메뉴 건너뛰기




Volumn 11, Issue 9, 2016, Pages 1423-1432

CMET Exon 14 Skipping: From the structure to the clinic

Author keywords

Cmet; Exon 14 skipping; NSCLC; Targeted therapies

Indexed keywords

MESENCHYMAL EPITHELIAL TRANSITION FACTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG; SCATTER FACTOR RECEPTOR;

EID: 84987790603     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1016/j.jtho.2016.05.005     Document Type: Review
Times cited : (55)

References (86)
  • 3
    • 57149092131 scopus 로고    scopus 로고
    • Expression and mutational analysis of MET in human solid cancers
    • Ma PC, Tretiakova MS, Mackinnon AC, et al. Expression and mutational analysis of MET in human solid cancers. Genes Chromosomes Cancer. 2008;47:1025-1037.
    • (2008) Genes Chromosomes Cancer , vol.47 , pp. 1025-1037
    • Ma, P.C.1    Tretiakova, M.S.2    Mackinnon, A.C.3
  • 4
    • 0027965021 scopus 로고
    • Identification of a noveltype of alternative splicing of a tyrosine kinase receptor
    • Lee C-C, Yamada KM. Identification of a noveltype of alternative splicing of a tyrosine kinase receptor. J Biol Chem. 1994;269:19457-19461.
    • (1994) J Biol Chem , vol.269 , pp. 19457-19461
    • Lee, C.-C.1    Yamada, K.M.2
  • 5
    • 84962609567 scopus 로고    scopus 로고
    • Next-generation sequencing of pulmonary sarcomatoid carcinoma reveals high frequency of actionable MET gene mutations
    • Liu X, Jia Y, Stoopler MB, et al. Next-generation sequencing of pulmonary sarcomatoid carcinoma reveals high frequency of actionable MET gene mutations. J Clin Oncol. 2015;34:794-802.
    • (2015) J Clin Oncol , vol.34 , pp. 794-802
    • Liu, X.1    Jia, Y.2    Stoopler, M.B.3
  • 6
    • 84938815085 scopus 로고    scopus 로고
    • Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping
    • Paik PK, Drilon A, Fan P-D, et al. Response to MET inhibitors in patients with stage IV lung adenocarcinomas harboring MET mutations causing exon 14 skipping. Cancer Discov. 2015;5:842-849.
    • (2015) Cancer Discov , vol.5 , pp. 842-849
    • Paik, P.K.1    Drilon, A.2    Fan, P.-D.3
  • 7
    • 84938805958 scopus 로고    scopus 로고
    • Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors
    • Frampton GM, Ali SM, Rosenzweig M, et al. Activation of MET via diverse exon 14 splicing alterations occurs in multiple tumor types and confers clinical sensitivity to MET inhibitors. Cancer Discov. 2015;5: 850-860.
    • (2015) Cancer Discov , vol.5 , pp. 850-860
    • Frampton, G.M.1    Ali, S.M.2    Rosenzweig, M.3
  • 8
    • 84944474562 scopus 로고    scopus 로고
    • Gastrointestinal malignancies harbor actionable MET exon 14 deletions
    • Lee J, Ou SI, Lee JM, et al. Gastrointestinal malignancies harbor actionable MET exon 14 deletions. Oncotarget. 2015;6:28211-28222.
    • (2015) Oncotarget , vol.6 , pp. 28211-28222
    • Lee, J.1    Ou, S.I.2    Lee, J.M.3
  • 9
    • 0029134104 scopus 로고
    • Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud
    • Bladt F, Riethmacher D, Isenmann S, Aguzzi A, Birchmeier C. Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud. Nature. 1995;376:768-771.
    • (1995) Nature , vol.376 , pp. 768-771
    • Bladt, F.1    Riethmacher, D.2    Isenmann, S.3    Aguzzi, A.4    Birchmeier, C.5
  • 10
    • 84894059782 scopus 로고    scopus 로고
    • Glypican-1 regulates myoblast response to HGF via Met in a lipid raftdependent mechanism: Effect on migration of skeletal muscle precursor cells
    • Gutiérrez J, Cabrera D, Brandan E. Glypican-1 regulates myoblast response to HGF via Met in a lipid raftdependent mechanism: Effect on migration of skeletal muscle precursor cells. Skelet Muscle. 2014;4:5.
    • (2014) Skelet Muscle , vol.4 , pp. 5
    • Gutiérrez, J.1    Cabrera, D.2    Brandan, E.3
  • 11
    • 0031843614 scopus 로고    scopus 로고
    • Differential effects of hepatocyte growth factor isoforms on epithelial and endothelial tubulogenesis
    • Montesano R, Soriano JV, Malinda KM, et al. Differential effects of hepatocyte growth factor isoforms on epithelial and endothelial tubulogenesis. Cell Growth Differ. 1998;9:355-365.
