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Volumn 2, Issue OCT, 2014, Pages

Therapeutic antisense oligonucleotides against cancer: Hurdling to the clinic

Author keywords

Antisense; Cancer; Nanomedicine; Oligonucleotides; Therapeutics

Indexed keywords


EID: 84987630012     PISSN: None     EISSN: 22962646     Source Type: Journal    
DOI: 10.3389/fchem.2014.00087     Document Type: Article
Times cited : (99)

References (73)
  • 2
    • 0028850751 scopus 로고
    • Pharmacokinetics of antisense oligonucleotides
    • Agrawal, S., Temsamani, J., Galbraith, W., and Tang, J. (1995). Pharmacokinetics of antisense oligonucleotides. Clin. Pharmacokinet. 28, 7-16. doi: 10.2165/00003088-199528010-00002
    • (1995) Clin. Pharmacokinet , vol.28 , pp. 7-16
    • Agrawal, S.1    Temsamani, J.2    Galbraith, W.3    Tang, J.4
  • 3
    • 77956274546 scopus 로고    scopus 로고
    • Toxicity and cellular uptake of gold nanoparticles: what we have learned so far?
    • Alkilany, A. M., and Murphy, C. J. (2010). Toxicity and cellular uptake of gold nanoparticles: what we have learned so far? J. Nanopart. Res. 12, 2313-2333. doi: 10.1007/s11051-010-9911-8
    • (2010) J. Nanopart. Res , vol.12 , pp. 2313-2333
    • Alkilany, A.M.1    Murphy, C.J.2
  • 4
    • 23044452536 scopus 로고    scopus 로고
    • Phase II study of G3139, a Bcl-2 antisense oligonucleotide, in combination with dexamethasone and thalidomide in relapsed multiple myeloma patients
    • Badros, A. Z., Goloubeva, O., Rapoport, A. P., Ratterree, B., Gahres, N., Meisenberg, B., et al. (2005). Phase II study of G3139, a Bcl-2 antisense oligonucleotide, in combination with dexamethasone and thalidomide in relapsed multiple myeloma patients. J. Clin. Oncol. 23, 4089-4099. doi: 10.1200/JCO.2005.14.381
    • (2005) J. Clin. Oncol , vol.23 , pp. 4089-4099
    • Badros, A.Z.1    Goloubeva, O.2    Rapoport, A.P.3    Ratterree, B.4    Gahres, N.5    Meisenberg, B.6
  • 5
    • 48549097394 scopus 로고    scopus 로고
    • Accessing the therapeutic potential of immunostimulatory nucleic acids
    • Barchet, W., Wimmenauer, V., Schlee, M., and Hartmann, G. (2008). Accessing the therapeutic potential of immunostimulatory nucleic acids. Curr. Opin. Immunol. 20, 389-395. doi: 10.1016/j.coi.2008.07.007
    • (2008) Curr. Opin. Immunol , vol.20 , pp. 389-395
    • Barchet, W.1    Wimmenauer, V.2    Schlee, M.3    Hartmann, G.4
  • 6
    • 77949512140 scopus 로고    scopus 로고
    • RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform
    • Bennett, C. F., and Swayze, E. E. (2010). RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform. Annu. Rev. Pharmacol. Toxicol. 50, 259-293. doi: 10.1146/annurev.pharmtox.010909.105654
    • (2010) Annu. Rev. Pharmacol. Toxicol , vol.50 , pp. 259-293
    • Bennett, C.F.1    Swayze, E.E.2
  • 7
    • 0032524080 scopus 로고    scopus 로고
    • Crystal structures of B-DNA with incorporated 2'-deoxy-2'-fluoro-arabino-furanosyl thymines: implications of conformational preorganization for duplex stability
    • Berger, I., Tereshko, V., Ikeda, H., Marquez, V. E., and Egli, M. (1998). Crystal structures of B-DNA with incorporated 2'-deoxy-2'-fluoro-arabino-furanosyl thymines: implications of conformational preorganization for duplex stability. Nucleic Acids Res. 26, 2473-2480. doi: 10.1093/nar/26.10.2473
    • (1998) Nucleic Acids Res , vol.26 , pp. 2473-2480
    • Berger, I.1    Tereshko, V.2    Ikeda, H.3    Marquez, V.E.4    Egli, M.5
  • 8
    • 84907008349 scopus 로고    scopus 로고
    • Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model
    • Bestas, B., Moreno, P. M., Blomberg, K. E., Mohammad, D. K., Saleh, A. F., Sutlu, T., et al. (2014). Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model. J. Clin. Invest. 124, 4067-4081. doi: 10.1172/JCI76175
    • (2014) J. Clin. Invest , vol.124 , pp. 4067-4081
    • Bestas, B.1    Moreno, P.M.2    Blomberg, K.E.3    Mohammad, D.K.4    Saleh, A.F.5    Sutlu, T.6
  • 9
    • 0028114548 scopus 로고
    • Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding
    • Brown, D. A., Kang, S. H., Gryaznov, S. M., Dedionisio, L., Heidenreich, O., Sullivan, S., et al. (1994). Effect of phosphorothioate modification of oligodeoxynucleotides on specific protein binding. J. Biol. Chem. 269, 26801-26805.
