-
1
-
-
33845866857
-
Inflammation and metabolic disorders
-
DOI 10.1038/nature05485, PII NATURE05485
-
Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444:860-867. (Pubitemid 46024993)
-
(2006)
Nature
, vol.444
, Issue.7121
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
2
-
-
33747356154
-
Adipose tissue: From lipid storage compartment to endocrine organ
-
DOI 10.2337/db06-0263
-
Scherer PE. Adipose tissue: from lipid storage compartment to endocrine organ. Diabetes. 2006;55:1537-1545. (Pubitemid 44324105)
-
(2006)
Diabetes
, vol.55
, Issue.6
, pp. 1537-1545
-
-
Scherer, P.E.1
-
3
-
-
0027459878
-
Adipose expression of tumor necrosis factor-α: Direct role in obesity-linked insulin resistance
-
Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993;259:87-91. (Pubitemid 23036092)
-
(1993)
Science
, vol.259
, Issue.5091
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
4
-
-
0345861775
-
Adiponectin and Metabolic Syndrome
-
DOI 10.1161/01.ATV.0000099786.99623.EF
-
Matsuzawa Y, Funahashi T, Kihara S, Shimomura I. Adiponectin and metabolic syndrome. Arterioscler Thromb Vasc Biol. 2004;24:29-33. (Pubitemid 38082408)
-
(2004)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.24
, Issue.1
, pp. 29-33
-
-
Matsuzawa, Y.1
Funahashi, T.2
Kihara, S.3
Shimomura, I.4
-
5
-
-
15844381594
-
Enhanced expression of PAI-1 in visceral fat: Possible contributor to vascular disease in obesity
-
DOI 10.1038/nm0796-800
-
Shimomura I, Funahashi T, Takahashi M, Maeda K, Kotani K, Nakamura T, Yamashita S, Miura M, Fukuda Y, Takemura K, Tokunaga K, Matsuzawa Y. Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nat Med. 1996;2:800-803. (Pubitemid 26225097)
-
(1996)
Nature Medicine
, vol.2
, Issue.7
, pp. 800-803
-
-
Shimomura, I.1
Funahashi, T.2
Takahashi, M.3
Maeda, K.4
Kotani, K.5
Nakamura, T.6
Yamashita, S.7
Miura, M.8
Fukuda, Y.9
Takemura, K.10
Tokunaga, K.11
Matsuzawa, Y.12
-
6
-
-
0347985272
-
Obesity-induced inflammatory changes in adipose tissue
-
DOI 10.1172/JCI200320514
-
Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest. 2003;112:1785-1788. (Pubitemid 38063699)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.12
, pp. 1785-1788
-
-
Wellen, K.E.1
Hotamisligil, G.S.2
-
7
-
-
18244370762
-
Inflammation, stress, and diabetes
-
DOI 10.1172/JCI200525102
-
Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest. 2005;115:1111-1119. (Pubitemid 40629025)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.5
, pp. 1111-1119
-
-
Wellen, K.E.1
Hotamisligil, G.S.2
-
8
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
-
DOI 10.1172/JCI200319451
-
Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest. 2003;112:1821-1830. (Pubitemid 38063705)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.12
, pp. 1821-1830
-
-
Xu, H.1
Barnes, G.T.2
Yang, Q.3
Tan, G.4
Yang, D.5
Chou, C.J.6
Sole, J.7
Nichols, A.8
Ross, J.S.9
Tartaglia, L.A.10
Chen, H.11
-
9
-
-
70349859675
-
Multiple levels of regulation determine the role of the receptor for AGE (RAGE) as common soil in inflammation, immune responses and diabetes mellitus and its complications
-
Bierhaus A, Nawroth PP. Multiple levels of regulation determine the role of the receptor for AGE (RAGE) as common soil in inflammation, immune responses and diabetes mellitus and its complications. Diabetologia. 2009;52:2251-2263.
-
(2009)
Diabetologia.
, vol.52
, pp. 2251-2263
-
-
Bierhaus, A.1
Nawroth, P.P.2
-
10
-
-
0033615356
-
N(epsilon)-(carboxymethyl) lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression
-
Kislinger T, Fu C, Huber B, Qu W, Taguchi A, Du Yan S, Hofmann M, Yan SF, Pischetsrieder M, Stern D, Schmidt AM. N(epsilon)-(carboxymethyl) lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression. J Biol Chem. 1999;274:31740-31749.