    • (1998) Cell Growth Differ , vol.9 , pp. 355-365
    • Montesano, R.1    Soriano, J.V.2    Malinda, K.M.3
  • 12
    • 30544452034 scopus 로고    scopus 로고
    • Hepatocyte growth factor promotes lymphatic vessel formation and function
    • Kajiya K, Hirakawa S, Ma B, Drinnenberg I, Detmar M. Hepatocyte growth factor promotes lymphatic vessel formation and function. EMBO J. 2005;24:2885-2895.
    • (2005) EMBO J , vol.24 , pp. 2885-2895
    • Kajiya, K.1    Hirakawa, S.2    Ma, B.3    Drinnenberg, I.4    Detmar, M.5
  • 14
    • 33644887722 scopus 로고    scopus 로고
    • The molecular and clinical impact of hepatocyte growth factor, its receptor, activators, and inhibitors in wound healing
    • Conway K, Price P, Harding KG, Jiang WG. The molecular and clinical impact of hepatocyte growth factor, its receptor, activators, and inhibitors in wound healing. Wound Repair Regen. 2006;14:2-10.
    • (2006) Wound Repair Regen , vol.14 , pp. 2-10
    • Conway, K.1    Price, P.2    Harding, K.G.3    Jiang, W.G.4
  • 15
    • 0038115223 scopus 로고    scopus 로고
    • HGF receptor upregulation contributes to the angiogenic phenotype of human endothelial cells and promotes angiogenesis in vitro
    • Ding S, Merkulova-rainon T, Han ZC. HGF receptor upregulation contributes to the angiogenic phenotype of human endothelial cells and promotes angiogenesis in vitro. Blood. 2003;101:4816-4822.
    • (2003) Blood , vol.101 , pp. 4816-4822
    • Ding, S.1    Merkulova-Rainon, T.2    Han, Z.C.3
  • 16
    • 33748310896 scopus 로고    scopus 로고
    • Regulatory role of c-Met in insulin-like growth factor-I receptor-mediated migration and invasion of human pancreatic carcinoma cells
    • Bauer TW, Somcio RJ, Fan F, Liu W, Johnson M, Lesslie DP, et al. Regulatory role of c-Met in insulin-like growth factor-I receptor-mediated migration and invasion of human pancreatic carcinoma cells. Mol Cancer Ther. 2006;5:1676-1682.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1676-1682
    • Bauer, T.W.1    Somcio, R.J.2    Fan, F.3    Liu, W.4    Johnson, M.5    Lesslie, D.P.6
  • 17
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman JA, Zejnullahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science. 2007;316: 1039-1043.
    • (2007) Science , vol.316 , pp. 1039-1043
    • Engelman, J.A.1    Zejnullahu, K.2    Mitsudomi, T.3
  • 19
    • 42949138783 scopus 로고    scopus 로고
    • HGF increases cisplatin resistance via down-regulation of AIF in lung cancer cells
    • Chen JT, Huang CY, Chiang YY, et al. HGF increases cisplatin resistance via down-regulation of AIF in lung cancer cells. Am J Respir Cell Mol Biol. 2008;38:559-565.
    • (2008) Am J Respir Cell Mol Biol , vol.38 , pp. 559-565
    • Chen, J.T.1    Huang, C.Y.2    Chiang, Y.Y.3
  • 20
    • 84877578990 scopus 로고    scopus 로고
    • Modulation of c-Met signaling and cellular sensitivity to radiation: Potential implications for therapy
    • Bhardwaj V, Cascone T, Cortez MA, et al. Modulation of c-Met signaling and cellular sensitivity to radiation: potential implications for therapy. Cancer. 2013;119: 1768-1775.
    • (2013) Cancer , vol.119 , pp. 1768-1775
    • Bhardwaj, V.1    Cascone, T.2    Cortez, M.A.3
  • 21
    • 0037401065 scopus 로고    scopus 로고
    • Radiation stimulates HGF receptor/c-Met expression that leads to amplifying cellular response to HGF stimulation via upregulated receptor tyrosine phosphorylation and MAP kinase activity in pancreatic cancer cells
    • Qian LW, Mizumoto K, Inadome N, et al. Radiation stimulates HGF receptor/c-Met expression that leads to amplifying cellular response to HGF stimulation via upregulated receptor tyrosine phosphorylation and MAP kinase activity in pancreatic cancer cells. Int J Cancer. 2003;104:542-549.
    • (2003) Int J Cancer , vol.104 , pp. 542-549
    • Qian, L.W.1    Mizumoto, K.2    Inadome, N.3
  • 22
    • 0028351702 scopus 로고
    • A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
    • Ponzetto C, Bardelli A, Zhen Z, et al. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell. 1994;77:261-271.
    • (1994) Cell , vol.77 , pp. 261-271
    • Ponzetto, C.1    Bardelli, A.2    Zhen, Z.3
  • 23
    • 17544371922 scopus 로고    scopus 로고
    • Pathways downstream of Shc and Grb2 are required for cell transformation by the Tpr-Met oncoprotein
    • Fixman ED, Fournier TM, Kamikura DM, Naujokas MA, Park M. Pathways downstream of Shc and Grb2 are required for cell transformation by the Tpr-Met oncoprotein. J Biol Chem. 1996;271:13116-13122.
