-
1
-
-
2642709177
-
Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV outpatient study investigators
-
Palella FJ Jr, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 1998; 338:853-860.
-
(1998)
N Engl J Med
, vol.338
, pp. 853-860
-
-
Palella, F.J.1
Delaney, K.M.2
Moorman, A.C.3
-
2
-
-
13944254982
-
Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection
-
Flynn NM, Forthal DN, Harro CD, et al. Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection. J Infect Dis 2005; 191:654-665.
-
(2005)
J Infect Dis
, vol.191
, pp. 654-665
-
-
Flynn, N.M.1
Forthal, D.N.2
Harro, C.D.3
-
3
-
-
33845433434
-
Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand
-
Pitisuttithum P, Gilbert P, Gurwith M, et al. Randomized, double-blind, placebo-controlled efficacy trial of a bivalent recombinant glycoprotein 120 HIV-1 vaccine among injection drug users in Bangkok, Thailand. J Infect Dis 2006; 194:1661-1671.
-
(2006)
J Infect Dis
, vol.194
, pp. 1661-1671
-
-
Pitisuttithum, P.1
Gilbert, P.2
Gurwith, M.3
-
4
-
-
84862904805
-
Extended follow-up confirms early vaccine-enhanced risk of HIV acquisition and demonstrates waning effect over time among participants in a randomized trial of recombinant adenovirus HIV vaccine (Step study)
-
Duerr A, Huang Y, Buchbinder S, et al. Extended follow-up confirms early vaccine-enhanced risk of HIV acquisition and demonstrates waning effect over time among participants in a randomized trial of recombinant adenovirus HIV vaccine (Step Study). J Infect Dis 2012; 206:258-266.
-
(2012)
J Infect Dis
, vol.206
, pp. 258-266
-
-
Duerr, A.1
Huang, Y.2
Buchbinder, S.3
-
5
-
-
79959301474
-
Safety and efficacy of the HVTN 503/Phambili study of a clade-B-based HIV-1 vaccine in South Africa: A doubleblind, randomised, placebo-controlled test-of-concept phase 2b study
-
Gray GE, Allen M, Moodie Z, et al. Safety and efficacy of the HVTN 503/Phambili study of a clade-B-based HIV-1 vaccine in South Africa: a doubleblind, randomised, placebo-controlled test-of-concept phase 2b study. Lancet Infect Dis 2011; 11:507-515.
-
(2011)
Lancet Infect Dis
, vol.11
, pp. 507-515
-
-
Gray, G.E.1
Allen, M.2
Moodie, Z.3
-
6
-
-
84887865083
-
Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine
-
Hammer SM, Sobieszczyk ME, Janes H, et al. Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine. N Engl J Med 2013; 369:2083-2092.
-
(2013)
N Engl J Med
, vol.369
, pp. 2083-2092
-
-
Hammer, S.M.1
Sobieszczyk, M.E.2
Janes, H.3
-
7
-
-
73349094086
-
Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand
-
Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, et al. Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N Engl J Med 2009; 361:2209-2220.
-
(2009)
N Engl J Med
, vol.361
, pp. 2209-2220
-
-
Rerks-Ngarm, S.1
Pitisuttithum, P.2
Nitayaphan, S.3
-
8
-
-
84859393693
-
Immune-correlates analysis of an HIV-1 vaccine efficacy trial
-
Haynes BF, Gilbert PB, McElrath MJ, et al. Immune-correlates analysis of an HIV-1 vaccine efficacy trial. N Engl J Med 2012; 366:1275-1286.
-
(2012)
N Engl J Med
, vol.366
, pp. 1275-1286
-
-
Haynes, B.F.1
Gilbert, P.B.2
McElrath, M.J.3
-
9
-
-
84945929301
-
Immune correlates of vaccine protection against HIV-1 acquisition
-
Corey L, Gilbert PB, Tomaras GD, et al. Immune correlates of vaccine protection against HIV-1 acquisition. Sci Transl Med 2015; 7:310rv317.
-
(2015)
Sci Transl Med
, vol.7
, pp. 310rv317
-
-
Corey, L.1
Gilbert, P.B.2
Tomaras, G.D.3
-
10
-
-
84962295972
-
Approaches to preventive and therapeutic HIV vaccines
-
Gray GE, Laher F, Lazarus E, et al. Approaches to preventive and therapeutic HIV vaccines. Curr Opin Virol 2016; 17:104-109.
-
(2016)
Curr Opin Virol
, vol.17
, pp. 104-109
-
-
Gray, G.E.1
Laher, F.2
Lazarus, E.3
-
11
-
-
84876414249
-
Vaccine and immunotherapeutic interventions
-
Pantaleo G, Levy Y. Vaccine and immunotherapeutic interventions. Curr Opin HIV AIDS 2013; 8:236-242.
