Fever

TheScientificWorldJournal

Volumn 10, Issue , 2010, Pages 490-503

  Bartfai, Tamas ^a   Conti, Bruno ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Antipyretic; Fever; Hypothalamus; Interleukin; Temperature

Indexed keywords

ACETYLSALICYLIC ACID; ADRENOMEDULLIN; ANTIPYRETIC AGENT; AS 1; BOMBESIN; CORTICOTROPIN RELEASING FACTOR; EM 77; ENDOGENOUS PYROGEN; IBUPROFEN; INTERLEUKIN 1 RECEPTOR ACCESSORY PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 1 RECEPTOR TYPE II; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PARACETAMOL; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PYROGEN; ROFECOXIB; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VALDECOXIB;

BODY TEMPERATURE MEASUREMENT; CHEMICAL STRUCTURE; CIRCADIAN RHYTHM; DRUG DESIGN; DRUG MECHANISM; DRUG STRUCTURE; DRUG TARGETING; FEVER; HEAT SENSITIVITY; HUMAN; NERVE CELL NETWORK; NONHUMAN; PATHOGENESIS; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; THERMOGENESIS; THERMOREGULATION;

ASPIRIN; FEVER; HOMEOSTASIS; HUMANS;

EID: 77951705889     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/tsw.2010.50     Document Type: Review

References (56)