    • (1994) J. Biol. Chem , vol.269 , pp. 26801-26805
    • Brown, D.A.1    Kang, S.H.2    Gryaznov, S.M.3    Dedionisio, L.4    Heidenreich, O.5    Sullivan, S.6
  • 10
    • 79959393938 scopus 로고    scopus 로고
    • Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies
    • Chauhan, V. P., Stylianopoulos, T., Boucher, Y., and Jain, R. K. (2011). Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies. Annu. Rev. Chem. Biomol. Eng. 2, 281-298. doi: 10.1146/annurev-chembioeng-061010-114300
    • (2011) Annu. Rev. Chem. Biomol. Eng , vol.2 , pp. 281-298
    • Chauhan, V.P.1    Stylianopoulos, T.2    Boucher, Y.3    Jain, R.K.4
  • 11
    • 84863655863 scopus 로고    scopus 로고
    • Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner
    • Chauhan, V. P., Stylianopoulos, T., Martin, J. D., Popovic, Z., Chen, O., Kamoun, W. S., et al. (2012). Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner. Nat. Nanotechnol. 7, 383-388. doi: 10.1038/nnano.2012.45
    • (2012) Nat. Nanotechnol , vol.7 , pp. 383-388
    • Chauhan, V.P.1    Stylianopoulos, T.2    Martin, J.D.3    Popovic, Z.4    Chen, O.5    Kamoun, W.S.6
  • 13
    • 0030943935 scopus 로고    scopus 로고
    • Comparative pharmacokinetics, tissue distribution, and tumor accumulation of phosphorothioate, phosphorodithioate, and methylphosphonate oligonucleotides in nude mice
    • Delong, R. K., Nolting, A., Fisher, M., Chen, Q., Wickstrom, E., Kligshteyn, M., et al. (1997). Comparative pharmacokinetics, tissue distribution, and tumor accumulation of phosphorothioate, phosphorodithioate, and methylphosphonate oligonucleotides in nude mice. Antisense Nucleic Acid Drug Dev. 7, 71-77. doi: 10.1089/oli.1.1997.7.71
    • (1997) Antisense Nucleic Acid Drug Dev , vol.7 , pp. 71-77
    • Delong, R.K.1    Nolting, A.2    Fisher, M.3    Chen, Q.4    Wickstrom, E.5    Kligshteyn, M.6
  • 14
    • 18844429452 scopus 로고    scopus 로고
    • In vivo bioavailability and pharmacokinetics of a c-MYC antisense phosphorodiamidate morpholino oligomer, AVI-4126, in solid tumors
    • Devi, G. R., Beer, T. M., Corless, C. L., Arora, V., Weller, D. L., and Iversen, P. L. (2005). In vivo bioavailability and pharmacokinetics of a c-MYC antisense phosphorodiamidate morpholino oligomer, AVI-4126, in solid tumors. Clin. Cancer Res. 11, 3930-3938. doi: 10.1158/1078-0432.CCR-04-2091
    • (2005) Clin. Cancer Res , vol.11 , pp. 3930-3938
    • Devi, G.R.1    Beer, T.M.2    Corless, C.L.3    Arora, V.4    Weller, D.L.5    Iversen, P.L.6
  • 15
    • 84902179753 scopus 로고    scopus 로고
    • Gold nanoparticles for nucleic acid delivery
    • Ding, Y., Jiang, Z., Saha, K., Kim, C. S., Kim, S. T., Landis, R. F., et al. (2014). Gold nanoparticles for nucleic acid delivery. Mol. Ther. 22, 1075-1083. doi: 10.1038/mt.2014.30
    • (2014) Mol. Ther , vol.22 , pp. 1075-1083
    • Ding, Y.1    Jiang, Z.2    Saha, K.3    Kim, C.S.4    Kim, S.T.5    Landis, R.F.6
  • 16
    • 84877908608 scopus 로고    scopus 로고
    • Influence of diverse chemical modifications on the ADME characteristics and toxicology of antisense oligonucleotides
    • Dirin, M., and Winkler, J. (2013). Influence of diverse chemical modifications on the ADME characteristics and toxicology of antisense oligonucleotides. Expert Opin. Biol. Ther. 13, 875-888. doi: 10.1517/14712598.2013.774366
    • (2013) Expert Opin. Biol. Ther , vol.13 , pp. 875-888
    • Dirin, M.1    Winkler, J.2
  • 17
    • 84904412647 scopus 로고    scopus 로고
    • Development of therapeutic splice-switching oligonucleotides
    • Disterer, P., Kryczka, A., Liu, Y., Badi, Y. E., Wong, J. J., Owen, J. S., et al. (2014). Development of therapeutic splice-switching oligonucleotides. Hum. Gene Ther. 25, 587-598. doi: 10.1089/hum.2013.234
    • (2014) Hum. Gene Ther , vol.25 , pp. 587-598
    • Disterer, P.1    Kryczka, A.2    Liu, Y.3    Badi, Y.E.4    Wong, J.J.5    Owen, J.S.6
  • 18
    • 0001900381 scopus 로고
    • A dinucleoside phosphorothioate
    • Eckstein, F. (1967). A dinucleoside phosphorothioate. Tetrahedron Lett. 8, 1157-1160. doi: 10.1016/S0040-4039(00)90656-7