-
(2013)
Curr Opin HIV AIDS
, vol.8
, pp. 236-242
-
-
Pantaleo, G.1
Levy, Y.2
-
12
-
-
0006582115
-
Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection
-
Kaslow RA, Carrington M, Apple R, et al. Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection. Nat Med 1996; 2:405-411.
-
(1996)
Nat Med
, vol.2
, pp. 405-411
-
-
Kaslow, R.A.1
Carrington, M.2
Apple, R.3
-
13
-
-
34548134145
-
A whole-genome association study of major determinants for host control of HIV-1
-
Fellay J, Shianna KV, Ge D, et al. A whole-genome association study of major determinants for host control of HIV-1. Science 2007; 317:944-947.
-
(2007)
Science
, vol.317
, pp. 944-947
-
-
Fellay, J.1
Shianna, K.V.2
Ge, D.3
-
14
-
-
78650084232
-
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation
-
International HIV Controllers Study. Pereyra F, Jia X, McLaren P, et al. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science 2010; 330:1551-1557.
-
(2010)
Science
, vol.330
, pp. 1551-1557
-
-
Pereyra, F.1
Jia, X.2
McLaren, P.3
-
15
-
-
84879614980
-
Unravelling the mechanisms of durable control of HIV-1
-
Walker BD, Yu XG. Unravelling the mechanisms of durable control of HIV-1. Nat Rev Immunol 2013; 13:487-498.
-
(2013)
Nat Rev Immunol
, vol.13
, pp. 487-498
-
-
Walker, B.D.1
Yu, X.G.2
-
16
-
-
34249852256
-
HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype
-
Sáez-Cirión A, Lacabaratz C, Lambotte O, et al. HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype. Proc Natl Acad Sci U S A 2007; 104:6776-6781.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 6776-6781
-
-
Sáez-Cirión, A.1
Lacabaratz, C.2
Lambotte, O.3
-
17
-
-
67649213034
-
Heterogeneity in HIV suppression by CD8 T cells from HIV controllers: Association with gagspecific CD8 T cell responses
-
Sáez-Cirión A, Sinet M, Shin SY, et al. Heterogeneity in HIV suppression by CD8 T cells from HIV controllers: association with Gagspecific CD8 T cell responses. J Immunol 2009; 182:7828-7837.
-
(2009)
J Immunol
, vol.182
, pp. 7828-7837
-
-
Sáez-Cirión, A.1
Sinet, M.2
Shin, S.Y.3
-
18
-
-
0030659177
-
Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy
-
Chun TW, Stuyver L, Mizell SB, et al. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc Natl Acad Sci U S A 1997; 94:13193-13197.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 13193-13197
-
-
Chun, T.W.1
Stuyver, L.2
Mizell, S.B.3
-
19
-
-
0030913366
-
Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection
-
Chun TW, Carruth L, Finzi D, et al. Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection. Nature 1997; 387:183-188.
-
(1997)
Nature
, vol.387
, pp. 183-188
-
-
Chun, T.W.1
Carruth, L.2
Finzi, D.3
-
20
-
-
14444273439
-
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy
-
Finzi D, Hermankova M, Pierson T, et al. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 1997; 278:1295-1300.
-
(1997)
Science
, vol.278
, pp. 1295-1300
-
-
Finzi, D.1
Hermankova, M.2
Pierson, T.3
-
21
-
-
0030712305
-
Recovery of replication-competent HIV despite prolonged suppression of plasma viremia
-
Wong JK, Hezareh M, Günthard HF, et al. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science 1997; 278:1291-1295.
-
(1997)
Science
, vol.278
, pp. 1291-1295
-
-
Wong, J.K.1
Hezareh, M.2
Günthard, H.F.3
-
22
-
-
0038579210
-
Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells
-
Siliciano JD, Kajdas J, Finzi D, et al. Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nat Med 2003; 9:727-728.
-
(2003)
Nat Med
, vol.9
, pp. 727-728
-
-
Siliciano, J.D.1
Kajdas, J.2
Finzi, D.3
-
23
-
-
68349139711
-
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
-
Chomont N, El-Far M, Ancuta P, et al. HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat Med 2009; 15:893-900.
-
(2009)
Nat Med
, vol.15
, pp. 893-900
-
-
Chomont, N.1
El-Far, M.2
Ancuta, P.3
-
24
-
-
84893761231
-
HIV-1 persistence in CD4+ T cells with stem cell-like properties
-
Buzon MJ, Sun H, Li C, Shaw A, et al. HIV-1 persistence in CD4+ T cells with stem cell-like properties. Nat Med 2014; 20:139-142.
