Low dose γ-rays activate immune functions via induction of glutathione and delay tumor growth

Journal of Radiation Research

Volumn 45, Issue 1, 2004, Pages 33-39

  Kojima, Shuji ^a   Nakayama, Keiko ^a   Ishida, Hirokazu ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Glutathione (GSH); Immune function Interferon ; Low dose gamma rays; Tumor suppression

Indexed keywords

CYTOTOXICITY; IRRADIATION; MAMMALS; PEPTIDES; TUMORS;

GAMMA-RAYS; GLUTATHIONE (GSH); GLUTHATHIONE; IMMUNE FUNCTION; IMMUNE FUNCTION INTERFERON-Γ; LOW DOSE; LOW-DOSE GAMMA-RAY; NATURAL KILLER; TUMOR GROWTH; TUMOR SUPPRESSION;

GAMMA RAYS;

GLUTATHIONE;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; EHRLICH ASCITES TUMOR; GAMMA RADIATION; IMMUNE FUNCTION TEST; INOCULATION; MALE; MOUSE; MOUSE STRAIN; NATURAL KILLER CELL; NONHUMAN; RADIATION DOSE; REDUCTION; TUMOR GROWTH; WHOLE BODY RADIATION;

EID: 2542616885     PISSN: 04493060     EISSN: None     Source Type: Journal    
DOI: 10.1269/jrr.45.33     Document Type: Article

References (23)

1. Ikushima, T., Aritomi, H. and Morishita, J. (1996) Radioadaptive: Efficient repair of radiation induced DNA damage in adapted cells. Mutat. Res. 358: 193-198.
2. Nogami, M., Huang, J. T., James, S. J., Lubinski, J. M. and Makinodan, T. (1993) Mice chronically exposed to low dose ionizing radiation possess splenocytes with enhanced poliferation capacity and elevated levels of HSP-70 mRNA and protein. Int. J. Radiat. Res. 63: 775-786.
3. Luckey, T. D. (1982) Physiological benefits from small levels of ionizing radiation. Health. Phys. 43: 771-789.
4. Yonezawa, M., Misonoh, J. and Hosokawa, Y. (1996) Two types of X-ray-induced radioresistance in mice: Presence of 4 dose ranges with distinct biological effects. Mutat. Res. 358: 237-243.
5. Liu, S. Z., Hann, Z. B. and Liu, W. H. (1994) Changes in lymphocytes reactivity to modulatory factors following low dose ionizing radiation. Biomed. Environ. Sci. 7: 130-135.
6. Liu, S. Z., Xu, S., Zhang, Y. C. and Zhao, Y. (1994) Signal transduction in lymphocytes after low dose radiation. Clin. Med. J. (Engl.) 107: 431-436.
7. Chen, S. L., Cai, L., Meng, Q. Y., Xu, S., Wan, H. and Liu, S. Z. (2000) Low-dose whole body irradiation (LD-WBI) changes protein expression of mouse thymocytes: Effect of a LD-WBI-enhanced protein RIP10 on cell proliferation and spontenous or radiation- induced thymocytes apoptosis. Toxicol. Sci. 55: 97-106.
8. Ibuki, Y. and Goto, R. (1994) Enhancement of concanavalin A- Induced proliferation of splenocytes by small-dose-irradiated macrophages. J. Radiat. Res. 35: 83-91.
9. Meister, A. and Anderson, M. N. (1983) Glutathione. Annu. Rev. Biochem. 52: 611-660.
10. Phalavani, M. A. and Harris, M. D. (1998) Effect of in vitro generation of oxygen free radicals on T cell function in young and old rats. Free Radic. Biol. Med. 25: 903-913.
11. Kojima, S., Matsuki, O., Nomura, T., Kubodera, A., Honda, Y., Honda, S., Tanooka, H., Wakasugi, H. and Yamaoka, K. (1998) Induction of mRNAs for glutathione-related proteins in mouse liver by small doses of γ-rays. Biochim. Biophys. Acta 1381: 312-318.
12. Kojima, S., Matsumori, S., Ishida, H. and Yamaoka, K. (2000) Possible role of elevation of glutathione in the acquisition of enhanced proliferation of mouse splenocytes exposed to small-dose γ-rays. Int. J. Radiat. Biol. 76: 1641-1647.
13. Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem, 193: 265-275.
14. Luckey, T. D. (1991) Radiation Hormesis, CRC Press, Boca Raton
15. Safwat, A. (2000) The immunobiology of low-dose total-body irradiation: more questions than answers. Radiat. Res. 153: 599-604.
16. Prussia, B. (1991) Lymphokine activated killer cells. Natural killer cells and cytokines. Curr. Opin. Immunol. 3: 49-55.
17. Furukawa, T., Meydani, S. N. and Blumberg, J. B. (1990) The potential benefits of dietary glutathione on immune function and other practical implications. In: Glutathione: Metabolism and Physiological Functions. Ed. Vina, J., pp. 351-366. CRC Press, Boca Raton, FL.
18. Meydani, S. N. (1991) Dietary modulation of the immune response in the aged. Age 14: 108-115.
19. Nguyen, Q. H., Roberts, R. L., Ank, B. J., Lin, S. L., Lau, C. K. and Stiehm, E. R. (1998) Enhancement of antibody-dependent cellular cytotoxicity of neonatal cells by interleukin-2 (IL-2) and IL-12. Clin. Diagn. Lab. Immunol. 5: 98-104.
20. Sakamoto, K., Miyamoto, M. and Watabe, N. (1987) The effect of small-dose total body irradiation on tumor control. Jpn. J. Cancer Chemother. 14: 1545-1549.
21. Hosoi, Y. and Sakamoto, K. (1993) Suppressive effect of small dose total body irradiation on lung metastasis: Dose dependency and effective period. Radiother. Oncol. 26: 177-179.
22. Vicker, M. G., Bultmann, H., Glade, U. and Hâfker, T. (1991) Ionizing radiation at small dose induces inflammatory reaction in human blood. Radiat. Res. 128: 251-257.
23. Ishi, K., Hosoi, Y., Ono, T. and Sakamoto, K. (1996) Enhanced proliferation and IL-1 production of mouse splenocytes by small dose whole body X-irradiation. Physiol. Chem. Phys. Med. NMR 28: 7-14.