;26:25-30.
11. Hyde Z, Flicker L, Hankey GJ, Almeida OP, McCaul KA, Chubb SA, Yeap BB. Prevalence and predictors of sexual problems in men aged 75-95 years: A population-based study. J Sex Med 2012;9:442-453.
12. Gacci M, Eardley I, Giuliano F, Hatzichristou D, Kaplan SA, Maggi M, McVary KT, Mirone V, Porst H, Roehrborn CG. Critical analysis of the relationship between sexual dysfunctions and lower urinary tract symptoms due to benign prostatic hyperplasia. Eur Urol 2011;60:809-825.
13. Parazzini F, Menchini Fabris F, Bortolotti A, Calabrò A, Chatenoud L, Colli E, Landoni M, Lavezzari M, Turchi P, Sessa A, Mirone V. Frequency and determinants of erectile dysfunction in Italy. Eur Urol 2000;37:43-49.
14. Ponholzer A, Temml C, Mock K, Marszalek M, Obermayr R, Madersbacher S. Prevalence and risk factors for erectile dysfunction in 2869 men using a validated questionnaire. Eur Urol 2005;47:80-85.
15. Mialon A, Berchtold A, Michaud PA, Gmel G, Suris JC. Sexual dysfunction among young men: Prevalence and associated factors. J Adol Health 2012;51:25-31.
16. Martins FG, Abdo CH. Erectile dysfunction and correlated factors in Brazilian men aged 18-40 years. J Sex Med 2010;7:2166-2173.
17. Pescatori ES, Giammusso B, Piubello G, Gentile V, Farina FP. Journey into the realm of requests for help presented to sexual medicine specialists: Introducing male sexual distress. J Sex Med 2007;4:762-770.
18. NIH consensus development panel on impotence. JAMA 1993;270:83-90.
19. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation. J Chronic Dis 1987;40:373-383.
20. National Institutes of Health, National Heart, Lung, and Blood Institute. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults-The Evidence Report. Obes Res 1998;6(suppl):51-210S.
21. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Costa F, American Heart Association; National Heart, Lung, and Blood Institute. Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005;112:2735-2752.
22. American Association of Clinical Endocrinologists. Medical guidelines for clinical practice for the evaluation and treatment of hypogonadism in adult male patients-2002 update. Endocr Pract 2002;8:440-456.
23. Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The International Index of Erectile Function (IIEF): A multidimensional scale for assessment of erectile dysfunction. Urology 1997;49:822-830.
24. Cappelleri JC, Rosen RC, Smith MD, Mishra A, Osterloh IH. Diagnostic evaluation of the erectile function domain of the International Index of Erectile Function. Urology 1999;54:346-351.
25. Kaye JA, Jick H. Incidence of erectile dysfunction and characteristics of patients before and after the introduction of sildenafil in the United Kingdom: Cross sectional study with comparison patients. Br Med J 2003;22:424-425.
26. Braun M, Wassmer G, Klotz T, Reifenrath B, Mathers M, Engelmann U. Epidemiology of erectile dysfunction: Results of the "Cologne Male Survey". Int J Impot Res 2000;12:305-311.
27. Martin-Morales A, Sanchez-Cruz JJ, Saenz de Tejada I, Rodriguez-Vela L, Jimenez-Cruz JF, Burgos-Rodriguez R. Prevalence and independent risk factors for erectile dysfunction in Spain: Results of the Epidemiologia de la Disfunction Erectil MAsculina Study. J Urol 2001;166:569-574.
28. De Berardis G, Pellegrini F, Franciosi M, Pamparana F, Morelli P, Tognoni G, Nicolucci A, EDEN Study Group. Management of erectile dysfunction in general practice. J Sex Med 2009;6:1127-1134.
29. Akre C, Michaud PA, Suris JC. "I'll look it up on the web first": Barriers and overcoming barriers to consult for sexual dysfunction among young men. Swiss Med Wkly 2010;140:348-353.
30. Angst J. Sexual problems in healthy and depressed persons. Int Clin Psychopharmacol 1998;13(suppl 6):S1-4.
31. Gratzke C, Angulo J, Chitaley K, Dai YT, Kim NN, Paick JS, Simonsen U, Uckert S, Wespes E, Andersson KE, Lue TF, Stief CG. Anatomy, physiology, and pathophysiology of erectile dysfunction. J Sex Med 2010;7:445-475.
32. Aversa A, Rossi F, Francomano D, Bruzziches R, Bertone C, Santiemma V, Spera G. Early endothelial dysfunction as a marker of vasculogenic erectile dysfunction in young habitual cannabis users. Int J Impot Res 2008;20:566-573.
33. Shamloul R, Bella AJ. Impact of cannabis use on male sexual health. J Sex Med 2011;8:971-975.
34. Mannino DM, Klevens RM, Flanders WD. Cigarette smoking: An independent risk factor for impotence? Am J Epidemiol 1994;140:1003-1008.
35. Nicolosi A, Moreira ED Jr, Shirai M, Bin Tambi MI, Glasser DB. Epidemiology of erectile dysfunction in four countries: Cross-national study of the prevalence and correlates of erectile dysfunction. Urology 2003;61:201-206.
36. Rosen RC, Wing R, Schneider S, Gendrano N. Epidemiology of erectile dysfunction: The role of medical comorbidities and lifestyle factors. Urol Clin North Am 2005;32:403-417.
37. Harte CB, Meston CM. Acute effects of nicotine on physiological and subjective sexual arousal in nonsmoking men: A randomized, double-blind, placebo-controlled trial. J Sex Med 2008;5:110-121.
38. Gades NM, Jacobson DJ, McGree ME, St Sauver JL, Lieber MM, Nehra A, Girman CJ, Jacobsen SJ. Longitudinal evaluation of sexual function in a male cohort: The Olmsted county study of urinary symptoms and health status among men. J Sex Med 2009;6:2455-2466.
39. Deveci S, O'Brien K, Ahmed A, Parker M, Guhring P, Mulhall JP. Can the International Index of Erectile Function distinguish between organic and psychogenic erectile function? BJU Int 2008;102:354-356.
40. Schouten BW, Bohnen AM, Bosch JL, Bernsen RM, Deckers JW, Dohle GR, Thomas S. Erectile dysfunction prospectively associated with cardiovascular disease in the Dutch general population: Results from the Krimpen Study. Int J Impot Res 2008;20:92-99.
41. Chew KK, Finn J, Stuckey B, Gibson N, Sanfilippo F, Bremner A, Thompson P, Hobbs M, Jamrozik K. Erectile dysfunction as a predictor for subsequent atherosclerotic cardiovascular events: Findings from a linked-data study. J Sex Med 2010;7:192-202.
42. Kupelian V, Shabsigh R, Araujo AB, O'Donnell AB, McKinlay JB. Erectile dysfunction as a predictor of the metabolic syndrome in aging men: Results from the Massachusetts Male Aging Study. J Urol 2006;176:222-226.
43. Brotons FB, Campos JC, Gonzalez-Correales R, Martín-Morales A, Moncada I, Pomerol JM. Core document on erectile dysfunction: Key aspects in the care of a patient with erectile dysfunction. Int J Impot Res 2004;16(2 suppl):S26-39.
44. Travison TG, Hall SA, Fisher WA, Araujo AB, Rosen RC, McKinlay JB, Sand MS. Correlates of PDE5i use among subjects with erectile dysfunction in two population based surveys. J Sex Med 2011;8:3051-3057.