-
(2014)
Nat Med
, vol.20
, pp. 139-142
-
-
Buzon, M.J.1
Sun, H.2
Li, C.3
Shaw, A.4
-
25
-
-
0035908122
-
Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells
-
Kim CH, Rott LS, Clark-Lewis I, et al. Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells. J Exp Med 2001; 193:1373-1381.
-
(2001)
J Exp Med
, vol.193
, pp. 1373-1381
-
-
Kim, C.H.1
Rott, L.S.2
Clark-Lewis, I.3
-
26
-
-
0034606359
-
Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
-
Breitfeld D, Ohl L, Kremmer E, et al. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med 2000; 192:1545-1552.
-
(2000)
J Exp Med
, vol.192
, pp. 1545-1552
-
-
Breitfeld, D.1
Ohl, L.2
Kremmer, E.3
-
27
-
-
0034606348
-
CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
-
Schaerli P, Willimann K, Lang AB, et al. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med 2000; 192:1553-1562.
-
(2000)
J Exp Med
, vol.192
, pp. 1553-1562
-
-
Schaerli, P.1
Willimann, K.2
Lang, A.B.3
-
28
-
-
84874519282
-
Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production
-
Perreau M, Savoye AL, De Crignis E, et al. Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production. J Exp Med 2013; 210:143-156.
-
(2013)
J Exp Med
, vol.210
, pp. 143-156
-
-
Perreau, M.1
Savoye, A.L.2
De Crignis, E.3
-
29
-
-
84973131619
-
+ and tfh cells are responsible for persistent HIV-1 transcription in treated aviremic individuals
-
+ and Tfh cells are responsible for persistent HIV-1 transcription in treated aviremic individuals. Nat Med 2016; 22:754-761.
-
(2016)
Nat Med
, vol.22
, pp. 754-761
-
-
Banga, R.1
Procopio, F.A.2
Noto, A.3
-
30
-
-
84922611542
-
B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers
-
Fukazawa Y, Lum R, Okoye AA, et al. B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers. Nat Med 2015; 21:132-139.
-
(2015)
Nat Med
, vol.21
, pp. 132-139
-
-
Fukazawa, Y.1
Lum, R.2
Okoye, A.A.3
-
31
-
-
84893830170
-
Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues
-
Fletcher CV, Staskus K, Wietgrefe SW, et al. Persistent HIV-1 replication is associated with lower antiretroviral drug concentrations in lymphatic tissues. Proc Natl Acad Sci U S A 2014; 111:2307-2312.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. 2307-2312
-
-
Fletcher, C.V.1
Staskus, K.2
Wietgrefe, S.W.3
-
32
-
-
34249829895
-
Elevated expression levels of inhibitory receptor programmed death 1 on simian immunodeficiency virus-specific CD8 T cells during chronic infection but not after vaccination
-
Velu V, Kannanganat S, Ibegbu C, et al. Elevated expression levels of inhibitory receptor programmed death 1 on simian immunodeficiency virus-specific CD8 T cells during chronic infection but not after vaccination. J Virol 2007; 81:5819-5828.
-
(2007)
J Virol
, vol.81
, pp. 5819-5828
-
-
Velu, V.1
Kannanganat, S.2
Ibegbu, C.3
-
33
-
-
84883796903
-
Antibodies in HIV-1 vaccine development and therapy
-
Klein F, Mouquet H, Dosenovic P, et al. Antibodies in HIV-1 vaccine development and therapy. Science 2013; 341:1199-1204.
-
(2013)
Science
, vol.341
, pp. 1199-1204
-
-
Klein, F.1
Mouquet, H.2
Dosenovic, P.3
-
34
-
-
84887626950
-
Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys
-
Barouch DH, Whitney JB, Moldt B, et al. Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature 2013; 503:224-228.
-
(2013)
Nature
, vol.503
, pp. 224-228
-
-
Barouch, D.H.1
Whitney, J.B.2
Moldt, B.3
-
35
-
-
84907379431
-
Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice
-
Halper-Stromberg A, Lu CL, Klein F, et al. Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice. Cell 2014; 158:989-999.
-
(2014)
Cell
, vol.158
, pp. 989-999
-
-
Halper-Stromberg, A.1
Lu, C.L.2
Klein, F.3
-
36
-
-
84870562234
-
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice
-
Klein F, Halper-Stromberg A, Horwitz JA, et al. HIV therapy by a combination of broadly neutralizing antibodies in humanized mice. Nature 2012; 492:118-122.