1. Wood, H. (1880) Fever, Study in Morbid and Normal Physiology. Smithsonian Contributions to Knowledge 357, Washington, D.C.
2. Senator, M. (1873) Untersuchungen uber d. Fieberhalten.
3. Welch, W.H. (1888) General Pathology of Fever. WJM Doran Printers.
4. Ott, J. (1884) The relation of the nervous system to the temperature of the body. J. Nerv. Ment. Dis. 11(2), 141-152.
5. Aronsohn and Sachs (1886) Pflugers Arch.
6. Morrison, S.F., Nakamura, K., and Madden, C.J. (2008) Central control of thermogenesis in mammals. Exp. Physiol. 93, 773-797.
7. Nakamura, Y., Nakamura, K., and Morrison, S.F. (2009) Different populations of prostaglandin EP3 receptor-expressing preoptic neurons project to two fever-mediating sympathoexcitatory brain regions. Neuroscience 161(2), 614-620.
8. Lazarus, M., Yoshida, K., Coppari, R., Bass, C.E., Mochizuki, T., Lowell, B.B., and Saper, C.B. (2007) EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. Nat. Neurosci. 10, 1131-1133.
9. Kluger, M.J., Kozak, W., Leon, L.R., and Conn, C.A. (1998) The use of knockout mice to understand the role of cytokines in fever. Clin. Exp. Pharmacol. Physiol. 25, 141-144.
10. Sundgren-Andersson, A.K., Ostlund, P., and Bartfai, T. (1998) Simultaneous measurement of brain and core temperature in the rat during fever, hyperthermia, hypothermia and sleep. Neuroimmunomodulation 5, 241-247. (Pubitemid 28423704)
11. Conti, B., Sanchez-Alavez, M., Winsky-Sommerer, R., Morale, M.C., Lucero, J., Brownell, S., Fabre, V., Huitron-Resendiz, S., Henriksen, S., Zorrilla, E.P., de Lecea, L., and Bartfai, T. (2006) Transgenic mice with a reduced core body temperature have an increased life span. Science 314, 825-828. (Pubitemid 44706650)
12. Dinarello, C.A. (1979) Production of endogenous pyrogen. Fed. Proc. 38, 52-56.
13. Dinarello, C.A. (2004) Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed. J. Endotoxin Res. 10, 201-222.
14. Beutler, B.A. (2009) TLRs and innate immunity. Blood 113, 1399-1407.
15. Kawai, T. and Akira, S. (2007) Signaling to NF-kappaB by Toll-like receptors. Trends Mol. Med. 13, 460-469.
16. Blatteis, C.M., Hunter, W.S., Busija, D.W., Llanos, Q.J., Ahokas, R.A., and Mashburn, T.A., Jr. (1986) Thermoregulatory and acute-phase responses to endotoxin of full- term-pregnant rabbits. J. Appl. Physiol. 60, 1578-1583.
17. Beutler, B. (2004) Innate immunity: an overview. Mol. Immunol. 40, 845-859.
18. Beutler, B., Hoebe, K., Du, X., and Ulevitch, R.J. (2003) How we detect microbes and respond to them: the Toll-like receptors and their transducers. J. Leukoc. Biol. 74, 479-485.
19. Dinarello, C.A. (1996) Biologic basis for interleukin-1 in disease. Blood 87, 2095-2147.
20. Xu, Y., Tao, X., Shen, B., Horng, T., Medzhitov, R., Manley, J.L., and Tong, L. (2000) Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature 408, 111-115.
21. Rubartelli, A. and Sitia, R. (1991) Interleukin 1 beta and thioredoxin are secreted through a novel pathway of secretion. Biochem. Soc. Trans. 19, 255-259.
22. Ryan, J.G. and Kastner, D.L. (2008) Fevers, genes, and innate immunity. Curr. Topics Microbiol. Immunol. 321, 169-184.
23. Huemer, C. and Huemer, M. (2006) Periodic fever syndromes. Z. Rheumatol. 65, 595-598, 600-603. [German]
24. Dube, C.M., Brewster, A.L., Richichi, C., Zha, Q., and Baram, T.Z. (2007) Fever, febrile seizures and epilepsy. Trends Neurosci. 30, 490-496.
25. Vezzani, A., Moneta, D., Conti, M., Richichi, C., Ravizza, T., De Luigi, A., De Simoni, M.G., Sperk, G., Andell-Jonsson, S., Lundkvist, J., Iverfeldt, K., and Bartfai, T. (2000) Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice. Proc. Natl. Acad. Sci. U. S. A. 97, 11534-11539.
26. Emsley, H.C., Smith, C.J., Georgiou, R.F., Vail, A., Hopkins, S.J., Rothwell, N.J., and Tyrrell, P.J. (2005) A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients. J. Neurol. Neurosurg. Psychiatry 76, 1366-1372.
27. Samuelsson, B., Granstrom, E., Green, K., Hamberg, M., and Hammarstrom, S. (1975) Prostaglandins. Annu. Rev. Biochem. 44, 669-695.
28. Blatteis, C.M., Li, S., Li, Z., Feleder, C., and Perlik, V. (2005) Cytokines, PGE2 and endotoxic fever: a re-assessment. Prostaglandins Other Lipid Mediat. 76, 1-18.
29. Vane, J.R. (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat. New Biol. 231, 232-235.
30. Vane, J.R. and Botting, R.M. (1997) Mechanism of action of aspirin-like drugs. Semin. Arthritis Rheum. 26, 2-10.
31. Oka, T. (2004) Prostaglandin E2 as a mediator of fever: the role of prostaglandin e (EP) receptors. Front. Biosci. 1, 3046-3057.
