The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia

Science

Volumn 353, Issue 6306, 2016, Pages 1393-1398

  Song, Kun ^a,d   Wang, Hong ^a   Kamm, Gretel B ^a   Pohle, Jörg ^a   De Castro Reis, Fernanda ^b   Heppenstall, Paul ^b,c   Wende, Hagen ^a   Siemens, Jan ^a,c  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY EMBL   (Italy)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^d MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSIENT RECEPTOR POTENTIAL CHANNEL M2; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRPM2 PROTEIN, MOUSE;

ABNORMALITY; BODY TEMPERATURE; BRAIN; HOMEOSTASIS; NERVOUS SYSTEM; NEUROLOGY; PROTEIN; THERMOREGULATION;

ANIMAL CELL; ARTICLE; BODY TEMPERATURE; CELL SUBPOPULATION; CONTROLLED STUDY; ENZYME INHIBITION; FEVER; HIGH TEMPERATURE; HOMEOSTASIS; HUMAN; HUMAN CELL; HYPOTHALAMUS; HYPOTHERMIA; IN VIVO STUDY; MOUSE; NERVE CELL; NONHUMAN; PREOPTIC AREA; PRIORITY JOURNAL; SENSOR; TEMPERATURE SENSITIVITY; THERMOREGULATION; ANIMAL; C57BL MOUSE; CYTOLOGY; FEMALE; GENETICS; HEAT; MUTANT MOUSE STRAIN; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; BODY TEMPERATURE REGULATION; FEMALE; FEVER; HOT TEMPERATURE; HYPOTHERMIA; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; NEURONS; PREOPTIC AREA; TRPM CATION CHANNELS;

EID: 84986290296     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf7537     Document Type: Article

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