Context matters: The importance of dimerization-induced conformation of the LukGH leukocidin of Staphylococcus aureus for the generation of neutralizing antibodies

mAbs

Volumn 8, Issue 7, 2016, Pages 1347-1360

  Badarau, Adriana ^a   Rouha, Harald ^a   Malafa, Stefan ^a,d   Battles, Michael B ^b,e   Walker, Laura ^b   Nielson, Nels ^b   Dolezilkova, Ivana ^a   Teubenbacher, Astrid ^a   Banerjee, Srijib ^a   Maierhofer, Barbara ^a   Weber, Susanne ^a   Stulik, Lukas ^a   Logan, Derek T ^c   Welin, Martin ^c   Mirkina, Irina ^a   Pleban, Clara ^a   Zauner, Gerhild ^a   Gross, Karin ^a   Jägerhofer, Michaela ^a   Magyarics, Zoltán ^a   Nagy, Eszter ^a   more..

^a Vienna Biocenter   (Austria)

^b Adimab LLC   (United States)

^c SARomics Biostructures AB   (Sweden)

^d MEDICAL UNIVERSITY OF VIENNA   (Austria)

^e BOEHRINGER INGELHEIM RCV GMBH AND CO KG   (Austria)

Author keywords

Conformational epitope; LukGH; Staphylococcus aureus; toxin neutralization; X ray crystal structure

Indexed keywords

LEUKOCIDIN; NEUTRALIZING ANTIBODY; PENICILLIN DERIVATIVE; STREPTOMYCIN; BACTERIAL PROTEIN; LEUKOCIDIN AB, STAPHYLOCOCCUS AUREUS; MONOCLONAL ANTIBODY;

AFFINITY CHROMATOGRAPHY; ARTICLE; CELL VIABILITY ASSAY; CIRCULAR DICHROISM; CONFORMATION; CONTROLLED STUDY; CRYSTALLIZATION; DIMERIZATION; ELECTROSPRAY MASS SPECTROMETRY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IC50; IMMUNE SYSTEM; IMMUNOBLOTTING; KNOWLEDGE; NONHUMAN; SIGNAL TRANSDUCTION; SIZE EXCLUSION CHROMATOGRAPHY; STAPHYLOCOCCUS AUREUS; VIRUS NEUTRALIZATION; X RAY CRYSTALLOGRAPHY; ANIMAL; CHEMISTRY; IMMUNOLOGY;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; BACTERIAL PROTEINS; DIMERIZATION; HUMANS; LEUKOCIDINS;

EID: 84984871095     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.1080/19420862.2016.1215791     Document Type: Article

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