-
(2012)
Nature
, vol.492
, pp. 118-122
-
-
Klein, F.1
Halper-Stromberg, A.2
Horwitz, J.A.3
-
37
-
-
84885338257
-
HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice
-
Horwitz JA, Halper-Stromberg A, Mouquet H, et al. HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice. Proc Natl Acad Sci U S A 2013; 110:16538-16543.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 16538-16543
-
-
Horwitz, J.A.1
Halper-Stromberg, A.2
Mouquet, H.3
-
38
-
-
84907212727
-
Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques
-
Shingai M, Donau OK, Plishka RJ, et al. Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques. J Exp Med 2014; 211:2061-2074.
-
(2014)
J Exp Med
, vol.211
, pp. 2061-2074
-
-
Shingai, M.1
Donau, O.K.2
Plishka, R.J.3
-
39
-
-
84928405730
-
Viraemia suppressedin HIV-1-infectedhumans by broadly neutralizing antibody 3BNC117
-
Caskey M, Klein F, Lorenzi JC, et al. Viraemia suppressedin HIV-1-infectedhumans by broadly neutralizing antibody 3BNC117. Nature 2015; 522:487-491.
-
(2015)
Nature
, vol.522
, pp. 487-491
-
-
Caskey, M.1
Klein, F.2
Lorenzi, J.C.3
-
40
-
-
84966341056
-
HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1
-
Schoofs T, Klein F, Braunschweig M, et al. HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1. Science 2016; 352:997-1001.
-
(2016)
Science
, vol.352
, pp. 997-1001
-
-
Schoofs, T.1
Klein, F.2
Braunschweig, M.3
-
41
-
-
84966397893
-
Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo
-
Lu CL, Murakowski DK, Bournazos S, et al. Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo. Science 2016; 352:1001-1004.
-
(2016)
Science
, vol.352
, pp. 1001-1004
-
-
Lu, C.L.1
Murakowski, D.K.2
Bournazos, S.3
-
42
-
-
84922982202
-
Improving neutralization potency and breadth by combining broadly reactive HIV-1 antibodies targeting major neutralization epitopes
-
Kong R, Louder MK, Wagh K, et al. Improving neutralization potency and breadth by combining broadly reactive HIV-1 antibodies targeting major neutralization epitopes. J Virol 2015; 89:2659-2671.
-
(2015)
J Virol
, vol.89
, pp. 2659-2671
-
-
Kong, R.1
Louder, M.K.2
Wagh, K.3
-
43
-
-
84954445565
-
Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection
-
Lynch RM, Boritz E, Coates EE, et al. Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection. Sci Transl Med 2015; 7:319ra206.
-
(2015)
Sci Transl Med
, vol.7
, pp. 319ra206
-
-
Lynch, R.M.1
Boritz, E.2
Coates, E.E.3
-
44
-
-
84887627657
-
Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia
-
Shingai M, Nishimura Y, Klein F, et al. Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia. Nature 2013; 503:277-280.
-
(2013)
Nature
, vol.503
, pp. 277-280
-
-
Shingai, M.1
Nishimura, Y.2
Klein, F.3
-
45
-
-
84976406858
-
HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption
-
Scheid JF, Horwitz JA, Bar-On Y, et al. HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption. Nature 2016; 535:556-560.
-
(2016)
Nature
, vol.535
, pp. 556-560
-
-
Scheid, J.F.1
Horwitz, J.A.2
Bar-On, Y.3
-
46
-
-
84878981012
-
Barriers to a cure for HIV: New ways to target and eradicate HIV-1 reservoirs
-
Katlama C, Deeks SG, Autran B, et al. Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs. Lancet 2013; 381:2109-2117.
-
(2013)
Lancet
, vol.381
, pp. 2109-2117
-
-
Katlama, C.1
Deeks, S.G.2
Autran, B.3
-
47
-
-
84864243685
-
HIV: Shock and kill
-
Deeks SG. HIV: shock and kill. Nature 2012; 487:439-440.
-
(2012)
Nature
, vol.487
, pp. 439-440
-
-
Deeks, S.G.1
-
48
-
-
84891932867
-
Safety, tolerability, and immunogenicity of repeated doses of derma vir, a candidate therapeutic HIV vaccine, in HIV-infected patients receiving combination antiretroviral therapy: Results of the ACTG 5176 trial
-
Rodriguez B, Asmuth DM, Matining RM, et al. Safety, tolerability, and immunogenicity of repeated doses of Derma Vir, a candidate therapeutic HIV vaccine, in HIV-infected patients receiving combination antiretroviral therapy: results of the ACTG 5176 trial. J Acquir Immune Defic Syndr 2013; 64:351-359.
-
(2013)
J Acquir Immune Defic Syndr
, vol.64
, pp. 351-359
-
-
Rodriguez, B.1
Asmuth, D.M.2
Matining, R.M.3
-
49
-
-
84860745751
-
Single derma vir immunization: Dose-dependent expansion of precursor/memory T cells against all HIV antigens in HIV-1 infected individuals
-
Lisziewicz J, Bakare N, Calarota SA, et al. Single Derma Vir immunization: dose-dependent expansion of precursor/memory T cells against all HIV antigens in HIV-1 infected individuals. PLoS One 2012; 7:e35416.
