메뉴 건너뛰기




Volumn 139, Issue 10, 2016, Pages 2157-2168

Low-dose radiation may be a novel approach to enhance the effectiveness of cancer therapeutics

Author keywords

adaptive response; cancer; hormesis; low dose radiation

Indexed keywords

MANGANESE SUPEROXIDE DISMUTASE; REACTIVE OXYGEN METABOLITE;

EID: 84986562981     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.30235     Document Type: Review
Times cited : (70)

References (140)
  • 1
  • 2
    • 33745700690 scopus 로고    scopus 로고
    • Biologically based analysis of lung cancer incidence in a large Canadian occupational cohort with low-dose ionizing radiation exposure, and comparison with Japanese atomic bomb survivors
    • Hazelton WD, Moolgavkar SH, Curtis SB, et al. Biologically based analysis of lung cancer incidence in a large Canadian occupational cohort with low-dose ionizing radiation exposure, and comparison with Japanese atomic bomb survivors. J Toxicol Environ Health Part A 2006;69:1013–38.
    • (2006) J Toxicol Environ Health Part A , vol.69 , pp. 1013-1038
    • Hazelton, W.D.1    Moolgavkar, S.H.2    Curtis, S.B.3
  • 3
    • 68549117093 scopus 로고    scopus 로고
    • Health outcomes of low-dose ionizing radiation exposure among medical workers: a cohort study of the Canadian national dose registry of radiation workers
    • Zielinski JM, Garner MJ, Band PR, et al. Health outcomes of low-dose ionizing radiation exposure among medical workers: a cohort study of the Canadian national dose registry of radiation workers. Int J Occupation Med Environ Health 2009;22:149–56.
    • (2009) Int J Occupation Med Environ Health , vol.22 , pp. 149-156
    • Zielinski, J.M.1    Garner, M.J.2    Band, P.R.3
  • 4
    • 84872072510 scopus 로고    scopus 로고
    • Radiation and the risk of chronic lymphocytic and other leukemias among chornobyl cleanup workers
    • Zablotska LB, Bazyka D, Lubin JH, et al. Radiation and the risk of chronic lymphocytic and other leukemias among chornobyl cleanup workers. Environ Health Perspect 2013;121:59–65.
    • (2013) Environ Health Perspect , vol.121 , pp. 59-65
    • Zablotska, L.B.1    Bazyka, D.2    Lubin, J.H.3
  • 5
    • 84931334521 scopus 로고    scopus 로고
    • Cancer Mortality through 2005 among a Pooled Cohort of U.S. nuclear workers exposed to external ionizing radiation
    • Schubauer-Berigan MK, Daniels RD, Bertke SJ, et al. Cancer Mortality through 2005 among a Pooled Cohort of U.S. nuclear workers exposed to external ionizing radiation. Radiat Res 2015;183:620–31.
    • (2015) Radiat Res , vol.183 , pp. 620-631
    • Schubauer-Berigan, M.K.1    Daniels, R.D.2    Bertke, S.J.3
  • 6
    • 0026570108 scopus 로고
    • Cancer mortality survey in a spa area (Misasa, Japan) with a high radon background
    • Mifune M, Sobue T, Arimoto H, et al. Cancer mortality survey in a spa area (Misasa, Japan) with a high radon background. Japan J Cancer Res Gann 1992;83:1–5.
    • (1992) Japan J Cancer Res Gann , vol.83 , pp. 1-5
    • Mifune, M.1    Sobue, T.2    Arimoto, H.3
  • 7
    • 0023244672 scopus 로고
    • Environmental radiation and cancer in India
    • Nambi KS, Soman SD. Environmental radiation and cancer in India. Health Phys 1987;52:653–7.
    • (1987) Health Phys , vol.52 , pp. 653-657
    • Nambi, K.S.1    Soman, S.D.2
  • 8
    • 0025395054 scopus 로고
    • Epidemiological investigation of radiological effects in high background radiation areas of Yangjiang, China
    • Wei LX, Zha YR, Tao ZF, et al. Epidemiological investigation of radiological effects in high background radiation areas of Yangjiang, China. J Radiat Res 1990;31:119–36.
    • (1990) J Radiat Res , vol.31 , pp. 119-136
    • Wei, L.X.1    Zha, Y.R.2    Tao, Z.F.3
  • 9
    • 84923094967 scopus 로고    scopus 로고
    • Lung cancer hormesis in high impact states where nuclear testing occurred
    • Lehrer S, Rosenzweig KE. Lung cancer hormesis in high impact states where nuclear testing occurred. Clin Lung Cancer 2015;16:152–5.
    • (2015) Clin Lung Cancer , vol.16 , pp. 152-155
    • Lehrer, S.1    Rosenzweig, K.E.2
  • 10
    • 84937398402 scopus 로고    scopus 로고
    • Cancer mortality among people living in areas with various levels of natural background radiation
    • 1559325815592391
    • Dobrzynski L, Fornalski KW, Feinendegen LE. Cancer mortality among people living in areas with various levels of natural background radiation. Dose Response 2015;13:1559325815592391
    • (2015) Dose Response , vol.13
    • Dobrzynski, L.1    Fornalski, K.W.2    Feinendegen, L.E.3
  • 11
    • 84938563709 scopus 로고    scopus 로고
    • Long-term effects of radiation exposure on health
    • Kamiya K, Ozasa K, Akiba S, et al. Long-term effects of radiation exposure on health. Lancet 2015;386:469–78.
    • (2015) Lancet , vol.386 , pp. 469-478
    • Kamiya, K.1    Ozasa, K.2    Akiba, S.3
  • 12
    • 0025348196 scopus 로고
    • The 1986 and 1988 UNSCEAR (United Nations Scientific Committee on the Effects of Atomic Radiation) reports: findings and implications
    • Mettler FA, Sinclair WK, Anspaugh L, et al. The 1986 and 1988 UNSCEAR (United Nations Scientific Committee on the Effects of Atomic Radiation) reports: findings and implications. Health Phys 1990;58:241–50.
    • (1990) Health Phys , vol.58 , pp. 241-250
    • Mettler, F.A.1    Sinclair, W.K.2    Anspaugh, L.3
  • 13
    • 57049167149 scopus 로고    scopus 로고
    • Hormesis predicts low-dose responses better than threshold models
    • Calabrese EJ, Stanek EJ, III, Nascarella MA, et al. Hormesis predicts low-dose responses better than threshold models. Int J Toxicol 2008;27:369–78.
    • (2008) Int J Toxicol , vol.27 , pp. 369-378
    • Calabrese, E.J.1    Stanek, E.J.2    Nascarella, M.A.3
  • 15
    • 36849020390 scopus 로고    scopus 로고
    • Low-dose radiation-induced protective process and implications for risk assessment, cancer prevention, and cancer therapy
    • Scott BR. Low-dose radiation-induced protective process and implications for risk assessment, cancer prevention, and cancer therapy. Dose Response 2007;5:131–49.
    • (2007) Dose Response , vol.5 , pp. 131-149
    • Scott, B.R.1
  • 16
    • 67349272929 scopus 로고    scopus 로고
    • It's time for a new low-dose-radiation risk assessment paradigm–one that acknowledges hormesis
    • Scott BR. It's time for a new low-dose-radiation risk assessment paradigm–one that acknowledges hormesis. Dose Response 2008;6:333–51.
    • (2008) Dose Response , vol.6 , pp. 333-351
    • Scott, B.R.1
  • 17
    • 0024893226 scopus 로고
    • Radiation hormesis. A new concept in radiological science
    • Liu SZ. Radiation hormesis. A new concept in radiological science. Chin Med J 1989;102:750–5.
    • (1989) Chin Med J , vol.102 , pp. 750-755
    • Liu, S.Z.1
  • 18
    • 0025316479 scopus 로고
    • Radithor and the era of mild radium therapy
    • Macklis RM. Radithor and the era of mild radium therapy. JAMA 1990;264:614–8.
    • (1990) JAMA , vol.264 , pp. 614-618
    • Macklis, R.M.1
  • 19
    • 14044276801 scopus 로고    scopus 로고
    • Evidence for beneficial low level radiation effects and radiation hormesis
    • Feinendegen LE. Evidence for beneficial low level radiation effects and radiation hormesis. Br J Radiol 2005;78:3–7.
    • (2005) Br J Radiol , vol.78 , pp. 3-7
    • Feinendegen, L.E.1
  • 20
    • 0020398149 scopus 로고
    • Physiological benefits from low levels of ionizing radiation
    • Luckey TD. Physiological benefits from low levels of ionizing radiation. Health Phys 1982;43:771–89.