-
(1999)
J Biol Chem.
, vol.274
, pp. 31740-31749
-
-
Kislinger, T.1
Fu, C.2
Huber, B.3
Qu, W.4
Taguchi, A.5
Du Yan, S.6
Hofmann, M.7
Yan, S.F.8
Pischetsrieder, M.9
Stern, D.10
Schmidt, A.M.11
-
11
-
-
84865647121
-
The diverse ligand repertoire of the receptor for advanced glycation endproducts and pathways to the complications of diabetes
-
Ramasamy R, Yan SF, Schmidt AM. The diverse ligand repertoire of the receptor for advanced glycation endproducts and pathways to the complications of diabetes. Vascul Pharmacol. 2012;57:160-167.
-
(2012)
Vascul Pharmacol.
, vol.57
, pp. 160-167
-
-
Ramasamy, R.1
Yan, S.F.2
Schmidt, A.M.3
-
12
-
-
0035656173
-
Diabetes-associated sustained activation of the transcription factor nuclear factor-κB
-
Bierhaus A, Schiekofer S, Schwaninger M, et al. Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB. Diabetes. 2001;50:2792-2808. (Pubitemid 33733131)
-
(2001)
Diabetes
, vol.50
, Issue.12
, pp. 2792-2808
-
-
Bierhaus, A.1
Schiekofer, S.2
Schwaninger, M.3
Andrassy, M.4
Humpert, P.M.5
Chen, J.6
Hong, M.7
Luther, T.8
Henle, T.9
Kloting, I.10
Morcos, M.11
Hofmann, M.12
Tritschler, H.13
Weigle, B.14
Kasper, M.15
Smith, M.16
Perry, G.17
Schmidt, A.-M.18
Stern, D.M.19
Haring, H.-U.20
Schleicher, E.21
Nawroth, P.P.22
more..
-
13
-
-
1842455402
-
N epsilon-(carboxymethyl)lysine (CML) as a biomarker of oxidative stress in long-lived tissue proteins
-
Shaw JN, Baynes JW, Thorpe SR. N epsilon-(carboxymethyl)lysine (CML) as a biomarker of oxidative stress in long-lived tissue proteins. Methods Mol Biol. 2002;186:129-137.
-
(2002)
Methods Mol Biol.
, vol.186
, pp. 129-137
-
-
Shaw, J.N.1
Baynes, J.W.2
Thorpe, S.R.3
-
14
-
-
0029923574
-
The advanced glycation end product, Nepsilon-(carboxymethyl)lysine, is a product of both lipid peroxidation and glycoxidation reactions
-
Fu MX, Requena JR, Jenkins AJ, Lyons TJ, Baynes JW, Thorpe SR. The advanced glycation end product, Nepsilon-(carboxymethyl)lysine, is a product of both lipid peroxidation and glycoxidation reactions. J Biol Chem. 1996;271:9982-9986.
-
(1996)
J Biol Chem.
