Monocyte chemoattractant protein-1 has prosclerotic effects both in a mouse model of experimental diabetes and in vitro in human mesangial cells

Diabetologia

Volumn 51, Issue 1, 2008, Pages 198-207

  Giunti, S ^a,c   Tesch, G H ^b   Pinach, S ^a   Burt, D J ^a   Cooper, M E ^c   Cavallo Perin, P ^a   Camussi, G ^a   Gruden, G ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b MONASH MEDICAL CENTRE   (Australia)

^c BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

Author keywords

CCR2; Chemokine (C C motif) receptor 2; Diabetic nephropathy; Experimental diabetes; Fibronectin; Glomerulosclerosis; Glomerulus; MCP 1; Mesangial cells; Monocyte chemoattractant protein 1

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR; COLLAGEN TYPE 4; FIBRONECTIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN KINASE C; RECOMBINANT PROTEIN; STREPTOZOCIN; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL DIABETES MELLITUS; GLOMERULUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CORTEX; MESANGIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCLEROSIS; WESTERN BLOTTING;

ANIMALS; CHEMOKINE CCL2; COLLAGEN TYPE IV; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBRONECTINS; HUMANS; MESANGIAL CELLS; MICE; MODELS, BIOLOGICAL; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 36648999997     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0837-3     Document Type: Article

References (50)