    • (1967) Tetrahedron Lett , vol.8 , pp. 1157-1160
    • Eckstein, F.1
  • 19
    • 79953054576 scopus 로고    scopus 로고
    • The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect
    • Fang, J., Nakamura, H., and Maeda, H. (2011). The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Adv. Drug Deliv. Rev. 63, 136-151. doi: 10.1016/j.addr.2010.04.009
    • (2011) Adv. Drug Deliv. Rev , vol.63 , pp. 136-151
    • Fang, J.1    Nakamura, H.2    Maeda, H.3
  • 20
    • 67649271530 scopus 로고    scopus 로고
    • Antisense oligonucleotide pharmacokinetics and metabolism
    • Geary, R. S. (2009). Antisense oligonucleotide pharmacokinetics and metabolism. Expert Opin. Drug Metab. Toxicol. 5, 381-391. doi: 10.1517/17425250902877680
    • (2009) Expert Opin. Drug Metab. Toxicol , vol.5 , pp. 381-391
    • Geary, R.S.1
  • 21
    • 33645822110 scopus 로고    scopus 로고
    • G3139 and other CpG-containing immunostimulatory phosphorothioate oligodeoxynucleotides are potent suppressors of the growth of human tumor xenografts in nude mice
    • Gekeler, V., Gimmnich, P., Hofmann, H. P., Grebe, C., Rommele, M., Leja, A., et al. (2006). G3139 and other CpG-containing immunostimulatory phosphorothioate oligodeoxynucleotides are potent suppressors of the growth of human tumor xenografts in nude mice. Oligonucleotides 16, 83-93. doi: 10.1089/oli.2006.16.83
    • (2006) Oligonucleotides , vol.16 , pp. 83-93
    • Gekeler, V.1    Gimmnich, P.2    Hofmann, H.P.3    Grebe, C.4    Rommele, M.5    Leja, A.6
  • 22
    • 0036848796 scopus 로고    scopus 로고
    • Pharmacokinetics, toxicity, and efficacy of ends-modified raf antisense oligodeoxyribonucleotide encapsulated in a novel cationic liposome
    • Gokhale, P. C., Zhang, C., Newsome, J. T., Pei, J., Ahmad, I., Rahman, A., et al. (2002). Pharmacokinetics, toxicity, and efficacy of ends-modified raf antisense oligodeoxyribonucleotide encapsulated in a novel cationic liposome. Clin. Cancer Res. 8, 3611-3621.
    • (2002) Clin. Cancer Res , vol.8 , pp. 3611-3621
    • Gokhale, P.C.1    Zhang, C.2    Newsome, J.T.3    Pei, J.4    Ahmad, I.5    Rahman, A.6
  • 24
    • 0031821074 scopus 로고    scopus 로고
    • In vivo distribution and metabolism of a phosphorothioate oligonucleotide within rat liver after intravenous administration
    • Graham, M. J., Crooke, S. T., Monteith, D. K., Cooper, S. R., Lemonidis, K. M., Stecker, K. K., et al. (1998). In vivo distribution and metabolism of a phosphorothioate oligonucleotide within rat liver after intravenous administration. J. Pharmacol. Exp. Ther. 286, 447-458.
    • (1998) J. Pharmacol. Exp. Ther , vol.286 , pp. 447-458
    • Graham, M.J.1    Crooke, S.T.2    Monteith, D.K.3    Cooper, S.R.4    Lemonidis, K.M.5    Stecker, K.K.6
  • 25
    • 79955093434 scopus 로고    scopus 로고
    • Genetic therapies for RNA mis-splicing diseases
    • Hammond, S. M., and Wood, M. J. (2011). Genetic therapies for RNA mis-splicing diseases. Trends Genet. 27, 196-205. doi: 10.1016/j.tig.2011.02.004
    • (2011) Trends Genet , vol.27 , pp. 196-205
    • Hammond, S.M.1    Wood, M.J.2
  • 26
    • 0033045917 scopus 로고    scopus 로고
    • Correlation of toxicity and pharmacokinetic properties of a phosphorothioate oligonucleotide designed to inhibit ICAM-1
    • Henry, S. P., Templin, M. V., Gillett, N., Rojko, J., and Levin, A. A. (1999). Correlation of toxicity and pharmacokinetic properties of a phosphorothioate oligonucleotide designed to inhibit ICAM-1. Toxicol. Pathol. 27, 95-100. doi: 10.1177/019262339902700117
    • (1999) Toxicol. Pathol , vol.27 , pp. 95-100
    • Henry, S.P.1    Templin, M.V.2    Gillett, N.3    Rojko, J.4    Levin, A.A.5
  • 28
    • 80054114844 scopus 로고    scopus 로고
    • A phase 1 dose escalation, pharmacokinetic, and pharmacodynamic evaluation of eIF-4E antisense oligonucleotide LY2275796 in patients with advanced cancer
    • Hong, D. S., Kurzrock, R., Oh, Y., Wheler, J., Naing, A., Brail, L., et al. (2011). A phase 1 dose escalation, pharmacokinetic, and pharmacodynamic evaluation of eIF-4E antisense oligonucleotide LY2275796 in patients with advanced cancer. Clin. Cancer Res. 17, 6582-6591. doi: 10.1158/1078-0432.CCR-11-0430
