Comparative pharmacokinetics, tissue distribution, and tumor accumulation of phosphorothioate, phosphorodithioate, and methylphosphonate oligonucleotides in nude mice

Antisense and Nucleic Acid Drug Development

Volumn 7, Issue 2, 1997, Pages 71-77

  Delong, R K ^a   Nolting, A ^a   Fisher, M ^a   Chen, Q ^a   Wickstrom, E ^b   Kligshteyn, M ^b   Demirdji, S ^c   Caruthers, M ^c   Juliano, R L ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; CARBON 14; COMPLEMENTARY DNA; METHYLPHOSPHONIC ACID; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; PHOSPHORODITHIOIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA SEQUENCE; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG METABOLISM; DRUG TISSUE LEVEL; DRUG TUMOR LEVEL; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; ISOTOPE LABELING; KIDNEY; LIVER; MOUSE; NONHUMAN; NUDE MOUSE; ONCOGENE K RAS; PANCREAS TUMOR; PRIORITY JOURNAL; RADIOMETRY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SPLEEN; TISSUE DISTRIBUTION;

EID: 0030943935     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1997.7.71     Document Type: Article

References (4)

1. AGRAWAL, S., and GOODCHILD, J. (1987). Oligonucleoside methylphosphonates: Synthesis and enzymic degradation. Tetrahedron Lett. 28, 3539-3542.
2. AGRAWAL, S., TEMSAMANI, J., GALBRAITH, W., and TANG, J. (1995). Pharmacokinetics of antisense oligonucleotides. Clin. Pharmacokinetics 28, 7-16.
3. AGRAWAL, S., TEMSAMANI, J., and TANG, J.Y. (1991). Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice. Proc. Natl. Acad. Sci. USA 88, 7595-7599.
4. ZHANG, R., YAN, J., SHAHINIAN, H., AMIN, G., LU, Z., LIU, T., SAAG, M.S., JIANG, Z., TEMSAMANI, J., MARTIN, R.R., SCHECHTER, P.J., AGRAWAL, S., and DIASIO, R.B. (1995). Pharmacokinetics of an anti-human immunodeficiency virus antisense oligodeoxynucleotide phosphorothioate (GEM91) in HIV-infected subjects. Clin. Pharmacol. Ther. 58, 45-53.