-
(2012)
PLoS One
, vol.7
, pp. e35416
-
-
Lisziewicz, J.1
Bakare, N.2
Calarota, S.A.3
-
50
-
-
84924033633
-
Synthetic consensus HIV-1 DNA induces potent cellular immune responses and synthesis of granzyme B, perforin in HIV infected individuals
-
Morrow MP, Tebas P, Yan J, et al. Synthetic consensus HIV-1 DNA induces potent cellular immune responses and synthesis of granzyme B, perforin in HIV infected individuals. Mol Ther 2015; 23:591-601.
-
(2015)
Mol Ther
, vol.23
, pp. 591-601
-
-
Morrow, M.P.1
Tebas, P.2
Yan, J.3
-
51
-
-
84896490282
-
Safety and efficacy of the peptidebased therapeutic vaccine for HIV-1, vacc-4x: A phase 2 randomised, doubleblind, placebo-controlled trial
-
Pollard RB, Rockstroh JK, Pantaleo G, et al. Safety and efficacy of the peptidebased therapeutic vaccine for HIV-1, Vacc-4x: a phase 2 randomised, doubleblind, placebo-controlled trial. Lancet Infect Dis 2014; 14:291-300.
-
(2014)
Lancet Infect Dis
, vol.14
, pp. 291-300
-
-
Pollard, R.B.1
Rockstroh, J.K.2
Pantaleo, G.3
-
52
-
-
84868279081
-
HIV-1 tat B-cell epitope vaccination was ineffectual in preventing viral rebound after ART cessation: HIV rebound with current ART appears to be due to infection with new endogenous founder virus and not to resurgence of preexisting tat-dependent viremia
-
Goldstein G, Damiano E, Donikyan M, et al. HIV-1 Tat B-cell epitope vaccination was ineffectual in preventing viral rebound after ART cessation: HIV rebound with current ART appears to be due to infection with new endogenous founder virus and not to resurgence of preexisting Tat-dependent viremia. Hum Vaccin Immunother 2012; 8:1425-1430.
-
(2012)
Hum Vaccin Immunother
, vol.8
, pp. 1425-1430
-
-
Goldstein, G.1
Damiano, E.2
Donikyan, M.3
-
53
-
-
84886711245
-
Therapeutic vaccination using cationic liposome-adjuvanted HIV type 1 peptides representing HLA-supertype-restricted subdominant T cell epitopes: Safety, immunogenicity, and feasibility in Guinea-Bissau
-
Román VR, Jensen KJ, Jensen SS, et al. Therapeutic vaccination using cationic liposome-adjuvanted HIV type 1 peptides representing HLA-supertype-restricted subdominant T cell epitopes: safety, immunogenicity, and feasibility in Guinea-Bissau. AIDS Res Hum Retroviruses 2013; 29:1504-1512.
-
(2013)
AIDS Res Hum Retroviruses
, vol.29
, pp. 1504-1512
-
-
Román, V.R.1
Jensen, K.J.2
Jensen, S.S.3
-
54
-
-
84872351363
-
Adjuvanted HLA-supertype restricted subdominant peptides induce new T-cell immunity during untreated HIV-1-infection
-
Karlsson I, Brandt L, Vinner L, et al. Adjuvanted HLA-supertype restricted subdominant peptides induce new T-cell immunity during untreated HIV-1-infection. Clin Immunol 2013; 146:120-130.
-
(2013)
Clin Immunol
, vol.146
, pp. 120-130
-
-
Karlsson, I.1
Brandt, L.2
Vinner, L.3
-
55
-
-
84886950797
-
Safety, immunogenicity and efficacy assessment of HIV immunotherapy in a multicentre, double-blind, randomised, placebo-controlled phase Ib human trial
-
Boffito M, Fox J, Bowman C, et al. Safety, immunogenicity and efficacy assessment of HIV immunotherapy in a multicentre, double-blind, randomised, placebo-controlled phase Ib human trial. Vaccine 2013; 31:5680-5686.
-
(2013)
Vaccine
, vol.31
, pp. 5680-5686
-
-
Boffito, M.1
Fox, J.2
Bowman, C.3
-
56
-
-
84928563445
-
HIV-1 tat immunization restores immune homeostasis and attacks the HAART-resistant blood HIV DNA: Results of a randomized phase II exploratory clinical trial
-
Ensoli F, Cafaro A, Casabianca A, et al. HIV-1 Tat immunization restores immune homeostasis and attacks the HAART-resistant blood HIV DNA: results of a randomized phase II exploratory clinical trial. Retrovirology 2015; 12:33.