    • (1996) J Biol Chem , vol.271 , pp. 13116-13122
    • Fixman, E.D.1    Fournier, T.M.2    Kamikura, D.M.3    Naujokas, M.A.4    Park, M.5
  • 24
    • 0029855280 scopus 로고    scopus 로고
    • Interaction between Gab1 and the c-Met receptor tyosine kinase is responsible for epithelial morphogenesis
    • Weidner KM, Di Cesare S, Sachs M, Brinkmann V, Behrens J, Birchmeier W. Interaction between Gab1 and the c-Met receptor tyosine kinase is responsible for epithelial morphogenesis. Nature. 1996;384: 173-176.
    • (1996) Nature , vol.384 , pp. 173-176
    • Weidner, K.M.1    Di Cesare, S.2    Sachs, M.3    Brinkmann, V.4    Behrens, J.5    Birchmeier, W.6
  • 25
    • 84925872286 scopus 로고    scopus 로고
    • CMET in NSCLC: Can we cut off the head of the Hydra? From the pathway to the resistance
    • Van Der Steen N, Pauwels P, Gil-Bazo I, et al. cMET in NSCLC: can we cut off the head of the Hydra? From the pathway to the resistance. Cancers. 2015;7: 556-573.
    • (2015) Cancers , vol.7 , pp. 556-573
    • Van Der Steen, N.1    Pauwels, P.2    Gil-Bazo, I.3
  • 26
    • 0027322529 scopus 로고
    • Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger
    • Graziani A, Gramaglia D, dalla Zonca P, Comoglio PM. Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger. J Biol Chem. 1993;268:9165-9168.
    • (1993) J Biol Chem , vol.268 , pp. 9165-9168
    • Graziani, A.1    Gramaglia, D.2    Dalla, Z.P.3    Comoglio, P.M.4
  • 27
    • 0035793091 scopus 로고    scopus 로고
    • Anti-Apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-Activated protein kinase pathways
    • Xiao GH, Jeffers M, Bellacosa A, Mitsuuchi Y, Vande Woude GF, Testa JR. Anti-Apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-Activated protein kinase pathways. Proc Natl Acad Sci U S A. 2001;98:247-252.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 247-252
    • Xiao, G.H.1    Jeffers, M.2    Bellacosa, A.3    Mitsuuchi, Y.4    Vande, W.G.F.5    Testa, J.R.6
  • 28
    • 0037050212 scopus 로고    scopus 로고
    • Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis
    • Zhang Y-W, Wang L-M, Jove R, Vande Woude GF. Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis. Oncogene. 2002;21:217-226.
    • (2002) Oncogene , vol.21 , pp. 217-226
    • Zhang, Y.-W.1    Wang, L.-M.2    Jove, R.3    Vande, W.G.F.4
  • 29
    • 0036007194 scopus 로고    scopus 로고
    • Activation of NF-kB is essential for hepatocyte growth factor-mediated proliferation and tubulogenesis
    • Müller M, Morotti A, Ponzetto C. Activation of NF-kB is essential for hepatocyte growth factor-mediated proliferation and tubulogenesis. Mol Cell Biol. 2002;22: 1060-1072.
    • (2002) Mol Cell Biol , vol.22 , pp. 1060-1072
    • Müller, M.1    Morotti, A.2    Ponzetto, C.3
  • 30
    • 14944348618 scopus 로고    scopus 로고
    • Role of NF-kappaB signaling in hepatocyte growth factor/scatter factor-mediated cell protection
    • Fan S, Gao M, Meng Q, et al. Role of NF-kappaB signaling in hepatocyte growth factor/scatter factor-mediated cell protection. Oncogene. 2005;24:1749-1766.
    • (2005) Oncogene , vol.24 , pp. 1749-1766
    • Fan, S.1    Gao, M.2    Meng, Q.3
  • 31
    • 0035930341 scopus 로고    scopus 로고
    • Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein
    • Peschard P, Fournier TM, Lamorte L, et al. Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. Mol Cell. 2001;8:995-1004.
    • (2001) Mol Cell , vol.8 , pp. 995-1004
    • Peschard, P.1    Fournier, T.M.2    Lamorte, L.3
  • 32
    • 79958214335 scopus 로고    scopus 로고
    • GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migration
    • Parachoniak CA, Luo Y, Abella JV, Keen JH, Park M. GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migration. Dev Cell. 2011;20:751-763.
    • (2011) Dev Cell , vol.20 , pp. 751-763
    • Parachoniak, C.A.1    Luo, Y.2    Abella, J.V.3    Keen, J.H.4    Park, M.5
  • 33
    • 0027337146 scopus 로고
    • Proteolytic processing of the hepatocyte growth factor/scatter receptor by furin
    • Shibamoto S. Proteolytic processing of the hepatocyte growth factor/scatter receptor by furin. FEBS Lett. 1993;328:25-29.