, vol.271
, pp. 9982-9986
-
-
Fu, M.X.1
Requena, J.R.2
Jenkins, A.J.3
Lyons, T.J.4
Baynes, J.W.5
Thorpe, S.R.6
-
15
-
-
0032538529
-
Generation of protein carbonyls by glycoxidation and lipoxidation reactions with autoxidation products of ascorbic acid and polyunsaturated fatty acids
-
DOI 10.1016/S0014-5793(98)01079-5, PII S0014579398010795
-
Miyata T, Inagi R, Asahi K, Yamada Y, Horie K, Sakai H, Uchida K, Kurokawa K. Generation of protein carbonyls by glycoxidation and lipoxidation reactions with autoxidation products of ascorbic acid and polyunsaturated fatty acids. FEBS Lett. 1998;437:24-28. (Pubitemid 28498234)
-
(1998)
FEBS Letters
, vol.437
, Issue.1-2
, pp. 24-28
-
-
Miyata, T.1
Inagi, R.2
Asahi, K.3
Yamada, Y.4
Horie, K.5
Sakai, H.6
Uchida, K.7
Kurokawa, K.8
-
16
-
-
2942692013
-
ε- (carboxymethyl)lysine in hearts of diabetic patients: Generation and characterisation of a monoclonal anti-CML antibody
-
DOI 10.1016/j.bbalip.2003.07.002, PII S1388198104000058
-
Schalkwijk CG, Baidoshvili A, Stehouwer CDA, van Hinsbergh VWM, Niessen HWM. Increased accumulation of the glycoxidation product n-epsilon- (carboxymethyl)lysine in hearts of diabetic patients: Generation and characterisation of a monoclonal anti-cml antibody. Bba-Mol Cell Biol L. 2004;1636:82-89 (Pubitemid 38780784)
-
(2004)
Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
, vol.1636
, Issue.2-3
, pp. 82-89
-
-
Schalkwijk, C.G.1
Baidoshvili, A.2
Stehouwer, C.D.A.3
Van Hinsbergh, V.W.M.4
Niessen, H.W.M.5
-
18
-
-
84872864013
-
Advanced glycation endproducts and its receptor for advanced glycation endproducts in obesity
-
Gaens KH, Stehouwer CD, Schalkwijk CG. Advanced glycation endproducts and its receptor for advanced glycation endproducts in obesity. Curr Opin Lipidol. 2013;24:4-11.
-
(2013)
Curr Opin Lipidol.
, vol.24
, pp. 4-11
-
-
Gaens, K.H.1
Stehouwer, C.D.2
Schalkwijk, C.G.3
-
19
-
-
84857360407
-
Endogenous formation of Nε-(carboxymethyl)lysine is increased in fatty livers and induces inflammatory markers in an in vitro model of hepatic steatosis
-
Gaens KH, Niessen PM, Rensen SS, Buurman WA, Greve JW, Driessen A, Wolfs MG, Hofker MH, Bloemen JG, Dejong CH, Stehouwer CD, Schalkwijk CG. Endogenous formation of Nε-(carboxymethyl)lysine is increased in fatty livers and induces inflammatory markers in an In vitro model of hepatic steatosis. J Hepatol. 2012;56:647-655.
-
(2012)
J Hepatol.
, vol.56
, pp. 647-655
-
-
Gaens, K.H.1
Niessen, P.M.2
Rensen, S.S.3
Buurman, W.A.4
Greve, J.W.5
Driessen, A.6
Wolfs, M.G.7
Hofker, M.H.8
Bloemen, J.G.9
Dejong, C.H.10
Stehouwer, C.D.11
Schalkwijk, C.G.12
-
20
-
-
58149265310
-
Weight increase is associated with skeletal muscle immunostaining for advanced glycation end products, receptor for advanced glycation end products, and oxidation injury
-
de la Maza MP, Uribarri J, Olivares D, Hirsch S, Leiva L, Barrera G, Bunout D. Weight increase is associated with skeletal muscle immunostaining for advanced glycation end products, receptor for advanced glycation end products, and oxidation injury. Rejuvenation Res. 2008;11:1041-1048
-
(2008)
Rejuvenation Res.
