메뉴 건너뛰기




Volumn 24, Issue 3, 2007, Pages 424-430

Low-dose radiation stimulates the proliferation of normal human lung fibroblasts via a transient activation of Raf and Akt

Author keywords

Akt; Cell proliferation; Low dose radiation; Normal human diploid cells; Raf

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; PROTEIN KINASE B; PROTEIN P21; PROTEIN P53; RAF PROTEIN;

EID: 38349029063     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (48)

References (37)
  • 1
    • 0029942186 scopus 로고    scopus 로고
    • Activation and phosphorylation of a pleck-strin homology domain containin protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors
    • Andjekovic, M., Jakubowicz, T., Cron, P., Ming, X. F., Han, J. W., et al.. (1996) Activation and phosphorylation of a pleck-strin homology domain containin protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. Proc. Natl. Acad. Sci. USA 93, 5699-5704.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 5699-5704
    • Andjekovic, M.1    Jakubowicz, T.2    Cron, P.3    Ming, X.F.4    Han, J.W.5
  • 3
    • 0032874677 scopus 로고    scopus 로고
    • Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: Possible sites for intervention with anti-neoplastic drugs
    • Blalock, W. L., Weinstein-Oppenheimer, C., Chang, F., Hoyle, P. E., Wang, X. Y., et al. (1999) Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs. Leukemia 13, 1109-1166.
    • (1999) Leukemia , vol.13 , pp. 1109-1166
    • Blalock, W.L.1    Weinstein-Oppenheimer, C.2    Chang, F.3    Hoyle, P.E.4    Wang, X.Y.5
  • 4
    • 0038458970 scopus 로고    scopus 로고
    • Developing a scientific basis for radiation risk estimates: Goal of the DOE low dose research program
    • Brooks, A. L. (2003) Developing a scientific basis for radiation risk estimates: goal of the DOE low dose research program. Health Phys. 85, 85-93.
    • (2003) Health Phys , vol.85 , pp. 85-93
    • Brooks, A.L.1
  • 5
    • 0032819345 scopus 로고    scopus 로고
    • Research of the adaptive response induced by low-dose-radiation: Where have we been and where should we go?
    • Cai, L. (1999) Research of the adaptive response induced by low-dose-radiation: where have we been and where should we go? Hum. Exp. Toxicol. 18, 419-425.
    • (1999) Hum. Exp. Toxicol , vol.18 , pp. 419-425
    • Cai, L.1
  • 6
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley, L. C. (2002) The phosphoinositide 3-kinase pathway. Science 296, 1655.
    • (2002) Science , vol.296 , pp. 1655
    • Cantley, L.C.1
  • 7
    • 0037030519 scopus 로고    scopus 로고
    • Ionizing radiation activates Erb-B receptorr dependent Akt and p70 S6 kinase signaling in carcinoma cells
    • Contessa, J. N., Hampton, J., Lammering, G, Mikkelsen, R. B., Dent, P., et al. (2002) Ionizing radiation activates Erb-B receptorr dependent Akt and p70 S6 kinase signaling in carcinoma cells. Oncogene 21, 4032-4041.
    • (2002) Oncogene , vol.21 , pp. 4032-4041
    • Contessa, J.N.1    Hampton, J.2    Lammering, G.3    Mikkelsen, R.B.4    Dent, P.5
  • 8
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta, S. R., Brunet, A., and Greenberg, M. E. (1999) Cellular survival: a play in three Akts, Genes Dev. 13, 2905-2927.
    • (1999) Genes Dev , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 9
    • 0032815618 scopus 로고    scopus 로고
    • Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death
    • Dent, P., Reardon, D. B., Park, J. S., Bowers, G, Logsdon, C., et al. (1999) Radiation-induced release of transforming growth factor alpha activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death. Mol. Biol. Cell 10, 2493-2506.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 2493-2506
    • Dent, P.1    Reardon, D.B.2    Park, J.S.3    Bowers, G.4    Logsdon, C.5
  • 10
    • 19944430124 scopus 로고    scopus 로고
    • Regulation of Raf-1 by direct feedback phosphorylation
    • Dougherty, M. K., Muller, J., Ritt, D. A., Zhou, M., Zhou, X. Z., et al.. (2005) Regulation of Raf-1 by direct feedback phosphorylation. Mol. Cell 17, 215-224.
    • (2005) Mol. Cell , vol.17 , pp. 215-224
    • Dougherty, M.K.1    Muller, J.2    Ritt, D.A.3    Zhou, M.4    Zhou, X.Z.5
  • 11
    • 0037102157 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation
    • Edwards, E., Geng, L., Tan, J., Onishko, H., Donnelly, E., et al.. (2002) Phosphatidylinositol 3-kinase/Akt signaling in the response of vascular endothelium to ionizing radiation. Cancer Res. 62, 4671-4677.
    • (2002) Cancer Res , vol.62 , pp. 4671-4677
    • Edwards, E.1    Geng, L.2    Tan, J.3    Onishko, H.4    Donnelly, E.5
  • 14
    • 0031039024 scopus 로고    scopus 로고
    • Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
    • Franke, T. F., Kaplan, D. R., Cantley, L. C., and Toker, A. (1997) Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 275, 665.
    • (1997) Science , vol.275 , pp. 665
    • Franke, T.F.1    Kaplan, D.R.2    Cantley, L.C.3    Toker, A.4
  • 15
  • 16
    • 0037099522 scopus 로고    scopus 로고
    • Ras mediates radioresistance through both phosphatidylinositol 3-kinase-dependent and Raf-dependent but mitogen-activated protein kinase/extracellular signal-regulated kinase kinase: Independent signaling pathways
    • Grana, T. M., Rusyn, E. V., Zhou, H., Sartor, C. I., and Cox, A. D. (2002) Ras mediates radioresistance through both phosphatidylinositol 3-kinase-dependent and Raf-dependent but mitogen-activated protein kinase/extracellular signal-regulated kinase kinase: independent signaling pathways. Cancer Res. 62, 4142-4150.
    • (2002) Cancer Res , vol.62 , pp. 4142-4150
    • Grana, T.M.1    Rusyn, E.V.2    Zhou, H.3    Sartor, C.I.4    Cox, A.D.5
  • 17
    • 1842865963 scopus 로고    scopus 로고
    • The role of signal transduction pathways in drug and radiation resistance
    • Grant, S., Fisher, P. B., and Dent, P. (2002a) The role of signal transduction pathways in drug and radiation resistance. Cancer Treat. Res. 112, 89-108.
    • (2002) Cancer Treat. Res , vol.112 , pp. 89-108
    • Grant, S.1    Fisher, P.B.2    Dent, P.3
  • 19
    • 0031806483 scopus 로고    scopus 로고
    • Calcium-dependent stimulation of mitogen-activated protein kinase activity in A431 cells by low doses of ionizing radiation
    • Kavanagh, B. D., Dent, P., Schmidt-Ullrich, R. K., Chen, P., and Mikkelsen, R. B. (1998) Calcium-dependent stimulation of mitogen-activated protein kinase activity in A431 cells by low doses of ionizing radiation. Radiat. Res. 149, 579-587.
    • (1998) Radiat. Res , vol.149 , pp. 579-587
    • Kavanagh, B.D.1    Dent, P.2    Schmidt-Ullrich, R.K.3    Chen, P.4    Mikkelsen, R.B.5
  • 20
    • 0029764557 scopus 로고    scopus 로고
    • The effect of low-dose irradiation on proliferation of mammalian cells in vitro
    • Korystov, Y. N., Eliseeva, N. A., Kublik, L. N., and Narimanov, A. A. (1996) The effect of low-dose irradiation on proliferation of mammalian cells in vitro. Radiat. Res. 146, 329-332.
    • (1996) Radiat. Res , vol.146 , pp. 329-332
    • Korystov, Y.N.1    Eliseeva, N.A.2    Kublik, L.N.3    Narimanov, A.A.4
  • 21
    • 0034682469 scopus 로고    scopus 로고
    • Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53
    • Lee, S. W., Fang, L., Igarashi, M., Ouchi, T., Lu, K. P., et al. (2000) Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53. Proc. Natl. Acad. Sci. USA 97, 8302-8305.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 8302-8305
    • Lee, S.W.1    Fang, L.2    Igarashi, M.3    Ouchi, T.4    Lu, K.P.5
  • 22
  • 23
    • 0028307190 scopus 로고
    • The molecular basis for cell cycle delays following ionizing radiation: A review
    • Maity, A., McKenna, W. G., and Muschel, R. J. (1994) The molecular basis for cell cycle delays following ionizing radiation: a review. Radiother. Oncol. 31, 1-13.
    • (1994) Radiother. Oncol , vol.31 , pp. 1-13
    • Maity, A.1    McKenna, W.G.2    Muschel, R.J.3
  • 24
    • 0028825531 scopus 로고
    • Ras target proteins in eukaryotic cells
    • Marshall, M. S. (1995) Ras target proteins in eukaryotic cells. FASEB J. 9, 1311-1318.
    • (1995) FASEB J , vol.9 , pp. 1311-1318
    • Marshall, M.S.1
  • 25
    • 23444440323 scopus 로고    scopus 로고
    • A-Raf and Raf-1 work together to influence transient ERK phosphorylation and G1/S cell cycle progression
    • Mercer, K., Giblett, S., Oakden, A., Brown, J., Marais R., et al. (2005) A-Raf and Raf-1 work together to influence transient ERK phosphorylation and G1/S cell cycle progression. Oncogene 24, 5207-5217
    • (2005) Oncogene , vol.24 , pp. 5207-5217
    • Mercer, K.1    Giblett, S.2    Oakden, A.3    Brown, J.4    Marais, R.5
  • 26
    • 0041672477 scopus 로고    scopus 로고
    • Extreme sensitivity of adult neurogenesis to low doses of X-irradiation