    • (1993) FEBS Lett , vol.328 , pp. 25-29
    • Shibamoto, S.1
  • 34
    • 3142595278 scopus 로고    scopus 로고
    • Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor
    • Stamos J, Lazarus RA, Yao X, Kirchhofer D, Wiesmann C. Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor. EMBO J. 2004;23:2325-2335.
    • (2004) EMBO J , vol.23 , pp. 2325-2335
    • Stamos, J.1    Lazarus, R.A.2    Yao, X.3    Kirchhofer, D.4    Wiesmann, C.5
  • 35
    • 3142619403 scopus 로고    scopus 로고
    • The Sema domain of Met is necessary for receptor dimerization and activation
    • Kong-Beltran M, Stamos J, Wickramasinghe D. The Sema domain of Met is necessary for receptor dimerization and activation. Cancer Cell. 2004;6:75-84.
    • (2004) Cancer Cell , vol.6 , pp. 75-84
    • Kong-Beltran, M.1    Stamos, J.2    Wickramasinghe, D.3
  • 36
    • 3543004714 scopus 로고    scopus 로고
    • Insights into function of PSI domains from structure of the Met receptor PSI domain
    • Kozlov G, Perreault A, Schrag JD, et al. Insights into function of PSI domains from structure of the Met receptor PSI domain. Biochem Biophys Res Commun. 2004;321:234-240.
    • (2004) Biochem Biophys Res Commun , vol.321 , pp. 234-240
    • Kozlov, G.1    Perreault, A.2    Schrag, J.D.3
  • 37
    • 0242268455 scopus 로고    scopus 로고
    • Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a
    • Schiering N, Knapp S, Marconi M, et al. Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a. Proc Natl Acad Sci U S A. 2003;100:12654-12659.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 12654-12659
    • Schiering, N.1    Knapp, S.2    Marconi, M.3
  • 38
    • 0034693753 scopus 로고    scopus 로고
    • Met receptor tyrosine kinase: Enhanced signaling through adapter proteins
    • Furge KA, Zhang YW, Vande Woude GF. Met receptor tyrosine kinase: Enhanced signaling through adapter proteins. Oncogene. 2000;19:5582-5589.
    • (2000) Oncogene , vol.19 , pp. 5582-5589
    • Furge, K.A.1    Zhang, Y.W.2    Vande, W.G.F.3
  • 39
    • 0030857005 scopus 로고    scopus 로고
    • Functional analysis of the polypyrimidine tract in pre-mRNA splicing
    • Coolidge CJ, Seely RJ, Patton JG. Functional analysis of the polypyrimidine tract in pre-mRNA splicing. Nucleic Acids Res. 1997;25:888-895.
    • (1997) Nucleic Acids Res , vol.25 , pp. 888-895
    • Coolidge, C.J.1    Seely, R.J.2    Patton, J.G.3
  • 40
    • 0030953474 scopus 로고    scopus 로고
    • A minimal spliceosomal complex A recognizes the branch site and polypyrimidine tract
    • Query CC, McCaw PS, Sharp PA. A minimal spliceosomal complex A recognizes the branch site and polypyrimidine tract. Microbiology. 1997;17:2944-2953.
    • (1997) Microbiology , vol.17 , pp. 2944-2953
    • Query, C.C.1    McCaw, P.S.2    Sharp, P.A.3
  • 41
    • 0036948420 scopus 로고    scopus 로고
    • Allosteric cascade of spliceosome activation
    • Brow DA. Allosteric cascade of spliceosome activation. Annu Rev Genet. 2002;36:333-360.
    • (2002) Annu Rev Genet , vol.36 , pp. 333-360
    • Brow, D.A.1
  • 42
    • 0037073946 scopus 로고    scopus 로고
    • Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome
    • Makarov EM, Makarova OV, Urlaub H, et al. Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome. Science. 2002;298: 2205-2208.
    • (2002) Science , vol.298 , pp. 2205-2208
    • Makarov, E.M.1    Makarova, O.V.2    Urlaub, H.3
  • 43
    • 44949246374 scopus 로고    scopus 로고
    • Nought may endure but mutability": Spliceosome dynamics and the regulation of splicing
    • Smith DJ, Query CC, Konarska MM. "Nought may endure but mutability": spliceosome dynamics and the regulation of splicing. Mol Cell. 2008;30:657-666.
    • (2008) Mol Cell , vol.30 , pp. 657-666
    • Smith, D.J.1    Query, C.C.2    Konarska, M.M.3
  • 44
    • 84863255704 scopus 로고    scopus 로고
    • Evolution of SR protein and hnRNP splicing regulatory factors
    • Busch A, Hertel KJ. Evolution of SR protein and hnRNP splicing regulatory factors. Wiley Interdiscip Rev RNA. 2012;3:1-12.
