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Volumn 15, Issue 6, 2016, Pages 1113-1125

A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance

Author keywords

premature aging; RAP1; shelterins; telomerase; telomeres

Indexed keywords

RAP1 PROTEIN; TELOMERASE;

EID: 84984710609     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12517     Document Type: Article
Times cited : (36)

References (46)
  • 1
    • 84871261880 scopus 로고    scopus 로고
    • Human Rap1 interacts directly with telomeric DNA and regulates TRF2 localization at the telomere
    • Arat NO, Griffith JD (2012) Human Rap1 interacts directly with telomeric DNA and regulates TRF2 localization at the telomere. J. Biol. Chem. 287, 41583–41594.
    • (2012) J. Biol. Chem. , vol.287 , pp. 41583-41594
    • Arat, N.O.1    Griffith, J.D.2
  • 2
    • 0034632717 scopus 로고    scopus 로고
    • Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    • Artandi SE, Chang S, Lee SL, Alson S, Gottlieb GJ, Chin L, DePinho RA (2000) Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 406, 641–645.
    • (2000) Nature , vol.406 , pp. 641-645
    • Artandi, S.E.1    Chang, S.2    Lee, S.L.3    Alson, S.4    Gottlieb, G.J.5    Chin, L.6    DePinho, R.A.7
  • 3
    • 84958214784 scopus 로고    scopus 로고
    • Shelterin protects chromosome ends by compacting telomeric chromatin
    • Bandaria JN, Qin P, Berk V, Chu S, Yildiz A (2016) Shelterin protects chromosome ends by compacting telomeric chromatin. Cell 164, 735–746.
    • (2016) Cell , vol.164 , pp. 735-746
    • Bandaria, J.N.1    Qin, P.2    Berk, V.3    Chu, S.4    Yildiz, A.5
  • 5
    • 33846517601 scopus 로고    scopus 로고
    • Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis
    • Blanco R, Munoz P, Flores JM, Klatt P, Blasco MA (2007) Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis. Genes Dev. 21, 206–220.
    • (2007) Genes Dev. , vol.21 , pp. 206-220
    • Blanco, R.1    Munoz, P.2    Flores, J.M.3    Klatt, P.4    Blasco, M.A.5
  • 6
    • 22944488871 scopus 로고    scopus 로고
    • Telomeres and human disease: ageing, cancer and beyond
    • Blasco MA (2005) Telomeres and human disease: ageing, cancer and beyond. Nat. Rev. Genet. 6, 611–622.
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 611-622
    • Blasco, M.A.1
  • 8
    • 23844540299 scopus 로고    scopus 로고
    • Effects of telomerase and telomere length on epidermal stem cell behavior
    • Flores I, Cayuela ML, Blasco MA (2005) Effects of telomerase and telomere length on epidermal stem cell behavior. Science 309, 1253–1256.
    • (2005) Science , vol.309 , pp. 1253-1256
    • Flores, I.1    Cayuela, M.L.2    Blasco, M.A.3
  • 11
    • 0343228751 scopus 로고    scopus 로고
    • Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis
    • Gonzalez-Suarez E, Samper E, Flores JM, Blasco MA (2000) Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nat. Genet. 26, 114–117.
    • (2000) Nat. Genet. , vol.26 , pp. 114-117
    • Gonzalez-Suarez, E.1    Samper, E.2    Flores, J.M.3    Blasco, M.A.4
  • 13
    • 0022402513 scopus 로고
    • Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
    • Greider CW, Blackburn EH (1985) Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43, 405–413.
    • (1985) Cell , vol.43 , pp. 405-413
    • Greider, C.W.1    Blackburn, E.H.2
  • 14
    • 7244251599 scopus 로고    scopus 로고
    • Phosphorylation of H2AX at short telomeres in T cells and fibroblasts
    • Hao LY, Strong MA, Greider CW (2004) Phosphorylation of H2AX at short telomeres in T cells and fibroblasts. J. Biol. Chem. 279, 45148–45154.
    • (2004) J. Biol. Chem. , vol.279 , pp. 45148-45154
    • Hao, L.Y.1    Strong, M.A.2    Greider, C.W.3