-
(2015)
Retrovirology
, vol.12
, pp. 33
-
-
Ensoli, F.1
Cafaro, A.2
Casabianca, A.3
-
57
-
-
78649720290
-
Therapeutic immunization with HIV-1 tat reduces immune activation and loss of regulatory T-cells and improves immune function in subjects on HAART
-
Ensoli B, Bellino S, Tripiciano A, et al. Therapeutic immunization with HIV-1 Tat reduces immune activation and loss of regulatory T-cells and improves immune function in subjects on HAART. PLoS One 2010; 5:e13540.
-
(2010)
PLoS One
, vol.5
, pp. e13540
-
-
Ensoli, B.1
Bellino, S.2
Tripiciano, A.3
-
58
-
-
84895059984
-
Synthetic HIV-1 matrix protein p17-based AT20-KLH therapeutic immunization in HIV-1-infected patients receiving antiretroviral treatment: A phase I safety and immunogenicity study
-
Iaria ML, Fiorentini S, Focà E, et al. Synthetic HIV-1 matrix protein p17-based AT20-KLH therapeutic immunization in HIV-1-infected patients receiving antiretroviral treatment: a phase I safety and immunogenicity study. Vaccine 2014; 32:1072-1078.
-
(2014)
Vaccine
, vol.32
, pp. 1072-1078
-
-
Iaria, M.L.1
Fiorentini, S.2
Focà, E.3
-
59
-
-
84954509568
-
Dendritic cell immunotherapy for HIV-1 infection using autologous HIV-1 RNA: A randomized, double-blind, placebo-controlled clinical trial
-
Jacobson JM, Routy JP, Welles S, et al. Dendritic cell immunotherapy for HIV-1 infection using autologous HIV-1 RNA: a randomized, double-blind, placebo-controlled clinical trial. J Acquir Immune Defic Syndr 2016; 72:31-38.
-
(2016)
J Acquir Immune Defic Syndr
, vol.72
, pp. 31-38
-
-
Jacobson, J.M.1
Routy, J.P.2
Welles, S.3
-
60
-
-
84896822363
-
Exome analysis of HIV patients submitted to dendritic cells therapeutic vaccine reveals an association of CNOT1 gene with response to the treatment
-
Moura R, Pontillo A, D'Adamo P, et al. Exome analysis of HIV patients submitted to dendritic cells therapeutic vaccine reveals an association of CNOT1 gene with response to the treatment. J Int AIDS Soc 2014; 17:18938.
-
(2014)
J Int AIDS Soc
, vol.17
, pp. 18938
-
-
Moura, R.1
Pontillo, A.2
D'Adamo, P.3
-
61
-
-
84988421189
-
Dendritic cells used in anti-HIV immunotherapy showed different modulation in anti-HIV genes expression: New concept for the improvement of patients' selection criteria
-
in press
-
Pontillo A, Reis EC, da Silva LT, et al. Dendritic cells used in anti-HIV immunotherapy showed different modulation in anti-HIV genes expression: new concept for the improvement of patients' selection criteria. J Cell Immunother 2016; 002. in press (doi:10.1016/j.jocit.2016.03.002).
-
(2016)
J Cell Immunother
, pp. 002
-
-
Pontillo, A.1
Reis, E.C.2
Da Silva, L.T.3
-
62
-
-
84959121365
-
Immunization of HIV-1-infected persons with autologous dendritic cells transfected with mRNA encoding HIV-1 gag and nef: Results of a randomized, placebo-controlled clinical trial
-
Gandhi RT, Kwon DS, Macklin EA, et al. Immunization of HIV-1-infected persons with autologous dendritic cells transfected with mRNA encoding HIV-1 Gag and Nef: results of a randomized, placebo-controlled clinical trial. J Acquir Immune Defic Syndr 2016; 71:246-253.
-
(2016)
J Acquir Immune Defic Syndr
, vol.71
, pp. 246-253
-
-
Gandhi, R.T.1
Kwon, D.S.2
Macklin, E.A.3
-
63
-
-
84971647396
-
Therapeutic vaccination with dendritic cells loaded with autologous HIV type 1-infected apoptotic cells
-
Macatangay BJ, Riddler SA, Wheeler ND, et al. Therapeutic vaccination with dendritic cells loaded with autologous HIV type 1-infected apoptotic cells. J Infect Dis 2016; 213:1400-1409.
-
(2016)
J Infect Dis
, vol.213
, pp. 1400-1409
-
-
Macatangay, B.J.1
Riddler, S.A.2
Wheeler, N.D.3
-
64
-
-
84872037286
-
A dendritic cell-based vaccine elicits T cell responses associated with control of HIV-1 replication
-
García F, Climent N, Guardo AC, et al. A dendritic cell-based vaccine elicits T cell responses associated with control of HIV-1 replication. Sci Transl Med 2013; 5:166ra2.
