메뉴 건너뛰기




Volumn 84, Issue , 2016, Pages 1-9

Quercetin nanoparticles induced autophagy and apoptosis through AKT/ERK/Caspase-3 signaling pathway in human neuroglioma cells: In vitro and in vivo

Author keywords

Apoptosis; Autophagy; Neuroglioma; Quercetin nanoparticle

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NANOPARTICLE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN P53; QUERCETIN;

EID: 84986538316     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2016.08.055     Document Type: Article
Times cited : (118)

References (44)
  • 2
    • 84925834341 scopus 로고    scopus 로고
    • Multifocal and multicentric glioblastoma with leptomeningeal gliomatosis: a case report and review of the literature
    • [2] Shakur, S.F., Bit-Ivan, E., Watkin, W.G., Merrell, R.T., Farhat, H.I., Multifocal and multicentric glioblastoma with leptomeningeal gliomatosis: a case report and review of the literature. Case Rep. Med., 2013, 2013, 132679.
    • (2013) Case Rep. Med. , vol.2013 , pp. 132679
    • Shakur, S.F.1    Bit-Ivan, E.2    Watkin, W.G.3    Merrell, R.T.4    Farhat, H.I.5
  • 4
    • 1942473768 scopus 로고    scopus 로고
    • Quercetin, an anti-oxidant bioflavonoid, attenuates diabetic nephropathy in rats
    • [4] Anjaneyulu, M., Chopra, K., Quercetin, an anti-oxidant bioflavonoid, attenuates diabetic nephropathy in rats. Clin. Exp. Pharmacol. Phys. 31 (2004), 244–248.
    • (2004) Clin. Exp. Pharmacol. Phys. , vol.31 , pp. 244-248
    • Anjaneyulu, M.1    Chopra, K.2
  • 5
    • 84939433036 scopus 로고    scopus 로고
    • Quercetin intraperitoneal administration ameliorates lipopolysaccharide-induced systemic inflammation in mice
    • [5] Liao, Y.R., Lin, J.Y., Quercetin intraperitoneal administration ameliorates lipopolysaccharide-induced systemic inflammation in mice. Life Sci. 137 (2015), 89–97.
    • (2015) Life Sci. , vol.137 , pp. 89-97
    • Liao, Y.R.1    Lin, J.Y.2
  • 6
    • 84959569531 scopus 로고    scopus 로고
    • Evaluation of antiviral activities of houttuynia cordata thunb extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infection
    • [6] Chiow, K.H., Phoon, M.C., Putti, T., Tan, B.K., Chow, V.T., Evaluation of antiviral activities of houttuynia cordata thunb extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infection. Asian Pac. J. Trop. Med. 9 (2016), 1–7.
    • (2016) Asian Pac. J. Trop. Med. , vol.9 , pp. 1-7
    • Chiow, K.H.1    Phoon, M.C.2    Putti, T.3    Tan, B.K.4    Chow, V.T.5
  • 9
    • 84862807211 scopus 로고    scopus 로고
    • Quercetin prevents ethanol-induced dyslipidemia and mitochondrial oxidative damage
    • [9] Tang, Y., Gao, C., Xing, M., Li, Y., Zhu, L., Wang, D., Yang, X., Liu, L., Yao, P., Quercetin prevents ethanol-induced dyslipidemia and mitochondrial oxidative damage. Food Chem. Toxicol. 50 (2012), 1194–1200.
    • (2012) Food Chem. Toxicol. , vol.50 , pp. 1194-1200
    • Tang, Y.1    Gao, C.2    Xing, M.3    Li, Y.4    Zhu, L.5    Wang, D.6    Yang, X.7    Liu, L.8    Yao, P.9
  • 10
    • 84908232698 scopus 로고    scopus 로고
    • Quercetin attenuates renal ischemia/reperfusion injury via an activation of AMP-activated protein kinase-regulated autophagy pathway
    • [10] Chen, B.L., Wang, L.T., Huang, K.H., Wang, C.C., Chiang, C.K., Liu, S.H., Quercetin attenuates renal ischemia/reperfusion injury via an activation of AMP-activated protein kinase-regulated autophagy pathway. J. Nutr. Biochem. 25 (2014), 1226–1234.