32. Oka, T., Oka, K., Scammell, T.E., Lee, C., Kelly, J.F., Nantel, F., Elmquist, J.K., and Saper, C.B. (2000) Relationship of EP(1-4) prostaglandin receptors with rat hypothalamic cell groups involved in lipopolysaccharide fever responses. J. Comp. Neurol. 428, 20-32.
33. Narumiya, S. and FitzGerald, G.A. (2001) Genetic and pharmacological analysis of prostanoid receptor function. J. Clin. Invest. 108, 25-30.
34. Hartke, J.R. and Lundy, M.W. (2001) Bone anabolic therapy with selective prostaglandin analogs. J. Musculoskelet. Neuronal Interact. 2, 25-31.
35. Ushikubi, F., Segi, E., Sugimoto, Y., Murata, T., Matsuoka, T., Kobayashi, T., Hizaki, H., Tuboi, K., Katsuyama, M., Ichikawa, A., Tanaka, T., Yoshida, N., and Narumiya, S. (1998) Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature 395, 281-284. (Pubitemid 28447553)
36. Sanchez-Alavez, M., Tabarean, I.V., Behrens, M.M., and Bartfai, T. (2006) Ceramide mediates the rapid phase of febrile response to IL-1{beta}. Proc. Natl. Acad. Sci. U. S. A. 103, 2904-2908.
37. Caterina, M.J. and Julius, D. (2001) The vanilloid receptor: a molecular gateway to the pain pathway. Annu. Rev. Neurosci. 24, 487-517.
38. Jordt, S.E., McKemy, D.D., and Julius, D. (2003) Lessons from peppers and peppermint: the molecular logic of thermosensation. Curr. Opin. Neurobiol. 13, 487-492.
39. Shibata, M., Hori, T., Kiyohara, T., Nakashima, T., and Asami, T. (1988) Responses of anterior hypothalamic-preoptic thermosensitive neurons to substance P and capsaicin. Neuropharmacology 27, 143-148. (Pubitemid 18052355)
40. Nelson, D.O. and Prosser, C.L. (1981) Intracellular recordings from thermosensitive preoptic neurons. Science 213, 787-789.
41. Boulant, J.A. (1981) Hypothalamic mechanisms in thermoregulation. Fed. Proc. 40, 2843-2850.
42. Koga, H., Hori, T., Kiyohara, T., and Nakashima, T. (1987) Responses of preoptic thermosensitive neurons to changes in blood pressure. Brain Res. Bull. 18, 749-755.
43. Hori, T., Yamasaki, M., Kiyohara, T., and Shibata, M. (1986) Responses of preoptic thermosensitive neurons to poikilothermia-inducing peptides - bombesin and neurotensin. Pflugers Arch. 407, 558-560.
44. Wechselberger, M., Wright, C.L., Bishop, G.A., and Boulant, J.A. (2006) Ionic channels and conductance-based models for hypothalamic neuronal thermosensitivity. Am. J. Physiol. Regul. Integr. Comp. Physiol. 291, R518-529.
45. Boulant, J.A. and Dean, J.B. (1986) Temperature receptors in the central nervous system. Annu. Rev. Physiol. 48, 639-654.
46. Burgoon, P.W., Burry, R.W., and Boulant, J.A. (1997) Neuronal thermosensitivity and survival of rat hypothalamic slices in recording chambers. Brain Res. 777, 31-41. (Pubitemid 28015729)
47. Tabarean, I.V., Conti, B., Behrens, M., Korn, H., and Bartfai, T. (2005) Electrophysiological properties and thermosensitivity of mouse preoptic and anterior hypothalamic neurons in culture. Neuroscience 135, 433-449. (Pubitemid 41317382)
48. Eberwine, J. and Crino, P. (2001) Analysis of mRNA populations from single live and fixed cells of the central nervous system. Current Protocols in Neuroscience. Chap. 5, Unit 5.3. Wiley.
49. Bartfai, T., Behrens, M.M., Gaidarova, S., Pemberton, J., Shivanyuk, A., and Rebek, J., Jr. (2003) A low molecular weight mimic of the Toll/IL-1 receptor/resistance domain inhibits IL-1 receptor-mediated responses. Proc. Natl. Acad. Sci. U. S. A. 100, 7971-7976.
50. Davis, C.N., Mann, E., Behrens, M.M., Gaidarova, S., Rebek, M., Rebek, J., Jr., and Bartfai, T. (2006) MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics. Proc. Natl. Acad. Sci. U. S. A. 103, 2953-2958.
51. (2009) Aspirin for the prevention of cardiovascular disease: U.S. Preventive Services Task Force recommendation statement. Ann. Intern. Med. 150, 396-404.
52. Ermondi, G., Caron, G., Lawrence, R., and Longo, D. (2004) Docking studies on NSAID/COX-2 isozyme complexes using contact statistics analysis. J. Comput. Aided Mol. Des. 18, 683-696.
53. Pouplana, R., Lozano, J.J., Perez, C., and Ruiz, J. (2002) Structure-based QSAR study on differential inhibition of human prostaglandin endoperoxide H synthase-2 (COX-2) by nonsteroidal anti-inflammatory drugs. J. Comput. Aided Mol. Des. 16, 683-709.
54. Trummlitz, G. and van Ryn, J. (2002) Designing selective COX-2 inhibitors: molecular modeling approaches. Curr. Opin. Drug Discov. Dev. 5, 550-561.
55. Hoak, J.C. (1983) Mechanisms of action: aspirin. Thromb. Res. 4, 47-51.
56. Chai, Z., Alheim, K., Lundkvist, J., Gatti, S., and Bartfai, T. (1996) Subchronic glucocorticoid pretreatment reversibly attenuates IL-beta induced fever in rats; IL-6 mRNA is elevated while IL-1 alpha and IL-1 beta mRNAs are suppressed, in the CNS. Cytokine 8, 227-237.