-
1
-
-
84939975736
-
Role of the AMPK signaling pathway in early brain injury after subarachnoid hemorrhage in rats
-
An, J.Y., Zhou, L.L., Sun, P., Pang, H.G., Li, D.D., Li, Y., Zhang, M., Song, J.N., Role of the AMPK signaling pathway in early brain injury after subarachnoid hemorrhage in rats. Acta Neurochir. 157 (2015), 781–792.
-
(2015)
Acta Neurochir.
, vol.157
, pp. 781-792
-
-
An, J.Y.1
Zhou, L.L.2
Sun, P.3
Pang, H.G.4
Li, D.D.5
Li, Y.6
Zhang, M.7
Song, J.N.8
-
2
-
-
84895878715
-
Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: interference of AMPK/PGC-1alpha pathway
-
Ashabi, G., Khodagholi, F., Khalaj, L., Goudarzvand, M., Nasiri, M., Activation of AMP-activated protein kinase by metformin protects against global cerebral ischemia in male rats: interference of AMPK/PGC-1alpha pathway. Metab. Brain Dis. 29 (2014), 47–58.
-
(2014)
Metab. Brain Dis.
, vol.29
, pp. 47-58
-
-
Ashabi, G.1
Khodagholi, F.2
Khalaj, L.3
Goudarzvand, M.4
Nasiri, M.5
-
3
-
-
84877319532
-
The rationale of targeting mammalian target of rapamycin for ischemic stroke
-
Chong, Z.Z., Yao, Q.Q., Li, H.H., The rationale of targeting mammalian target of rapamycin for ischemic stroke. Cell Signal 25 (2013), 1598–1607.
-
(2013)
Cell Signal
, vol.25
, pp. 1598-1607
-
-
Chong, Z.Z.1
Yao, Q.Q.2
Li, H.H.3
-
4
-
-
3042818799
-
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
-
Corradetti, M.N., Inoki, K., Bardeesy, N., DePinho, R.A., Guan, K.L., Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev. 18 (2004), 1533–1538.
-
(2004)
Genes Dev.
, vol.18
, pp. 1533-1538
-
-
Corradetti, M.N.1
Inoki, K.2
Bardeesy, N.3
DePinho, R.A.4
Guan, K.L.5
-
5
-
-
84902320353
-
mTORC2, the “other” mTOR, is a new player in energy balance regulation
-
Cota, D., mTORC2, the “other” mTOR, is a new player in energy balance regulation. Mol. Metab. 3 (2014), 349–350.
-
(2014)
Mol. Metab.
, vol.3
, pp. 349-350
-
-
Cota, D.1
-
7
-
-
46349090692
-
Mechanisms of ischemic brain damage
-
Doyle, K.P., Simon, R.P., Stenzel-Poore, M.P., Mechanisms of ischemic brain damage. Neuropharmacology 55 (2008), 310–318.
-
(2008)
Neuropharmacology
, vol.55
, pp. 310-318
-
-
Doyle, K.P.1
Simon, R.P.2
Stenzel-Poore, M.P.3
-
8
-
-
80053544728
-
Modeling stroke in mice - middle cerebral artery occlusion with the filament model
-
Engel, O., Kolodziej, S., Dirnagl, U., Prinz, V., Modeling stroke in mice - middle cerebral artery occlusion with the filament model. J. Vis. Exp., 2011, 2423.
-
(2011)
J. Vis. Exp.
, pp. 2423
-
-
Engel, O.1
Kolodziej, S.2
Dirnagl, U.3
Prinz, V.4
-
9
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
Gwinn, D.M., Shackelford, D.B., Egan, D.F., Mihaylova, M.M., Mery, A., Vasquez, D.S., Turk, B.E., Shaw, R.J., AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol. Cell. 30 (2008), 214–226.
-
(2008)
Mol. Cell.
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
10
-
-
84948569863
-
AMPK and autophagy in glucose/glycogen metabolism
-
Ha, J., Guan, K.L., Kim, J., AMPK and autophagy in glucose/glycogen metabolism. Mol. Asp. Med. 46 (2015), 46–62.
-
(2015)
Mol. Asp. Med.
, vol.46
, pp. 46-62
-
-
Ha, J.1
Guan, K.L.2
Kim, J.3
-
11
-
-
79951807242
-
AMPK and autophagy get connected
-
Hardie, D.G., AMPK and autophagy get connected. EMBO J. 30 (2011), 634–635.
-
(2011)
EMBO J.