    • (2014) J. Nutr. Biochem. , vol.25 , pp. 1226-1234
    • Chen, B.L.1    Wang, L.T.2    Huang, K.H.3    Wang, C.C.4    Chiang, C.K.5    Liu, S.H.6
  • 11
    • 84893824463 scopus 로고    scopus 로고
    • Quercetin induces mitochondrial mediated apoptosis and protective autophagy in human glioblastoma U373MG cells
    • [11] Kim, H., Moon, J.Y., Ahn, K.S., Cho, S.K., Quercetin induces mitochondrial mediated apoptosis and protective autophagy in human glioblastoma U373MG cells. Oxid. Med. Cell. Longev., 2013, 2013, 596496.
    • (2013) Oxid. Med. Cell. Longev. , vol.2013 , pp. 596496
    • Kim, H.1    Moon, J.Y.2    Ahn, K.S.3    Cho, S.K.4
  • 12
    • 84898599397 scopus 로고    scopus 로고
    • Computational modeling of magnetic nanoparticle targeting to stent surface under high gradient field
    • [12] Wang, S., Zhou, Y., Tan, J., Xu, J., Yang, J., Liu, Y., Computational modeling of magnetic nanoparticle targeting to stent surface under high gradient field. Comput. Mech. 53 (2014), 403–412.
    • (2014) Comput. Mech. , vol.53 , pp. 403-412
    • Wang, S.1    Zhou, Y.2    Tan, J.3    Xu, J.4    Yang, J.5    Liu, Y.6
  • 14
    • 84882425413 scopus 로고    scopus 로고
    • Nanoparticle-and liposome-carried drugs: new strategies for active targeting and drug delivery across blood-brain barrier
    • [14] Leonor Pinzon-Daza, M., Campia, I., Kopecka, J., Garzon, R., Ghigo, D., Rigant, C., Nanoparticle-and liposome-carried drugs: new strategies for active targeting and drug delivery across blood-brain barrier. Curr. Drug Metab. 14 (2013), 625–640.
    • (2013) Curr. Drug Metab. , vol.14 , pp. 625-640
    • Leonor Pinzon-Daza, M.1    Campia, I.2    Kopecka, J.3    Garzon, R.4    Ghigo, D.5    Rigant, C.6
  • 16
    • 84879357128 scopus 로고    scopus 로고
    • Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipidaccumulation in diabetic rats
    • [16] Wang, W., Wang, C., Ding, X.Q., Pan, Y., Gu, T.T., Wang, M.X., Liu, Y.L., Wang, F.M., Wang, S.J., Kong, L.D., Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipidaccumulation in diabetic rats. Br. J. Pharmacol. 169 (2013), 1352–1371.
    • (2013) Br. J. Pharmacol. , vol.169 , pp. 1352-1371
    • Wang, W.1    Wang, C.2    Ding, X.Q.3    Pan, Y.4    Gu, T.T.5    Wang, M.X.6    Liu, Y.L.7    Wang, F.M.8    Wang, S.J.9    Kong, L.D.10
  • 17
    • 68149139456 scopus 로고    scopus 로고
    • The autophagy effector Beclin 1: a novel BH3-only protein
    • [17] Sinha, S., Levine, B., The autophagy effector Beclin 1: a novel BH3-only protein. Oncogene 27:Suppl. 1 (2008), S137–S148.
    • (2008) Oncogene , vol.27 , pp. S137-S148
    • Sinha, S.1    Levine, B.2
  • 19
    • 84920504512 scopus 로고    scopus 로고
    • mTOR: a pharmacologic target for autophagy regulation
    • [19] Kim, Y.C., Guan, K.L., mTOR: a pharmacologic target for autophagy regulation. J. Clin. Investig. 125 (2015), 25–32.
    • (2015) J. Clin. Investig. , vol.125 , pp. 25-32
    • Kim, Y.C.1    Guan, K.L.2
  • 20
    • 84924763751 scopus 로고    scopus 로고
    • Current clinical regulation of PI3K/PTEN/Akt/mTOR signalling in treatment of human cancer
    • [20] Lim, H.J., Crowe, P., Yang, J.L., Current clinical regulation of PI3K/PTEN/Akt/mTOR signalling in treatment of human cancer. J. Cancer Res. Clin. Oncol. 141 (2015), 671–689.
