Andrographolide ameliorates diabetic nephropathy by attenuating hyperglycemia-mediated renal oxidative stress and inflammation via Akt/NF-κB pathway

Molecular and Cellular Endocrinology

Volumn 437, Issue , 2016, Pages 268-279

  Ji, Xiaoqian ^a   Li, Changzheng ^a   Ou, Yitao ^a   Li, Ning ^a   Yuan, Kai ^c   Yang, Guizhi ^a   Chen, Xiaoyan ^c   Yang, Zhicheng ^a   Liu, Bing ^a   Cheung, Wai W ^d   Wang, Lijing ^a   Huang, Ren ^b   Lan, Tian ^a  

^a GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

^b Guangdong Laboratory Animals Monitoring Institute   (China)

^c GUANGZHOU MEDICAL UNIVERSITY   (China)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Akt; Andrographolide; Diabetic nephropathy; Inflammation; NF B; Oxidative stress

Indexed keywords

ANDROGRAPHOLIDE; CREATININE; CYTOKINE; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; TRIACYLGLYCEROL; DITERPENE; DNA; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; STREPTOZOCIN;

ALBUMINURIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DRUG MECHANISM; EXTRACELLULAR MATRIX; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN TISSUE; HYPERGLYCEMIA; INFLAMMATION; KIDNEY HYPERTROPHY; KIDNEY MASS; MALE; MESANGIUM CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RENAL PROTECTION; UREA NITROGEN BLOOD LEVEL; ANIMAL; C57BL MOUSE; CELL NUCLEUS; CELL PROLIFERATION; COMPLICATION; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DRUG EFFECTS; GLOMERULUS; HYPERTROPHY; KIDNEY; LIPID DIET; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; CELL NUCLEUS; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DIET, HIGH-FAT; DITERPENES; DNA; EXTRACELLULAR MATRIX; GLUCOSE; HUMANS; HYPERGLYCEMIA; HYPERTROPHY; INFLAMMATION; KIDNEY; KIDNEY GLOMERULUS; MALE; MESANGIAL CELLS; MICE, INBRED C57BL; NADP; NF-KAPPA B; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-AKT; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STREPTOZOCIN;

EID: 84985914842     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2016.06.029     Document Type: Article

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