, vol.30
, pp. 634-635
-
-
Hardie, D.G.1
-
12
-
-
75749114797
-
mTOR signaling: at the crossroads of plasticity, memory and disease
-
Hoeffer, C.A., Klann, E., mTOR signaling: at the crossroads of plasticity, memory and disease. Trends Neurosci. 33 (2010), 67–75.
-
(2010)
Trends Neurosci.
, vol.33
, pp. 67-75
-
-
Hoeffer, C.A.1
Klann, E.2
-
13
-
-
84924809439
-
Deacetylation of nuclear LC3 drives autophagy initiation under starvation
-
Huang, R., Xu, Y., Wan, W., Shou, X., Qian, J., You, Z., Liu, B., Chang, C., Zhou, T., Lippincott-Schwartz, J., Liu, W., Deacetylation of nuclear LC3 drives autophagy initiation under starvation. Mol. Cell. 57 (2015), 456–466.
-
(2015)
Mol. Cell.
, vol.57
, pp. 456-466
-
-
Huang, R.1
Xu, Y.2
Wan, W.3
Shou, X.4
Qian, J.5
You, Z.6
Liu, B.7
Chang, C.8
Zhou, T.9
Lippincott-Schwartz, J.10
Liu, W.11
-
14
-
-
84938270248
-
Ischemic preconditioning provides neuroprotection by induction of AMP-activated protein kinase-dependent autophagy in a rat model of ischemic stroke
-
Jiang, T., Yu, J.T., Zhu, X.C., Tan, L., Ischemic preconditioning provides neuroprotection by induction of AMP-activated protein kinase-dependent autophagy in a rat model of ischemic stroke. Mol. Neurobiol. 51 (2014), 220–229.
-
(2014)
Mol. Neurobiol.
, vol.51
, pp. 220-229
-
-
Jiang, T.1
Yu, J.T.2
Zhu, X.C.3
Tan, L.4
-
15
-
-
84896334276
-
Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy
-
Jiang, T.J., Yu, J.T., Zhu, X.C., Wang, H.F., Tan, M.S., Cao, L., Zhang, Q.Q., Gao, L., Shi, J.Q., Zhang, Y.D., Tan, L., Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy. Br. J. Pharmacol. 171 (2014), 3146–3157.
-
(2014)
Br. J. Pharmacol.
, vol.171
, pp. 3146-3157
-
-
Jiang, T.J.1
Yu, J.T.2
Zhu, X.C.3
Wang, H.F.4
Tan, M.S.5
Cao, L.6
Zhang, Q.Q.7
Gao, L.8
Shi, J.Q.9
Zhang, Y.D.10
Tan, L.11
-
16
-
-
65249176304
-
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
-
Jung, C.H., Jun, C.B., Ro, S.H., Kim, Y.M., Otto, N.M., Cao, J., Kundu, M., Kim, D.H., ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol. Biol. Cell. 20 (2009), 1992–2003.
-
(2009)
Mol. Biol. Cell.
, vol.20
, pp. 1992-2003
-
-
Jung, C.H.1
Jun, C.B.2
Ro, S.H.3
Kim, Y.M.4
Otto, N.M.5
Cao, J.6
Kundu, M.7
Kim, D.H.8
-
17
-
-
79551598347
-
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
-
Kim, J., Kundu, M., Viollet, B., Guan, K.L., AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. NAt. Cell. Biol. 13 (2011), 132–141.
-
(2011)
NAt. Cell. Biol.
, vol.13
, pp. 132-141
-
-
Kim, J.1
Kundu, M.2
Viollet, B.3
Guan, K.L.4
-
18
-
-
50849106068
-
Melatonin prevents ischemic brain injury through activation of the mTOR/p70S6 kinase signaling pathway
-
Koh, P.O., Melatonin prevents ischemic brain injury through activation of the mTOR/p70S6 kinase signaling pathway. Neurosci. Lett. 444 (2008), 74–78.
-
(2008)
Neurosci. Lett.
, vol.444
, pp. 74-78
-
-
Koh, P.O.1
-
19
-
-
84939988991
-
The dual role of autophagy under hypoxia-involvement of interaction between autophagy and apoptosis
-
Li, M., Tan, J., Miao, Y., Lei, P., Zhang, Q., The dual role of autophagy under hypoxia-involvement of interaction between autophagy and apoptosis. Apoptosis 20 (2015), 769–777.
-
(2015)
Apoptosis
, vol.20
, pp. 769-777
-
-
Li, M.1
Tan, J.2
Miao, Y.3
Lei, P.4
Zhang, Q.5
-
20
-
-
84984763363
-
Mechanisms, challenges and opportunities in stroke
-
Lo, E.H., Dalkara, T., Moskowitz, M.A., Mechanisms, challenges and opportunities in stroke. Nat. Rev. Neurosci. 4 (2003), 399–415.