    • (2015) J. Cancer Res. Clin. Oncol. , vol.141 , pp. 671-689
    • Lim, H.J.1    Crowe, P.2    Yang, J.L.3
  • 21
    • 84937838193 scopus 로고    scopus 로고
    • Inhibition of notch signaling promotes the adipogenic differentiation of mesenchymal stem cells through autophagy activation and PTEN-PI3K/AKT/mTOR pathway
    • [21] Song, B.Q., Chi, Y., Li, X., Du, W.J., Han, Z.B., Tian, J.J., Li, J.J., Chen, F., Wu, H.H., Han, L.X., et al. Inhibition of notch signaling promotes the adipogenic differentiation of mesenchymal stem cells through autophagy activation and PTEN-PI3K/AKT/mTOR pathway. Cell. Physiol. Biochem. 36 (2015), 1991–2002.
    • (2015) Cell. Physiol. Biochem. , vol.36 , pp. 1991-2002
    • Song, B.Q.1    Chi, Y.2    Li, X.3    Du, W.J.4    Han, Z.B.5    Tian, J.J.6    Li, J.J.7    Chen, F.8    Wu, H.H.9    Han, L.X.10
  • 22
    • 84934936167 scopus 로고    scopus 로고
    • Targeting mTOR signaling pathways and related negative feedback loops for the treatment of acute myeloid leukemia
    • [22] Carneiro, B.A., Kaplan, J.B., Altman, J.K., Giles, F.J., Platanias, L.C., Targeting mTOR signaling pathways and related negative feedback loops for the treatment of acute myeloid leukemia. Cancer Biol. Ther. 16 (2015), 648–656.
    • (2015) Cancer Biol. Ther. , vol.16 , pp. 648-656
    • Carneiro, B.A.1    Kaplan, J.B.2    Altman, J.K.3    Giles, F.J.4    Platanias, L.C.5
  • 23
    • 73649089980 scopus 로고    scopus 로고
    • ERK and cell death: mechanisms of ERK-induced cell death—apoptosis, autophagy and senescence
    • [23] Cagnol, S., Chambard, J.C., ERK and cell death: mechanisms of ERK-induced cell death—apoptosis, autophagy and senescence. FEBS J. 277 (2010), 2–21.
    • (2010) FEBS J. , vol.277 , pp. 2-21
    • Cagnol, S.1    Chambard, J.C.2
  • 24
    • 0034672063 scopus 로고    scopus 로고
    • Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells
    • [24] Ogier-Denis, E., Pattingre, S., El Benna, J., Codogno, P., Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells. J. Biol. Chem. 275 (2000), 39090–39095.
    • (2000) J. Biol. Chem. , vol.275 , pp. 39090-39095
    • Ogier-Denis, E.1    Pattingre, S.2    El Benna, J.3    Codogno, P.4
  • 27
    • 85015601350 scopus 로고    scopus 로고
    • Autophagy activation prevents sevoflurane-induced neurotoxicity in H4 human neuroglioma cells
    • [27] Zhou, Y.F., Wang, Q.X., Zhou, H.Y., Chen, G., Autophagy activation prevents sevoflurane-induced neurotoxicity in H4 human neuroglioma cells. Acta Pharmacol. Sin. 37 (2016), 580–588.
    • (2016) Acta Pharmacol. Sin. , vol.37 , pp. 580-588
    • Zhou, Y.F.1    Wang, Q.X.2    Zhou, H.Y.3    Chen, G.4
  • 28
    • 79952066487 scopus 로고    scopus 로고
    • Chemistry and biochemistry of dietary polyphenols
    • [28] Tsao, R., Chemistry and biochemistry of dietary polyphenols. Nutrients 2 (2010), 1231–1246.
    • (2010) Nutrients , vol.2 , pp. 1231-1246
    • Tsao, R.1
  • 29
    • 84893378720 scopus 로고    scopus 로고
    • Protective effect of quercetin against oxidative stress and brain edema in an experimental rat model of subarachnoid hemorrhage
    • [29] Dong, Y.S., Wang, J.L., Feng, D.Y., Qin, H.Z., Wen, H., Yin, Z.M., Gao, G.D., Li, C., Protective effect of quercetin against oxidative stress and brain edema in an experimental rat model of subarachnoid hemorrhage. Int. J. Med. Sci. 11 (2014), 282–290.