  • 15
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley CB, Futcher AB, Greider CW (1990) Telomeres shorten during ageing of human fibroblasts. Nature 345, 458–460.
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 16
    • 0033153424 scopus 로고    scopus 로고
    • Disease states associated with telomerase deficiency appear earlier in mice with short telomeres
    • Herrera E, Samper E, Martin-Caballero J, Flores JM, Lee HW, Blasco MA (1999) Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J. 18, 2950–2960.
    • (1999) EMBO J. , vol.18 , pp. 2950-2960
    • Herrera, E.1    Samper, E.2    Martin-Caballero, J.3    Flores, J.M.4    Lee, H.W.5    Blasco, M.A.6
  • 17
    • 84912075249 scopus 로고    scopus 로고
    • TALEN gene knockouts reveal no requirement for the conserved human shelterin protein Rap1 in telomere protection and length regulation
    • Kabir S, Hockemeyer D, de Lange T (2014) TALEN gene knockouts reveal no requirement for the conserved human shelterin protein Rap1 in telomere protection and length regulation. Cell Rep. 9, 1273–1280.
    • (2014) Cell Rep. , vol.9 , pp. 1273-1280
    • Kabir, S.1    Hockemeyer, D.2    de Lange, T.3
  • 18
    • 0035899938 scopus 로고    scopus 로고
    • spRap1 and spRif1, recruited to telomeres by Taz1, are essential for telomere function in fission yeast
    • Kanoh J, Ishikawa F (2001) spRap1 and spRif1, recruited to telomeres by Taz1, are essential for telomere function in fission yeast. Curr. Biol. 11, 1624–1630.
    • (2001) Curr. Biol. , vol.11 , pp. 1624-1630
    • Kanoh, J.1    Ishikawa, F.2
  • 19
    • 0026657008 scopus 로고
    • C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae
    • Kyrion G, Boakye KA, Lustig AJ (1992) C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae. Mol. Cell. Biol. 12, 5159–5173.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 5159-5173
    • Kyrion, G.1    Boakye, K.A.2    Lustig, A.J.3
  • 20
    • 24944460598 scopus 로고    scopus 로고
    • Shelterin: the protein complex that shapes and safeguards human telomeres
    • de Lange T (2005) Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 19, 2100–2110.
    • (2005) Genes Dev. , vol.19 , pp. 2100-2110
    • de Lange, T.1
  • 22
    • 0034716904 scopus 로고    scopus 로고
    • Identification of human Rap1: implications for telomere evolution
    • Li B, Oestreich S, de Lange T (2000) Identification of human Rap1: implications for telomere evolution. Cell 101, 471–483.
    • (2000) Cell , vol.101 , pp. 471-483
    • Li, B.1    Oestreich, S.2    de Lange, T.3
  • 25
    • 0025252456 scopus 로고
    • Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length
    • Lustig AJ, Kurtz S, Shore D (1990) Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length. Science 250, 549–553.
    • (1990) Science , vol.250 , pp. 549-553
    • Lustig, A.J.1    Kurtz, S.2    Shore, D.3
  • 27
    • 78349270933 scopus 로고    scopus 로고
    • Role of shelterin in cancer and aging
    • Martinez P, Blasco MA (2010) Role of shelterin in cancer and aging. Aging Cell 9, 653–666.
    • (2010) Aging Cell , vol.9 , pp. 653-666
    • Martinez, P.1    Blasco, M.A.2
  • 28
    • 79952017845 scopus 로고    scopus 로고
    • Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins
    • Martinez P, Blasco MA (2011) Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins. Nat. Rev. Cancer 11, 161–176.
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 161-176
    • Martinez, P.1    Blasco, M.A.2
  • 29
    • 59049097927 scopus 로고    scopus 로고
    • MSH2 deficiency abolishes the anticancer and pro-aging activity of short telomeres