    • (2012) Wiley Interdiscip Rev RNA , vol.3 , pp. 1-12
    • Busch, A.1    Hertel, K.J.2
  • 45
    • 0028878235 scopus 로고
    • Effects of secondary structure on pre-mRNA splicing: Hairpins sequestering the 50 but not the 30 splice site inhibit intron processing in Nicotiana plumbaginifolia
    • Liu HX, Goodall GJ, Kole R, Filipowicz W. Effects of secondary structure on pre-mRNA splicing: hairpins sequestering the 50 but not the 30 splice site inhibit intron processing in Nicotiana plumbaginifolia. EMBO J. 1995;14:377-388.
    • (1995) EMBO J , vol.14 , pp. 377-388
    • Liu, H.X.1    Goodall, G.J.2    Kole, R.3    Filipowicz, W.4
  • 46
    • 10044274340 scopus 로고    scopus 로고
    • Influence of RNA secondary structure on the pre-mRNA splicing process
    • Buratti E, Baralle FE. Influence of RNA secondary structure on the pre-mRNA splicing process. Mol Cell Biol. 2004;24:10505-10514.
    • (2004) Mol Cell Biol , vol.24 , pp. 10505-10514
    • Buratti, E.1    Baralle, F.E.2
  • 47
    • 84885354288 scopus 로고    scopus 로고
    • Aberrant alternative splicing is another hallmark of cancer
    • Ladomery M. Aberrant alternative splicing is another hallmark of cancer. Int J Cell Biol. 2013;2013.
    • (2013) Int J Cell Biol , vol.2013
    • Ladomery, M.1
  • 48
    • 33750712731 scopus 로고    scopus 로고
    • An alternatively spliced form of Met receptor is tumorigenic
    • Lee J-H, Gao CF, Lee CC, Kim MD, Vande Woude GF. An alternatively spliced form of Met receptor is tumorigenic. Exp Mol Med. 2006;38:565-573.
    • (2006) Exp Mol Med , vol.38 , pp. 565-573
    • Lee, J.-H.1    Gao, C.F.2    Lee, C.C.3    Kim, M.D.4    Vande, W.G.F.5
  • 49
    • 0028966171 scopus 로고
    • Alternatively spliced Juxtamembrane domain of a tyrosine kinase receptor is a multifunctional regulatory site
    • Lee C-C, Yamada KM. Alternatively spliced Juxtamembrane domain of a tyrosine kinase receptor is a multifunctional regulatory site. J Biol Chem. 1995;270: 507-510.
    • (1995) J Biol Chem , vol.270 , pp. 507-510
    • Lee, C.-C.1    Yamada, K.M.2
  • 50
    • 31544462584 scopus 로고    scopus 로고
    • Somatic mutations lead to an oncogenic deletion of Met in lung cancer
    • Kong-Beltran M, Seshagiri S, Zha J, et al. Somatic mutations lead to an oncogenic deletion of Met in lung cancer. Cancer Res. 2006;66:283-289.
    • (2006) Cancer Res , vol.66 , pp. 283-289
    • Kong-Beltran, M.1    Seshagiri, S.2    Zha, J.3
  • 51
    • 0033595154 scopus 로고    scopus 로고
    • Loss of the exon encoding the juxtamembrane domain is essential for the oncogenic activation of TPR-MET
    • Vigna E, Gramaglia D, Longati P, Bardelli A, Comoglio PM. Loss of the exon encoding the juxtamembrane domain is essential for the oncogenic activation of TPR-MET. Oncogene. 1999;18:4275-4281.
    • (1999) Oncogene , vol.18 , pp. 4275-4281
    • Vigna, E.1    Gramaglia, D.2    Longati, P.3    Bardelli, A.4    Comoglio, P.M.5
  • 52
    • 84949235040 scopus 로고    scopus 로고
    • MET gene exon 14 deletion created using the CRISPR/Cas9 system enhances cellular growth and sensitivity to a MET inhibitor
    • Togashi Y, Mizuuchi H, Tomida S, et al. MET gene exon 14 deletion created using the CRISPR/Cas9 system enhances cellular growth and sensitivity to a MET inhibitor. Lung Cancer. 2015;90:590-597.
    • (2015) Lung Cancer , vol.90 , pp. 590-597
    • Togashi, Y.1    Mizuuchi, H.2    Tomida, S.3
  • 53
    • 0034641890 scopus 로고    scopus 로고
    • A novel germ line juxtamembrane Met mutation in human gastric cancer
    • Lee JH, Han SU, Cho H, et al. A novel germ line juxtamembrane Met mutation in human gastric cancer. Oncogene. 2000;19:4947-4953.
    • (2000) Oncogene , vol.19 , pp. 4947-4953
    • Lee, J.H.1    Han, S.U.2    Cho, H.3
  • 54
    • 61549138135 scopus 로고    scopus 로고
    • Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers
    • Onozato R, Kosaka T, Kuwano H, Sekido Y, Yatabe Y, Mitsudomi T. Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers. J Thorac Oncol. 2009;4:5-11.