    • (2014) Int. J. Med. Sci. , vol.11 , pp. 282-290
    • Dong, Y.S.1    Wang, J.L.2    Feng, D.Y.3    Qin, H.Z.4    Wen, H.5    Yin, Z.M.6    Gao, G.D.7    Li, C.8
  • 30
    • 85000351067 scopus 로고    scopus 로고
    • Quercetin suppresses immune cell accumulation and improves mitochondrial gene expression in adipose tissue of diet-induced obese mice
    • [30] Kobori, M., Takahashi, Y., Sakurai, M., Akimoto, Y., Tsushida, T., Oike, H., Ippoushi, K., Quercetin suppresses immune cell accumulation and improves mitochondrial gene expression in adipose tissue of diet-induced obese mice. Mol. Nutr. Food Res. 60 (2016), 300–312.
    • (2016) Mol. Nutr. Food Res. , vol.60 , pp. 300-312
    • Kobori, M.1    Takahashi, Y.2    Sakurai, M.3    Akimoto, Y.4    Tsushida, T.5    Oike, H.6    Ippoushi, K.7
  • 31
    • 84882425413 scopus 로고    scopus 로고
    • Nanoparticle-and liposome-carried drugs: new strategies for active targeting and drug delivery across blood-brain barrier
    • [31] Leonor Pinzon-Daza, M., Campia, I., Kopecka, J., Garzon, R., Ghigo, D., Rigant, C., Nanoparticle-and liposome-carried drugs: new strategies for active targeting and drug delivery across blood-brain barrier. Curr. Drug Metab. 14 (2013), 625–640.
    • (2013) Curr. Drug Metab. , vol.14 , pp. 625-640
    • Leonor Pinzon-Daza, M.1    Campia, I.2    Kopecka, J.3    Garzon, R.4    Ghigo, D.5    Rigant, C.6
  • 32
    • 33747762229 scopus 로고    scopus 로고
    • Exploiting the enhanced permeability and retention effect for tumor targeting
    • [32] Iyer, A.K., Khaled, G., Fang, J., Maeda, H., Exploiting the enhanced permeability and retention effect for tumor targeting. Drug Discov. Today 11 (2006), 812–818.
    • (2006) Drug Discov. Today , vol.11 , pp. 812-818
    • Iyer, A.K.1    Khaled, G.2    Fang, J.3    Maeda, H.4
  • 33
    • 79960838501 scopus 로고    scopus 로고
    • Self-assembled nanoparticles based on hyaluronic acid-ceramide (HA-CE) and Pluronic for tumor-targeted delivery of docetaxel
    • [33] Cho, H.J., Yoon, H.Y., Koo, H., Ko, S.H., Shim, J.S., Lee, J.H., Kim, K., Chan, K.I., Kim, D.D., Self-assembled nanoparticles based on hyaluronic acid-ceramide (HA-CE) and Pluronic for tumor-targeted delivery of docetaxel. Biomaterials 32 (2011), 7181–7190.
    • (2011) Biomaterials , vol.32 , pp. 7181-7190
    • Cho, H.J.1    Yoon, H.Y.2    Koo, H.3    Ko, S.H.4    Shim, J.S.5    Lee, J.H.6    Kim, K.7    Chan, K.I.8    Kim, D.D.9
  • 34
    • 84920504512 scopus 로고    scopus 로고
    • mTOR: a pharmacologic target for autophagy regulation
    • [34] Kim, Y.C., Guan, K.L., mTOR: a pharmacologic target for autophagy regulation. J. Clin. Investig. 125 (2015), 25–32.
    • (2015) J. Clin. Investig. , vol.125 , pp. 25-32
    • Kim, Y.C.1    Guan, K.L.2
  • 35
    • 84883589459 scopus 로고    scopus 로고
    • Combined effects of PI3K and SRC kinase inhibitors with imatinib on intracellular calcium levels, autophagy, and apoptosis in CML-PBL cells
    • [35] Ciarcia, R., Damiano, S., Montagnaro, S., Pagnini, U., Ruocco, A., Caparrotti, G., d'Angelo, D., Boffo, S., Morales, F., Rizzolio, F., et al. Combined effects of PI3K and SRC kinase inhibitors with imatinib on intracellular calcium levels, autophagy, and apoptosis in CML-PBL cells. Cell Cycle 12 (2013), 2839–2848.