    • (1982) Health Phys , vol.43 , pp. 771-789
    • Luckey, T.D.1
  • 21
    • 0028491729 scopus 로고
    • Radiation hormesis in relation to radiation protection
    • Smith H. Radiation hormesis in relation to radiation protection. Chin Med J 1994;107:615–23.
    • (1994) Chin Med J , vol.107 , pp. 615-623
    • Smith, H.1
  • 22
    • 0037171647 scopus 로고    scopus 로고
    • Cellular communication and bystander effects: a critical review for modelling low-dose radiation action
    • Ballarini F, Biaggi M, Ottolenghi A, et al. Cellular communication and bystander effects: a critical review for modelling low-dose radiation action. Mutat Res 2002;501:1–12.
    • (2002) Mutat Res , vol.501 , pp. 1-12
    • Ballarini, F.1    Biaggi, M.2    Ottolenghi, A.3
  • 23
    • 72949123931 scopus 로고    scopus 로고
    • Control of the G2/M checkpoints after exposure to low doses of ionising radiation: implications for hyper-radiosensitivity
    • Fernet M, Megnin-Chanet F, Hall J, et al. Control of the G2/M checkpoints after exposure to low doses of ionising radiation: implications for hyper-radiosensitivity. DNA Repair 2010;9:48–57.
    • (2010) DNA Repair , vol.9 , pp. 48-57
    • Fernet, M.1    Megnin-Chanet, F.2    Hall, J.3
  • 24
    • 84941765734 scopus 로고    scopus 로고
    • Association of ATM activation and DNA repair with induced radioresistance after low-dose irradiation
    • Enns L, Rasouli-Nia A, Hendzel M, et al. Association of ATM activation and DNA repair with induced radioresistance after low-dose irradiation. Radiat Protect Dosimetry 2015;166:131–6.
    • (2015) Radiat Protect Dosimetry , vol.166 , pp. 131-136
    • Enns, L.1    Rasouli-Nia, A.2    Hendzel, M.3
  • 25
    • 0038627355 scopus 로고    scopus 로고
    • Studies on the mechanism of the suppressive effect of low dose radiation on cancer metastasis
    • Fu HQLX, Chen YB. Studies on the mechanism of the suppressive effect of low dose radiation on cancer metastasis. J Radiat Res Radiat Proc 1997;15:41–3.
    • (1997) J Radiat Res Radiat Proc , vol.15 , pp. 41-43
    • Fu, H.Q.L.X.1    Chen, Y.B.2
  • 26
    • 84935507294 scopus 로고    scopus 로고
    • Additive protection by LDR and FGF21 treatment against diabetic nephropathy in type 2 diabetes model
    • Shao M, Yu L, Zhang F, et al. Additive protection by LDR and FGF21 treatment against diabetic nephropathy in type 2 diabetes model. Am J Physiol Endocrinol Metab 2015;309:E45–54.
    • (2015) Am J Physiol Endocrinol Metab , vol.309 , pp. 45-54
    • Shao, M.1    Yu, L.2    Zhang, F.3
  • 27
    • 83455172618 scopus 로고    scopus 로고
    • Low-dose-rate, low-dose irradiation delays neurodegeneration in a model of retinitis pigmentosa
    • Otani A, Kojima H, Guo C, et al. Low-dose-rate, low-dose irradiation delays neurodegeneration in a model of retinitis pigmentosa. Am J Pathol 2012;180:328–36.
    • (2012) Am J Pathol , vol.180 , pp. 328-336
    • Otani, A.1    Kojima, H.2    Guo, C.3
  • 28
    • 0031840032 scopus 로고    scopus 로고
    • Induction of mRNAs for glutathione synthesis-related proteins in mouse liver by low doses of gamma-rays
    • Kojima S, Matsuki O, Nomura T, et al. Induction of mRNAs for glutathione synthesis-related proteins in mouse liver by low doses of gamma-rays. Biochim Biophys Acta 1998;1381:312–8.
    • (1998) Biochim Biophys Acta , vol.1381 , pp. 312-318
    • Kojima, S.1    Matsuki, O.2    Nomura, T.3
  • 29
    • 13844266168 scopus 로고    scopus 로고
    • Oxidative stress, radiation-adaptive responses, and aging
    • Miura Y. Oxidative stress, radiation-adaptive responses, and aging. J Radiat Res 2004;45:357–72.
    • (2004) J Radiat Res , vol.45 , pp. 357-372
    • Miura, Y.1
  • 30
    • 58349107293 scopus 로고    scopus 로고
    • Reduction in mutation frequency by very low-dose gamma irradiation of Drosophila melanogaster germ cells
    • Ogura K, Magae J, Kawakami Y, et al. Reduction in mutation frequency by very low-dose gamma irradiation of Drosophila melanogaster germ cells. Radiat Res 2009;171:1–8.
    • (2009) Radiat Res , vol.171 , pp. 1-8
    • Ogura, K.1    Magae, J.2    Kawakami, Y.3
  • 31
    • 0032819345 scopus 로고    scopus 로고
    • Research of the adaptive response induced by low-dose radiation: where have we been and where should we go?
    • Cai L. Research of the adaptive response induced by low-dose radiation: where have we been and where should we go? Hum Exp Toxicol 1999;18:419–25.
    • (1999) Hum Exp Toxicol , vol.18 , pp. 419-425
    • Cai, L.1
  • 32
    • 0033002298 scopus 로고    scopus 로고
    • Different induction of adaptive response to ionizing radiation in normal and neoplastic cells
    • Park SH, Lee Y, Jeong K, et al. Different induction of adaptive response to ionizing radiation in normal and neoplastic cells. Cell Biol Toxicol 1999;15:111–9.
    • (1999) Cell Biol Toxicol , vol.15 , pp. 111-119
    • Park, S.H.1    Lee, Y.2    Jeong, K.3
  • 33
    • 0033804073 scopus 로고    scopus 로고
    • Adaptive response is differently induced depending on the sensitivity to radiation-induced cell death in mouse epidermal cells
    • Lee SJ, Choi SA, Cho CK, et al. Adaptive response is differently induced depending on the sensitivity to radiation-induced cell death in mouse epidermal cells. Cell Biol Toxicol 2000;16:175–84.
    • (2000) Cell Biol Toxicol , vol.16 , pp. 175-184
    • Lee, S.J.1    Choi, S.A.2    Cho, C.K.3
  • 34
    • 3442902816 scopus 로고    scopus 로고
    • Differential activation of the phosphatidylinositol 3'-kinase/Akt survival pathway by ionizing radiation in tumor and primary endothelial cells
    • Zingg D, Riesterer O, Fabbro D, et al. Differential activation of the phosphatidylinositol 3'-kinase/Akt survival pathway by ionizing radiation in tumor and primary endothelial cells. Cancer Res 2004;64:5398–406.
    • (2004) Cancer Res , vol.64 , pp. 5398-5406
    • Zingg, D.1    Riesterer, O.2    Fabbro, D.3
  • 35
    • 84927588372 scopus 로고    scopus 로고
    • Peculiarities of DNA damage caused by exogenous nitric oxide combined with fractionated low dose ionizing radiation in normal and tumor cells
    • Muzalov II, Mikhailenko VM. Peculiarities of DNA damage caused by exogenous nitric oxide combined with fractionated low dose ionizing radiation in normal and tumor cells. Exp Oncol 2015;37:40–3.
    • (2015) Exp Oncol , vol.37 , pp. 40-43
    • Muzalov, I.I.1    Mikhailenko, V.M.2
  • 36
    • 84979753569 scopus 로고    scopus 로고
    • Differential response and priming dose effect on the proteome of human fibroblast and stem cells induced by exposure to low doses of ionizing radiation
    • Hauptmann M, Haghdoost S, Gomolka M, et al. Differential response and priming dose effect on the proteome of human fibroblast and stem cells induced by exposure to low doses of ionizing radiation. Radiat Res 2016;185:299–312.
    • (2016) Radiat Res , vol.185 , pp. 299-312
    • Hauptmann, M.1    Haghdoost, S.2    Gomolka, M.3
  • 37
    • 0034025226 scopus 로고    scopus 로고
    • Low-dose whole-body irradiation (LD-WBI) changes protein expression of mouse thymocytes: effect of a LD-WBI-enhanced protein RIP10 on cell proliferation and spontaneous or radiation-induced thymocyte apoptosis
    • Chen SL, Cai L, Meng QY, et al. Low-dose whole-body irradiation (LD-WBI) changes protein expression of mouse thymocytes: effect of a LD-WBI-enhanced protein RIP10 on cell proliferation and spontaneous or radiation-induced thymocyte apoptosis. Toxicol Sci 2000;55:97–106.