-
(2003)
Nat. Rev. Neurosci.
, vol.4
, pp. 399-415
-
-
Lo, E.H.1
Dalkara, T.2
Moskowitz, M.A.3
-
21
-
-
4344594807
-
Apoptosis, autophagy, and more
-
Lockshin, R.A., Zakeri, Z., Apoptosis, autophagy, and more. Int. J. Biochem. Cell Biol. 36 (2004), 2405–2419.
-
(2004)
Int. J. Biochem. Cell Biol.
, vol.36
, pp. 2405-2419
-
-
Lockshin, R.A.1
Zakeri, Z.2
-
22
-
-
0024494427
-
Reversible middle cerebral artery occlusion without craniectomy in rats
-
Longa, E.Z., Weinstein, P.R., Carlson, S., Cummins, R., Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20 (1989), 84–91.
-
(1989)
Stroke
, vol.20
, pp. 84-91
-
-
Longa, E.Z.1
Weinstein, P.R.2
Carlson, S.3
Cummins, R.4
-
23
-
-
12844281251
-
AMPK, the metabolic syndrome and cancer
-
Luo, Z.J., Saha, A.K., Xiang, X.Q., Ruderman, N.B., AMPK, the metabolic syndrome and cancer. Trends Pharmacol. Sci. 26 (2005), 69–76.
-
(2005)
Trends Pharmacol. Sci.
, vol.26
, pp. 69-76
-
-
Luo, Z.J.1
Saha, A.K.2
Xiang, X.Q.3
Ruderman, N.B.4
-
24
-
-
84881162906
-
mTOR signaling in neural stem cells: from basic biology to disease
-
Magri, L., Galli, R., mTOR signaling in neural stem cells: from basic biology to disease. Cell. Mol. Life Sci. 70 (2013), 2887–2898.
-
(2013)
Cell. Mol. Life Sci.
, vol.70
, pp. 2887-2898
-
-
Magri, L.1
Galli, R.2
-
25
-
-
84879607026
-
Function of the master energy regulator adenosine monophosphate-activated protein kinase in stroke
-
Manwani, B., McCullough, L.D., Function of the master energy regulator adenosine monophosphate-activated protein kinase in stroke. J. Neurosci. Res. 91 (2013), 1018–1029.
-
(2013)
J. Neurosci. Res.
, vol.91
, pp. 1018-1029
-
-
Manwani, B.1
McCullough, L.D.2
-
26
-
-
84880921355
-
Increased phosphorylation of mTOR is involved in remote ischemic preconditioning of hippocampus in mice
-
Mehrjerdi, F.Z., Aboutaleb, N., Habibey, R., Ajami, M., Soleimani, M., Arabian, M., Niknazar, S., Davoodi, S.H., Pazoki-Toroudi, P., Increased phosphorylation of mTOR is involved in remote ischemic preconditioning of hippocampus in mice. Brain Res. 1526 (2013), 94–101.
-
(2013)
Brain Res.
, vol.1526
, pp. 94-101
-
-
Mehrjerdi, F.Z.1
Aboutaleb, N.2
Habibey, R.3
Ajami, M.4
Soleimani, M.5
Arabian, M.6
Niknazar, S.7
Davoodi, S.H.8
Pazoki-Toroudi, P.9
-
27
-
-
84923331803
-
AMP-activated protein kinase: structure, function, and role in pathological processes
-
Novikova, D.S., Garabadzhiu, A.V., Melino, G., Barlev, N.A., Tribulovich, V.G., AMP-activated protein kinase: structure, function, and role in pathological processes. Biochemistry 80 (2015), 127–144.
-
(2015)
Biochemistry
, vol.80
, pp. 127-144
-
-
Novikova, D.S.1
Garabadzhiu, A.V.2
Melino, G.3
Barlev, N.A.4
Tribulovich, V.G.5
-
28
-
-
84931009111
-
Autophagy mediates astrocyte death during zinc-potentiated ischemia–reperfusion injury
-
Pan, R., Timmins, G.S., Liu, W., Liu, K.J., Autophagy mediates astrocyte death during zinc-potentiated ischemia–reperfusion injury. Biol. Trace Elem. Res. 166 (2015), 89–95.
-
(2015)
Biol. Trace Elem. Res.