    • (2011) Clin. Cancer Res , vol.17 , pp. 6582-6591
    • Hong, D.S.1    Kurzrock, R.2    Oh, Y.3    Wheler, J.4    Naing, A.5    Brail, L.6
  • 29
    • 84878955971 scopus 로고    scopus 로고
    • Efficacy and safety of mipomersen sodium (Kynamro)
    • Hovingh, K., Besseling, J., and Kastelein, J. (2013). Efficacy and safety of mipomersen sodium (Kynamro). Expert Opin. Drug Saf. 12, 569-579. doi: 10.1517/14740338.2013.793670
    • (2013) Expert Opin. Drug Saf , vol.12 , pp. 569-579
    • Hovingh, K.1    Besseling, J.2    Kastelein, J.3
  • 30
    • 17144436717 scopus 로고
    • Pharmacology and toxicology of phosphorothioate oligonucleotides in the mouse, rat, monkey and man
    • Iversen, P. L., Copple, B. L., and Tewary, H. K. (1995). Pharmacology and toxicology of phosphorothioate oligonucleotides in the mouse, rat, monkey and man. Toxicol. Lett. 82-83, 425-430. doi: 10.1016/0378-4274(95)03572-9
    • (1995) Toxicol. Lett , vol.82-83 , pp. 425-430
    • Iversen, P.L.1    Copple, B.L.2    Tewary, H.K.3
  • 31
    • 0342748741 scopus 로고    scopus 로고
    • A lipid carrier with a membrane active component and a small complex size are required for efficient cellular delivery of anti-sense phosphorothioate oligonucleotides
    • Jaaskelainen, I., Peltola, S., Honkakoski, P., Monkkonen, J., and Urtti, A. (2000). A lipid carrier with a membrane active component and a small complex size are required for efficient cellular delivery of anti-sense phosphorothioate oligonucleotides. Eur. J. Pharm. Sci. 10, 187-193. doi: 10.1016/S0928-0987(00)00068-3
    • (2000) Eur. J. Pharm. Sci , vol.10 , pp. 187-193
    • Jaaskelainen, I.1    Peltola, S.2    Honkakoski, P.3    Monkkonen, J.4    Urtti, A.5
  • 32
    • 84870240636 scopus 로고    scopus 로고
    • Delivery of molecular and cellular medicine to solid tumors
    • Jain, R. K. (2012). Delivery of molecular and cellular medicine to solid tumors. Adv. Drug Deliv. Rev. 64, 353-365. doi: 10.1016/j.addr.2012.09.011
    • (2012) Adv. Drug Deliv. Rev , vol.64 , pp. 353-365
    • Jain, R.K.1
  • 33
    • 0141790758 scopus 로고    scopus 로고
    • Drug delivery and transport to solid tumors
    • Jang, S. H., Wientjes, M. G., Lu, D., and Au, J. L. (2003). Drug delivery and transport to solid tumors. Pharm. Res. 20, 1337-1350. doi: 10.1023/A:1025785505977
    • (2003) Pharm. Res , vol.20 , pp. 1337-1350
    • Jang, S.H.1    Wientjes, M.G.2    Lu, D.3    Au, J.L.4
  • 34
    • 67249122712 scopus 로고    scopus 로고
    • Biological barriers to therapy with antisense and siRNA oligonucleotides
    • Juliano, R., Bauman, J., Kang, H., and Ming, X. (2009). Biological barriers to therapy with antisense and siRNA oligonucleotides. Mol. Pharm. 6, 686-695. doi: 10.1021/mp900093r
    • (2009) Mol. Pharm , vol.6 , pp. 686-695
    • Juliano, R.1    Bauman, J.2    Kang, H.3    Ming, X.4
  • 35
    • 84860707063 scopus 로고    scopus 로고
    • The chemistry and biology of oligonucleotide conjugates
    • Juliano, R. L., Ming, X., and Nakagawa, O. (2012). The chemistry and biology of oligonucleotide conjugates. Acc. Chem. Res. 45, 1067-1076. doi: 10.1021/ar2002123
    • (2012) Acc. Chem. Res , vol.45 , pp. 1067-1076
    • Juliano, R.L.1    Ming, X.2    Nakagawa, O.3
  • 36
    • 0026524798 scopus 로고
    • Conformational rigidity of specific pyrimidine residues in tRNA arises from posttranscriptional modifications that enhance steric interaction between the base and the 2'-hydroxyl group
    • Kawai, G., Yamamoto, Y., Kamimura, T., Masegi, T., Sekine, M., Hata, T., et al. (1992). Conformational rigidity of specific pyrimidine residues in tRNA arises from posttranscriptional modifications that enhance steric interaction between the base and the 2'-hydroxyl group. Biochemistry 31, 1040-1046. doi: 10.1021/bi00119a012
    • (1992) Biochemistry , vol.31 , pp. 1040-1046
    • Kawai, G.1    Yamamoto, Y.2    Kamimura, T.3    Masegi, T.4    Sekine, M.5    Hata, T.6
  • 37
    • 0025811531 scopus 로고