    • (2000) Toxicol Sci , vol.55 , pp. 97-106
    • Chen, S.L.1    Cai, L.2    Meng, Q.Y.3
  • 38
    • 0031049875 scopus 로고    scopus 로고
    • Enhancement of mitogen-stimulated proliferation of low dose radiation-adapted mouse splenocytes
    • Hyun SJ, Yoon MY, Kim TH, et al. Enhancement of mitogen-stimulated proliferation of low dose radiation-adapted mouse splenocytes. Anticancer Res 1997;17:225–9.
    • (1997) Anticancer Res , vol.17 , pp. 225-229
    • Hyun, S.J.1    Yoon, M.Y.2    Kim, T.H.3
  • 39
    • 38349029063 scopus 로고    scopus 로고
    • Low-dose radiation stimulates the proliferation of normal human lung fibroblasts via a transient activation of Raf and Akt
    • Kim CS, Kim JK, Nam SY, et al. Low-dose radiation stimulates the proliferation of normal human lung fibroblasts via a transient activation of Raf and Akt. Molecules Cells 2007;24:424–30.
    • (2007) Molecules Cells , vol.24 , pp. 424-430
    • Kim, C.S.1    Kim, J.K.2    Nam, S.Y.3
  • 40
    • 34548850034 scopus 로고    scopus 로고
    • Low-dose of ionizing radiation enhances cell proliferation via transient ERK1/2 and p38 activation in normal human lung fibroblasts
    • Kim CS, Kim JM, Nam SY, et al. Low-dose of ionizing radiation enhances cell proliferation via transient ERK1/2 and p38 activation in normal human lung fibroblasts. J Radiat Res 2007;48:407–15.
    • (2007) J Radiat Res , vol.48 , pp. 407-415
    • Kim, C.S.1    Kim, J.M.2    Nam, S.Y.3
  • 41
    • 0035879004 scopus 로고    scopus 로고
    • Extremely low-dose ionizing radiation causes activation of mitogen-activated protein kinase pathway and enhances proliferation of normal human diploid cells
    • Suzuki K, Kodama S, Watanabe M. Extremely low-dose ionizing radiation causes activation of mitogen-activated protein kinase pathway and enhances proliferation of normal human diploid cells. Cancer Res 2001;61:5396–401.
    • (2001) Cancer Res , vol.61 , pp. 5396-5401
    • Suzuki, K.1    Kodama, S.2    Watanabe, M.3
  • 42
    • 70349315551 scopus 로고    scopus 로고
    • Evidence for radiation hormesis after in vitro exposure of human lymphocytes to low doses of ionizing radiation
    • Rithidech KN, Scott BR. Evidence for radiation hormesis after in vitro exposure of human lymphocytes to low doses of ionizing radiation. Dose Response 2008;6:252–71.
    • (2008) Dose Response , vol.6 , pp. 252-271
    • Rithidech, K.N.1    Scott, B.R.2
  • 43
    • 7944219768 scopus 로고    scopus 로고
    • Low-dose radiation (LDR) induces hematopoietic hormesis: LDR-induced mobilization of hematopoietic progenitor cells into peripheral blood circulation
    • Li W, Wang G, Cui J, et al. Low-dose radiation (LDR) induces hematopoietic hormesis: LDR-induced mobilization of hematopoietic progenitor cells into peripheral blood circulation. Exp Hematol 2004;32:1088–96.
    • (2004) Exp Hematol , vol.32 , pp. 1088-1096
    • Li, W.1    Wang, G.2    Cui, J.3
  • 44
    • 0033956255 scopus 로고    scopus 로고
    • Induction of cell-proliferation hormesis and cell-survival adaptive response in mouse hematopoietic cells by whole-body low-dose radiation
    • Wang GJ, Cai L. Induction of cell-proliferation hormesis and cell-survival adaptive response in mouse hematopoietic cells by whole-body low-dose radiation. Toxicol Sci Off J Soc Toxicol 2000;53:369–76.
    • (2000) Toxicol Sci Off J Soc Toxicol , vol.53 , pp. 369-376
    • Wang, G.J.1    Cai, L.2
  • 45
    • 79958109691 scopus 로고    scopus 로고
    • The low-dose ionizing radiation stimulates cell proliferation via activation of the MAPK/ERK pathway in rat cultured mesenchymal stem cells
    • Liang X, So YH, Cui J, et al. The low-dose ionizing radiation stimulates cell proliferation via activation of the MAPK/ERK pathway in rat cultured mesenchymal stem cells. J Radiat Res 2011;52:380–6.
    • (2011) J Radiat Res , vol.52 , pp. 380-386
    • Liang, X.1    So, Y.H.2    Cui, J.3
  • 46
    • 84860285299 scopus 로고    scopus 로고
    • Low-dose radiation stimulates Wnt/beta-catenin signaling, neural stem cell proliferation and neurogenesis of the mouse hippocampus in vitro and in vivo
    • Wei LC, Ding YX, Liu YH, et al. Low-dose radiation stimulates Wnt/beta-catenin signaling, neural stem cell proliferation and neurogenesis of the mouse hippocampus in vitro and in vivo. Curr Alzheimer Res 2012;9:278–89.
    • (2012) Curr Alzheimer Res , vol.9 , pp. 278-289
    • Wei, L.C.1    Ding, Y.X.2    Liu, Y.H.3
  • 47
    • 77957223592 scopus 로고    scopus 로고
    • Acceleration of diabetic wound healing by low-dose radiation is associated with peripheral mobilization of bone marrow stem cells
    • Guo WY, Wang GJ, Wang P, et al. Acceleration of diabetic wound healing by low-dose radiation is associated with peripheral mobilization of bone marrow stem cells. Radiat Res 2010;174:467–79.
    • (2010) Radiat Res , vol.174 , pp. 467-479
    • Guo, W.Y.1    Wang, G.J.2    Wang, P.3
  • 48
    • 0017257355 scopus 로고
    • Ionizing radiation and the immune response
    • Anderson RE, Warner NL. Ionizing radiation and the immune response. Adv Immunol 1976;24:215–335.
    • (1976) Adv Immunol , vol.24 , pp. 215-335
    • Anderson, R.E.1    Warner, N.L.2
  • 49
    • 2442649386 scopus 로고    scopus 로고
    • Single low doses of X rays inhibit the development of experimental tumor metastases and trigger the activities of NK cells in mice
    • Cheda A, Wrembel-Wargocka J, Lisiak E, et al. Single low doses of X rays inhibit the development of experimental tumor metastases and trigger the activities of NK cells in mice. Radiat Res 2004;161:335–40.
    • (2004) Radiat Res , vol.161 , pp. 335-340
    • Cheda, A.1    Wrembel-Wargocka, J.2    Lisiak, E.3
  • 50
    • 0036206370 scopus 로고    scopus 로고
    • Elevation of glutathione induced by low-dose gamma rays and its involvement in increased natural killer activity
    • Kojima S, Ishida H, Takahashi M, et al. Elevation of glutathione induced by low-dose gamma rays and its involvement in increased natural killer activity. Radiat Res 2002;157:275–80.
    • (2002) Radiat Res , vol.157 , pp. 275-280
    • Kojima, S.1    Ishida, H.2    Takahashi, M.3
  • 51
    • 0028453816 scopus 로고
    • Signal transduction in lymphocytes after low dose radiation
    • Liu SZ, Su Xu, Zhang YC, et al. Signal transduction in lymphocytes after low dose radiation. Chin Med J 1994;107:431–6.
    • (1994) Chin Med J , vol.107 , pp. 431-436
    • Liu, S.Z.1    Su, X.2    Zhang, Y.C.3
  • 52
    • 84916938395 scopus 로고    scopus 로고
    • Low-dose ionizing radiation induces direct activation of natural killer cells and provides a novel approach for adoptive cellular immunotherapy
    • Yang G, Kong Q, Wang G, et al. Low-dose ionizing radiation induces direct activation of natural killer cells and provides a novel approach for adoptive cellular immunotherapy. Cancer Biother Radiopharmaceut 2014;29:428–34.
