Changes in zinc transporter 8 autoantibodies following type 1 diabetes onset: The type 1 diabetes genetics consortium autoantibody workshop

Diabetes Care

Volumn 38, Issue , 2015, Pages S14-S20

  Wenzlau, Janet M ^a   Frisch, Lisa M ^a   Hutton, John C ^a   Fain, Pamela R ^a   Davidson, Howard W ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; UNCLASSIFIED DRUG; ZINC TRANSPORTER; ZINC TRANSPORTER 8; ZINC TRANSPORTER 8 AUTOANTIBODY; CATION TRANSPORT PROTEIN; HLA ANTIGEN; SLC30A8 PROTEIN, HUMAN;

AFRICAN AMERICAN; ANCESTRY GROUP; ANTIBODY DETECTION; ANTIBODY TITER; ARTICLE; BLACK PERSON; CONTROLLED STUDY; DISEASE DURATION; DRB1 GENE; FEMALE; GENE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC VARIABILITY; HAPLOTYPE; HISPANIC; HOMOZYGOSITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PROTEIN DOMAIN; RADIOIMMUNOPRECIPITATION; SEQUENCE ALIGNMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SLC30A8 GENE; ADOLESCENT; AGE DISTRIBUTION; ALLELE; BLOOD; CHILD; DIABETES MELLITUS, TYPE 1; GENE LINKAGE DISEQUILIBRIUM; GENETICS; IMMUNOLOGY; INFANT; NEWBORN; PANCREAS ISLET; PRESCHOOL CHILD; PREVALENCE; YOUNG ADULT;

ADOLESCENT; AGE DISTRIBUTION; ALLELES; AUTOANTIBODIES; CATION TRANSPORT PROTEINS; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FEMALE; HAPLOTYPES; HLA ANTIGENS; HUMANS; INFANT; INFANT, NEWBORN; ISLETS OF LANGERHANS; LINKAGE DISEQUILIBRIUM; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PREVALENCE; YOUNG ADULT;

EID: 84984691321     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dcs15-2004     Document Type: Article

References (42)