    • Duplex stabilities of phosphorothioate, methylphosphonate, and RNA analogs of two DNA 14-mers
    • Kibler-Herzog, L., Zon, G., Uznanski, B., Whittier, G., and Wilson, W. D. (1991). Duplex stabilities of phosphorothioate, methylphosphonate, and RNA analogs of two DNA 14-mers. Nucleic Acids Res. 19, 2979-2986. doi: 10.1093/nar/19.11.2979
    • (1991) Nucleic Acids Res , vol.19 , pp. 2979-2986
    • Kibler-Herzog, L.1    Zon, G.2    Uznanski, B.3    Whittier, G.4    Wilson, W.D.5
  • 38
    • 0032473890 scopus 로고    scopus 로고
    • LNA (Locked Nucleic Acids): synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition
    • Koshkin, A. A., Singh, S. K., Nielsen, P., Rajwanshi, V. K., Kumar, R., Meldgaard, M., et al. (1998). LNA (Locked Nucleic Acids): synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition. Tetrahedron 54, 3607-3630. doi: 10.1016/S0040-4020(98)00094-5
    • (1998) Tetrahedron , vol.54 , pp. 3607-3630
    • Koshkin, A.A.1    Singh, S.K.2    Nielsen, P.3    Rajwanshi, V.K.4    Kumar, R.5    Meldgaard, M.6
  • 39
    • 1542303755 scopus 로고    scopus 로고
    • P-chirality-dependent immune activation by phosphorothioate CpG oligodeoxynucleotides
    • Krieg, A. M., Guga, P., and Stec, W. (2003). P-chirality-dependent immune activation by phosphorothioate CpG oligodeoxynucleotides. Oligonucleotides 13, 491-499. doi: 10.1089/154545703322860807
    • (2003) Oligonucleotides , vol.13 , pp. 491-499
    • Krieg, A.M.1    Guga, P.2    Stec, W.3
  • 40
    • 0029565353 scopus 로고
    • Phosphorothioate oligodeoxynucleotides: antisense or anti-protein?
    • Krieg, A. M., and Stein, C. A. (1995). Phosphorothioate oligodeoxynucleotides: antisense or anti-protein? Antisense Res. Dev. 5, 241.
    • (1995) Antisense Res. Dev , vol.5 , pp. 241
    • Krieg, A.M.1    Stein, C.A.2
  • 41
    • 0032750621 scopus 로고    scopus 로고
    • 2'-carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation
    • Manoharan, M. (1999). 2'-carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation. Biochim. Biophys. Acta 1489, 117-130. doi: 10.1016/S0167-4781(99)00138-4
    • (1999) Biochim. Biophys. Acta , vol.1489 , pp. 117-130
    • Manoharan, M.1
  • 42
    • 0035915492 scopus 로고    scopus 로고
    • Oligonucleotide lipoplexes: the influence of oligonucleotide composition on complexation
    • Meidan, V. M., Glezer, J., Amariglio, N., Cohen, J. S., and Barenholz, Y. (2001). Oligonucleotide lipoplexes: the influence of oligonucleotide composition on complexation. Biochim. Biophys. Acta 1568, 177-182. doi: 10.1016/S0304-4165(01)00216-1
    • (2001) Biochim. Biophys. Acta , vol.1568 , pp. 177-182
    • Meidan, V.M.1    Glezer, J.2    Amariglio, N.3    Cohen, J.S.4    Barenholz, Y.5
  • 43
    • 0023057552 scopus 로고
    • The use of single-stranded DNA and RNase H to promote quantitative "hybrid arrest of translation" of mRNA/DNA hybrids in reticulocyte lysate cell-free translations
    • Minshull, J., and Hunt, T. (1986). The use of single-stranded DNA and RNase H to promote quantitative "hybrid arrest of translation" of mRNA/DNA hybrids in reticulocyte lysate cell-free translations. Nucleic Acids Res. 14, 6433-6451. doi: 10.1093/nar/14.16.6433
    • (1986) Nucleic Acids Res , vol.14 , pp. 6433-6451
    • Minshull, J.1    Hunt, T.2
  • 44
    • 35348909784 scopus 로고    scopus 로고
    • Imaging and modulating antisense microdistribution in solid human xenograft tumor models
    • Mocanu, J. D., Yip, K. W., Skliarenko, J., Shi, W., Busson, P., Lo, K. W., et al. (2007). Imaging and modulating antisense microdistribution in solid human xenograft tumor models. Clin. Cancer Res. 13, 5935-5941. doi: 10.1158/1078-0432.CCR-06-3085
    • (2007) Clin. Cancer Res , vol.13 , pp. 5935-5941
    • Mocanu, J.D.1    Yip, K.W.2    Skliarenko, J.3    Shi, W.4    Busson, P.5    Lo, K.W.6
  • 45
    • 0027168725 scopus 로고
    • Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression
    • Monia, B. P., Lesnik, E. A., Gonzalez, C., Lima, W. F., McGee, D., Guinosso, C. J., et al. (1993). Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression. J. Biol. Chem. 268, 14514-14522.
