-
3
-
-
84899639879
-
Cytokines in inflammatory bowel disease
-
Neurath MF. Cytokines in inflammatory bowel disease. Nat Rev Immunol 2014;14:329-42.
-
(2014)
Nat Rev Immunol
, vol.14
, pp. 329-342
-
-
Neurath, M.F.1
-
4
-
-
34248136340
-
Inflammatory bowel disease: Clinical aspects and established and evolving therapies
-
Baumgart DC, Sandborn WJ. Inflammatory bowel disease: Clinical aspects and established and evolving therapies. Lancet 2007;369:1641-57.
-
(2007)
Lancet
, vol.369
, pp. 1641-1657
-
-
Baumgart, D.C.1
Sandborn, W.J.2
-
6
-
-
84860557456
-
New therapies for inflammatory bowel disease: From the bench to the bedside
-
Danese S. New therapies for inflammatory bowel disease: From the bench to the bedside. Gut 2012;61:918-32.
-
(2012)
Gut
, vol.61
, pp. 918-932
-
-
Danese, S.1
-
8
-
-
0029418619
-
Structure elucidation of two tryptophan-derived, high affinity AH receptor ligands
-
Rannug U, Rannug A, Sjoberg U, et al. Structure elucidation of two tryptophan-derived, high affinity AH receptor ligands. Chem Biol 1995;2:841-5.
-
(1995)
Chem Biol
, vol.2
, pp. 841-845
-
-
Rannug, U.1
Rannug, A.2
Sjoberg, U.3
-
9
-
-
0038768712
-
Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals
-
Denison MS, Nagy SR. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol 2003;43:309-34.
-
(2003)
Annu Rev Pharmacol Toxicol
, vol.43
, pp. 309-334
-
-
Denison, M.S.1
Nagy, S.R.2
-
10
-
-
42649106556
-
The aryl hydrocarbon receptor links th17-cell-mediated autoimmunity to environmental toxins
-
Veldhoen M, Hirota K, Westendorf AM, et al. The aryl hydrocarbon receptor links th17-cell-mediated autoimmunity to environmental toxins. Nature 2008;453:106-9.
-
(2008)
Nature
, vol.453
, pp. 106-109
-
-
Veldhoen, M.1
Hirota, K.2
Westendorf, A.M.3
-
11
-
-
42649095378
-
Control of T[reg] and T[h]17 cell differentiation by the aryl hydrocarbon receptor
-
Quintana FJ, Basso AS, Iglesias AH, et al. Control of T[reg] and T[h]17 cell differentiation by the aryl hydrocarbon receptor. Nature 2008;453:65-71.
-
(2008)
Nature
, vol.453
, pp. 65-71
-
-
Quintana, F.J.1
Basso, A.S.2
Iglesias, A.H.3
-
12
-
-
77951242329
-
Activation of aryl hydrocarbon receptor suppresses experimental autoimmune uveoretinitis by inducing differentiation of regulatory T cells
-
Zhang L, Ma J, Takeuchi M, et al. Activation of aryl hydrocarbon receptor suppresses experimental autoimmune uveoretinitis by inducing differentiation of regulatory T cells. Invest Ophthalmol Vis Sci 2010;51:2109-17.
-
(2010)
Invest Ophthalmol Vis Sci
, vol.51
, pp. 2109-2117
-
-
Zhang, L.1
Ma, J.2
Takeuchi, M.3
-
13
-
-
77955859470
-
Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and foxp3[+] regulatory T cells
-
Gandhi R, Kumar D, Burns EJ, et al. Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and foxp3[+] regulatory T cells. Nat Immunol 2010;11:846-53.
-
(2010)
Nat Immunol
, vol.11
, pp. 846-853
-
-
Gandhi, R.1
Kumar, D.2
Burns, E.J.3
-
14
-
-
77955903212
-
The aryl hydrocarbon receptor interacts with c-maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
-
Apetoh L, Quintana FJ, Pot C, et al. The aryl hydrocarbon receptor interacts with c-maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat Immunol 2010;11:854-61.
-
(2010)
Nat Immunol
, vol.11
, pp. 854-861
-
-
Apetoh, L.1
Quintana, F.J.2
Pot, C.3
-
15
-
-
78650560167
-
Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynureninedependent mechanism
-
Nguyen NT, Kimura A, Nakahama T, et al. Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynureninedependent mechanism. Proc Natl Acad Sci U S A 2010;107:19961-6.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 19961-19966
-
-
Nguyen, N.T.1
Kimura, A.2
Nakahama, T.3
-
16
-
-
78650547540
-
An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis
-
Quintana FJ, Murugaiyan G, Farez MF, et al. An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 2010;107:20768-73.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 20768-20773
-
-
Quintana, F.J.1
Murugaiyan, G.2
Farez, M.F.3
-
17
-
-
79959918506
-
Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract
-
Monteleone I, Rizzo A, Sarra M, et al. Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract. Gastroenterology 2011;141:237-48 e1.
