Nontelomeric Role for Rap1 in Regulating Metabolism and Protecting against Obesity

Cell Reports

Volumn 3, Issue 6, 2013, Pages 1847-1856

  Yeung, Frank ^a   Ramírez, Cristina M ^a   Mateos Gomez, Pedro A ^a   Pinzaru, Alexandra ^a   Ceccarini, Giovanni ^b,c   Kabir, Shaheen ^c   Fernández Hernando, Carlos ^a   Sfeir, Agnel ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY HOSPITAL OF PISA   (Italy)

^c ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; GLYCINE; RAP1 PROTEIN; THREONINE;

ADIPOCYTE; ALLELE; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL DIFFERENTIATION; CONTROLLED STUDY; FATTY LIVER; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE INTOLERANCE; HOMEOSTASIS; IN VITRO STUDY; IN VIVO STUDY; INSULIN RESISTANCE; LIPID STORAGE; LIVER METABOLISM; MALE; METABOLIC REGULATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; WHITE ADIPOSE TISSUE;

AMINO ACID SEQUENCE; ANIMALS; BODY WEIGHT; HUMANS; MICE; MOLECULAR SEQUENCE DATA; OBESITY; RAP1 GTP-BINDING PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TELOMERE; TELOMERE-BINDING PROTEINS;

MAMMALIA;

EID: 84879771334     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2013.05.032     Document Type: Article

References (33)