, vol.11
, pp. 1041-1048
-
-
De La Maza, M.P.1
Uribarri, J.2
Olivares, D.3
Hirsch, S.4
Leiva, L.5
Barrera, G.6
Bunout, D.7
-
21
-
-
34249801223
-
ε-(carboxymethyl)lysine from Amadori products
-
DOI 10.1080/10715760701332425, PII 778898455
-
Mera K, Nagai R, Haraguchi N, Fujiwara Y, Araki T, Sakata N, Otagiri M. Hypochlorous acid generates N epsilon-(carboxymethyl)lysine from Amadori products. Free Radic Res. 2007;41:713-718. (Pubitemid 46845592)
-
(2007)
Free Radical Research
, vol.41
, Issue.6
, pp. 713-718
-
-
Mera, K.1
Nagai, R.2
Haraguchi, N.3
Fujiwara, Y.4
Araki, T.5
Sakata, N.6
Otagiri, M.7
-
22
-
-
7444262475
-
Advanced glycation end products-modified proteins and oxidized LDL mediate down-regulation of leptin in mouse adipocytes via CD36
-
DOI 10.1016/j.bbrc.2004.10.015, PII S0006291X04023095
-
Unno Y, Sakai M, Sakamoto Y, Kuniyasu A, Nakayama H, Nagai R, Horiuchi S. Advanced glycation end products-modified proteins and oxidized LDL mediate down-regulation of leptin in mouse adipocytes via CD36. Biochem Biophys Res Commun. 2004;325:151-156. (Pubitemid 39441173)
-
(2004)
Biochemical and Biophysical Research Communications
, vol.325
, Issue.1
, pp. 151-156
-
-
Unno, Y.1
Sakai, M.2
Sakamoto, Y.-I.3
Kuniyasu, A.4
Nakayama, H.5
Nagai, R.6
Horiuchi, S.7
-
23
-
-
1042289790
-
Cellular Carbonyl Stress Enhances the Expression of Plasminogen Activator Inhibitor-1 in Rat White Adipocytes via Reactive Oxygen Species-dependent Pathway
-
DOI 10.1074/jbc.M304222200
-
Uchida Y, Ohba K, Yoshioka T, Irie K, Muraki T, Maru Y. Cellular carbonyl stress enhances the expression of plasminogen activator inhibitor-1 in rat white adipocytes via reactive oxygen species-dependent pathway. J Biol Chem. 2004;279:4075-4083. (Pubitemid 38198991)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.6
, pp. 4075-4083
-
-
Uchida, Y.1
Ohba, K.-I.2
Yoshioka, T.3
Irie, K.4
Muraki, T.5
Maru, Y.6
-
24
-
-
79959797020
-
Targeted reduction of advanced glycation improves renal function in obesity
-
Harcourt BE, Sourris KC, Coughlan MT, et al. Targeted reduction of advanced glycation improves renal function in obesity. Kidney Int. 2011;80:190-198.
-
(2011)
Kidney Int.
, vol.80
, pp. 190-198
-
-
Harcourt, B.E.1
Sourris, K.C.2
Coughlan, M.T.3
-
25
-
-
77953525199
-
Receptor for advanced glycation end-products (RAGE) regulation of adiposity and adiponectin is associated with atherogenesis in apoE-deficient mouse
-
Ueno H, Koyama H, Shoji T, Monden M, Fukumoto S, Tanaka S, Otsuka Y, Mima Y, Morioka T, Mori K, Shioi A, Yamamoto H, Inaba M, Nishizawa Y. Receptor for advanced glycation end-products (RAGE) regulation of adiposity and adiponectin is associated with atherogenesis in apoE-deficient mouse. Atherosclerosis. 2010;211:431-436.
-
(2010)
Atherosclerosis
, vol.211
, pp. 431-436
-
-
Ueno, H.1
Koyama, H.2
Shoji, T.3
Monden, M.4
Fukumoto, S.5
Tanaka, S.6
Otsuka, Y.7
Mima, Y.8
Morioka, T.9
Mori, K.10
Shioi, A.11
Yamamoto, H.12
Inaba, M.13
Nishizawa, Y.14
-
26
-
-
52649114296
-
Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs
-
Tikellis C, Thomas MC, Harcourt BE, Coughlan MT, Pete J, Bialkowski K, Tan A, Bierhaus A, Cooper ME, Forbes JM. Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs. Am J Physiol Endocrinol Metab. 2008;295:E323-E330.
-
(2008)
Am J Physiol Endocrinol Metab.
, vol.295
-
-
Tikellis, C.1
Thomas, M.C.2
Harcourt, B.E.3
Coughlan, M.T.4
Pete, J.5
Bialkowski, K.6
Tan, A.7
Bierhaus, A.8
Cooper, M.E.9
Forbes, J.M.10
-
27
-
-
84857554882
-
RAGE influences obesity in mice. Effects of the presence of RAGE on weight gain, AGE accumulation, and insulin levels in mice on a high fat diet
-
Leuner B, Max M, Thamm K, Kausler C, Yakobus Y, Bierhaus A, Sel S, Hofmann B, Silber RE, Simm A, Nass N. RAGE influences obesity in mice. Effects of the presence of RAGE on weight gain, AGE accumulation, and insulin levels in mice on a high fat diet. Z Gerontol Geriatr. 2012;45:102-108.
-
(2012)
Z Gerontol Geriatr.
