The H274Y mutation in the influenza A/H1N1 neuraminidase active site following oseltamivir phosphate treatment leave virus severely compromised both in vitro and in vivo

Antiviral Research

Volumn 55, Issue 2, 2002, Pages 307-317

  Ives, J A L ^a   Carr, J A ^a   Mendel, D B ^b   Tai, C Y ^b   Lambkin, R ^c   Kelly, L ^c   Oxford, J S ^c   Hayden, F G ^d   Roberts, N A ^a  

^a ROCHE PRODUCTS LTD   (United Kingdom)

^b GILEAD SCIENCES   (United States)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Animal models; Influenza; Neuraminidase; Oseltamivir phosphate; Resistance

Indexed keywords

4 ACETAMIDO 5 AMINO 3 (1 ETHYLPROPOXY) 1 CYCLOHEXENE 1 CARBOXYLIC ACID; HISTIDINE; OSELTAMIVIR; SIALIDASE; TYROSINE; VIRUS ENZYME;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; ENZYME ACTIVE SITE; EXPERIMENTAL INFECTION; FEMALE; HUMAN; HUMAN EXPERIMENT; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA VIRUS; MOUSE; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; VIRUS CULTURE; VIRUS INFECTION; VIRUS INFECTIVITY; VIRUS MUTATION; VIRUS REPLICATION;

ACETAMIDES; AMINO ACID SUBSTITUTION; ANIMALS; ANTIVIRAL AGENTS; BODY WEIGHT; CELL LINE; DISEASE MODELS, ANIMAL; DRUG RESISTANCE, VIRAL; FERRETS; FEVER; HUMANS; INFLAMMATION; INFLUENZA A VIRUS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA, HUMAN; MICE; MICE, INBRED BALB C; MUTAGENESIS, SITE-DIRECTED; MUTATION; NEURAMINIDASE; OSELTAMIVIR; SEQUENCE ANALYSIS, DNA; VIRUS REPLICATION;

ANIMALIA; INFLUENZA VIRUS; MUSTELA PUTORIUS FURO;

EID: 0036294323     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(02)00053-0     Document Type: Article

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