    • (2014) Cancer Biother Radiopharmaceut , vol.29 , pp. 428-434
    • Yang, G.1    Kong, Q.2    Wang, G.3
  • 53
    • 32644434747 scopus 로고    scopus 로고
    • Low dose radiation induced immunomodulation: effect on macrophages and CD8+ T cells
    • Pandey R, Shankar BS, Sharma D, et al. Low dose radiation induced immunomodulation: effect on macrophages and CD8+ T cells. Int J Radiat Biol 2005;81:801–12.
    • (2005) Int J Radiat Biol , vol.81 , pp. 801-812
    • Pandey, R.1    Shankar, B.S.2    Sharma, D.3
  • 54
    • 0042784427 scopus 로고    scopus 로고
    • Contribution of inflammatory cytokine release to activation of resident peritoneal macrophages after in vivo low-dose gamma-irradiation
    • Ibuki Y, Goto R. Contribution of inflammatory cytokine release to activation of resident peritoneal macrophages after in vivo low-dose gamma-irradiation. J Radiat Res 1999;40:253–62.
    • (1999) J Radiat Res , vol.40 , pp. 253-262
    • Ibuki, Y.1    Goto, R.2
  • 55
    • 84887561907 scopus 로고    scopus 로고
    • Low-dose irradiation programs macrophage differentiation to an iNOS(+)/M1 phenotype that orchestrates effective T cell immunotherapy
    • Klug F, Prakash H, Huber PE, et al. Low-dose irradiation programs macrophage differentiation to an iNOS(+)/M1 phenotype that orchestrates effective T cell immunotherapy. Cancer Cell 2013;24:589–602.
    • (2013) Cancer Cell , vol.24 , pp. 589-602
    • Klug, F.1    Prakash, H.2    Huber, P.E.3
  • 56
    • 33846879013 scopus 로고    scopus 로고
    • Effects of low-dose irradiation on enhancement of immunity by dendritic cells
    • Shigematsu A, Adachi Y, Koike-Kiriyama N, et al. Effects of low-dose irradiation on enhancement of immunity by dendritic cells. J Radiat Res 2007;48:51–5.
    • (2007) J Radiat Res , vol.48 , pp. 51-55
    • Shigematsu, A.1    Adachi, Y.2    Koike-Kiriyama, N.3
  • 57
    • 0029189647 scopus 로고
    • Enhanced mitogen-induced proliferation of rat splenocytes by low-dose whole-body X-irradiation
    • Ishii K, Yamaoka K, Hosoi Y, et al. Enhanced mitogen-induced proliferation of rat splenocytes by low-dose whole-body X-irradiation. Physiol Chem Phys Med NMR 1995;27:17–23.
    • (1995) Physiol Chem Phys Med NMR , vol.27 , pp. 17-23
    • Ishii, K.1    Yamaoka, K.2    Hosoi, Y.3
  • 58
    • 0028456120 scopus 로고
    • Changes in lymphocyte reactivity to modulatory factors following low dose ionizing radiation
    • Liu SZ, Han ZB, Liu WH. Changes in lymphocyte reactivity to modulatory factors following low dose ionizing radiation. Biomed Environ Sci 1994;7:130–5.
    • (1994) Biomed Environ Sci , vol.7 , pp. 130-135
    • Liu, S.Z.1    Han, Z.B.2    Liu, W.H.3
  • 59
    • 8044257707 scopus 로고    scopus 로고
    • Stimulatory effect of low dose X-irradiation on the expression of the human T lymphocyte CD2 surface antigen
    • Sambani C, Thomou H, Kitsiou P. Stimulatory effect of low dose X-irradiation on the expression of the human T lymphocyte CD2 surface antigen. Int J Radiat Biol 1996;70:711–7.
    • (1996) Int J Radiat Biol , vol.70 , pp. 711-717
    • Sambani, C.1    Thomou, H.2    Kitsiou, P.3
  • 60
    • 2542486713 scopus 로고    scopus 로고
    • Role of CD28/B7 costimulation and IL-12/IL-10 interaction in the radiation-induced immune changes
    • Liu SZ, Jin SZ, Liu XD, et al. Role of CD28/B7 costimulation and IL-12/IL-10 interaction in the radiation-induced immune changes. BMC Immunol 2001;2:8
    • (2001) BMC Immunol , vol.2 , pp. 8
    • Liu, S.Z.1    Jin, S.Z.2    Liu, X.D.3
  • 61
    • 67349239049 scopus 로고    scopus 로고
    • T-regulatory cell modulation: the future of cancer immunotherapy?
    • Nizar S, Copier J, Meyer B, et al. T-regulatory cell modulation: the future of cancer immunotherapy? Br J Cancer 2009;100:1697–703.
    • (2009) Br J Cancer , vol.100 , pp. 1697-1703
    • Nizar, S.1    Copier, J.2    Meyer, B.3
  • 62
    • 0034237726 scopus 로고    scopus 로고
    • The role of low-dose total body irradiation in treatment of non-Hodgkin's lymphoma: a new look at an old method
    • Safwat A. The role of low-dose total body irradiation in treatment of non-Hodgkin's lymphoma: a new look at an old method. Radiother Oncol 2000;56:1–8.
    • (2000) Radiother Oncol , vol.56 , pp. 1-8
    • Safwat, A.1
  • 63
    • 77749252468 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by low-dose total body irradiationis associated with selectively decreasing the proportion and number of T regulatory cells
    • Liu R, Xiong S, Zhang L, et al. Enhancement of antitumor immunity by low-dose total body irradiationis associated with selectively decreasing the proportion and number of T regulatory cells. Cell Mol Immunol 2010;7:157–62.
    • (2010) Cell Mol Immunol , vol.7 , pp. 157-162
    • Liu, R.1    Xiong, S.2    Zhang, L.3
  • 64
    • 84907328955 scopus 로고    scopus 로고
    • Low-dose splenic radiation inhibits liver tumor development of rats through functional changes in CD4+CD25+Treg cells
    • Wang B, Li B, Dai Z, et al. Low-dose splenic radiation inhibits liver tumor development of rats through functional changes in CD4+CD25+Treg cells. Int J Biochem Cell Biol 2014;55:98–108.
    • (2014) Int J Biochem Cell Biol , vol.55 , pp. 98-108
    • Wang, B.1    Li, B.2    Dai, Z.3
  • 65
    • 2542616885 scopus 로고    scopus 로고
    • Low dose gamma-rays activate immune functions via induction of glutathione and delay tumor growth
    • Kojima S, Nakayama K, Ishida H. Low dose gamma-rays activate immune functions via induction of glutathione and delay tumor growth. J Radiat Res 2004;45:33–9.
    • (2004) J Radiat Res , vol.45 , pp. 33-39
    • Kojima, S.1    Nakayama, K.2    Ishida, H.3
  • 66
    • 0029096189 scopus 로고
    • IL-12 synergizes with IL-2 to induce lymphokine-activated cytotoxicity and perforin and granzyme gene expression in fresh human NK cells
    • DeBlaker-Hohe DF, Yamauchi A, Yu CR, et al. IL-12 synergizes with IL-2 to induce lymphokine-activated cytotoxicity and perforin and granzyme gene expression in fresh human NK cells. Cellular Immunol 1995;165:33–43.
    • (1995) Cellular Immunol , vol.165 , pp. 33-43
    • DeBlaker-Hohe, D.F.1    Yamauchi, A.2    Yu, C.R.3
  • 67
    • 0036533489 scopus 로고    scopus 로고
    • Cytokines as a link between innate and adaptive antitumor immunity
    • Belardelli F, Ferrantini M. Cytokines as a link between innate and adaptive antitumor immunity. Trends Immunol 2002;23:201–8.
    • (2002) Trends Immunol , vol.23 , pp. 201-208
    • Belardelli, F.1    Ferrantini, M.2
  • 68
    • 0038627357 scopus 로고    scopus 로고
    • Expression of IL-10 in mouse spleen at mRNA and protein level after whole-body X-irradiation
    • Liu XDLS, Ma SM, Liu Y. Expression of IL-10 in mouse spleen at mRNA and protein level after whole-body X-irradiation. Chin J Radiol Med. Prot 2001;22:10–12.
    • (2001) Chin J Radiol Med. Prot , vol.22 , pp. 10-12
    • Liu, X.D.L.S.1    Ma, S.M.2    Liu, Y.3
  • 69
    • 79955828703 scopus 로고
    • Effect of whole-body x-irradiation on IFNg production by splenocytes
    • Yang YGLS. Effect of whole-body x-irradiation on IFNg production by splenocytes. J N Bethune Univ Med Sci 1989;15:11–3.
