An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy

Evolution

Volumn 70, Issue 11, 2016, Pages 2470-2484

  Bank, Claudia ^a,b,c   Renzette, Nicholas ^d   Liu, Ping ^d   Matuszewski, Sebastian ^a,b   Shim, Hyunjin ^a,b   Foll, Matthieu ^a,b,e   Bolon, Daniel N A ^d   Zeldovich, Konstantin B ^d   Kowalik, Timothy F ^d   Finberg, Robert W ^d   Wang, Jennifer P ^d   Jensen, Jeffrey D ^a,b,f  

^a EPFL   (Switzerland)

^b SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^c INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^f ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DEVELOPMENT; DRUG RESISTANCE; ENZYME ACTIVITY; EVOLUTIONARY BIOLOGY; EVOLUTIONARY THEORY; EXTINCTION; GENETIC ANALYSIS; GENOME; INFLUENZA; MUTATION; PUBLIC HEALTH; VACCINE;

INFLUENZA A VIRUS;

AMIDE; ANTIRETROVIRUS AGENT; FAVIPIRAVIR; PYRAZINE DERIVATIVE;

ANIMAL; ANTIVIRAL RESISTANCE; DOG; DRUG EFFECTS; GENETIC POLYMORPHISM; GENETICS; INFLUENZA A VIRUS (H1N1); MDCK CELL LINE; MOLECULAR EVOLUTION; MUTATION RATE;

AMIDES; ANIMALS; ANTI-RETROVIRAL AGENTS; DOGS; DRUG RESISTANCE, VIRAL; EVOLUTION, MOLECULAR; INFLUENZA A VIRUS, H1N1 SUBTYPE; MADIN DARBY CANINE KIDNEY CELLS; MUTATION RATE; POLYMORPHISM, GENETIC; PYRAZINES;

EID: 84987619338     PISSN: 00143820     EISSN: 15585646     Source Type: Journal    
DOI: 10.1111/evo.13041     Document Type: Article

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