    • (2013) Cell Cycle , vol.12 , pp. 2839-2848
    • Ciarcia, R.1    Damiano, S.2    Montagnaro, S.3    Pagnini, U.4    Ruocco, A.5    Caparrotti, G.6    d'Angelo, D.7    Boffo, S.8    Morales, F.9    Rizzolio, F.10
  • 36
    • 84891102849 scopus 로고    scopus 로고
    • The role of cell signalling in the crosstalk between autophagy and apoptosis
    • [36] Booth, L.A., Tavallai, S., Hamed, H.A., Cruickshanks, N., Dent, P., The role of cell signalling in the crosstalk between autophagy and apoptosis. Cell. Signal. 26 (2013), 549–555.
    • (2013) Cell. Signal. , vol.26 , pp. 549-555
    • Booth, L.A.1    Tavallai, S.2    Hamed, H.A.3    Cruickshanks, N.4    Dent, P.5
  • 37
    • 79956095420 scopus 로고    scopus 로고
    • Autophagosome formation and molecular mechanism of autophagy
    • [37] Tanida, I., Autophagosome formation and molecular mechanism of autophagy. Antioxid. Redox Signal. 14 (2010), 2201–2214.
    • (2010) Antioxid. Redox Signal. , vol.14 , pp. 2201-2214
    • Tanida, I.1
  • 39
    • 84880843826 scopus 로고    scopus 로고
    • Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells
    • [39] Viiri, J., Amadio, M., Marchesi, N., Hyttinen, J.M., Kivinen, N., Sironen, R., et al. Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells. PLoS One, 8, 2013, e69563.
    • (2013) PLoS One , vol.8 , pp. e69563
    • Viiri, J.1    Amadio, M.2    Marchesi, N.3    Hyttinen, J.M.4    Kivinen, N.5    Sironen, R.6
  • 40
    • 59749091850 scopus 로고    scopus 로고
    • A complex interplay between Akt, TSC2 and the two mTOR complexes
    • [40] Huang, J., Manning, B.D., A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem. Soc. Trans. 37 (2009), 217–222.
    • (2009) Biochem. Soc. Trans. , vol.37 , pp. 217-222
    • Huang, J.1    Manning, B.D.2
  • 41
    • 33646398838 scopus 로고    scopus 로고
    • Prolonged activation of ERK1,2 induces FADD-independent caspase 8 activation and cell death
    • [41] Cagnol, S., Van Obberghen-Schilling, E., Chambard, J.C., Prolonged activation of ERK1,2 induces FADD-independent caspase 8 activation and cell death. Apoptosis 11 (2006), 337–346.
    • (2006) Apoptosis , vol.11 , pp. 337-346
    • Cagnol, S.1    Van Obberghen-Schilling, E.2    Chambard, J.C.3
  • 42
    • 79952706662 scopus 로고    scopus 로고
    • Apoptogenic factors released from mitochondria
    • [42] Vaux, D.L., Apoptogenic factors released from mitochondria. Biochim. Biophys. Acta 1813 (2011), 546–550.
    • (2011) Biochim. Biophys. Acta , vol.1813 , pp. 546-550
    • Vaux, D.L.1
  • 43
    • 0036716281 scopus 로고    scopus 로고
    • The Bcl2 family: regulators of the cellular life-or-death switch
    • [43] Cory, S., Adams, J.M., The Bcl2 family: regulators of the cellular life-or-death switch. Nat. Rev. Cancer 2 (2002), 647–656.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 647-656
    • Cory, S.1    Adams, J.M.2
  • 44
    • 53149122044 scopus 로고    scopus 로고
    • ERK and JNK mediate TNFalpha-induced p53 activation in apoptotic and autophagic L929 cell death
    • [44] Cheng, Y., Qiu, F., Tashiro, S., Onodera, S., Ikejima, T., ERK and JNK mediate TNFalpha-induced p53 activation in apoptotic and autophagic L929 cell death. Biochem. Biophys. Res. Commun. 376 (2008), 483–488.
    • (2008) Biochem. Biophys. Res. Commun. , vol.376 , pp. 483-488
    • Cheng, Y.1    Qiu, F.2    Tashiro, S.3    Onodera, S.4    Ikejima, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.