    • (1989) J N Bethune Univ Med Sci , vol.15 , pp. 11-13
    • Yang, Y.G.L.S.1
  • 70
    • 0030569244 scopus 로고    scopus 로고
    • Thymocyte apoptosis in response to low-dose radiation
    • Liu SZZY, Mu Y, Su X, et al. Thymocyte apoptosis in response to low-dose radiation. Mutat Res 1996;358:185–91.
    • (1996) Mutat Res , vol.358 , pp. 185-191
    • Liu, S.Z.Z.Y.1    Mu, Y.2    Su, X.3
  • 71
    • 84924627915 scopus 로고    scopus 로고
    • Mutations of the human interferon alpha-2b (hIFN-alpha2b) gene in occupationally protracted low dose radiation exposed personnel
    • Shahid S, Mahmood N, Chaudhry MN, et al. Mutations of the human interferon alpha-2b (hIFN-alpha2b) gene in occupationally protracted low dose radiation exposed personnel. Cytokine 2015;73:181–9.
    • (2015) Cytokine , vol.73 , pp. 181-189
    • Shahid, S.1    Mahmood, N.2    Chaudhry, M.N.3
  • 72
    • 0025309180 scopus 로고
    • Induction of cytogenetic adaptive response of somatic and germ cells in vivo and in vitro by low-dose X-irradiation
    • Cai L, Liu SZ. Induction of cytogenetic adaptive response of somatic and germ cells in vivo and in vitro by low-dose X-irradiation. Int J Radiat Biol 1990;58:187–94.
    • (1990) Int J Radiat Biol , vol.58 , pp. 187-194
    • Cai, L.1    Liu, S.Z.2
  • 73
    • 0026844383 scopus 로고
    • Study on the mechanism of cytogenetic adaptive response induced by low dose radiation
    • Cai L, Liu SZ. Study on the mechanism of cytogenetic adaptive response induced by low dose radiation. Chin Med J 1992;105:277–83.
    • (1992) Chin Med J , vol.105 , pp. 277-283
    • Cai, L.1    Liu, S.Z.2
  • 74
    • 0028929603 scopus 로고
    • Induction of a cytogenetic adaptive response in germ cells of irradiated mice with very low-dose rate of chronic gamma-irradiation and its biological influence on radiation-induced DNA or chromosomal damage and cell killing in their male offspring
    • Cai L, Wang P. Induction of a cytogenetic adaptive response in germ cells of irradiated mice with very low-dose rate of chronic gamma-irradiation and its biological influence on radiation-induced DNA or chromosomal damage and cell killing in their male offspring. Mutagenesis 1995;10:95–100.
    • (1995) Mutagenesis , vol.10 , pp. 95-100
    • Cai, L.1    Wang, P.2
  • 75
    • 84896776514 scopus 로고    scopus 로고
    • Low-dose radiation induces renal SOD1 expression and activity in type 1 diabetic mice
    • Zhang C, Xing X, Zhang F, et al. Low-dose radiation induces renal SOD1 expression and activity in type 1 diabetic mice. Int J Radiat Biol 2014;90:224–30.
    • (2014) Int J Radiat Biol , vol.90 , pp. 224-230
    • Zhang, C.1    Xing, X.2    Zhang, F.3
  • 76
    • 84940448065 scopus 로고    scopus 로고
    • Study of the anti-inflammatory effects of low-dose radiation: The contribution of biphasic regulation of the antioxidative system in endothelial cells
    • Large M, Hehlgans S, Reichert S, et al. Study of the anti-inflammatory effects of low-dose radiation: The contribution of biphasic regulation of the antioxidative system in endothelial cells. Strahlenther Onkol 2015;191:742–49.
    • (2015) Strahlenther Onkol , vol.191 , pp. 742-749
    • Large, M.1    Hehlgans, S.2    Reichert, S.3
  • 77
    • 84880638935 scopus 로고    scopus 로고
    • Low-dose radiation activates Nrf1/2 through reactive species and the Ca(2+)/ERK1/2 signaling pathway in human skin fibroblast cells
    • Lee EK, Kim JA, Park SJ, et al. Low-dose radiation activates Nrf1/2 through reactive species and the Ca(2+)/ERK1/2 signaling pathway in human skin fibroblast cells. BMB Rep 2013;46:258–63.
    • (2013) BMB Rep , vol.46 , pp. 258-263
    • Lee, E.K.1    Kim, J.A.2    Park, S.J.3
  • 78
    • 84871824970 scopus 로고    scopus 로고
    • Low-dose radiation activates Akt and Nrf2 in the kidney of diabetic mice: a potential mechanism to prevent diabetic nephropathy
    • Xing X, Zhang C, Shao M, et al. Low-dose radiation activates Akt and Nrf2 in the kidney of diabetic mice: a potential mechanism to prevent diabetic nephropathy. Oxid Med Cell Longev 2012;2012:291087
    • (2012) Oxid Med Cell Longev , vol.2012 , pp. 291087
    • Xing, X.1    Zhang, C.2    Shao, M.3
  • 79
    • 10044231865 scopus 로고    scopus 로고
    • Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs
    • Murley JS, Kataoka Y, Cao D, et al. Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs. Radiat Res 2004;162:536–46.
    • (2004) Radiat Res , vol.162 , pp. 536-546
    • Murley, J.S.1    Kataoka, Y.2    Cao, D.3
  • 80
    • 34248221984 scopus 로고    scopus 로고
    • Nuclear factor-kappaB and manganese superoxide dismutase mediate adaptive radioresistance in low-dose irradiated mouse skin epithelial cells
    • Fan M, Ahmed KM, Coleman MC, et al. Nuclear factor-kappaB and manganese superoxide dismutase mediate adaptive radioresistance in low-dose irradiated mouse skin epithelial cells. Cancer Res 2007;67:3220–8.
    • (2007) Cancer Res , vol.67 , pp. 3220-3228
    • Fan, M.1    Ahmed, K.M.2    Coleman, M.C.3
  • 81
    • 84874066573 scopus 로고    scopus 로고
    • A manganese superoxide dismutase (SOD2)-mediated adaptive response
    • Grdina DJ, Murley JS, Miller RC, et al. A manganese superoxide dismutase (SOD2)-mediated adaptive response. Radiat Res 2013;179:115–24.
    • (2013) Radiat Res , vol.179 , pp. 115-124
    • Grdina, D.J.1    Murley, J.S.2    Miller, R.C.3
  • 82
    • 0028982493 scopus 로고
    • Thiol modulation of TNF alpha and IL-1 induced MnSOD gene expression and activation of NF-kappa B
    • Das KC, Lewis-Molock Y, White CW. Thiol modulation of TNF alpha and IL-1 induced MnSOD gene expression and activation of NF-kappa B. Mol Cell Biochem 1995;148:45–57.
    • (1995) Mol Cell Biochem , vol.148 , pp. 45-57
    • Das, K.C.1    Lewis-Molock, Y.2    White, C.W.3
  • 83
    • 3943107573 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    • Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, et al. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 2004;73:39–85.
    • (2004) Annu Rev Biochem , vol.73 , pp. 39-85
    • Sancar, A.1    Lindsey-Boltz, L.A.2    Unsal-Kacmaz, K.3
  • 84
    • 0035289717 scopus 로고    scopus 로고
    • Chromosomal stability and the DNA double-stranded break connection
    • van Gent DC, Hoeijmakers JH, Kanaar R. Chromosomal stability and the DNA double-stranded break connection. Nat Rev Genet 2001;2:196–206.
    • (2001) Nat Rev Genet , vol.2 , pp. 196-206
    • van Gent, D.C.1    Hoeijmakers, J.H.2    Kanaar, R.3
  • 85
    • 33750065724 scopus 로고    scopus 로고
    • Effects of low-dose gamma radiation on DNA damage, chromosomal aberration and expression of repair genes in human blood cells
    • Sudprasert W, Navasumrit P, Ruchirawat M. Effects of low-dose gamma radiation on DNA damage, chromosomal aberration and expression of repair genes in human blood cells. Int J Hyg Environ Health 2006;209:503–11.
    • (2006) Int J Hyg Environ Health , vol.209 , pp. 503-511
    • Sudprasert, W.1    Navasumrit, P.2    Ruchirawat, M.3
  • 86
    • 33847618236 scopus 로고    scopus 로고
    • Mammalian single-strand break repair: mechanisms and links with chromatin
    • Caldecott KW. Mammalian single-strand break repair: mechanisms and links with chromatin. DNA Repair 2007;6:443–53.