    • (2009) J Thorac Oncol , vol.4 , pp. 5-11
    • Onozato, R.1    Kosaka, T.2    Kuwano, H.3    Sekido, Y.4    Yatabe, Y.5    Mitsudomi, T.6
  • 55
    • 84923256369 scopus 로고    scopus 로고
    • Transcriptome meta-Analysis of lung cancer reveals recurrent aberrations in NRG1 and Hippo pathway genes
    • Dhanasekaran SM, Alejandro Balbin O, Chen G, et al. Transcriptome meta-Analysis of lung cancer reveals recurrent aberrations in NRG1 and Hippo pathway genes. Nat Commun. 2014;5:5893.
    • (2014) Nat Commun , vol.5 , pp. 5893
    • Dhanasekaran, S.M.1    Alejandro, B.O.2    Chen, G.3
  • 56
    • 0032530336 scopus 로고    scopus 로고
    • Structural basis of inhibitor selectivity in MAP kinases
    • Wang Z, Canagarajah BJ, Boehm JC, et al. Structural basis of inhibitor selectivity in MAP kinases. Structure. 1998;6:1117-1128.
    • (1998) Structure , vol.6 , pp. 1117-1128
    • Wang, Z.1    Canagarajah, B.J.2    Boehm, J.C.3
  • 57
    • 0033200390 scopus 로고    scopus 로고
    • Structural basis for selective inhibition of Src family kinases by PP1
    • Liu Y, Bishop A, Witucki L, et al. Structural basis for selective inhibition of Src family kinases by PP1. Chem Biol. 1999;6:671-678.
    • (1999) Chem Biol , vol.6 , pp. 671-678
    • Liu, Y.1    Bishop, A.2    Witucki, L.3
  • 58
    • 80052806086 scopus 로고    scopus 로고
    • Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal à epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK)
    • Cui JJ, Tran-dub M, Shen H, et al. Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal à epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). J Med Chem. 2011;54: 6342-6363.
    • (2011) J Med Chem , vol.54 , pp. 6342-6363
    • Cui, J.J.1    Tran-Dub, M.2    Shen, H.3
  • 59
    • 33144462553 scopus 로고    scopus 로고
    • Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752
    • Smolen GA, Sordella R, Muir B, et al. Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752. Proc Natl Acad Sci U S A. 2006;103: 2316-2321.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 2316-2321
    • Smolen, G.A.1    Sordella, R.2    Muir, B.3
  • 60
    • 84922718090 scopus 로고    scopus 로고
    • Crizotinib in ROS1- rearranged non-small-cell lung cancer
    • Shaw AT, Ou S-HI, Bang Y-J, et al. Crizotinib in ROS1- rearranged non-small-cell lung cancer. N Engl J Med. 2015;372:683-684.
    • (2015) N Engl J Med , vol.372 , pp. 683-684
    • Shaw, A.T.1    Ou, S.-H.I.2    Bang, Y.-J.3
  • 61
    • 79955458487 scopus 로고    scopus 로고
    • Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo METamplification
    • Ou S-HI, Kwak EL, Siwak-Tapp C, et al. Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo METamplification. J Thorac Oncol. 2011;6:942-946.
    • (2011) J Thorac Oncol , vol.6 , pp. 942-946
    • Ou, S.-H.I.1    Kwak, E.L.2    Siwak-Tapp, C.3
  • 62
    • 84891746435 scopus 로고    scopus 로고
    • Major partial response to crizotinib, a dual MET/ALK inhibitor, in a squamous cell lung (SCC) carcinoma patient with de novo c-MET amplification in the absence of ALK rearrangement
    • Schwab R, Petak I, Kollar M, et al. Major partial response to crizotinib, a dual MET/ALK inhibitor, in a squamous cell lung (SCC) carcinoma patient with de novo c-MET amplification in the absence of ALK rearrangement. Lung Cancer. 2014;83:109-111.
    • (2014) Lung Cancer , vol.83 , pp. 109-111
    • Schwab, R.1    Petak, I.2    Kollar, M.3
  • 63
    • 84862908734 scopus 로고    scopus 로고
    • Rapid radiographic and clinical improvement after treatment of a METamplified recurrent glioblastoma with a mesenchymalepithelial transition inhibitor
    • Chi AS, Batchelor TT, Kwak EL, et al. Rapid radiographic and clinical improvement after treatment of a METamplified recurrent glioblastoma with a mesenchymalepithelial transition inhibitor. J Clin Oncol. 2012;30:e30-e33.
    • (2012) J Clin Oncol , vol.30 , pp. e30-e33
    • Chi, A.S.1    Batchelor, T.T.2    Kwak, E.L.3
  • 64
    • 84863786449 scopus 로고    scopus 로고
    • Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF- 02341066) in gastric cancer positive for MET amplification
    • Okamoto W, Okamoto I, Arao T, et al. Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF- 02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012;11:1557-1564.
    • (2012) Mol Cancer Ther , vol.11 , pp. 1557-1564
    • Okamoto, W.1    Okamoto, I.2    Arao, T.3
  • 65
    • 84555190809 scopus 로고    scopus 로고
    • MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib
    • Lennerz JK, Kwak EL, Ackerman A, et al. MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. J Clin Oncol. 2011;29: 4803-4810.
