Quantitative assessment of organ distribution of dietary protein-bound 13C-labeled Nɛ-carboxymethyllysine after a chronic oral exposure in mice

Molecular Nutrition and Food Research

Volumn 60, Issue 11, 2016, Pages 2446-2456

  Tessier, Frédéric J ^a,b   Niquet Léridon, Céline ^b   Jacolot, Philippe ^b   Jouquand, Céline ^b   Genin, Michaël ^c   Schmidt, Ann Marie ^d   Grossin, Nicolas ^a   Boulanger, Eric ^a  

^a UNIV LILLE   (France)

^b INSTITUT POLYTECHNIQUE LASALLE BEAUVAIS   (France)

^c UNIV LILLE   (France)

^d NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Biodistribution; Carboxymethyllysine; Food; Glycation; Mass spectrometry; RAGE

Indexed keywords

ADVANCED GLYCATION END PRODUCT; LYSINE; N(6)-CARBOXYMETHYLLYSINE; PROTEIN INTAKE;

ANALOGS AND DERIVATIVES; ANALYSIS; ANIMAL; CHEMISTRY; DIET; HUMAN; KIDNEY; LIVER; METABOLISM; MOUSE; PROTEIN INTAKE;

ANIMALS; DIET; DIETARY PROTEINS; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; KIDNEY; LIVER; LYSINE; MICE;

EID: 84985990833     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201600140     Document Type: Article

References (35)