-
(2013)
Sci Transl Med
, vol.5
, pp. 166ra2
-
-
García, F.1
Climent, N.2
Guardo, A.C.3
-
65
-
-
84907841767
-
Dendritic cell-based therapeutic vaccine elicits polyfunctional HIV-specific T-cell immunity associated with control of viral load
-
Lévy Y, Thiébaut R, Montes M, et al. Dendritic cell-based therapeutic vaccine elicits polyfunctional HIV-specific T-cell immunity associated with control of viral load. Eur J Immunol 2012; 44:2802-2810.
-
(2012)
Eur J Immunol
, vol.44
, pp. 2802-2810
-
-
Lévy, Y.1
Thiébaut, R.2
Montes, M.3
-
66
-
-
84964330163
-
Intradermal injection of a tat oyi-based therapeutic HIV vaccine reduces of 1. 5 log copies/ml the HIV RNA rebound median and no HIV DNA rebound following cART interruption in a phase I/II randomized controlled clinical trial
-
Loret EP, Darque A, Jouve E, et al. Intradermal injection of a Tat Oyi-based therapeutic HIV vaccine reduces of 1. 5 log copies/ml the HIV RNA rebound median and no HIV DNA rebound following cART interruption in a phase I/II randomized controlled clinical trial. Retrovirology 2016; 13:21.
-
(2016)
Retrovirology
, vol.13
, pp. 21
-
-
Loret, E.P.1
Darque, A.2
Jouve, E.3
-
67
-
-
0031749740
-
Vaccination with IL-7 gene-modified autologous melanoma cells can enhance the antimelanoma lytic activity in peripheral blood of patients with a good clinical performance status: A clinical phase I study
-
Möller P, Sun Y, Dorbic T, et al. Vaccination with IL-7 gene-modified autologous melanoma cells can enhance the antimelanoma lytic activity in peripheral blood of patients with a good clinical performance status: a clinical phase I study. Br J Cancer 1998; 77:1907-1916.
-
(1998)
Br J Cancer
, vol.77
, pp. 1907-1916
-
-
Möller, P.1
Sun, Y.2
Dorbic, T.3
-
68
-
-
65249105408
-
Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment
-
Levy Y, Lacabaratz C, Weiss L, et al. Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment. J Clin Invest 2009; 119:997-1007.
-
(2009)
J Clin Invest
, vol.119
, pp. 997-1007
-
-
Levy, Y.1
Lacabaratz, C.2
Weiss, L.3
-
69
-
-
67650590873
-
IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection
-
Sereti I, Dunham RM, Spritzler J, et al. IL-7 administration drives T cell-cycle entry and expansion in HIV-1 infection. Blood 2009; 113:6304-6314.
-
(2009)
Blood
, vol.113
, pp. 6304-6314
-
-
Sereti, I.1
Dunham, R.M.2
Spritzler, J.3
-
70
-
-
84966539095
-
Repeated cycles of recombinant human interleukin 7 in HIV-infected patients with low CD4 T-cell reconstitution on antiretroviral therapy: Results of 2 phase II multicenter studies
-
Thiébaut R, Jarne A, Routy JP, et al. Repeated cycles of recombinant human interleukin 7 in HIV-infected patients with Low CD4 T-cell reconstitution on antiretroviral therapy: results of 2 phase II multicenter studies. Clin Infect Dis 2016; 62:1178-1185.
-
(2016)
Clin Infect Dis
, vol.62
, pp. 1178-1185
-
-
Thiébaut, R.1
Jarne, A.2
Routy, J.P.3
-
72
-
-
13744259064
-
IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART
-
Wang FX, Xu Y, Sullivan J, et al. IL-7 is a potent and proviral strain-specific inducer of latent HIV-1 cellular reservoirs of infected individuals on virally suppressive HAART. J Clin Invest 2005; 115:128-137.
-
(2005)
J Clin Invest
, vol.115
, pp. 128-137
-
-
Wang, F.X.1
Xu, Y.2
Sullivan, J.3
-
73
-
-
78650903022
-
HIV-1 viruses detected during episodic blips following interleukin-7 administration are similar to the viruses present before and after interleukin-7 therapy
-
Imamichi H, Degray G, Asmuth DM, et al. HIV-1 viruses detected during episodic blips following interleukin-7 administration are similar to the viruses present before and after interleukin-7 therapy. AIDS 2011; 25:159-164.