    • Martinez P, Siegl-Cachedenier I, Flores JM, Blasco MA (2009a) MSH2 deficiency abolishes the anticancer and pro-aging activity of short telomeres. Aging Cell 8, 2–17.
    • (2009) Aging Cell , vol.8 , pp. 2-17
    • Martinez, P.1    Siegl-Cachedenier, I.2    Flores, J.M.3    Blasco, M.A.4
  • 33
    • 3142616449 scopus 로고    scopus 로고
    • The human Rap1 protein complex and modulation of telomere length
    • O'Connor MS, Safari A, Liu D, Qin J, Songyang Z (2004) The human Rap1 protein complex and modulation of telomere length. J. Biol. Chem. 279, 28585–28591.
    • (2004) J. Biol. Chem. , vol.279 , pp. 28585-28591
    • O'Connor, M.S.1    Safari, A.2    Liu, D.3    Qin, J.4    Songyang, Z.5
  • 34
    • 0015844590 scopus 로고
    • A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon
    • Olovnikov AM (1973) A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J. Theor. Biol. 41, 181–190.
    • (1973) J. Theor. Biol. , vol.41 , pp. 181-190
    • Olovnikov, A.M.1
  • 35
    • 27144489538 scopus 로고    scopus 로고
    • Rap1 prevents telomere fusions by nonhomologous end joining
    • Pardo B, Marcand S (2005) Rap1 prevents telomere fusions by nonhomologous end joining. EMBO J. 24, 3117–3127.
    • (2005) EMBO J. , vol.24 , pp. 3117-3127
    • Pardo, B.1    Marcand, S.2
  • 37
    • 84960192466 scopus 로고    scopus 로고
    • TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions
    • Rai R, Chen Y, Lei M, Chang S (2016) TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions. Nat. Commun. 7, 10881.
    • (2016) Nat. Commun. , vol.7 , pp. 10881
    • Rai, R.1    Chen, Y.2    Lei, M.3    Chang, S.4
  • 39
    • 70350786918 scopus 로고    scopus 로고
    • Human RAP1 inhibits non-homologous end joining at telomeres
    • Sarthy J, Bae NS, Scrafford J, Baumann P (2009) Human RAP1 inhibits non-homologous end joining at telomeres. EMBO J. 28, 3390–3399.
    • (2009) EMBO J. , vol.28 , pp. 3390-3399
    • Sarthy, J.1    Bae, N.S.2    Scrafford, J.3    Baumann, P.4
  • 40
    • 77950196212 scopus 로고    scopus 로고
    • Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal
    • Sfeir A, Kabir S, van Overbeek M, Celli GB, de Lange T (2010) Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science 327, 1657–1661.
    • (2010) Science , vol.327 , pp. 1657-1661
    • Sfeir, A.1    Kabir, S.2    van Overbeek, M.3    Celli, G.B.4    de Lange, T.5
  • 41
    • 0025881033 scopus 로고
    • Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere length
    • Sussel L, Shore D (1991) Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere length. Proc. Natl Acad. Sci. USA 88, 7749–7753.
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 7749-7753
    • Sussel, L.1    Shore, D.2
  • 42
    • 0042420304 scopus 로고    scopus 로고
    • DNA damage foci at dysfunctional telomeres
    • Takai H, Smogorzewska A, de Lange T (2003) DNA damage foci at dysfunctional telomeres. Curr. Biol. 13, 1549–1556.
    • (2003) Curr. Biol. , vol.13 , pp. 1549-1556
    • Takai, H.1    Smogorzewska, A.2    de Lange, T.3
  • 44
    • 0015515155 scopus 로고
    • Origin of concatemeric T7 DNA
    • Watson JD (1972) Origin of concatemeric T7 DNA. Nat New Biol. 239, 197–201.
    • (1972) Nat New Biol. , vol.239 , pp. 197-201
    • Watson, J.D.1
  • 45
    • 79960112520 scopus 로고    scopus 로고
    • Human telomeric proteins occupy selective interstitial sites
    • Yang D, Xiong Y, Kim H, He Q, Li Y, Chen R, Songyang Z (2011) Human telomeric proteins occupy selective interstitial sites. Cell Res. 21, 1013–1027.
    • (2011) Cell Res. , vol.21 , pp. 1013-1027
    • Yang, D.1    Xiong, Y.2    Kim, H.3    He, Q.4    Li, Y.5    Chen, R.6    Songyang, Z.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.