    • (2011) J Clin Oncol , vol.29 , pp. 4803-4810
    • Lennerz, J.K.1    Kwak, E.L.2    Ackerman, A.3
  • 67
    • 81255138189 scopus 로고    scopus 로고
    • A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-Talk with EGFR and HER-3
    • Liu X, Wang Q, Yang G, et al. A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-Talk with EGFR and HER-3. Clin Cancer Res. 2011;17:7127-7138.
    • (2011) Clin Cancer Res , vol.17 , pp. 7127-7138
    • Liu, X.1    Wang, Q.2    Yang, G.3
  • 68
    • 83355166909 scopus 로고    scopus 로고
    • Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth
    • Yakes FM, Chen J, Tan J, et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth. Mol Cancer Ther. 2011;10:2298-2308.
    • (2011) Mol Cancer Ther , vol.10 , pp. 2298-2308
    • Yakes, F.M.1    Chen, J.2    Tan, J.3
  • 69
    • 84969257134 scopus 로고    scopus 로고
    • A novel crizotinibresistant solvent-front mutation responsive to cabozantinib therapy in a patient with ROS1-rearranged lung cancer
    • Drilon A, Somwar R, Wagner JP, et al. A novel crizotinibresistant solvent-front mutation responsive to cabozantinib therapy in a patient with ROS1-rearranged lung cancer. Clin Cancer Res. 2015;10:2351-2358.
    • (2015) Clin Cancer Res , vol.10 , pp. 2351-2358
    • Drilon, A.1    Somwar, R.2    Wagner, J.P.3
  • 70
    • 84878858856 scopus 로고    scopus 로고
    • Response to cabozantinib in patients with RET fusion-positive lung adenocarcinomas
    • Drilon A, Wang L, Hasanovic A, et al. Response to cabozantinib in patients with RET fusion-positive lung adenocarcinomas. Cancer Discov. 2013;3:630-635.
    • (2013) Cancer Discov , vol.3 , pp. 630-635
    • Drilon, A.1    Wang, L.2    Hasanovic, A.3
  • 71
    • 77950556450 scopus 로고    scopus 로고
    • Phase I study of daily administration of MGCD265 to patients with advanced malignancies (study 265-101) [abstract]
    • Kollmannsberger CK, Hurwitz H, Vlahovic G, et al. Phase I study of daily administration of MGCD265 to patients with advanced malignancies (study 265-101) [abstract]. J Clin Oncol. 2009;27(suppl):e14525.
    • (2009) J Clin Oncol , vol.27 , pp. e14525
    • Kollmannsberger, C.K.1    Hurwitz, H.2    Vlahovic, G.3
  • 72
    • 84948656597 scopus 로고    scopus 로고
    • Safety of onartuzumab in patients with solid tumors: Experience to date from the onartuzumab clinical trial program
    • Morley R, Cardenas A, Hawkins P, et al. Safety of onartuzumab in patients with solid tumors: Experience to date from the onartuzumab clinical trial program. PLoS One. 2015;10:e0139679.
    • (2015) PLoS One , vol.10 , pp. e0139679
    • Morley, R.1    Cardenas, A.2    Hawkins, P.3
  • 73
    • 84942844145 scopus 로고    scopus 로고
    • Depleting METexpressing tumor cells by ADCC provides a therapeutic advantage over inhibiting HGF/MET signaling
    • Hultberg A, Morello V, Huyghe L, et al. Depleting METexpressing tumor cells by ADCC provides a therapeutic advantage over inhibiting HGF/MET signaling. Cancer Res. 2015;75:3373-3383.
    • (2015) Cancer Res , vol.75 , pp. 3373-3383
    • Hultberg, A.1    Morello, V.2    Huyghe, L.3
  • 74
    • 84964388926 scopus 로고    scopus 로고
    • MET exon 14 mutations in non-small-cell lung cancer are associated with advanced age and stage-dependent MET genomic amplification and c-met overexpression
    • Awad MM, Oxnard GR, Jackman DM, et al. MET exon 14 mutations in non-small-cell lung cancer are associated with advanced age and stage-dependent MET genomic amplification and c-met overexpression. J Clin Oncol. 2016;34:721-730.
    • (2016) J Clin Oncol , vol.34 , pp. 721-730
    • Awad, M.M.1    Oxnard, G.R.2    Jackman, D.M.3
  • 75
    • 84938222817 scopus 로고    scopus 로고
    • MET mutation associated with responsiveness to crizotinib
    • Waqar SN, Morgensztern D, Sehn J. MET mutation associated with responsiveness to crizotinib. J Thorac Oncol. 2015;10:e29-e31.
    • (2015) J Thorac Oncol , vol.10 , pp. e29-e31
    • Waqar, S.N.1    Morgensztern, D.2    Sehn, J.3
  • 76
  • 77
    • 84947942831 scopus 로고    scopus 로고
    • MET 14 deletion in sarcomatoid non-small-cell lung cancer detected by next-generation sequencing and successfully treated with a MET inhibitor
    • Lee C, Usenko D, Frampton GM, McMahon C, Ali SM, Weiss J. MET 14 deletion in sarcomatoid non-small-cell lung cancer detected by next-generation sequencing and successfully treated with a MET inhibitor. J Thorac Oncol. 2015;10:e113-e114.
