Protective effect of quercetin against oxidative stress and brain edema in an experimental rat model of subarachnoid hemorrhage

International Journal of Medical Sciences

Volumn 11, Issue 3, 2014, Pages 282-290

  Dong, Yu Shu ^a,b   Wang, Ju Lei ^a,c   Feng, Da Yun ^a   Qin, Huai Zhou ^a   Wen, Hua ^b   Yin, Zhong Min ^b   Gao, Guo Dong ^a   Li, Chuan ^d  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b The 463 Hospital of Chinese PLA   (China)

^c WUHAN GENERAL HOSPITAL OF GUANGZHOU COMMAND   (China)

^d GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

Author keywords

Brain edema; Oxidative stress; Quercetin; Rat; Subarachnoid hemorrhage

Indexed keywords

ANTIOXIDANT; MALONALDEHYDE; NEUROPROTECTIVE AGENT; QUERCETIN;

ANIMAL; BRAIN EDEMA; BRAIN INJURIES; DISEASE MODEL; DRUG EFFECTS; LIPID PEROXIDATION; OXIDATIVE STRESS; PATHOPHYSIOLOGY; RAT; SUBARACHNOID HEMORRHAGE;

ANIMALS; ANTIOXIDANTS; BRAIN EDEMA; BRAIN INJURIES; DISEASE MODELS, ANIMAL; LIPID PEROXIDATION; MALONDIALDEHYDE; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; QUERCETIN; RATS; SUBARACHNOID HEMORRHAGE;

EID: 84893378720     PISSN: 14491907     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijms.7634     Document Type: Article

References (53)