-
(2011)
Gastroenterology
, vol.141
-
-
Monteleone, I.1
Rizzo, A.2
Sarra, M.3
-
18
-
-
84867407800
-
3,3'-diindolylmethane alleviates oxazolone-induced colitis through th2/th17 suppression and Treg induction
-
Huang Z, Jiang Y, Yang Y, et al. 3,3'-diindolylmethane alleviates oxazolone-induced colitis through th2/th17 suppression and Treg induction. Mol Immunol 2012;53:335-44.
-
(2012)
Mol Immunol
, vol.53
, pp. 335-344
-
-
Huang, Z.1
Jiang, Y.2
Yang, Y.3
-
19
-
-
80051676534
-
Activation of aryl hydrocarbon receptor [AHR] leads to reciprocal epigenetic regulation of foxp3 and IL-17 expression and amelioration of experimental colitis
-
Singh NP, Singh UP, Singh B, et al. Activation of aryl hydrocarbon receptor [AHR] leads to reciprocal epigenetic regulation of foxp3 and IL-17 expression and amelioration of experimental colitis. PLoS One 2011;6:e23522.
-
(2011)
PLoS One
, vol.6
-
-
Singh, N.P.1
Singh, U.P.2
Singh, B.3
-
20
-
-
0034894059
-
Blocking smad7 restores TGF-beta1 signalling in chronic inflammatory bowel disease
-
Monteleone G, Kumberova A, Croft NM, et al. Blocking smad7 restores TGF-beta1 signalling in chronic inflammatory bowel disease. J Clin Invest 2001;108:601-9.
-
(2001)
J Clin Invest
, vol.108
, pp. 601-609
-
-
Monteleone, G.1
Kumberova, A.2
Croft, N.M.3
-
21
-
-
0030995575
-
Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells
-
Monteleone G, Biancone L, Marasco R, et al. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 1997;112:1169-78.
-
(1997)
Gastroenterology
, vol.112
, pp. 1169-1178
-
-
Monteleone, G.1
Biancone, L.2
Marasco, R.3
-
22
-
-
62949223226
-
Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression
-
Fantini MC, Rizzo A, Fina D, et al. Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression. Gastroenterology 2009;136:1308-16, e13.
-
(2009)
Gastroenterology
, vol.136
, pp. 1308-1316
-
-
Fantini, M.C.1
Rizzo, A.2
Fina, D.3
-
23
-
-
33845647693
-
Inhibition of smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis
-
Boirivant M, Pallone F, Di Giacinto C, et al. Inhibition of smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis. Gastroenterology 2006;131:1786-98.
-
(2006)
Gastroenterology
, vol.131
, pp. 1786-1798
-
-
Boirivant, M.1
Pallone, F.2
Di Giacinto, C.3
-
24
-
-
77950534839
-
Notch signalling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor
-
Alam MS, Maekawa Y, Kitamura A, et al. Notch signalling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor. Proc Natl Acad Sci U S A 2010;107:59438.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 59438
-
-
Alam, M.S.1
Maekawa, Y.2
Kitamura, A.3
-
25
-
-
38849141814
-
Il-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
-
Sugimoto K, Ogawa A, Mizoguchi E, et al. Il-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J Clin Invest 2008;118:534-44.
-
(2008)
J Clin Invest
, vol.118
, pp. 534-544
-
-
Sugimoto, K.1
Ogawa, A.2
Mizoguchi, E.3
-
26
-
-
57449090428
-
Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease
-
Zenewicz LA, Yancopoulos GD, Valenzuela DM, et al. Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease. Immunity 2008;29:947-57.
-
(2008)
Immunity
, vol.29
, pp. 947-957
-
-
Zenewicz, L.A.1
Yancopoulos, G.D.2
Valenzuela, D.M.3
-
28
-
-
0028861975
-
Antibodies to interleukin 12 abrogate established experimental colitis in mice
-
Neurath MF, Fuss I, Kelsall BL, Stuber E, Strober W. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 1995;182:1281-90.
-
(1995)
J Exp Med
, vol.182
, pp. 1281-1290
-
-
Neurath, M.F.1
Fuss, I.2
Kelsall, B.L.3
Stuber, E.4
Strober, W.5
-
29
-
-
0037029649
-
The transcription factor t-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease
-
Neurath MF, Weigmann B, Finotto S, et al. The transcription factor t-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J Exp Med 2002;195:1129-43.
-
(2002)
J Exp Med
, vol.195
, pp. 1129-1143
-
-
Neurath, M.F.1
Weigmann, B.2
Finotto, S.3
-
30
-
-
34250026960
-
Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice
-
Elson CO, Cong Y, Weaver CT, et al. Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology 2007;132:2359-70.