1. Mauer SM, Steffes MW, Ellis EN, Sutherland DE, Brown DM, Goetz FC (1984) Structural-functional relationships in diabetic nephropathy. J Clin Invest 74:1143-1155
2. Cooper ME (2001) Interaction of metabolic and haemodynamic factors in mediating experimental diabetic nephropathy. Diabetologia 44:1957-1972
3. Furuta T, Saito T, Ootaka T et al (1993) The role of macrophages in diabetic glomerulosclerosis. Am J Kidney Dis 21:480-485
4. Gruden G, Setti G, Hayward A et al (2005) Mechanical stretch induces monocyte chemoattractant activity via an NF-κB-dependent monocyte chemoattractant protein-1-mediated pathway in human mesangial cells: inhibition by rosiglitazone. J Am Soc Nephrol 16:688-696
5. Sassy-Prigent C, Heudes D, Mandet C (2000) Early glomerular macrophage recruitment in streptozotocin-induced diabetic rats. Diabetes 49:466-475
6. Kato S, Luyckx VA, Ots M et al (1999) Renin-angiotensin blockade lowers MCP-1 expression in diabetic rats. Kidney Int 56:1037-1048
7. Pawluczyk IZ, Harris KP (1998) Cytokine interactions promote synergistic fibronectin accumulation by mesangial cells. Kidney Int 54:62-70
8. Viedt C, Vogel J, Athanasiou T et al (2002) Monocyte chemoattractant protein-1 induces proliferation and interleukin-6 production in human smooth muscle cells by differential activation of nuclear factor-κB and activator protein-1. Arterioscler Thromb Vasc Biol 22:914-920
9. Weber KS, Nelson PJ, Grone HJ, Weber C (1999) Expression of CCR2 by endothelial cells: implications for MCP-1 mediated wound injury repair and in vivo inflammatory activation of endothelium. Arterioscler Thromb Vasc Biol 19:2085-2093
10. Lundien MC, Mohammed KA, Nasreen N et al (2002) Induction of MCP-1 expression in airway epithelial cells: role of CCR2 receptor in airway epithelial injury. J Clin Immunol 22:144-152
11. Andjelkovic AV, Song L, Dzenko KA, Cong H, Pachter JS (2002) Functional expression of CCR2 by human fetal astrocytes. J Neurosci Res 70:219-231
12. Coughlan CM, McManus CM, Sharron M et al (2000) Expression of multiple functional chemokine receptors and monocyte chemoattractant protein-1 in human neurons. Neuroscience 97:591-600
13. Banisadr G, Queraud-Lesaux F, Boutterin MC et al (2002) Distribution, cellular localization and functional role of CCR2 chemokine receptors in adult rat brain. J Neurochem 81:257-269
14. Warren GL, Hulderman T, Mishra D et al (2005) Chemokine receptor CCR2 involvement in skeletal muscle regeneration. FASEB J 19:413-415
15. Moore BB, Kolodsick JE, Thannickal VJ et al (2005) CCR2-mediated recruitment of fibrocytes to the alveolar space after fibrotic injury. Am J Pathol 166:675-684
16. Roque M, Kim WJ, Gazdoin M et al (2002) CCR2 deficiency decreases intimal hyperplasia after arterial injury. Arterioscler Thromb Vasc Biol 22:554-559
17. Giunti S, Pinach S, Arnaldi L et al (2006) The MCP-1/CCR2 system has direct proinflammatory effects in human mesangial cells. Kidney Int 69:856-863
18. Gruden G, Thomas S, Burt D et al (1997) Mechanical stretch induces vascular permeability factor in human mesangial cells: mechanisms of signal transduction. Proc Natl Acad Sci U S A 94:12112-12116
19. Conaldi PG, Biancone L, Bottelli A et al (1998) HIV-1 kills renal tubular epithelial cells in vitro by triggering an apoptotic pathway involving caspase activation and Fas upregulation. J Clin Invest 102:2041-2049
20. Gruden G, Zonca S, Hayward A et al (2000) ATII mechanical stretch-induced fibronectin and transforming growth factor-beta1 production in human mesangial cells is p38 mitogen-activated protein kinase-dependent. Diabetes 49:655-661
21. Choi MG, Hynes RO (1979) Biosynthesis and processing of fibronectin in NIL.8 hamster cells. J Biol Chem 254:12050-12055
22. Mirzadegan T, Diehl F, Ebi B et al (2000) Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J Biol Chem 275:25562-25571
23. Jiang Y, Chen C, Li Z et al (1996) Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). J Biol Chem 271:17920-17926
24. Lin YZ, Yao SY, Veach RA, Torgerson TR, Hawiger J (1995) Inhibition of nuclear translocation of transcription factor NF-kB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. J Biol Chem 270:14255-14258
25. House C, Kemp BE (1987) Protein kinase C contains a pseudosubstrate prototope in its regulatory domain. Science 238:1726-1728
26. Lu B, Rutledge BJ, Gu L et al (1998) Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. J Exp Med 187:601-608
27. Lassila M, Seah KK, Allen TJ et al (2004) Accelerated nephropathy in diabetic apolipoprotein e-knockout mouse: role of advanced glycation end products. J Am Soc Nephrol 15:2125-2138
28. Ziyadeh FN (2004) Mediators of diabetic renal disease: the case for TGF-Beta as the major mediator. J Am Soc Nephrol 15:S55-S57
29. Lan Y, Zhou Q, Wu ZL (2004) NF-κB involved in transcription enhancement of TGF-beta 1 induced by Ox-LDL in rat mesangial cells. Chin Med J (Engl) 117:225-230
30. Chow FY, Nikolic-Paterson DJ, Ozols E, Atkins RC, Rollins BJ, Tesch GH (2006) Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice. Kidney Int 69:73-80
31. Gharaee-Kermani M, Denholm EM, Phan SH (1996) Costimulation of fibroblast collagen and transforming growth factor beta1 gene expression by monocyte chemoattractant protein-1 via specific receptors. J Biol Chem 271:17779-17784
32. Chana RS, Martin J, Rahman EU, Wheeler DC (2003) Monocyte adhesion to mesangial matrix modulates cytokine and metalloproteinase production. Kidney Int 63:889-898
33. Grandaliano G, Valente AJ, Rozek MM, Abboud HE (1994) Gamma interferon stimulates monocyte chemotactic protein (MCP-1) in human mesangial cells. J Lab Clin Med 123:282-289
34. Tylaska LA, Boring L, Weng W et al (2002) Ccr2 regulates the level of MCP-1/CCL2 in vitro and at inflammatory sites and controls T cell activation in response to alloantigen. Cytokine 18:184-190
35. Spinetti G, Wang M, Monticone R, Zhang J, Zhao D, Lakatta EG (2004) Rat aortic MCP-1 and its receptor CCR2 increase with age and alter vascular smooth muscle cell function. Arterioscler Thromb Vasc Biol 24:1397-1402
36. Kreisberg JI, Garoni JA, Radnik R, Ayo SH (1994) High glucose and TGF beta 1 stimulate fibronectin gene expression through a cAMP response element. Kidney Int 46:1019-1024
37. Hirakata M, Kaname S, Chung UG et al (1997) Tyrosine kinase dependent expression of TGF-beta induced by stretch in mesangial cells. Kidney Int 51:1028-1036
38. Kagami S, Border WA, Miller DE, Noble NA (1994) Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells. J Clin Invest 93:2431-2437
39. Wolf G, Jocks T, Zahner G, Panzer U, Stahl RA (2002) Existence of a regulatory loop between MCP-1 and TGF-beta in glomerular immune injury. Am J Physiol Renal Physiol 283:F1075-F1084
40. Ikehara K, Tada H, Kuboki K, Inokuchi T (2003) Role of protein kinase C-angiotensin II pathway for extracellular matrix production in cultured human mesangial cells exposed to high glucose levels. Diabetes Res Clin Pract 59:25-30
41. Viedt C, Dechend R, Fei J, Hansch GM, Kreuzer J, Orth SR (2002) MCP-1 induces inflammatory activation of human tubular epithelial cells: involvement of the transcription factors, nuclear factor-kappaB and activating protein-1. J Am Soc Nephrol 13:1534-1547
42. Schwarz M, Wahl M, Resch K, Radeke HH (2002) IFNgamma induces functional chemokine receptor expression in human mesangial cells. Clin Exp Immunol 128:285-294
43. Arefieva TI, Kukhtina NB, Antonova OA, Krasnikova TL (2005) MCP-1-stimulated chemotaxis of monocytic and endothelial cells is dependent on activation of different signaling cascades. Cytokine 31:439-446
44. Stamatovic SM, Keep RF, Kunkel SL, Andjelkovic AV (2003) Potential role of MCP-1 in endothelial cell tight junction 'opening': signaling via Rho and Rho kinase. J Cell Sci 116:4615-4628
45. Mellado M, Rodriguez-Frade JM, Aragay A et al (1998) The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor. J Immunol 161:805-813
46. Xie P, Browning DD, Hay N, Mackman N, Ye RD (2000) Activation of NF-kappa B by bradykinin through a Galpha(q)- and Gbeta gamma-dependent pathway that involves phosphoinositide 3-kinase and Akt. J Biol Chem 275:24907-24914
47. Cammarano MS, Minden A (2001) Dbl and the Rho GTPases activate NF kappa B by I kappa B kinase (IKK)-dependent and IKK-independent pathways. J Biol Chem 276:25876-25882
48. Digicaylioglu M, Lipton SA (2001) Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kappaB signalling cascades. Nature 412:641-647
49. Janssen U, Sowa E, Marchand P, Floege J, Phillips AO, Radeke HH (2002) Differential expression of MCP-1 and its receptor CCR2 in glucose primed human mesangial cells. Nephron 92:797-806
50. Charo IF, Taubman MB (2004) Chemokines in the pathogenesis of vascular disease. Circ Res 95:858-866