    • (1993) J. Biol. Chem , vol.268 , pp. 14514-14522
    • Monia, B.P.1    Lesnik, E.A.2    Gonzalez, C.3    Lima, W.F.4    McGee, D.5    Guinosso, C.J.6
  • 46
    • 0035916244 scopus 로고    scopus 로고
    • Ff gene 5 protein has a high binding affinity for single-stranded phosphorothioate DNA
    • Mou, T. C., Gray, C. W., Terwilliger, T. C., and Gray, D. M. (2001). Ff gene 5 protein has a high binding affinity for single-stranded phosphorothioate DNA. Biochemistry 40, 2267-2275. doi: 10.1021/bi002136f
    • (2001) Biochemistry , vol.40 , pp. 2267-2275
    • Mou, T.C.1    Gray, C.W.2    Terwilliger, T.C.3    Gray, D.M.4
  • 48
    • 0034193258 scopus 로고    scopus 로고
    • Role of extracellular matrix assembly in interstitial transport in solid tumors
    • Netti, P. A., Berk, D. A., Swartz, M. A., Grodzinsky, A. J., and Jain, R. K. (2000). Role of extracellular matrix assembly in interstitial transport in solid tumors. Cancer Res. 60, 2497-2503.
    • (2000) Cancer Res , vol.60 , pp. 2497-2503
    • Netti, P.A.1    Berk, D.A.2    Swartz, M.A.3    Grodzinsky, A.J.4    Jain, R.K.5
  • 49
    • 0026341239 scopus 로고
    • Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide
    • Nielsen, P. E., Egholm, M., Berg, R. H., and Buchardt, O. (1991). Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide. Science 254, 1497-1500. doi: 10.1126/science.1962210
    • (1991) Science , vol.254 , pp. 1497-1500
    • Nielsen, P.E.1    Egholm, M.2    Berg, R.H.3    Buchardt, O.4
  • 50
    • 0031016975 scopus 로고    scopus 로고
    • Solution structure of an RNA.2'-O-methylated RNA hybrid duplex containing an RNA.DNA hybrid segment at the center
    • Nishizaki, T., Iwai, S., Ohtsuka, E., and Nakamura, H. (1997). Solution structure of an RNA.2'-O-methylated RNA hybrid duplex containing an RNA.DNA hybrid segment at the center. Biochemistry 36, 2577-2585. doi: 10.1021/bi962297c
    • (1997) Biochemistry , vol.36 , pp. 2577-2585
    • Nishizaki, T.1    Iwai, S.2    Ohtsuka, E.3    Nakamura, H.4
  • 51
    • 0032560835 scopus 로고    scopus 로고
    • Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2'-O, 4'-C-methyleneribonucleosides
    • Obika, S., Nanbu, D., Hari, Y., Andoh, J.-I., Morio, K.-I., Doi, T., et al. (1998). Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2'-O, 4'-C-methyleneribonucleosides. Tetrahedron Lett. 39, 5401-5404. doi: 10.1016/S0040-4039(98)01084-3
    • (1998) Tetrahedron Lett , vol.39 , pp. 5401-5404
    • Obika, S.1    Nanbu, D.2    Hari, Y.3    Andoh, J.-I.4    Morio, K.-I.5    Doi, T.6
  • 52
    • 79955419204 scopus 로고    scopus 로고
    • Unlocked nucleic acid-an RNA modification with broad potential
    • Pasternak, A., and Wengel, J. (2011). Unlocked nucleic acid-an RNA modification with broad potential. Org. Biomol. Chem. 9, 3591-3597. doi: 10.1039/c0ob01085e
    • (2011) Org. Biomol. Chem , vol.9 , pp. 3591-3597
    • Pasternak, A.1    Wengel, J.2
  • 53
    • 0029034897 scopus 로고
    • Cell and tissue distribution of synthetic oligonucleotides in healthy and tumor-bearing nude mice. An autoradiographic, immunohistological, and direct fluorescence microscopy study
    • Plenat, F., Klein-Monhoven, N., Marie, B., Vignaud, J. M., and Duprez, A. (1995). Cell and tissue distribution of synthetic oligonucleotides in healthy and tumor-bearing nude mice. An autoradiographic, immunohistological, and direct fluorescence microscopy study. Am. J. Pathol. 147, 124-135.