    • (2007) DNA Repair , vol.6 , pp. 443-453
    • Caldecott, K.W.1
  • 87
    • 84879953282 scopus 로고    scopus 로고
    • DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapy
    • Mladenov E, Magin S, Soni A, et al. DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapy. Front Oncol 2013;3:113
    • (2013) Front Oncol , vol.3 , pp. 113
    • Mladenov, E.1    Magin, S.2    Soni, A.3
  • 88
    • 0021354123 scopus 로고
    • Adaptive response of human lymphocytes to low concentrations of radioactive thymidine
    • Olivieri G, Bodycote J, Wolff S. Adaptive response of human lymphocytes to low concentrations of radioactive thymidine. Science 1984;223:594–7.
    • (1984) Science , vol.223 , pp. 594-597
    • Olivieri, G.1    Bodycote, J.2    Wolff, S.3
  • 89
    • 0023853462 scopus 로고
    • Human lymphocytes exposed to low doses of ionizing radiations become refractory to high doses of radiation as well as to chemical mutagens that induce double-strand breaks in DNA
    • Wolff S, Afzal V, Wiencke JK, et al. Human lymphocytes exposed to low doses of ionizing radiations become refractory to high doses of radiation as well as to chemical mutagens that induce double-strand breaks in DNA. Int J Radiat Biol Relat Stud Phys Chem Med 1988;53:39–47.
    • (1988) Int J Radiat Biol Relat Stud Phys Chem Med , vol.53 , pp. 39-47
    • Wolff, S.1    Afzal, V.2    Wiencke, J.K.3
  • 90
    • 0031903261 scopus 로고    scopus 로고
    • Change of glutathione peroxidase synthesis along with that of superoxide dismutase synthesis in mice spleens after low-dose X-ray irradiation
    • Yamaoka K, Kojima S, Takahashi M, et al. Change of glutathione peroxidase synthesis along with that of superoxide dismutase synthesis in mice spleens after low-dose X-ray irradiation. Biochim Biophys Acta 1998;1381:265–70.
    • (1998) Biochim Biophys Acta , vol.1381 , pp. 265-270
    • Yamaoka, K.1    Kojima, S.2    Takahashi, M.3
  • 91
    • 0029117310 scopus 로고
    • What to do at an end: DNA double-strand-break repair
    • Weaver DT. What to do at an end: DNA double-strand-break repair. Trends Genet 1995;11:388–92.
    • (1995) Trends Genet , vol.11 , pp. 388-392
    • Weaver, D.T.1
  • 92
    • 84929575955 scopus 로고    scopus 로고
    • Dose response and adaptive response of non-homologous end joining repair genes and proteins in resting human peripheral blood mononuclear cells exposed to gamma radiation
    • Shelke S, Das B. Dose response and adaptive response of non-homologous end joining repair genes and proteins in resting human peripheral blood mononuclear cells exposed to gamma radiation. Mutagenesis 2015;30:365–79.
    • (2015) Mutagenesis , vol.30 , pp. 365-379
    • Shelke, S.1    Das, B.2
  • 93
    • 84926347357 scopus 로고    scopus 로고
    • Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair
    • Nakajima NI, Hagiwara Y, Oike T, et al. Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair. PLoS One 2015;10:e0122582
    • (2015) PLoS One , vol.10
    • Nakajima, N.I.1    Hagiwara, Y.2    Oike, T.3
  • 94
    • 84928413006 scopus 로고    scopus 로고
    • Low dose radiation induced senescence of human mesenchymal stromal cells and impaired the autophagy process
    • Alessio N, Del Gaudio S, Capasso S, et al. Low dose radiation induced senescence of human mesenchymal stromal cells and impaired the autophagy process. Oncotarget 2015;6:8155–66.
    • (2015) Oncotarget , vol.6 , pp. 8155-8166
    • Alessio, N.1    Del Gaudio, S.2    Capasso, S.3
  • 95
    • 84865364870 scopus 로고    scopus 로고
    • Playing the end game: DNA double-strand break repair pathway choice
    • Chapman JR, Taylor MR, Boulton SJ. Playing the end game: DNA double-strand break repair pathway choice. Mol Cell 2012;47:497–510.
    • (2012) Mol Cell , vol.47 , pp. 497-510
    • Chapman, J.R.1    Taylor, M.R.2    Boulton, S.J.3
  • 96
    • 80755187806 scopus 로고    scopus 로고
    • Double-strand break end resection and repair pathway choice
    • Symington LS, Gautier J. Double-strand break end resection and repair pathway choice. Annu Rev Genet 2011;45:247–71.
    • (2011) Annu Rev Genet , vol.45 , pp. 247-271
    • Symington, L.S.1    Gautier, J.2
  • 97
    • 34247602569 scopus 로고    scopus 로고
    • Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK
    • Costantini S, Woodbine L, Andreoli L, et al. Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK. DNA Repair 2007;6:712–22.
    • (2007) DNA Repair , vol.6 , pp. 712-722
    • Costantini, S.1    Woodbine, L.2    Andreoli, L.3
  • 98
    • 77953373821 scopus 로고    scopus 로고
    • Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair
    • Loser DA, Shibata A, Shibata AK, et al. Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair. Mol Cancer Ther 2010;9:1775–87.
    • (2010) Mol Cancer Ther , vol.9 , pp. 1775-1787
    • Loser, D.A.1    Shibata, A.2    Shibata, A.K.3
  • 99
    • 0042632901 scopus 로고    scopus 로고
    • Pathways of DNA double-strand break repair during the mammalian cell cycle
    • Rothkamm K, Kruger I, Thompson LH, et al. Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol Cell Biol 2003;23:5706–15.
    • (2003) Mol Cell Biol , vol.23 , pp. 5706-5715
    • Rothkamm, K.1    Kruger, I.2    Thompson, L.H.3
  • 100
    • 70350763838 scopus 로고    scopus 로고
    • ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2
    • Beucher A, Birraux J, Tchouandong L, et al. ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2. Embo J 2009;28:3413–27.
    • (2009) Embo J , vol.28 , pp. 3413-3427
    • Beucher, A.1    Birraux, J.2    Tchouandong, L.3
  • 101
    • 0006470452 scopus 로고    scopus 로고
    • Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses
    • Amundson SA, Bittner M, Chen Y, et al. Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses. Oncogene 1999;18:3666–72. Jr.:-.
    • (1999) Oncogene , vol.18 , pp. 3666-3672
    • Amundson, S.A.1    Bittner, M.2    Chen, Y.3
  • 102
    • 0035887145 scopus 로고    scopus 로고
    • Profiling of cancer cells using protein microarrays: discovery of novel radiation-regulated proteins
    • Sreekumar A, Nyati MK, Varambally S, et al. Profiling of cancer cells using protein microarrays: discovery of novel radiation-regulated proteins. Cancer Res 2001;61:7585–93.
    • (2001) Cancer Res , vol.61 , pp. 7585-7593
    • Sreekumar, A.1    Nyati, M.K.2    Varambally, S.3
  • 103
    • 84947759652 scopus 로고    scopus 로고
    • Baicalein Inhibits MCF-7 Cell Proliferation In Vitro, Induces Radiosensitivity, and Inhibits Hypoxia Inducible Factor
    • Gade S, Gandhi NM. Baicalein Inhibits MCF-7 Cell Proliferation In Vitro, Induces Radiosensitivity, and Inhibits Hypoxia Inducible Factor. J Environ Pathol Toxicol Oncol 2015;34:299–308.
    • (2015) J Environ Pathol Toxicol Oncol , vol.34 , pp. 299-308
    • Gade, S.1    Gandhi, N.M.2
  • 104
    • 84943739348 scopus 로고    scopus 로고
    • CD47 receptor globally regulates metabolic pathways that control resistance to ionizing radiation
    • Miller TW, Soto-Pantoja DR, Schwartz AL, et al. CD47 receptor globally regulates metabolic pathways that control resistance to ionizing radiation. J Biol Chem 2015;290:24858–74.
    • (2015) J Biol Chem , vol.290 , pp. 24858-24874
    • Miller, T.W.1    Soto-Pantoja, D.R.2    Schwartz, A.L.3
  • 105
    • 84898052710 scopus 로고    scopus 로고
    • Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response
    • Lall R, Ganapathy S, Yang M, et al. Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response. Cell Death Differ 2014;21:836–44.
