A lipid carrier with a membrane active component and a small complex size are required for efficient cellular delivery of anti-sense phosphorothioate oligonucleotides

European Journal of Pharmaceutical Sciences

Volumn 10, Issue 3, 2000, Pages 187-193

  Jääskeläinen, Ilpo ^a   Peltola, Sari ^a   Honkakoski, Paavo ^a   Mönkkönen, Jukka ^a   Urtti, Arto ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Delivery; Liposomes; Membrane active peptides; Oligonucleotides; Polymers; Retinal pigment epithelium

Indexed keywords

1,2 DIOLEOYL 3 PHOSPHATIDYLETHANOLAMINE; 1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; 4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; ANTISENSE OLIGONUCLEOTIDE; BUFFER; CATION; CHOLESTEROL; DENDRIMER; DOPE; DRUG CARRIER; LIPID; LUCIFERASE; MESSENGER RNA; N [1 (2,3 DIOLEOYLOXY)PROPYL] N,N,N TRIMETHYLAMMONIUM METHYLSULFATE; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE; PEPTIDE; POLYAMIDOAMINE; POLYAMINE; POLYETHYLENEIMINE; POLYLYSINE; POLYMER; UNCLASSIFIED DRUG; WATER;

ANIMAL CELL; ARTICLE; CELL LINE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; ELECTRICITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; NONHUMAN; PARTICLE SIZE; PHOTOMETRY; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; TECHNIQUE;

CELL LINE; DRUG CARRIERS; HUMANS; LIPIDS; LIPOSOMES; LUCIFERASES; OLIGONUCLEOTIDES, ANTISENSE; ORGANOTHIOPHOSPHORUS COMPOUNDS; PARTICLE SIZE; TRANSFECTION;

EID: 0342748741     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(00)00068-3     Document Type: Article

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