    • (2015) J Thorac Oncol , vol.10 , pp. e113-e114
    • Lee, C.1    Usenko, D.2    Frampton, G.M.3    McMahon, C.4    Ali, S.M.5    Weiss, J.6
  • 78
    • 84887111018 scopus 로고    scopus 로고
    • Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in EGFR-mutant non-small cell lung cancer: A new era begins
    • Remon J, Morán T, Majem M, et al. Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in EGFR-mutant non-small cell lung cancer: A new era begins. Cancer Treat Rev. 2014;40:93-101.
    • (2014) Cancer Treat Rev , vol.40 , pp. 93-101
    • Remon, J.1    Morán, T.2    Majem, M.3
  • 79
    • 84962074480 scopus 로고    scopus 로고
    • Non-small cell lung cancer cells acquire resistance to the ALK inhibitor alectinib by activating alternative receptor tyrosine kinases
    • Isozaki H, Ichihara E, Takigawa N, et al. Non-small cell lung cancer cells acquire resistance to the ALK inhibitor alectinib by activating alternative receptor tyrosine kinases. Cancer Res. 2015;76:1506-1516.
    • (2015) Cancer Res , vol.76 , pp. 1506-1516
    • Isozaki, H.1    Ichihara, E.2    Takigawa, N.3
  • 81
    • 84942933342 scopus 로고    scopus 로고
    • Mechanism of resistance and novel targets mediating resistance to EGFR and c-Met tyrosine kinase inhibitors in non-small cell lung cancer
    • Botting GM, Rastogi I, Chhabra G, Nlend M, Puri N. Mechanism of resistance and novel targets mediating resistance to EGFR and c-Met tyrosine kinase inhibitors in non-small cell lung cancer. PLoS One. 2015;10:1-17.
    • (2015) PLoS One , vol.10 , pp. 1-17
    • Botting, G.M.1    Rastogi, I.2    Chhabra, G.3    Nlend, M.4    Puri, N.5
  • 82
    • 84940021977 scopus 로고    scopus 로고
    • Overexpression of FGFR2 contributes to inherent resistance to MET inhibitors in MET-Amplified patient-derived gastric cancer xenografts
    • Liu K, Song X, Zhu M, Ma H. Overexpression of FGFR2 contributes to inherent resistance to MET inhibitors in MET-Amplified patient-derived gastric cancer xenografts. Oncol Lett. 2015;10:2003-2008.
    • (2015) Oncol Lett , vol.10 , pp. 2003-2008
    • Liu, K.1    Song, X.2    Zhu, M.3    Ma, H.4
  • 83
    • 84921390342 scopus 로고    scopus 로고
    • Truncated RAF kinases drive resistance to MET inhibition in MET-Addicted cancer cells
    • Petti C, Picco G, Martelli ML, et al. Truncated RAF kinases drive resistance to MET inhibition in MET-Addicted cancer cells. Oncotarget. 2015;6:221-233.
    • (2015) Oncotarget , vol.6 , pp. 221-233
    • Petti, C.1    Picco, G.2    Martelli, M.L.3
  • 84
    • 23844490782 scopus 로고    scopus 로고
    • Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-Treated chemorefractory lung adenocarcinomas
    • Taron M, Ichinose Y, Rosell R, et al. Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-Treated chemorefractory lung adenocarcinomas. Clin Cancer Res. 2005;11:5878-5885.
    • (2005) Clin Cancer Res , vol.11 , pp. 5878-5885
    • Taron, M.1    Ichinose, Y.2    Rosell, R.3
  • 85
    • 80053386829 scopus 로고    scopus 로고
    • Effect of crizotinib on overall survival in patients with advanced non-smallcell lung cancer harbouring ALK gene rearrangement: A retrospective analysis
    • Shaw AT, Yeap BY, Solomon BJ, et al. Effect of crizotinib on overall survival in patients with advanced non-smallcell lung cancer harbouring ALK gene rearrangement: A retrospective analysis. Lancet Oncol. 2011;12: 1004-1012.
    • (2011) Lancet Oncol , vol.12 , pp. 1004-1012
    • Shaw, A.T.1    Yeap, B.Y.2    Solomon, B.J.3
  • 86
    • 84858335323 scopus 로고    scopus 로고
    • C-MET/phospho-MET protein expression and MET gene copy number in nonsmall cell lung carcinomas
    • Tsuta K, Kozu Y, Mimae T, et al. c-MET/phospho-MET protein expression and MET gene copy number in nonsmall cell lung carcinomas. J Thorac Oncol. 2012;7: 331-339.
    • (2012) J Thorac Oncol , vol.7 , pp. 331-339
    • Tsuta, K.1    Kozu, Y.2    Mimae, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.