    • (1995) Am. J. Pathol , vol.147 , pp. 124-135
    • Plenat, F.1    Klein-Monhoven, N.2    Marie, B.3    Vignaud, J.M.4    Duprez, A.5
  • 54
    • 23944493932 scopus 로고    scopus 로고
    • Non-CpG-containing antisense 2'-methoxyethyl oligonucleotides activate a proinflammatory response independent of Toll-like receptor 9 or myeloid differentiation factor 88
    • Senn, J. J., Burel, S., and Henry, S. P. (2005). Non-CpG-containing antisense 2'-methoxyethyl oligonucleotides activate a proinflammatory response independent of Toll-like receptor 9 or myeloid differentiation factor 88. J. Pharmacol. Exp. Ther. 314, 972-979. doi: 10.1124/jpet.105.084004
    • (2005) J. Pharmacol. Exp. Ther , vol.314 , pp. 972-979
    • Senn, J.J.1    Burel, S.2    Henry, S.P.3
  • 55
    • 33645216969 scopus 로고    scopus 로고
    • Polyethylenimine-based antisense oligodeoxynucleotides of IL-4 suppress the production of IL-4 in a murine model of airway inflammation
    • Seong, J. H., Lee, K. M., Kim, S. T., Jin, S. E., and Kim, C. K. (2006). Polyethylenimine-based antisense oligodeoxynucleotides of IL-4 suppress the production of IL-4 in a murine model of airway inflammation. J. Gene Med. 8, 314-323. doi: 10.1002/jgm.848
    • (2006) J. Gene Med , vol.8 , pp. 314-323
    • Seong, J.H.1    Lee, K.M.2    Kim, S.T.3    Jin, S.E.4    Kim, C.K.5
  • 57
    • 0029086725 scopus 로고
    • Characterization of binding sites, extent of binding, and drug interactions of oligonucleotides with albumin
    • Srinivasan, S. K., Tewary, H. K., and Iversen, P. L. (1995). Characterization of binding sites, extent of binding, and drug interactions of oligonucleotides with albumin. Antisense Res. Dev. 5, 131-139.
    • (1995) Antisense Res. Dev , vol.5 , pp. 131-139
    • Srinivasan, S.K.1    Tewary, H.K.2    Iversen, P.L.3
  • 59
    • 75649138331 scopus 로고    scopus 로고
    • Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents
    • Stein, C. A., Hansen, J. B., Lai, J., Wu, S., Voskresenskiy, A., Hog, A., et al. (2010). Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents. Nucleic Acids Res. 38, e3. doi: 10.1093/nar/gkp841
    • (2010) Nucleic Acids Res , vol.38
    • Stein, C.A.1    Hansen, J.B.2    Lai, J.3    Wu, S.4    Voskresenskiy, A.5    Hog, A.6
  • 60
    • 67651166593 scopus 로고    scopus 로고
    • A proteomic study reveals unspecific apoptosis induction and reduction of glycolytic enzymes by the phosphorothioate antisense oligonucleotide oblimersen in human melanoma cells
    • Stessl, M., Marchetti-Deschmann, M., Winkler, J., Lachmann, B., Allmaier, G., and Noe, C. R. (2009). A proteomic study reveals unspecific apoptosis induction and reduction of glycolytic enzymes by the phosphorothioate antisense oligonucleotide oblimersen in human melanoma cells. J. Proteomics 72, 1019-1030. doi: 10.1016/j.jprot.2009.06.001
    • (2009) J. Proteomics , vol.72 , pp. 1019-1030
    • Stessl, M.1    Marchetti-Deschmann, M.2    Winkler, J.3    Lachmann, B.4    Allmaier, G.5    Noe, C.R.6
  • 61
    • 0030479079 scopus 로고    scopus 로고
    • Enhanced biological activity of antisense oligonucleotides complexed with glycosylated poly-L-lysine
    • Stewart, A. J., Pichon, C., Meunier, L., Midoux, P., Monsigny, M., and Roche, A. C. (1996). Enhanced biological activity of antisense oligonucleotides complexed with glycosylated poly-L-lysine. Mol. Pharmacol. 50, 1487-1494.
    • (1996) Mol. Pharmacol , vol.50 , pp. 1487-1494
    • Stewart, A.J.1    Pichon, C.2    Meunier, L.3    Midoux, P.4    Monsigny, M.5    Roche, A.C.6
  • 62
    • 78649877710 scopus 로고    scopus 로고
    • Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates
    • Straarup, E. M., Fisker, N., Hedtjarn, M., Lindholm, M. W., Rosenbohm, C., Aarup, V., et al. (2010). Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates. Nucleic Acids Res. 38, 7100-7111. doi: 10.1093/nar/gkq457
    • (2010) Nucleic Acids Res , vol.38 , pp. 7100-7111
    • Straarup, E.M.1    Fisker, N.2    Hedtjarn, M.3    Lindholm, M.W.4    Rosenbohm, C.5    Aarup, V.6
  • 63
    • 0030862707 scopus 로고    scopus 로고
    • Morpholino antisense oligomers: design, preparation, and properties
    • Summerton, J., and Weller, D. (1997). Morpholino antisense oligomers: design, preparation, and properties. Antisense Nucleic Acid Drug Dev. 7, 187-195. doi: 10.1089/oli.1.1997.7.187
    • (1997) Antisense Nucleic Acid Drug Dev , vol.7 , pp. 187-195
    • Summerton, J.1    Weller, D.2