1. Rosamond W, Flegal K, Furie K, et al. Heart disease and stroke statistics-2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2008; 117: 25-146.
2. Lai L, Morgan MK. Incidence of subarachnoid hemorrhage: an Australian national hospital morbidity database analysis. J Clin Neurosci 2012; 19: 733-739.
3. Bakker AM, Dorhout Mees SM, Algra A, et al. Extent of acute hydrocephalus after aneurismal subarachnoid hemorrhage as a risk factor for delayed cerebral infarction. Stroke 2007; 38: 2496-2499.
4. Fatima A. Sehba, Jack Hou, Ryszard M. Pluta, et al. The importance of early brain injury after subarachnoid hemorrhage. Prog Neurobiol 2012; 97: 14-37.
5. Yushu Dong, Yue Li, Dayun Feng, et al. Protective effect of HIF-1α against hippocampal apoptosis and cognitive dysfunction in an experimental rat model of subarachnoid hemorrhage. Brain Res 2013; 1517: 114-121.
6. Doczi T, Joo F, Adam G, et al. Blood-brain barrier damage during the acute stage of subarachnoid hemorrhage, as exemplified by a new animal model. Neurosurgery 1986; 18: 733-739.
7. Hua Lu, Dong-Mei Zhang, Hui-Ling Chen, et al. N-acetylcysteine suppresses oxidative stress in experimental rats with subarachnoid hemorrhage. J Clin Neurosci 2009; 16: 684-648.
8. Peter H. Proctor. Free Radicals and Human Disease. CRC Handbook of Free Radicals and Antioxidants 1989; 1: 209-221.
9. Rossi R, Dalle-Donne I, Milzani A, et al. Oxidized forms of glutathione in peripheral blood as biomarkers of oxidative stress. Clin Chem 2006; 52: 1406-1414.
10. Wu J, Hua Y, Keep RF, et al. Oxidative brain injury from extravasated erythrocytes after intracerebral hemorrhage. Brain Res 2009; 953: 45-52.
11. Hall NC, Packard BA, Hall CL, et al. Protein oxidation and enzyme susceptibility in white and gray matter with in vitro oxidative stress: relevance to brain injury from intracerebral hemorrhage. Cell Mol Biol 2000; 46: 673-683.
12. Choi YJ, Kang JS, Park JH, et al. Polyphenolic flavonoids differ in their antiapoptotic efficacy in hydrogen peroxide treated human vascular endothelial cells. J Nutr 2003; 133: 985-991.
13. Rice-Evans CA, Miller NJ, Bolwell PG, et al. The relative antioxidant activities of plant derived polyphenolic flavonoids. Free Radic Res 1995; 22: 375-383.
14. Ferrali M, Signorini C, Ciccoli L, et al. Protection of erythrocytes against oxidative damage and autologous immunoglobulin G (IgG) binding by iron chelator fluor-benzoil-pyridoxal hydrazone. Biochem Pharmacol 2000; 59: 1365-1373.
15. Pavanato A, Tunon MJ, Camposs S, et al. Effects of quercetin on liver damage in rats with carbon tetrachloride-induced cirrhosis. Dig Dis Sci 2003; 48: 824-829.
16. Okamoto T. Safety of quercetin for clinical application. Int J Mol Med 2005; 16: 275-278.
17. Prunell GF, Mathiesen T, Diemer NH, et al. Experimental subarachnoid hemorrhage: subarachnoid blood volume, mortality rate, neuronal death, cerebral blood flow, and perfusion pressure in three different rat models. Neurosurgery 2003; 52: 165-175.
18. Yamaguchi M, Zhou C, Nanda A, et al. Ras protein contributes to cerebral vasospasm in a canine double-hemorrhage model. Stroke 2004; 35: 1750-1755.
19. Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254.
20. Oyanagui Y. Revaluation of assay methods and establishment of kit for superoxide dismutase activity. Anal Biochem 1984; 142: 290-296.
21. Wheeler CR, Salzman JA, Elsayed NM, et al. Automated assays for superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase activity. Anal Biochem 1990; 184: 193-199.
22. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95: 351-358.
23. Xi G, Hua Y, Bhasin RR, et al. Mechanisms of edema formation after intracerebral hemorrhage: effects of extravasated red blood cells on blood flow and blood-brain barrier integrity. Stroke 2001; 32: 2932-2938.
24. Liu S, Tang J, Ostrowski RP, et al. Oxidative stress after subarachnoid hemorrhage in gp91phox knockout mice. Can J Neurol Sci 2007; 34: 356-361.
25. Pyne-Geithman GJ, Caudell DN, Prakash P, et al. Glutathione peroxidase and subarachnoid hemorrhage: implications for the role of oxidative stress in cerebral vasospasm. Neurol Res 2009; 31: 195-199.
26. Marzatico F, Gaetani P, Cafe C, et al. Antioxidant enzymatic activities after experimental subarachnoid hemorrhage in rats. Acta Neurol Scand 1993; 87: 62-66.
27. Gaetani P, Marzatico F, Rodriguezy Baena R, et al. Arachidonic acid metabolism and pathophysiologic aspects of subarachnoid hemorrhage in rats. Stroke 1990; 21: 328-332.