1. Aberg K., Dai F., Sun G., Keighley E.D., Indugula S.R., Roberts S.T., Zhang Q., Smelser D., Viali S., Tuitele J., et al. Susceptibility loci for adiposity phenotypes on 8p, 9p, and 16q in American Samoa and Samoa. Obesity (Silver Spring) 2009, 17:518-524.
2. Almén M.S., Jacobsson J.A., Moschonis G., Benedict C., Chrousos G.P., Fredriksson R., Schiöth H.B. Genome wide analysis reveals association of a FTO gene variant with epigenetic changes. Genomics 2012, 99:132-137.
3. Arat N.O., Griffith J.D. Human Rap1 interacts directly with telomeric DNA and regulates TRF2 localization at the telomere. J.Biol. Chem. 2012, 287:41583-41594.
4. Arkan M.C., Hevener A.L., Greten F.R., Maeda S., Li Z.W., Long J.M., Wynshaw-Boris A., Poli G., Olefsky J., Karin M. IKK-beta links inflammation to obesity-induced insulin resistance. Nat. Med. 2005, 11:191-198.
5. Celli G.B., de Lange T. DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion. Nat. Cell Biol. 2005, 7:712-718.
6. Chen Y., Rai R., Zhou Z.R., Kanoh J., Ribeyre C., Yang Y., Zheng H., Damay P., Wang F., Tsujii H., et al. A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms. Nat. Struct. Mol. Biol. 2011, 18:213-221.
7. Costet P., Legendre C., Moré J., Edgar A., Galtier P., Pineau T. Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis. J.Biol. Chem. 1998, 273:29577-29585.
8. de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 2005, 19:2100-2110.
9. Fujita K., Horikawa I., Mondal A.M., Jenkins L.M., Appella E., Vojtesek B., Bourdon J.C., Lane D.P., Harris C.C. Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence. Nat. Cell Biol. 2010, 12:1205-1212.
10. Gardner J.P., Li S., Srinivasan S.R., Chen W., Kimura M., Lu X., Berenson G.S., Aviv A. Rise in insulin resistance is associated with escalated telomere attrition. Circulation 2005, 111:2171-2177.
11. Gesta S., Tseng Y.H., Kahn C.R. Developmental origin of fat: tracking obesity to its source. Cell 2007, 131:242-256.
12. Hardy C.F., Sussel L., Shore D. A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes Dev. 1992, 6:801-814.
13. Kabir S., Sfeir A., de Lange T. Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions. Cell Cycle 2010, 9:4061-4067.
14. Kanoh J., Ishikawa F. spRap1 and spRif1, recruited to telomeres by Taz1, are essential for telomere function in fission yeast. Curr. Biol. 2001, 11:1624-1630.
15. Kurtz S., Shore D. RAP1 protein activates and silences transcription of mating-type genes in yeast. Genes Dev. 1991, 5:616-628.
16. Kyrion G., Liu K., Liu C., Lustig A.J. RAP1 and telomere structure regulate telomere position effects in Saccharomyces cerevisiae. Genes Dev. 1993, 7(7A):1146-1159.
17. Lee O.H., Kim H., He Q., Baek H.J., Yang D., Chen L.Y., Liang J., Chae H.K., Safari A., Liu D., Songyang Z. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. Mol. Cell. Proteomics 2011, 10. M110.001628.
18. Leone T.C., Lehman J.J., Finck B.N., Schaeffer P.J., Wende A.R., Boudina S., Courtois M., Wozniak D.F., Sambandam N., Bernal-Mizrachi C., et al. PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol. 2005, 3:e101.
19. Li B., Oestreich S., de Lange T. Identification of human Rap1: implications for telomere evolution. Cell 2000, 101:471-483.
20. Lustig A.J., Kurtz S., Shore D. Involvement of the silencer and UAS binding protein RAP1 in regulation of telomere length. Science 1990, 250:549-553.
21. Martinez P., Thanasoula M., Carlos A.R., Gómez-López G., Tejera A.M., Schoeftner S., Dominguez O., Pisano D.G., Tarsounas M., Blasco M.A. Mammalian Rap1 controls telomere function and gene expression through binding to telomeric and extratelomeric sites. Nat. Cell Biol. 2010, 12:768-780.
22. Meyre D., Lecoeur C., Delplanque J., Francke S., Vatin V., Durand E., Weill J., Dina C., Froguel P. A genome-wide scan for childhood obesity-associated traits in French families shows significant linkage on chromosome 6q22.31-q23.2. Diabetes 2004, 53:803-811.
23. Murillo-Ortiz B., Albarrán-Tamayo F., Arenas-Aranda D., Benítez-Bribiesca L., Malacara-Hernández J.M., Martínez-Garza S., Hernández-González M., Solorio S., Garay-Sevilla M.E., Mora-Villalpando C. Telomere length and type 2 diabetes in males, a premature aging syndrome. Aging Male 2012, 15:54-58.
24. Nakae J., Kitamura T., Kitamura Y., Biggs W.H., Arden K.C., Accili D. The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev. Cell 2003, 4:119-129.
25. Pardo B., Marcand S. Rap1 prevents telomere fusions by nonhomologous end joining. EMBO J. 2005, 24:3117-3127.
26. Sahin E., Colla S., Liesa M., Moslehi J., Müller F.L., Guo M., Cooper M., Kotton D., Fabian A.J., Walkey C., et al. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature 2011, 470:359-365.
27. Salpea K.D., Humphries S.E. Telomere length in atherosclerosis and diabetes. Atherosclerosis 2010, 209:35-38.
28. Sfeir A., Kabir S., van Overbeek M., Celli G.B., de Lange T. Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Science 2010, 327:1657-1661.
29. Shen Q., Zhao X., Yu L., Zhang Z., Zhou D., Kan M., Zhang D., Cao L., Xing Q., Yang Y., et al. Association of leukocyte telomere length with type 2 diabetes in mainland Chinese populations. J.Clin. Endocrinol. Metab. 2012, 97:1371-1374.
30. Shore D. RAP1: a protean regulator in yeast. Trends Genet. 1994, 10:408-412.
31. Shore D., Nasmyth K. Purification and cloning of a DNA binding protein from yeast that binds to both silencer and activator elements. Cell 1987, 51:721-732.
32. Teo H., Ghosh S., Luesch H., Ghosh A., Wong E.T., Malik N., Orth A., de Jesus P., Perry A.S., Oliver J.D., et al. Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression. Nat. Cell Biol. 2010, 12:758-767.
33. Yang D., Xiong Y., Kim H., He Q., Li Y., Chen R., Songyang Z. Human telomeric proteins occupy selective interstitial sites. Cell Res. 2011, 21:1013-1027.