    • Mizumatsu, S., Monje, M., Morhardt, D., Rola, R., Palmer, T., et al. (2003) Extreme sensitivity of adult neurogenesis to low doses of X-irradiation. Cancer Res. 63, 4021-4027.
    • (2003) Cancer Res , vol.63 , pp. 4021-4027
    • Mizumatsu, S.1    Monje, M.2    Morhardt, D.3    Rola, R.4    Palmer, T.5
  • 28
    • 0037028291 scopus 로고    scopus 로고
    • Identification of radiation-specific responses from gene expression profile
    • Park, W. Y., Hwang, C. I., Im, C. N., Kang, M. J., Woo, J. H., et al. (2002) Identification of radiation-specific responses from gene expression profile. Oncogene 21, 8521-8525.
    • (2002) Oncogene , vol.21 , pp. 8521-8525
    • Park, W.Y.1    Hwang, C.I.2    Im, C.N.3    Kang, M.J.4    Woo, J.H.5
  • 29
    • 0032080807 scopus 로고    scopus 로고
    • Direct evidence that apoptosis enhances tumor responses to fractionated radiotherapy
    • Rupnow, B. A., Murtha, A. D., Alarcon, R. M., Giaccia, A. J., and Knox, S. J. (1998) Direct evidence that apoptosis enhances tumor responses to fractionated radiotherapy. Cancer Res. 58, 1779-1784.
    • (1998) Cancer Res , vol.58 , pp. 1779-1784
    • Rupnow, B.A.1    Murtha, A.D.2    Alarcon, R.M.3    Giaccia, A.J.4    Knox, S.J.5
  • 30
    • 33644786244 scopus 로고    scopus 로고
    • Regulation and role of Raf-1/B-Raf heterodimerization
    • Rushworth, L. K., Hindley, A. D., O'Neill, E., and Kolch, W. (2006) Regulation and role of Raf-1/B-Raf heterodimerization. Mol. Cell. Biol. 26, 2262-2272.
    • (2006) Mol. Cell. Biol , vol.26 , pp. 2262-2272
    • Rushworth, L.K.1    Hindley, A.D.2    O'Neill, E.3    Kolch, W.4
  • 32
    • 0032843987 scopus 로고    scopus 로고
    • Pharmacological inhibition of Ras-transformed epithelial cell growth is linked to down-regulation of epidermal growth factor related peptides
    • Sizemore, N., Cox, A. D., Barnard, J. A., Oldham, S. M., Reynolds, E. R., et al. (1999) Pharmacological inhibition of Ras-transformed epithelial cell growth is linked to down-regulation of epidermal growth factor related peptides. Gastroenterology 117, 567-576.
    • (1999) Gastroenterology , vol.117 , pp. 567-576
    • Sizemore, N.1    Cox, A.D.2    Barnard, J.A.3    Oldham, S.M.4    Reynolds, E.R.5
  • 33
    • 0028354791 scopus 로고
    • Can colony size be used to detect low-dose effects?
    • Spadinger, I., Marples, B., Matthews, J., and Skov, K. (1994) Can colony size be used to detect low-dose effects? Radiat. Res. 138, S21-S24.
    • (1994) Radiat. Res , vol.138
    • Spadinger, I.1    Marples, B.2    Matthews, J.3    Skov, K.4
  • 34
    • 0035879004 scopus 로고    scopus 로고
    • Extremely low-dose ionizing radiation causes activation of mitogen-activated protein kinase pathway and enhances proliferation of normal human diploid cells
    • Suzuki, K., Kodama, S., and Watanabe, M. (2001) Extremely low-dose ionizing radiation causes activation of mitogen-activated protein kinase pathway and enhances proliferation of normal human diploid cells. Cancer Res. 61, 5396-5401.
    • (2001) Cancer Res , vol.61 , pp. 5396-5401
    • Suzuki, K.1    Kodama, S.2    Watanabe, M.3
  • 35
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • Vivanco, I. and Sawyers, C. L. (2002) The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer 2, 489.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 489
    • Vivanco, I.1    Sawyers, C.L.2
  • 36
    • 0344121661 scopus 로고    scopus 로고
    • Gene expression changes in mouse brain after exposure to low-dose ionizing radiation
    • Yin, E., Nelson, D. O., Coleman, M. A., Peterson, L. E., and Wyrobek, A. J. (2003) Gene expression changes in mouse brain after exposure to low-dose ionizing radiation. Int. J. Radiat. Biol. 79, 759-775.
    • (2003) Int. J. Radiat. Biol , vol.79 , pp. 759-775
    • Yin, E.1    Nelson, D.O.2    Coleman, M.A.3    Peterson, L.E.4    Wyrobek, A.J.5
  • 37
    • 0036841293 scopus 로고    scopus 로고
    • Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage
    • Kandel, E. S., Skeen, J., Majewski, N., Di Cristofano, A., Pandolfi, P. P., et al. (2002) Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage. Mol. Cell. Biol. 22, 7831-7841.
    • (2002) Mol. Cell. Biol , vol.22 , pp. 7831-7841
    • Kandel, E.S.1    Skeen, J.2    Majewski, N.3    Di Cristofano, A.4    Pandolfi, P.P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.