  • 64
    • 34250819325 scopus 로고    scopus 로고
    • Poly(ethylene glycol)-modified nanocarriers for tumor-targeted and intracellular delivery
    • Van Vlerken, L. E., Vyas, T. K., and Amiji, M. M. (2007). Poly(ethylene glycol)-modified nanocarriers for tumor-targeted and intracellular delivery. Pharm. Res. 24, 1405-1414. doi: 10.1007/s11095-007-9284-6
    • (2007) Pharm. Res , vol.24 , pp. 1405-1414
    • Van Vlerken, L.E.1    Vyas, T.K.2    Amiji, M.M.3
  • 65
    • 33745213356 scopus 로고    scopus 로고
    • Plasma protein binding of an antisense oligonucleotide targeting human ICAM-1 (ISIS 2302)
    • Watanabe, T. A., Geary, R. S., and Levin, A. A. (2006). Plasma protein binding of an antisense oligonucleotide targeting human ICAM-1 (ISIS 2302). Oligonucleotides 16, 169-180. doi: 10.1089/oli.2006.16.169
    • (2006) Oligonucleotides , vol.16 , pp. 169-180
    • Watanabe, T.A.1    Geary, R.S.2    Levin, A.A.3
  • 66
    • 82755161958 scopus 로고    scopus 로고
    • Silencing disease genes in the laboratory and the clinic
    • Watts, J. K., and Corey, D. R. (2012). Silencing disease genes in the laboratory and the clinic. J. Pathol. 226, 365-379. doi: 10.1002/path.2993
    • (2012) J. Pathol , vol.226 , pp. 365-379
    • Watts, J.K.1    Corey, D.R.2
  • 67
    • 0034958529 scopus 로고    scopus 로고
    • Toxicity and toxicokinetics of a phosphorothioate oligonucleotide against the c-myc oncogene in cynomolgus monkeys
    • Webb, M. S., Tortora, N., Cremese, M., Kozlowska, H., Blaquiere, M., Devine, D. V., et al. (2001). Toxicity and toxicokinetics of a phosphorothioate oligonucleotide against the c-myc oncogene in cynomolgus monkeys. Antisense Nucleic Acid Drug Dev. 11, 155-163. doi: 10.1089/108729001300338681
    • (2001) Antisense Nucleic Acid Drug Dev , vol.11 , pp. 155-163
    • Webb, M.S.1    Tortora, N.2    Cremese, M.3    Kozlowska, H.4    Blaquiere, M.5    Devine, D.V.6
  • 68
    • 77955098945 scopus 로고    scopus 로고
    • Off-target effects related to the phosphorothioate modification of nucleic acids
    • Winkler, J., Stessl, M., Amartey, J., and Noe, C. R. (2010). Off-target effects related to the phosphorothioate modification of nucleic acids. Chem. Med. Chem. 5, 1344-1352. doi: 10.1002/cmdc.201000156
    • (2010) Chem. Med. Chem , vol.5 , pp. 1344-1352
    • Winkler, J.1    Stessl, M.2    Amartey, J.3    Noe, C.R.4
  • 69
    • 50049136079 scopus 로고    scopus 로고
    • The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer
    • Wisse, E., Jacobs, F., Topal, B., Frederik, P., and De Geest, B. (2008). The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer. Gene Ther. 15, 1193-1199. doi: 10.1038/gt.2008.60
    • (2008) Gene Ther , vol.15 , pp. 1193-1199
    • Wisse, E.1    Jacobs, F.2    Topal, B.3    Frederik, P.4    De Geest, B.5
  • 70
    • 84901717596 scopus 로고    scopus 로고
    • Intracellular fate of spherical nucleic acid nanoparticle conjugates
    • Wu, X. A., Choi, C. H., Zhang, C., Hao, L., and Mirkin, C. A. (2014). Intracellular fate of spherical nucleic acid nanoparticle conjugates. J. Am. Chem. Soc. 136, 7726-7733. doi: 10.1021/ja503010a
    • (2014) J. Am. Chem. Soc , vol.136 , pp. 7726-7733
    • Wu, X.A.1    Choi, C.H.2    Zhang, C.3    Hao, L.4    Mirkin, C.A.5
  • 72
    • 84934435712 scopus 로고    scopus 로고
    • Systemic delivery and pre-clinical evaluation of nanoparticles containing antisense oligonucleotides and siRNAs
    • Zhang, C., Newsome, J. T., Mewani, R., Pei, J., Gokhale, P. C., and Kasid, U. N. (2009). Systemic delivery and pre-clinical evaluation of nanoparticles containing antisense oligonucleotides and siRNAs. Methods Mol. Biol. 480, 65-83. doi: 10.1007/978-1-59745-429-2_5
    • (2009) Methods Mol. Biol , vol.480 , pp. 65-83
    • Zhang, C.1    Newsome, J.T.2    Mewani, R.3    Pei, J.4    Gokhale, P.C.5    Kasid, U.N.6
  • 73
    • 79953767743 scopus 로고    scopus 로고
    • Down-modulation of cancer targets using locked nucleic acid (LNA)-based antisense oligonucleotides without transfection
    • Zhang, Y., Qu, Z., Kim, S., Shi, V., Liao, B., Kraft, P., et al. (2011). Down-modulation of cancer targets using locked nucleic acid (LNA)-based antisense oligonucleotides without transfection. Gene Ther. 18, 326-333. doi: 10.1038/gt.2010.133
    • (2011) Gene Ther , vol.18 , pp. 326-333
    • Zhang, Y.1    Qu, Z.2    Kim, S.3    Shi, V.4    Liao, B.5    Kraft, P.6


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