    • (2014) Cell Death Differ , vol.21 , pp. 836-844
    • Lall, R.1    Ganapathy, S.2    Yang, M.3
  • 106
    • 55249120467 scopus 로고    scopus 로고
    • Low-dose radiation does not induce proliferation in tumor cells in vitro and in vivo
    • Jiang H, Xu Y, Li W, et al. Low-dose radiation does not induce proliferation in tumor cells in vitro and in vivo. Radiat Res 2008;170:477–87.
    • (2008) Radiat Res , vol.170 , pp. 477-487
    • Jiang, H.1    Xu, Y.2    Li, W.3
  • 107
    • 4544323746 scopus 로고    scopus 로고
    • Enhancement of radiation-induced apoptosis by preirradiation with low-dose X-rays in human leukemia MOLT-4 cells
    • Chen Z, Sakai K. Enhancement of radiation-induced apoptosis by preirradiation with low-dose X-rays in human leukemia MOLT-4 cells. J Radiat Res 2004;45:239–43.
    • (2004) J Radiat Res , vol.45 , pp. 239-243
    • Chen, Z.1    Sakai, K.2
  • 108
    • 84954410448 scopus 로고    scopus 로고
    • Low-dose radiation induces cell proliferation in human embryonic lung fibroblasts but not in lung cancer cells: importance of ERK1/2 and AKT signaling pathways
    • 1559325815622174
    • Liang X, Gu J, Yu D, et al. Low-dose radiation induces cell proliferation in human embryonic lung fibroblasts but not in lung cancer cells: importance of ERK1/2 and AKT signaling pathways. Dose Response 2016;14:1559325815622174
    • (2016) Dose Response , vol.14
    • Liang, X.1    Gu, J.2    Yu, D.3
  • 109
    • 84899098009 scopus 로고    scopus 로고
    • Influence of ionizing radiation on ovarian carcinoma SKOV- 3 xenografts in nude mice under hypoxic conditions
    • Zhang YC, Jiang G, Gao H, et al. Influence of ionizing radiation on ovarian carcinoma SKOV- 3 xenografts in nude mice under hypoxic conditions. Asian Pac J Cancer Prev 2014;15:2353–8.
    • (2014) Asian Pac J Cancer Prev , vol.15 , pp. 2353-2358
    • Zhang, Y.C.1    Jiang, G.2    Gao, H.3
  • 110
    • 84879593508 scopus 로고    scopus 로고
    • Fractionated low-dose radiation exposure potentiates proliferation of implanted tumor cells
    • Gerashchenko BI, Ryabchenko NM, Glavin OA, et al. Fractionated low-dose radiation exposure potentiates proliferation of implanted tumor cells. Exp Oncol 2013;35:69–71.
    • (2013) Exp Oncol , vol.35 , pp. 69-71
    • Gerashchenko, B.I.1    Ryabchenko, N.M.2    Glavin, O.A.3
  • 111
    • 0032772066 scopus 로고    scopus 로고
    • Adaptive response and its variation in human normal and tumour cells
    • Raaphorst GP, Boyden S. Adaptive response and its variation in human normal and tumour cells. Int J Radiat Biol 1999;75:865–73.
    • (1999) Int J Radiat Biol , vol.75 , pp. 865-873
    • Raaphorst, G.P.1    Boyden, S.2
  • 112
    • 3242881897 scopus 로고    scopus 로고
    • An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome
    • O'Driscoll M, Gennery AR, Seidel J, et al. An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome. DNA Repair 2004;3:1227–35.
    • (2004) DNA Repair , vol.3 , pp. 1227-1235
    • O'Driscoll, M.1    Gennery, A.R.2    Seidel, J.3
  • 113
    • 36949021811 scopus 로고    scopus 로고
    • The clinical manifestation of a defective response to DNA double-strand breaks as exemplified by Nijmegen breakage syndrome
    • Demuth I, Digweed M. The clinical manifestation of a defective response to DNA double-strand breaks as exemplified by Nijmegen breakage syndrome. Oncogene 2007;26:7792–8.
    • (2007) Oncogene , vol.26 , pp. 7792-7798
    • Demuth, I.1    Digweed, M.2
  • 114
    • 52449114574 scopus 로고    scopus 로고
    • Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
    • Lavin MF. Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer. Nat Rev Mol Cell Biol 2008;9:759–69.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 759-769
    • Lavin, M.F.1
  • 115
    • 0033963184 scopus 로고    scopus 로고
    • Effects of low dose irradiation on TK6 and U937 cells: induction of p53 and its role in cell-cycle delay and the adaptive response
    • Hendrikse AS, Hunter AJ, Keraan M, et al. Effects of low dose irradiation on TK6 and U937 cells: induction of p53 and its role in cell-cycle delay and the adaptive response. Int J Radiat Biol 2000;76:11–21.
    • (2000) Int J Radiat Biol , vol.76 , pp. 11-21
    • Hendrikse, A.S.1    Hunter, A.J.2    Keraan, M.3
  • 116
    • 44349096312 scopus 로고    scopus 로고
    • Low-dose radiation induces adaptive response in normal cells, but not in tumor cells: in vitro and in vivo studies
    • Jiang H, Li W, Li X, et al. Low-dose radiation induces adaptive response in normal cells, but not in tumor cells: in vitro and in vivo studies. J Radiat Res 2008;49:219–30.
    • (2008) J Radiat Res , vol.49 , pp. 219-230
    • Jiang, H.1    Li, W.2    Li, X.3
  • 117
    • 84856214659 scopus 로고    scopus 로고
    • Low dose irradiation of thyroid cells reveals a unique transcriptomic and epigenetic signature in RET/PTC-positive cells
    • Abou-El-Ardat K, Monsieurs P, Anastasov N, et al. Low dose irradiation of thyroid cells reveals a unique transcriptomic and epigenetic signature in RET/PTC-positive cells. Mutat Res 2012;731:27–40.
    • (2012) Mutat Res , vol.731 , pp. 27-40
    • Abou-El-Ardat, K.1    Monsieurs, P.2    Anastasov, N.3
  • 118
    • 84917732597 scopus 로고    scopus 로고
    • Low-dose gamma-irradiation induces dual radio-adaptive responses depending on the post-irradiation time by altering microRNA expression profiles in normal human dermal fibroblasts
    • Bae S, Kim K, Cha HJ, et al. Low-dose gamma-irradiation induces dual radio-adaptive responses depending on the post-irradiation time by altering microRNA expression profiles in normal human dermal fibroblasts. Int J Mol Med 2015;35:227–37.
    • (2015) Int J Mol Med , vol.35 , pp. 227-237
    • Bae, S.1    Kim, K.2    Cha, H.J.3
  • 119
    • 84928911710 scopus 로고    scopus 로고
    • Gene profiling characteristics of radioadaptive response in AG01522 normal human fibroblasts
    • Hou J, Wang F, Kong P, et al. Gene profiling characteristics of radioadaptive response in AG01522 normal human fibroblasts. PLoS One 2015;10:e0123316
    • (2015) PLoS One , vol.10
    • Hou, J.1    Wang, F.2    Kong, P.3
  • 120
    • 84949987935 scopus 로고    scopus 로고
    • Model Uncertainty via the Integration of Hormesis and LNT as the Default in Cancer Risk Assessment
    • 1559325815621764
    • Calabrese EJ. Model Uncertainty via the Integration of Hormesis and LNT as the Default in Cancer Risk Assessment. Dose Response 2015;13:1559325815621764
    • (2015) Dose Response , vol.13
    • Calabrese, E.J.1
  • 121
    • 84957058899 scopus 로고    scopus 로고
    • Urgent Change Needed to Radiation Protection Policy
    • Cuttler JM. Urgent Change Needed to Radiation Protection Policy. Health Phys 2016;110:267–70.
    • (2016) Health Phys , vol.110 , pp. 267-270
    • Cuttler, J.M.1
  • 122
    • 84957090346 scopus 로고    scopus 로고
    • Future of Radiation Protection Regulations
    • Doss M. Future of Radiation Protection Regulations. Health Phys 2016;110:274–5.
    • (2016) Health Phys , vol.110 , pp. 274-275
    • Doss, M.1
  • 123
    • 84958764866 scopus 로고    scopus 로고
    • Is the linear no-threshold dose-response paradigm still necessary for the assessment of health effects of low dose radiation?
    • Seong KM, Seo S, Lee D, et al. Is the linear no-threshold dose-response paradigm still necessary for the assessment of health effects of low dose radiation? J Korean Med Sci 2016;31:S10–23.