, vol.45
, pp. 102-108
-
-
Leuner, B.1
Max, M.2
Thamm, K.3
Kausler, C.4
Yakobus, Y.5
Bierhaus, A.6
Sel, S.7
Hofmann, B.8
Silber, R.E.9
Simm, A.10
Nass, N.11
-
28
-
-
84871735738
-
Receptor for advanced glycation end products regulates adipocyte hypertrophy and insulin sensitivity in mice: Involvement of Toll-like receptor 2
-
Monden M, Koyama H, Otsuka Y, et al. Receptor for advanced glycation end products regulates adipocyte hypertrophy and insulin sensitivity in mice: involvement of Toll-like receptor 2. Diabetes. 2013;62:478-489.
-
(2013)
Diabetes
, vol.62
, pp. 478-489
-
-
Monden, M.1
Koyama, H.2
Otsuka, Y.3
-
29
-
-
33947115243
-
Advanced glycation end products attenuate cellular insulin sensitivity by increasing the generation of intracellular reactive oxygen species in adipocytes
-
DOI 10.1016/j.diabres.2006.09.016, PII S0168822706004207
-
Unoki H, Bujo H, Yamagishi S, Takeuchi M, Imaizumi T, Saito Y. Advanced glycation end products attenuate cellular insulin sensitivity by increasing the generation of intracellular reactive oxygen species in adipocytes. Diabetes Res Clin Pract. 2007;76:236-244. (Pubitemid 46400134)
-
(2007)
Diabetes Research and Clinical Practice
, vol.76
, Issue.2
, pp. 236-244
-
-
Unoki, H.1
Bujo, H.2
Yamagishi, S.-i.3
Takeuchi, M.4
Imaizumi, T.5
Saito, Y.6
-
30
-
-
79960607593
-
AGE-induced interference of glucose uptake and transport as a possible cause of insulin resistance in adipocytes
-
Wu CH, Huang HW, Huang SM, Lin JA, Yeh CT, Yen GC. AGE-induced interference of glucose uptake and transport as a possible cause of insulin resistance in adipocytes. J Agric Food Chem. 2011;59:7978-7984.
-
(2011)
J Agric Food Chem.
, vol.59
, pp. 7978-7984
-
-
Wu, C.H.1
Huang, H.W.2
Huang, S.M.3
Lin, J.A.4
Yeh, C.T.5
Yen, G.C.6
-
31
-
-
67649135049
-
Plasma advanced glycation end products are decreased in obese children compared with lean controls
-
Sebeková K, Somoza V, Jarcusková M, Heidland A, Podracká L. Plasma advanced glycation end products are decreased in obese children compared with lean controls. Int J Pediatr Obes. 2009;4:112-118.
-
(2009)
Int J Pediatr Obes.
, vol.4
, pp. 112-118
-
-
Sebeková, K.1
Somoza, V.2
Jarcusková, M.3
Heidland, A.4
Podracká, L.5
-
32
-
-
84888418602
-
Total plasma nepsilon-(carboxymethyl) lysine and srage levels are inversely associated with a number of metabolic syndrome risk factors in non-diabetic young-to-middle-aged medication-free subjects
-
Sebekova K, Krivosikova Z, Gajdos M. Total plasma nepsilon- (carboxymethyl) lysine and srage levels are inversely associated with a number of metabolic syndrome risk factors in non-diabetic young-to-middle-aged medication-free subjects. Clin Chem Lab Med. 2013:1-11
-
(2013)
Clin Chem Lab Med.
, pp. 1-11
-
-
Sebekova, K.1
Krivosikova, Z.2
Gajdos, M.3
-
33
-
-
80052599568
-
Fat mass is inversely associated with serum carboxymethyl-lysine, an advanced glycation end product, in adults
-
Semba RD, Arab L, Sun K, Nicklett EJ, Ferrucci L. Fat mass is inversely associated with serum carboxymethyl-lysine, an advanced glycation end product, in adults. J Nutr. 2011;141:1726-1730.
-
(2011)
J Nutr.
, vol.141
, pp. 1726-1730
-
-
Semba, R.D.1
Arab, L.2
Sun, K.3
Nicklett, E.J.4
Ferrucci, L.5
|