Mapping of conformational autoantibody epitopes in ZNT8

Diabetes/Metabolism Research and Reviews

Volumn 27, Issue 8, 2011, Pages 883-886

  Wenzlau, Janet M ^a   Frisch, Lisa M ^a   Hutton, John C ^a   Davidson, Howard W ^a  

^a UNIVERSITY OF COLORADO DENVER   (United States)

Author keywords

Autoantibodies; Slc30A8; Type 1 diabetes; Zinc transporter 8

Indexed keywords

AUTOANTIBODY; EPITOPE; UNCLASSIFIED DRUG; ZINC TRANSPORTER; ZINC TRANSPORTER 8 PROTEIN;

ANTIGENICITY; ARTICLE; AUTOIMMUNITY; EPITOPE MAPPING; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MOLECULAR MODEL; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; SERUM; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; AUTOANTIBODIES; CATION TRANSPORT PROTEINS; DIABETES MELLITUS, TYPE 1; DNA PROBES; EPITOPES; HUMANS; MICE; POLYMORPHISM, GENETIC; PROTEIN CONFORMATION;

EID: 80855124133     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.1266     Document Type: Article

References (15)

1. Pihoker C, Gilliam LK, Hampe CS, Lernmark A. Autoantibodies in diabetes. Diabetes 2005; 54(Suppl. 2): S52-S61.
2. Wasserfall CH, Atkinson MA. Autoantibody markers for the diagnosis and prediction of type 1 diabetes. Autoimmun Rev 2006; 5: 424-428.
3. Wenzlau JM, Juhl K, Yu L, et al. The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc Natl Acad Sci U S A 2007; 104: 17040-17045.
4. Achenbach P, Lampasona V, Landherr U, et al. Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk. Diabetologia 2009; 52: 1881-1888.
5. Andersson C, Larsson K, Vaziri-Sani F, et al. The three ZNT8 autoantibody variants together improve the diagnostic sensitivity of childhood and adolescent type 1 diabetes. Autoimmunity 2011; 44: 394-405.
6. Kawasaki E, Uga M, Nakamura K, et al. Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes. Diabetologia 2008; 51: 2299-2302.
7. Lampasona V, Petrone A, Tiberti C, et al. Zinc transporter 8 antibodies complement GAD and IA-2 antibodies in the identification and characterization of adult-onset autoimmune diabetes: Non Insulin Requiring Autoimmune Diabetes (NIRAD) 4. Diabetes Care 2010; 33: 104-108.
8. De Grijse J, Asanghanwa M, Nouthe B, et al. Predictive power of screening for antibodies against insulinoma-associated protein 2 beta (IA-2beta) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease: implications for prevention trials. Diabetologia 2010; 53: 517-524.
9. Yu L, Rewers M, Gianani R, et al. Antiislet autoantibodies usually develop sequentially rather than simultaneously. J Clin Endocrinol Metab 1996; 81: 4264-4267.
10. Verge CF, Gianani R, Kawasaki E, et al. Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes 1996; 45: 926-933.
11. Wenzlau JM, Liu Y, Yu L, et al. A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes. Diabetes 2008; 57: 2693-2697.
12. Kelley LA, Sternberg MJ. Protein structure prediction on the Web: a case study using the Phyre server. Nat Protoc 2009; 4: 363-371.
13. Wenzlau JM, Moua O, Liu Y, Eisenbarth GS, Hutton JC, Davidson HW. Identification of a major humoral epitope in Slc30A8 (ZnT8). Ann N Y Acad Sci 2008; 1150: 252-255.
14. Weijers RN. Three-dimensional structure of beta-cell-specific zinc transporter, ZnT-8, predicted from the type 2 diabetes-associated gene variant SLC30A8 R325W. Diabetol Metab Syndr 2010; 2: 33.
15. Liu Y, Wenzlau JM, Yu L, et al. Conserved epitopes in the protein tyrosine phosphatase family of diabetes autoantigens. Ann N Y Acad Sci 2008; 1150: 245-247.