, vol.166
, pp. 89-95
-
-
Pan, R.1
Timmins, G.S.2
Liu, W.3
Liu, K.J.4
-
29
-
-
0033978633
-
Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells
-
Petiot, A., Ogier-Denis, E., Blommaart, E.E.F.C., Codogno, P., Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J. Biol. Chem. 275 (2000), 992–998.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 992-998
-
-
Petiot, A.1
Ogier-Denis, E.2
Blommaart, E.E.F.C.3
Codogno, P.4
-
30
-
-
84876411019
-
Pharmacological inhibition of the mTOR pathway impairs hippocampal development in mice
-
Raman, L., Kong, X.M., Kernie, S.G., Pharmacological inhibition of the mTOR pathway impairs hippocampal development in mice. Neurosci. Lett. 541 (2013), 9–14.
-
(2013)
Neurosci. Lett.
, vol.541
, pp. 9-14
-
-
Raman, L.1
Kong, X.M.2
Kernie, S.G.3
-
31
-
-
84926637731
-
A dual role for AMP-activated protein kinase (AMPK) during neonatal hypoxic-ischaemic brain injury in mice
-
Rousset, C.I., Leiper, F.C., Kichev, A., Gressens, P., Carling, D., Hagberg, H., Thornton, C., A dual role for AMP-activated protein kinase (AMPK) during neonatal hypoxic-ischaemic brain injury in mice. J. Neurochem. 133 (2015), 242–252.
-
(2015)
J. Neurochem.
, vol.133
, pp. 242-252
-
-
Rousset, C.I.1
Leiper, F.C.2
Kichev, A.3
Gressens, P.4
Carling, D.5
Hagberg, H.6
Thornton, C.7
-
32
-
-
84941178413
-
Metformin improves anxiety-like behaviors through AMPK-dependent regulation of autophagy following transient forebrain ischemia
-
Sarkaki, A., Farbood, Y., Badavi, M., Ashabi, G., Metformin improves anxiety-like behaviors through AMPK-dependent regulation of autophagy following transient forebrain ischemia. Metab. Brain Dis. 30 (2015), 1139–1150.
-
(2015)
Metab. Brain Dis.
, vol.30
, pp. 1139-1150
-
-
Sarkaki, A.1
Farbood, Y.2
Badavi, M.3
Ashabi, G.4
-
33
-
-
74449085859
-
Regulation of neural stem/progenitor cell maintenance by PI3K and mTOR
-
Sato, A., Sunayama, J., Matsuda, K.I., Tachibana, K., Sakurada, K., Tomiyama, A., Kayama, T., Kitanaka, C., Regulation of neural stem/progenitor cell maintenance by PI3K and mTOR. Neurosci. Lett. 470 (2010), 115–120.
-
(2010)
Neurosci. Lett.
, vol.470
, pp. 115-120
-
-
Sato, A.1
Sunayama, J.2
Matsuda, K.I.3
Tachibana, K.4
Sakurada, K.5
Tomiyama, A.6
Kayama, T.7
Kitanaka, C.8
-
34
-
-
67749111502
-
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
-
Shackelford, D.B., Shaw, R.J., The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat. Rev. Cancer 9 (2009), 563–575.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 563-575
-
-
Shackelford, D.B.1
Shaw, R.J.2
-
35
-
-
77949459392
-
AMPK exerts dual regulatory effects on the PI3K pathway
-
Tao, R., Gong, J., Luo, X.X., Luo, Z.J., AMPK exerts dual regulatory effects on the PI3K pathway. J. Mol. Signal, 5, 2010, 1.
-
(2010)
J. Mol. Signal
, vol.5
, pp. 1
-
-
Tao, R.1
Gong, J.2
Luo, X.X.3
Luo, Z.J.4
-
36
-
-
0028922528
-
The AMP-activated protein kinase gene is highly expressed in rat skeletal muscle. Alternative splicing and tissue distribution of the mRNA
-
Verhoeven, A.J., Woods, A., Brennan, C.H., Hawley, S.A., Hardie, D.G., Scott, J., Beir, R.K., Carling, D., The AMP-activated protein kinase gene is highly expressed in rat skeletal muscle. Alternative splicing and tissue distribution of the mRNA. Eur. J. Biochem. 228 (1995), 236–243.
-
(1995)
Eur. J. Biochem.
, vol.228
, pp. 236-243
-
-
Verhoeven, A.J.1
Woods, A.2
Brennan, C.H.3
Hawley, S.A.4
Hardie, D.G.5
Scott, J.6
Beir, R.K.7
Carling, D.8
-
37
-
-
50249189191
-
Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways
-
Wen, Y.D., Sheng, R., Zhang, L.S., Han, R., Zhang, X., Zhang, X.D., Han, F., Fukunaga, K., Qin, Z.H., Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. Autophagy 4 (2008), 762–769.