28. Lin CL, Hsu YT, Lin TK, et al. Increased levels of F2-isoprostanes following aneurismal subarachnoid hemorrhage in humans. Free Radic Biol Med 2006; 40: 1466-1473.
29. Hsieh YP, Lin CL, Shiue AL, et al. Correlation of F4-neuroprostanes levels in cerebrospinal fluid with outcome of aneurysmal subarachnoid hemorrhage in humans. Free Radic Biol Med 2009; 47: 814-824.
30. Sercombe R, Dinh YR, Gomis P. Cerebrovascular inflammation following subarachnoid hemorrhage. Jpn J Pharmacol 2002; 88: 227-249.
31. Ayer RE, Zhang JH. Oxidative stress in subarachnoid hemorrhage: significance in acute brain injury and vasospasm. Acta Neurochir 2008; 104: 33-41.
32. Bosoi CR, Yang X, Huynh J, et al. Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure. Free Radic Biol Med 2012; 52: 1228-1235.
33. Marmarou A. A review of progress in understanding the pathophysiology and treatment of brain edema. Neurosurg Focus 2007; 22: 1323-1329.
34. Claassen J, Carhuapoma JR, Kreiter KT, et al. Global cerebral edema after subarachnoid hemorrhage: frequency, predictors, and impact on outcome. Stroke 2002; 33: 1225-1232.
35. Matz PG, Copin JC, Chan PH. Cell death after exposure to subarachnoid hemolysate correlates inversely with expression of CuZn-superoxide dismutase. Stroke 2000; 31: 2450-2459.
36. Endo H, Nito C, Kamada H, et al. Reduction in oxidative stress by superoxide dismutase overexpression attenuates acute brain injury after subarachnoid hemorrhage via activation of Akt/glycogen synthase kinase-3beta survival signaling. J Cereber Blood F Met 2007; 27: 975-982.
37. Marnett LJ. Lipid peroxidation-DNA damage by malondialdehyde. Muta Res 1999; 424: 83-95.
38. Cini M, Fariello RG, Bianchetti A, et al. Studies on lipid peroxidation in the rat brain. Neurochem Res 1994; 19: 283-288.
39. Gul S, Bahadir B, Hanci V, Bektas S et al. Effect of vardenafil on cerebral vasospasm following experimental subarachnoid hemorrhage in rats. J Clin Neurosci 2010; 17: 1038-1041.
40. Gomis P, Graftieaux JP, Sercombe R, et al. Double-blind, placebo-controlled, pilot trial of high-dose methylprednisolone in aneurysmal subarachnoid hemorrhage. J Neurosurg 2010; 112: 681-688.
41. Shimoi K, Masuda S, Furugori M, et al. Radio protective effect of antioxidative flavonoids in γ-ray irradiated mice. Carcinogenesis 1994; 75: 2668-2672.
42. Zhang ZJ, Cheang LC, Wang MW, et al. Quercetin exerts a neuroprotective effect through inhibition of the iNOS/NO system and pro-inflammation gene expression in PC12 cells and in zebrafish. Int J Mol Med 2011; 27: 195-203.
43. Federico Dajas. Life or death: Neuroprotective and anticancer effects of quercetin. J Ethnopharmacol 2012; 143: 383-396.
44. Emerit J, Edeas M, Bricaire F. Neurodegenerative diseases and oxidative stress. Biomed Pharmacother 2004; 58: 39-46.
45. Ansari MA, Abdul HM, Joshi G, et al. Protective effect of quercetin in primary neurons against Alzheimer's disease. J Nutr Biochem 2009; 20: 269-275.
46. Carrasco-Pozo C, Mizgier M, Speisky L, et al. Differential protective effects of quercetin, resveratrol, rutin and epigallocatechin gallate against mitochondrial dysfunction induced by indomethacin in Caco-2 cells. Chem Biol Interact 2012; 195: 199-205.
47. Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol 2008; 585: 325-337.
48. Mira L, Fernandez MT, Santos M, et al. Interactions of flavonoids with iron and copper ions: a mechanism for their antioxidant activity. Free Radical Res 2002; 36: 1199-1208.
49. Bindoli A, Valente M, Cavallin L. Inhibitory action of quercetin on xanthine oxidase and xanthine dehydrogenase activity. Pharmacol Res Commun 1985; 17: 831-839.
50. Ishikawa Y, Sugiyama H, Stylianou E, et al. Bioflavonoid quercetin inhibits interleukin-1-induced transcriptional expression of monocyte chemoattractant protein-1 in glomerular cells via suppression of nuclear factor-kappaB. J Am Soc Nephrol 1999; 10: 2290-2296.
51. Germano A, Avella D, Imperatore C, et al. Time-course of blood-brain barrier permeability changes after experimental subarachnoid hemorrhage. Acta Neurochir 2000; 142: 575-580.
52. Park S, Yamaguchi M, Zhou C, et al. Neurovascular protection reduces early brain injury after subarachnoid hemorrhage. Stroke 2004; 35: 2412-2417.
53. Simard JM, Geng Z, Woo SK, et al. Glibenclamide reduces inflammation, vasogenic edema, and caspase-3 activation after subarachnoid hemorrhage. J Cereb Blood Flow Metab 2009; 29: 317-330.