1. Dang M, Rockell J, Wagner R, et al. Human type 1 diabetes is associated with T cell autoimmunity to zinc transporter 8. J Immunol 2011; 186:6056-6063
2. Énée É, Kratzer R, Arnoux JB, et al. ZnT8 is a major CD8+ T cell-recognized autoantigen in pediatric type 1 diabetes. Diabetes 2012;61:1779-1784
3. Scotto M, Afonso G, Larger E, et al. Zinc transporter (ZnT)8(186-194) is an immunodominant CD8+ T cell epitope in HLA-A2+ type 1 diabetic patients. Diabetologia 2012;55:2026-2031
4. Achenbach P, Lampasona V, Landherr U, et al. Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk. Diabetologia 2009;52:1881-1888
5. Andersson C, Larsson K, Vaziri-Sani F, et al. The three ZNT8 autoantibody variants together improve the diagnostic sensitivity of childhood and adolescent type 1 diabetes. Autoimmunity 2011;44:394-405
6. Gorus FK, Balti EV, Vermeulen I, et al.; Belgian Diabetes Registry. Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost-effective and age-independent strategy to identify rapid progressors to clinical onset among relatives of type 1 diabetic patients. Clin Exp Immunol 2013;171:82-90
7. Vermeulen I, Weets I, Asanghanwa M, et al.; Belgian Diabetes Registry. Contribution of antibodies against IA-2b and zinc transporter 8 to classification of diabetes diagnosed under 40 years of age. Diabetes Care 2011;34:1760-1765
8. Wenzlau JM, Juhl K, Yu L, et al. The cation efflux transporter ZnT8 (SLC30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci U S A 2007;104:17040-17045
9. Nielsen LB, Vaziri-Sani F, Pörksen S, et al.; Hvidoere Study Group on Childhood Diabetes. Relationship between ZnT8Ab, the SLC30A8 gene and disease progression in children with newly diagnosed type 1 diabetes. Autoimmunity 2011;44:616-623
10. Wenzlau JM, Walter M, Gardner TJ, et al. Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects. J Clin EndocrinolMetab 2010;95:4712-4719
11. Vaziri-Sani F, Oak S, Radtke J, et al. ZnT8 autoantibody titers in type 1 diabetes patients decline rapidly after clinical onset. Autoimmunity 2010;43:598-606
12. Lampasona V, Petrone A, Tiberti C, et al.; Non Insulin Requiring Autoimmune Diabetes (NIRAD) Study Group. Zinc transporter 8 antibodies complement GAD and IA-2 antibodies in the identification and characterization of adult-onset autoimmune diabetes: Non Insulin Requiring Autoimmune Diabetes (NIRAD) 4. Diabetes Care 2010;33:104-108
13. Wenzlau JM, Frisch LM, Hutton JC, Davidson HW. Mapping of conformational autoantibody epitopes in ZNT8. Diabetes Metab Res Rev 2011;27:883-886
14. Wenzlau JM, Liu Y, Yu L, et al. A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes. Diabetes 2008;57:2693-2697
15. Pascoe L, Tura A, Patel SK, et al.; RISC Consortium; U.K. Type 2 Diabetes Genetics Consortium. Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function. Diabetes 2007;56:3101-3104
16. Scott LJ, Mohlke KL, Bonnycastle LL, et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007;316:1341-1345
17. Saxena R, Voight BF, Lyssenko V, et al.; Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research. Genomewide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007;316:1331-1336
18. Sladek R, RocheleauG, Rung J, etal.Agenomewide association study identifies novel risk loci for type 2 diabetes. Nature 2007;445:881-885
19. Brorsson C, Bergholdt R, Sjögren M, et al. A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population. Mol Genet Metab 2008;94:386-388
20. Gohlke H, Ferrari U, Koczwara K, Bonifacio E, Illig T, Ziegler AG. SLC30A8 (ZnT8) Polymorphism is Associated with Young Age at Type 1 Diabetes Onset. Rev Diabet Stud 2008;5:25-27
21. Boitard C. Pancreatic islet autoimmunity. Presse Med 2012;41(12 P 2):e636-e650
22. GanMJ, Albanese-O'Neill A,HallerMJ. Type 1 diabetes: current concepts in epidemiology, pathophysiology, clinical care, and research. Curr Probl Pediatr Adolesc Health Care 2012;42:269-291
23. Lempainen J, Ilonen J. Influence of type 1 diabetes genes on disease progression: similarities and differences between countries. Curr Diab Rep 2012;12:447-455
24. Rich SS, Concannon P, Erlich H, et al. The Type 1 Diabetes Genetics Consortium. Ann N Y Acad Sci 2006;1079:1-8
25. Tsirogianni A, Pipi E, Soufleros K. Specificity of islet cell autoantibodies and coexistence with other organ specific autoantibodies in type 1 diabetes mellitus. Autoimmun Rev 2009;8:687-691
26. Mychaleckyj JC, Noble JA, Moonsamy PV, et al.; T1DGC. HLA genotyping in the international Type 1 Diabetes Genetics Consortium. Clin Trials 2010;7(Suppl.):S75-S87
27. Bingley PJ, Williams AJ, Colman PG, et al.; T1DGC. Measurement of islet cell antibodies in the Type 1 Diabetes Genetics Consortium: efforts to harmonize procedures among the laboratories. Clin Trials 2010;7(Suppl.):S56-S64
28. Wenzlau JM, Gardner TJ, Frisch LM, Davidson HW, Hutton JC. Development of a novel autoantibody assay for autoimmune gastritis in type 1 diabetic individuals. Diabetes Metab Res Rev 2011;27:887-890
29. Murgia C, Devirgiliis C, Mancini E, Donadel G, Zalewski P, Perozzi G. Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands. Nutr Metab Cardiovasc Dis 2009;19:431-439
30. Lange K, Sinsheimer JS, Sobel E. Association testing with MENDEL. Genet Epidemiol 2005; 29:36-50
31. Lange K, Weeks D, Boehnke M. Programs for Pedigree Analysis: MENDEL, FISHER, and dGENE. Genet Epidemiol 1988;5:471-472
32. Andersson C, Vaziri-Sani F, Delli A, et al.; BDD Study Group. Triple specificity of ZnT8 autoantibodies in relation to HLA and other islet autoantibodies in childhood and adolescent type 1 diabetes. Pediatr Diabetes 2013;14:97-105
33. Kawasaki E, Nakamura K, Kuriya G, et al. Differences in the humoral autoreactivity to zinc transporter 8 between childhood-and adult-onset type 1 diabetes in Japanese patients. Clin Immunol 2011;138:146-153
34. Long AE, Gillespie KM, Aitken RJ, Goode JC, Bingley PJ, Williams AJ. Humoral responses to islet antigen-2 and zinc transporter 8 are attenuated in patients carrying HLA-A∗24 alleles at the onset of type 1 diabetes. Diabetes 2013;62:2067-2071
35. Verge CF, Gianani R, Kawasaki E, et al. Number of autoantibodies (against insulin, GAD or ICA512/IA2) rather than particular autoantibody specificities determines risk of type I diabetes. J Autoimmun 1996;9:379-383
36. WinterWE, Schatz DA. Autoimmunemarkers in diabetes. Clin Chem 2011;57:168-175
37. Thrower SL, Bingley PJ. Prevention of type 1 diabetes. Br Med Bull 2011;99:73-88
38. Kawasaki E, Uga M, Nakamura K, et al. Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes. Diabetologia 2008;51:2299-2302
39. Yang L, Luo S, Huang G, et al. The diagnostic value of zinc transporter 8 autoantibody (ZnT8A) for type 1 diabetes in Chinese. Diabetes Metab Res Rev 2010;26:579-584
40. Brorsson C, Vaziri-Sani F, Bergholdt R, et al.; Danish Study Group of Childhood Diabetes. Correlations between islet autoantibody specificity and the SLC30A8 genotype with HLA-DQB1 and metabolic control in new onset type 1 diabetes. Autoimmunity 2011;44:107-114
41. Andersen ML, Vaziri-Sani F, Delli A, et al. Association between autoantibodies to the arginine variant of the zinc transporter 8 (ZnT8) and stimulated C-peptide levels in Danish children and adolescents with newly diagnosed type 1 diabetes. Pediatr Diabetes 2012;13:454-462
42. Delli AJ, Vaziri-Sani F, Lindblad B, et al.; Better Diabetes Diagnosis Study Group. Zinc transporter 8 autoantibodies and their association with SLC30A8 and HLA-DQ genes differ between immigrant and Swedish patients with newly diagnosed type 1 diabetes in the Better Diabetes Diagnosis study. Diabetes 2012;61:2556-2564