-
(2011)
AIDS
, vol.25
, pp. 159-164
-
-
Imamichi, H.1
Degray, G.2
Asmuth, D.M.3
-
74
-
-
47949097840
-
A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells
-
Bayer AL, Lee JY, de la Barrera A, et al. A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells. J Immunol 2008; 181:225-234.
-
(2008)
J Immunol
, vol.181
, pp. 225-234
-
-
Bayer, A.L.1
Lee, J.Y.2
De La-Barrera, A.3
-
75
-
-
84884264341
-
IL-7 modulates in vitro and in vivo human memory T regulatory cell functions through the CD39/ATP axis
-
Younas M, Hue S, Lacabaratz C, et al. IL-7 modulates in vitro and in vivo human memory T regulatory cell functions through the CD39/ATP axis. J Immunol 2013; 191:3161-3168.
-
(2013)
J Immunol
, vol.191
, pp. 3161-3168
-
-
Younas, M.1
Hue, S.2
Lacabaratz, C.3
-
76
-
-
84901660865
-
Quantifying and predicting the effect of exogenous interleukin-7 on CD4+ T cells in HIV-1 infection
-
Thiébaut R, Drylewicz J, Prague M. Quantifying and predicting the effect of exogenous interleukin-7 on CD4+ T cells in HIV-1 infection. PLoS Comput Biol 2014; 10:e1003630.
-
(2014)
PLoS Comput Biol
, vol.10
, pp. e1003630
-
-
Thiébaut, R.1
Drylewicz, J.2
Prague, M.3
-
77
-
-
33749338938
-
PD-1 is a regulator of virusspecific CD8+ T cell survival in HIV infection
-
Petrovas C, Casazza JP, Brenchley JM, et al. PD-1 is a regulator of virusspecific CD8+ T cell survival in HIV infection. J Exp Med 2006; 203:2281-2292.
-
(2006)
J Exp Med
, vol.203
, pp. 2281-2292
-
-
Petrovas, C.1
Casazza, J.P.2
Brenchley, J.M.3
-
78
-
-
33749009709
-
Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction
-
Trautmann L, Janbazian L, Chomont N, et al. Upregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction. Nat Med 2006; 12:1198-1202.
-
(2006)
Nat Med
, vol.12
, pp. 1198-1202
-
-
Trautmann, L.1
Janbazian, L.2
Chomont, N.3
-
79
-
-
34249800097
-
CTL fail to accumulate at sites of HIV-1 replication in lymphoid tissue
-
Connick E, Mattila T, Folkvord JM, et al. CTL fail to accumulate at sites of HIV-1 replication in lymphoid tissue. J Immunol 2007; 178:6975-6983.
-
(2007)
J Immunol
, vol.178
, pp. 6975-6983
-
-
Connick, E.1
Mattila, T.2
Folkvord, J.M.3
-
80
-
-
84938151164
-
Targeting mTOR catalytic site inhibits multiple steps of the HIV-1 lifecycle and suppresses HIV-1 viremia in humanized mice
-
Heredia A, Le N, Gartenhaus RB, et al. Targeting mTOR catalytic site inhibits multiple steps of the HIV-1 lifecycle and suppresses HIV-1 viremia in humanized mice. Proc Natl Acad Sci U S A 2015; 112:9412-9417.
-
(2015)
Proc Natl Acad Sci U S A
, vol.112
, pp. 9412-9417
-
-
Heredia, A.1
Le, N.2
Gartenhaus, R.B.3
-
81
-
-
84982993334
-
+ T cells expressing PD-1, TIGIT and LAG-3 contribute to HIV persistence during ART
-
+ T cells expressing PD-1, TIGIT and LAG-3 contribute to HIV persistence during ART. PLoS Pathog 2016; 12:1005761.
-
(2016)
PLoS Pathog
, vol.12
, pp. 1005761
-
-
Fromentin, R.1
Backeman, W.2
Lavani, M.B.3
-
82
-
-
84975221851
-
Engineered bispecific antibodies with exquisite HIV-1 neutralizing activity
-
Huang Y, Yu J, Lanzi A, et al. Engineered bispecific antibodies with exquisite HIV-1 neutralizing activity. Cell 2016; 165:1621-1631.
-
(2016)
Cell
, vol.165
, pp. 1621-1631
-
-
Huang, Y.1
Yu, J.2
Lanzi, A.3
-
83
-
-
84975270914
-
Bispecific anti-HIV-1 antibodies with enhanced breadth and potency
-
Bourzanos S, Gazumyan A, Seaman MS, et al. Bispecific anti-HIV-1 antibodies with enhanced breadth and potency. Cell 2016; 165:1609-1620.
-
(2016)
Cell
, vol.165
, pp. 1609-1620
-
-
Bourzanos, S.1
Gazumyan, A.2
Seaman, M.S.3
|