Diosmin reduces cerebral Aβ levels, tau hyperphosphorylation, neuroinflammation, and cognitive impairment in the 3xTg-AD mice

Journal of Neuroimmunology

Volumn 299, Issue , 2016, Pages 98-106

  Sawmiller, Darrell ^a,b   Habib, Ahsan ^a   Li, Song ^a,c   Darlington, Donna ^a   Hou, Huayan ^a   Tian, Jun ^a   Shytle, R Douglas ^a   Smith, Adam ^a   Giunta, Brian ^a   Mori, Takashi ^d   Tan, Jun ^a,b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c DALIAN MEDICAL UNIVERSITY   (China)

^d SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Alzheimer's disease; A ; Diosmin; GSK 3; Neuroinflammation; Tau; Secretase

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; CD40 ANTIGEN; DIOSMETIN; DIOSMIN; GAMMA SECRETASE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3BETA; INTERLEUKIN 12; NOTCH RECEPTOR; TAU PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; TUMOR NECROSIS FACTOR;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BRAIN CORTEX; BRAIN LEVEL; CELL ACTIVATION; COGNITIVE DEFECT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; EMBRYO; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEMALE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; IN VITRO STUDY; MALE; MICROGLIA; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN HYPERPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN SECRETION; SEX DIFFERENCE; 129 MOUSE; ANIMAL; ANTAGONISTS AND INHIBITORS; CHO CELL LINE; COGNITIVE DYSFUNCTION; CRICETULUS; DRUG EFFECTS; HAMSTER; HELA CELL LINE; HUMAN; INFLAMMATION; METABOLISM; NEWBORN; PHOSPHORYLATION; PHYSIOLOGY; TRANSGENIC MOUSE;

AMYLOID BETA-PEPTIDES; ANIMALS; ANIMALS, NEWBORN; CEREBRAL CORTEX; CHO CELLS; COGNITIVE DYSFUNCTION; CRICETINAE; CRICETULUS; DIOSMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HELA CELLS; HUMANS; INFLAMMATION; MALE; MICE; MICE, 129 STRAIN; MICE, TRANSGENIC; PHOSPHORYLATION; TAU PROTEINS;

EID: 84987784935     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2016.08.018     Document Type: Article

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