Discovery of dihydroquinoxalinone acetamides containing bicyclic amines as potent Bradykinin B1 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 16, 2008, Pages 4477-4481

  Chen, Jian Jeffrey ^a   Qian, Wenyuan ^a   Biswas, Kaustav ^a   Viswanadhan, Vellarkad N ^a   Askew, Benny C ^b   Hitchcock, Stephen ^a   Hungate, Randall W ^a   Arik, Leyla ^a   Johnson, Eileen ^a  

^a AMGEN INC   (United States)

^b Serono Research Institute   (United States)

Author keywords

Bradykinin B1; Dihydroquinoxalinone acetamides; Inflammation; Pain; Receptor antagonist; Sulfonamides

Indexed keywords

ACETAMIDE DERIVATIVE; AMINE; BETA AMINO ACID; BRADYKININ B1 RECEPTOR ANTAGONIST; DIAMINE DERIVATIVE;

ARTICLE; BINDING AFFINITY; BINDING ASSAY; IC 50; MOLECULAR MODEL; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

ACETAMIDES; ACETIC ACID; AMINES; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MODELS, CHEMICAL; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PROTEIN BINDING; QUINOXALINES; RECEPTOR, BRADYKININ B1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 48849096540     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.07.055     Document Type: Article

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