Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β

ACS Medicinal Chemistry Letters

Volumn 7, Issue 9, 2016, Pages 852-856

  Wang, Yikai ^a   Wach, Jean Yves ^a   Sheehan, Patrick ^a   Zhong, Cheng ^a   Zhan, Chenyang ^c   Harris, Richard ^c   Almo, Steven C ^c   Bishop, Joshua ^a,b   Haggarty, Stephen J ^a,b   Ramek, Alexander ^a   Berry, Kayla N ^a   O'Herin, Conor ^a   Koehler, Angela N ^a   Hung, Alvin W ^a,d   Young, Damian W ^a,e  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d Agency for Science   (Singapore)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Diversity oriented synthesis; fragment growing; fragment based drug discovery; GSK3

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; PROTEIN SERINE THREONINE KINASE INHIBITOR;

ARTICLE; BINDING SITE; DIVERSITY ORIENTED SYNTHESIS; DRUG DEVELOPMENT; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENANTIOMER; FLUOROMETRY; FRAGMENT BASED DRUG DISCOVERY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IC50; ISOTHERMAL TITRATION CALORIMETRY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; THERMOSTABILITY;

EID: 84986265041     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.6b00230     Document Type: Article

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