    • (2016) J Korean Med Sci , vol.31 , pp. S10-23
    • Seong, K.M.1    Seo, S.2    Lee, D.3
  • 124
    • 84961226402 scopus 로고    scopus 로고
    • Linear no-threshold model and standards for protection against radiation
    • Shamoun DY. Linear no-threshold model and standards for protection against radiation. Regulat Toxicol Pharmacol RTP 2016;77:49–53.
    • (2016) Regulat Toxicol Pharmacol RTP , vol.77 , pp. 49-53
    • Shamoun, D.Y.1
  • 125
    • 84900330267 scopus 로고    scopus 로고
    • Long-term low-dose alpha-particle enhanced the potential of malignant transformation in human bronchial epithelial cells through MAPK/Akt pathway
    • Liu W, Xiao L, Dong C, et al. Long-term low-dose alpha-particle enhanced the potential of malignant transformation in human bronchial epithelial cells through MAPK/Akt pathway. Biochem Biophys Res Commun 2014;447:388–93.
    • (2014) Biochem Biophys Res Commun , vol.447 , pp. 388-393
    • Liu, W.1    Xiao, L.2    Dong, C.3
  • 126
    • 77955286548 scopus 로고    scopus 로고
    • Low doses of ionizing radiation promote tumor growth and metastasis by enhancing angiogenesis
    • Sofia Vala I, Martins LR, Imaizumi N, et al. Low doses of ionizing radiation promote tumor growth and metastasis by enhancing angiogenesis. PLoS One 2010;5:e11222
    • (2010) PLoS One , vol.5
    • Sofia Vala, I.1    Martins, L.R.2    Imaizumi, N.3
  • 127
    • 84872863562 scopus 로고    scopus 로고
    • Long-term trend of thyroid cancer risk among Japanese atomic-bomb survivors: 60 years after exposure
    • Furukawa K, Preston D, Funamoto S, et al. Long-term trend of thyroid cancer risk among Japanese atomic-bomb survivors: 60 years after exposure. Int J Cancer 2013;132:1222–6.
    • (2013) Int J Cancer , vol.132 , pp. 1222-1226
    • Furukawa, K.1    Preston, D.2    Funamoto, S.3
  • 128
    • 84901004801 scopus 로고    scopus 로고
    • Exposure to low dose ionising radiation: Molecular and clinical consequences
    • Martin LM, Marples B, Lynch TH, et al. Exposure to low dose ionising radiation: Molecular and clinical consequences. Cancer Lett 2014;349:98–106.
    • (2014) Cancer Lett , vol.349 , pp. 98-106
    • Martin, L.M.1    Marples, B.2    Lynch, T.H.3
  • 129
    • 9644278078 scopus 로고    scopus 로고
    • Evasion of early cellular response mechanisms following low level radiation-induced DNA damage
    • Collis SJ, Schwaninger JM, Ntambi AJ, et al. Evasion of early cellular response mechanisms following low level radiation-induced DNA damage. J Biol Chem 2004;279:49624–32.
    • (2004) J Biol Chem , vol.279 , pp. 49624-49632
    • Collis, S.J.1    Schwaninger, J.M.2    Ntambi, A.J.3
  • 130
    • 84890963645 scopus 로고    scopus 로고
    • Determining if low dose hyper-radiosensitivity (HRS) can be exploited to provide a therapeutic advantage: a cell line study in four glioblastoma multiforme (GBM) cell lines
    • Schoenherr D, Krueger SA, Martin L, et al. Determining if low dose hyper-radiosensitivity (HRS) can be exploited to provide a therapeutic advantage: a cell line study in four glioblastoma multiforme (GBM) cell lines. Int J Radiat Biol 2013;89:1009–16.
    • (2013) Int J Radiat Biol , vol.89 , pp. 1009-1016
    • Schoenherr, D.1    Krueger, S.A.2    Martin, L.3
  • 131
    • 34249826347 scopus 로고    scopus 로고
    • Thresholds and transitions for activation of cellular radioprotective mechanisms - correlations between HRS/IRR and the 'inverse' dose-rate effect
    • Leonard BE. Thresholds and transitions for activation of cellular radioprotective mechanisms - correlations between HRS/IRR and the 'inverse' dose-rate effect. Int J Radiat Biol 2007;83:479–89.
    • (2007) Int J Radiat Biol , vol.83 , pp. 479-489
    • Leonard, B.E.1
  • 132
    • 84885444053 scopus 로고    scopus 로고
    • Low-dose radiation induces antitumor effects and erythrocyte system hormesis
    • Yu HS, Liu ZM, Yu XY, et al. Low-dose radiation induces antitumor effects and erythrocyte system hormesis. Asian Pac J Cancer Prev 2013;14:4121–6.
    • (2013) Asian Pac J Cancer Prev , vol.14 , pp. 4121-4126
    • Yu, H.S.1    Liu, Z.M.2    Yu, X.Y.3
  • 133
    • 12844265986 scopus 로고    scopus 로고
    • Suppression of thymic lymphoma induction by life-long low-dose-rate irradiation accompanied by immune activation in C57BL/6 mice
    • Ina Y, Tanooka H, Yamada T, et al. Suppression of thymic lymphoma induction by life-long low-dose-rate irradiation accompanied by immune activation in C57BL/6 mice. Radiat Res 2005;163:153–8.
    • (2005) Radiat Res , vol.163 , pp. 153-158
    • Ina, Y.1    Tanooka, H.2    Yamada, T.3
  • 134
    • 33749397869 scopus 로고    scopus 로고
    • [Antitumor effects by low dose total body irradiation]
    • Hosoi Y. [Antitumor effects by low dose total body irradiation]. Yakugaku Zasshi 2006;126:841–8.
    • (2006) Yakugaku Zasshi , vol.126 , pp. 841-848
    • Hosoi, Y.1
  • 135
    • 0033051757 scopus 로고    scopus 로고
    • The suppression of metastases and the change in host immune response after low-dose total-body irradiation in tumor-bearing rats
    • Hashimoto S, Shirato H, Hosokawa M, et al. The suppression of metastases and the change in host immune response after low-dose total-body irradiation in tumor-bearing rats. Radiat Res 1999;151:717–24.
    • (1999) Radiat Res , vol.151 , pp. 717-724
    • Hashimoto, S.1    Shirato, H.2    Hosokawa, M.3
  • 136
    • 84939575615 scopus 로고    scopus 로고
    • Effects of microbeam radiation therapy on normal and tumoral blood vessels
    • Bouchet A, Serduc R, Laissue JA, et al. Effects of microbeam radiation therapy on normal and tumoral blood vessels. Phys Med 2015;31:634–41.
    • (2015) Phys Med , vol.31 , pp. 634-641
    • Bouchet, A.1    Serduc, R.2    Laissue, J.A.3
  • 137
    • 77952098070 scopus 로고    scopus 로고
    • Effects of pulsed, spatially fractionated, microscopic synchrotron X-ray beams on normal and tumoral brain tissue
    • Brauer-Krisch E, Serduc R, Siegbahn EA, et al. Effects of pulsed, spatially fractionated, microscopic synchrotron X-ray beams on normal and tumoral brain tissue. Mutat Res 2010;704:160–6.
    • (2010) Mutat Res , vol.704 , pp. 160-166
    • Brauer-Krisch, E.1    Serduc, R.2    Siegbahn, E.A.3
  • 138
    • 84924267980 scopus 로고    scopus 로고
    • Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice
    • Favaudon V, Caplier L, Monceau V, et al. Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice. Sci Transl Med 2014;6:245ra93
    • (2014) Sci Transl Med , vol.6 , pp. 245ra93
    • Favaudon, V.1    Caplier, L.2    Monceau, V.3
  • 139
    • 84953223108 scopus 로고    scopus 로고
    • Global gene expression alterations as a crucial constituent of human cell response to low doses of ionizing radiation exposure
    • Sokolov M, Neumann R. Global gene expression alterations as a crucial constituent of human cell response to low doses of ionizing radiation exposure. Int J Mol Sci 2016;17:
    • (2016) Int J Mol Sci , vol.17
    • Sokolov, M.1    Neumann, R.2
  • 140
    • 84934275725 scopus 로고    scopus 로고
    • Data integration reveals key homeostatic mechanisms following low dose radiation exposure
    • Tilton SC, Matzke MM, Sowa MB, et al. Data integration reveals key homeostatic mechanisms following low dose radiation exposure. Toxicol Appl Pharmacol 2015;285:1–11.
    • (2015) Toxicol Appl Pharmacol , vol.285 , pp. 1-11
    • Tilton, S.C.1    Matzke, M.M.2    Sowa, M.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.