-
(2007)
Gastroenterology
, vol.132
, pp. 2359-2370
-
-
Elson, C.O.1
Cong, Y.2
Weaver, C.T.3
-
31
-
-
80054720170
-
A role of the aryl hydrocarbon receptor in attenuation of colitis
-
Furumatsu K, Nishiumi S, Kawano Y, et al. A role of the aryl hydrocarbon receptor in attenuation of colitis. Dig Dis Sci 2011;56:2532-44.
-
(2011)
Dig Dis Sci
, vol.56
, pp. 2532-2544
-
-
Furumatsu, K.1
Nishiumi, S.2
Kawano, Y.3
-
32
-
-
77955655540
-
Activation of the aryl hydrocarbon receptor pathway may ameliorate dextran sodium sulfate-induced colitis in mice
-
Takamura T, Harama D, Matsuoka S, et al. Activation of the aryl hydrocarbon receptor pathway may ameliorate dextran sodium sulfate-induced colitis in mice. Immunol Cell Biol 2010;88:685-9.
-
(2010)
Immunol Cell Biol
, vol.88
, pp. 685-689
-
-
Takamura, T.1
Harama, D.2
Matsuoka, S.3
-
33
-
-
84929955331
-
Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation
-
Gagliani N, Vesely MC, Iseppon A, et al. Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation. Nature 2015;523:221-5.
-
(2015)
Nature
, vol.523
, pp. 221-225
-
-
Gagliani, N.1
Vesely, M.C.2
Iseppon, A.3
-
34
-
-
78649880396
-
An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells
-
Mezrich JD, Fechner JH, Zhang X, et al. An interaction between kynurenine and the aryl hydrocarbon receptor can generate regulatory T cells. J Immunol 2010;185:3190-8.
-
(2010)
J Immunol
, vol.185
, pp. 3190-3198
-
-
Mezrich, J.D.1
Fechner, J.H.2
Zhang, X.3
-
35
-
-
84946475476
-
Preventative role of interleukin-17 producing regulatory T helper type 17 [Treg 17] cells in type 1 diabetes in non-obese diabetic mice
-
Bellemore SM, Nikoopour E, Schwartz JA, et al. Preventative role of interleukin-17 producing regulatory T helper type 17 [Treg 17] cells in type 1 diabetes in non-obese diabetic mice. Clin Exp Immunol 2015;182:2619.
-
(2015)
Clin Exp Immunol
, vol.182
, pp. 2619
-
-
Bellemore, S.M.1
Nikoopour, E.2
Schwartz, J.A.3
-
36
-
-
0142104985
-
Smad-dependent and smad-independent pathways in TGF-beta family signalling
-
Derynck R, Zhang YE. Smad-dependent and smad-independent pathways in TGF-beta family signalling. Nature 2003;425:577-84.
-
(2003)
Nature
, vol.425
, pp. 577-584
-
-
Derynck, R.1
Zhang, Y.E.2
-
37
-
-
0029956024
-
A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45rb[low] CD4+ T cells
-
Powrie F, Carlino J, Leach MW, Mauze S, Coffman RL. A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45rb[low] CD4+ T cells. J Exp Med 1996;183:2669-74.
-
(1996)
J Exp Med
, vol.183
, pp. 2669-2674
-
-
Powrie, F.1
Carlino, J.2
Leach, M.W.3
Mauze, S.4
Coffman, R.L.5
-
38
-
-
0034327176
-
Cutting edge: TGF-beta inhibits th type 2 development through inhibition of gata-3 expression
-
Gorelik L, Fields PE, Flavell RA. Cutting edge: TGF-beta inhibits th type 2 development through inhibition of gata-3 expression. J Immunol 2000;165:4773-7.
-
(2000)
J Immunol
, vol.165
, pp. 4773-4777
-
-
Gorelik, L.1
Fields, P.E.2
Flavell, R.A.3
-
40
-
-
0029995799
-
Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance
-
Neurath MF, Fuss I, Kelsall BL, et al. Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance. J Exp Med 1996;183:2605-16.
-
(1996)
J Exp Med
, vol.183
, pp. 2605-2616
-
-
Neurath, M.F.1
Fuss, I.2
Kelsall, B.L.3
-
41
-
-
84925064199
-
Mongersen, an oral smad7 antisense oligonucleotide, and Crohn's disease
-
Monteleone G, Neurath MF, Ardizzone S, et al. Mongersen, an oral smad7 antisense oligonucleotide, and Crohn's disease. N Engl J Med 2015;372:1104-13.
-
(2015)
N Engl J Med
, vol.372
, pp. 1104-1113
-
-
Monteleone, G.1
Neurath, M.F.2
Ardizzone, S.3
|