-
(2008)
Autophagy
, vol.4
, pp. 762-769
-
-
Wen, Y.D.1
Sheng, R.2
Zhang, L.S.3
Han, R.4
Zhang, X.5
Zhang, X.D.6
Han, F.7
Fukunaga, K.8
Qin, Z.H.9
-
38
-
-
84887618035
-
Ischemic post-conditioning facilitates brain recovery after stroke by promoting Akt/mTOR activity in nude rats
-
Xie, R., Wang, P., Ji, X.M., Zhao, H., Ischemic post-conditioning facilitates brain recovery after stroke by promoting Akt/mTOR activity in nude rats. J. Neurochem. 127 (2013), 723–732.
-
(2013)
J. Neurochem.
, vol.127
, pp. 723-732
-
-
Xie, R.1
Wang, P.2
Ji, X.M.3
Zhao, H.4
-
39
-
-
84899984684
-
Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease
-
Xu, Y.J., Liu, C.X., Chen, S.J., Ye, Y.J., Guo, M., Ren, Q., Liu, L., Zhang, H., Chong, Xu, Zhou, Q., Huang, S.L., Chen, L., Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease. Cell Signal 26 (2014), 1680–1689.
-
(2014)
Cell Signal
, vol.26
, pp. 1680-1689
-
-
Xu, Y.J.1
Liu, C.X.2
Chen, S.J.3
Ye, Y.J.4
Guo, M.5
Ren, Q.6
Liu, L.7
Zhang, H.8
Chong, X.9
Zhou, Q.10
Huang, S.L.11
Chen, L.12
-
40
-
-
84907960438
-
DAP1, a negative regulator of autophagy, controls SubAB-mediated apoptosis and autophagy
-
Yahiro, K., Tsutsuki, H., Ogura, K., Nagasawa, S., Moss, J., Noda, M., DAP1, a negative regulator of autophagy, controls SubAB-mediated apoptosis and autophagy. Infect. Immun. 82 (2014), 4899–4908.
-
(2014)
Infect. Immun.
, vol.82
, pp. 4899-4908
-
-
Yahiro, K.1
Tsutsuki, H.2
Ogura, K.3
Nagasawa, S.4
Moss, J.5
Noda, M.6
-
41
-
-
84924086597
-
Autophagy upregulation and apoptosis downregulation in DAHP and triptolide treated cerebral ischemia
-
Yang, Y., Gao, K.Q., Hu, Z.Y., Li, W.Y., Davies, H., Ling, S.C., Rudd, J.A., Fang, M., Autophagy upregulation and apoptosis downregulation in DAHP and triptolide treated cerebral ischemia. Mediat. Inflamm., 2015, 120198.
-
(2015)
Mediat. Inflamm.
, pp. 120198
-
-
Yang, Y.1
Gao, K.Q.2
Hu, Z.Y.3
Li, W.Y.4
Davies, H.5
Ling, S.C.6
Rudd, J.A.7
Fang, M.8
-
42
-
-
84924632105
-
Hypoxia induces microglia autophagy and neural inflammation injury in focal cerebral ischemia model
-
Yang, Z., Zhong, L., Zhong, S.C., Xian, R.H., Yuan, B.Q., Hypoxia induces microglia autophagy and neural inflammation injury in focal cerebral ischemia model. Exp. Mol. Pathol. 98 (2015), 219–224.
-
(2015)
Exp. Mol. Pathol.
, vol.98
, pp. 219-224
-
-
Yang, Z.1
Zhong, L.2
Zhong, S.C.3
Xian, R.H.4
Yuan, B.Q.5
-
43
-
-
77953699711
-
Termination of autophagy and reformation of lysosomes regulated by mTOR
-
Yu, L., McPhee, C.K., Zheng, L.X., Mardones, G., Rong, Y.G., Peng, J.Y., Mi, Na, Zhao, Y., Liu, Z.H., Wan, F.Y., Hailey, D.W., Oorschot V, Klumperman, J., Baehrecke, E.H., Lenardo, M.J., Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature 5 (2010), 942–946.
-
(2010)
Nature
, vol.5
, pp. 942-946
-
-
Yu, L.1
McPhee, C.K.2
Zheng, L.X.3
Mardones, G.4
Rong, Y.G.5
Peng, J.Y.6
Mi, N.7
Zhao, Y.8
Liu, Z.H.9
Wan, F.Y.10
Hailey, D.W.11
Oorschot12
Klumperman, J.13
Baehrecke, E.H.14
Lenardo, M.J.15
|