1. Roca, F., Grossin, N., Chassagne, P., Puisieux, F. et al., The angiogenic paradox in aging and age-related disorders and diseases. Ageing Res. Rev. 2014, 15, 146–160.
2. Nowotny, K., Jung, T., Höhn, A., Weber, D. et al., Advanced glycation end products and oxidative stress in type 2 diabetes mellitus. Biomolecules 2015, 5, 194–222.
3. Teerlink, T., Barto, R., Ten Brink, H. J., Schalkwijk, C. G., Measurement of Nepsilon-(carboxymethyl)lysine and Nepsilon-(carboxyethyl)lysine in human plasma protein by stable-isotope-dilution tandem mass spectrometry. Clin. Chem. 2004, 50, 1222–1228.
4. Delgado-Andrade, C., Tessier, F. J., Niquet-Leridon, C., Seiquer, I. et al., Study of the urinary and fecal excretion of Nε-carboxymethyllysine in young human volunteers. Amino. Acids. 2012, 43, 595–602.
5. Tessier, F., Obrenovich, M., Monnier, V. M., Structure and mechanism of formation of human lens fluorophore LM-1. Relationship to vesperlysine A and the advanced Maillard reaction in aging, diabetes, and cataractogenesis. J. Biol. Chem. 1999, 274, 20796–20804.
6. Baidoshvili, A., Krijnen, P. A., Kupreishvili, K., Ciurana, C. et al., N(epsilon)-(carboxymethyl)lysine depositions in intramyocardial blood vessels in human and rat acute myocardial infarction: a predictor or reflection of infarction? Arterioscler. Thromb. Vasc. Biol. 2006, 26, 2497–2503.
7. Thorpe, S. R., Baynes, J. W. CML, A brief history. International Congress Series 2002, 1245, 91–99.
8. Kislinger, T., Fu, C., Huber, B., Qu, W. et al. N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression. J. Biol. Chem. 1999, 274, 31740–31749.
9. Buetler, T. M., Leclerc, E., Baumeyer, A., Latado, H. et al., N(epsilon)-carboxymethyllysine-modified proteins are unable to bind to RAGE and activate an inflammatory response. Mol. Nutr. Food Res. 2008, 52, 370–378.
10. Boulanger, E, Wautier, M. P., Wautier, J. L., Boval, B. et al., AGEs bind to mesothelial cells via RAGE and stimulate VCAM-1 expression. Kidney Int 2002, 61, 148–156.
11. Boulanger, E., Grossin, N., Wautier, M. P., Taamma, R. et al. Mesothelial RAGE activation by AGEs enhances VEGF release and potentiates capillary tubes formation. Kidney Int. 2007, 71, 126–133.
12. Niquet-Léridon, C., Tessier, F. J., Quantification of N(ε)-carboxymethyl-lysine in selected chocolate-flavored drink mixes using high-performance liquid chromatography-linear ion trap tandem mass spectrometry. Food Chem. 2011, 126, 655–663.
13. Loaëc, G., Jacolot, P., Helou, C., Niquet-Léridon, C. et al. Acrylamide, 5-hydroxymethylfurfural and N(ε)-carboxymethyl-lysine in coffee substitutes and instant coffees. Food Addit. Contam. Part A 2014, 31, 593–604.
14. Hull, G. L. J., Woodside, J. V., Ames, J. M., Cuskelly, G. J., N-epsilon-(carboxymethyl)lysine content of foods commonly consumed in a western style diet. Food Chem. 2012, 131, 170–174.
15. Scheijen, J. L., Clevers, E., Engelen, L., Dagnelie, P. C. et al. Analysis of advanced glycation endproducts in selected food items by ultra-performance liquid chromatography tandem mass spectrometry: presentation of a dietary AGE database. Food Chem. 2016, 190, 1145–1150.
16. Hellwig, M., Matthes, R., Peto, A., Löbner, J. et al. N-ε-fructosyllysine and N-ε-carboxymethyllysine, but not lysinoalanine, are available for absorption after simulated gastrointestinal digestion. Amino. Acids 2014, 46, 289–299.
17. Somoza, V., Wenzel, E., Weiss, C., Clawin-Rädecker, I. et al., Dose-dependent utilisation of casein-linked lysinoalanine, N(epsilon)-fructoselysine and N(epsilon)-carboxymethyllysine in rats. Mol. Nutr. Food Res. 2006, 50, 833–841.
18. Alamir, I., Niquet-Léridon, C., Jacolot, P., Rodriguez, C. et al., Digestibility of extruded proteins and metabolic transit of Nε-carboxymethyllysine in rats. Amino. Acids. 2013, 44, 1441–1449.
19. Roncero-Ramos, I., Delgado-Andrade, C., Tessier, F. J., Niquet-Léridon, C. et al., Metabolic transit of N(ε)-carboxymethyl-lysine after consumption of AGEs from bread crust. Food Funct. 2013, 4, 1032–1039.
20. Grossin, N., Auger, F., Niquet-Leridon, C., Durieux, N. et al., Dietary CML-enriched protein induces functional arterial aging in a RAGE-dependent manner in mice. Mol. Nutr. Food Res. 2015, 59, 927–938.
21. Li, M., Zeng, M., He, Z., Zheng, Z. et al. Increased accumulation of protein-bound N(ε)-(carboxymethyl)lysine in tissues of healthy rats after chronic oral N(ε)-(carboxymethyl)lysine. J. Agric. Food Chem. 2015, 63, 1658–1663.
22. He, C., Sabol, J., Mitsuhashi, T., Vlassara, H., Dietary glycotoxins: inhibition of reactive products by aminoguanidine facilitates renal clearance and reduces tissue sequestration. Diabetes. 1999, 48, 1308–1315.
23. Bergmann, R., Helling, R., Heichert, C., Scheunemann, M. et al., Radio fluorination and positron emission tomography (PET) as a new approach to study the in vivo distribution and elimination of the advanced glycation endproducts N epsilon-carboxymethyllysine (CML) and N epsilon-carboxyethyllysine (CEL). Nahrung 2001, 45, 182–188.
24. Xu, H., Wang, Z., Wang, Y., Hu, S. et al., Biodistribution and elimination study of fluorine-18 labeled Nε-carboxymethyl-lysine following intragastric and intravenous administration. PLoS One 2013, 8, e57897.
25. Scholz, G., Baumeyer, A., Buetler, T., Foerster, A. et al., Metabolic fate (ADME) study of 14C-labeled specific AGE-modified β-lactoglobulin preparations in healthy Sprague Dawley rats. Poster presented at the 11th ISMR, held September 16-20, 2012, Nancy, France
26. Koschinsky, T., He, C. J., Mitsuhashi, T., Bucala, R. et al. Orally absorbed reactive glycation products (glycotoxins): an environmental risk factor in diabetic nephropathy. Proc. Natl. Acad. Sci. USA 1997, 94, 6474–6479.
27. Gaens, K. H., Goossens, G. H., Niessen, P. M., van Greevenbroek, M. M. et al. Nε-(carboxymethyl)lysine-receptor for advanced glycation end product axis is a key modulator of obesity-induced dysregulation of adipokine expression and insulin resistance. Arterioscler. Thromb. Vasc. Biol. 2014, 34, 1199–1208.
28. Schleicher, E. D., Wagner, E., Nerlich, A. G., Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. J. Clin. Invest. 1997, 99, 457–468.
29. Ling, X., Nagai, R., Sakashita, N., Takeya, M. et al., Immunohistochemical distribution and quantitative biochemical detection of advanced glycation end products in fetal to adult rats and in rats with streptozotocin-induced diabetes. Lab. Invest. 2001, 81, 845–861.
30. Karachalias, N., Babaei-Jadidi, R., Rabbani, N., Thornalley, P.J. Increased protein damage in renal glomeruli, retina, nerve, plasma and urine and its prevention by thiamine and benfotiamine therapy in a rat model of diabetes. Diabetologia. 2010, 53, 1506–1516.
31. Hellwig, M., Geissler, S., Matthes, R., Peto, A. et al., Transport of free and peptide-bound glycated amino acids: synthesis, transepithelial flux at Caco-2 cell monolayers, and interaction with apical membrane transport proteins. ChemBioChem. 2011, 12, 1270–1279.
32. Verzijl, N., DeGroot, J., Oldehinkel, E., Bank R. A. et al., Age-related accumulation of Maillard reaction products in human articular cartilage collagen. Biochem. J. 2000, 350, 381–387.
33. Schalkwijk, C. G., Baidoshvili, A., Stehouwer, C. D., van Hinsbergh, V. W. et al., Increased accumulation of the glycoxidation product Nepsilon-(carboxymethyl)lysine in hearts of diabetic patients: generation and characterisation of a monoclonal anti-CML antibody. Biochim. Biophys. Acta 2004, 1636, 82–89.
34. Gironès, X., Guimerà, A., Cruz-Sánchez, C. Z., Ortega, A. et al., N epsilon-carboxymethyllysine in brain aging, diabetes mellitus, and Alzheimer's disease. Free Radic. Biol. Med. 2004, 36, 1241–1247.
35. Southern, L., Williams, J., Esir, M. M., Immunohistochemical study of N-epsilon-carboxymethyl lysine (CML) in human brain: relation to vascular dementia. BMC Neurol. 2007, 7, 35.