Small molecule inhibitors targeting tec kinase block unconventional secretion of fibroblast growth factor 2

Journal of Biological Chemistry

Volumn 291, Issue 34, 2016, Pages 17787-17803

  La Venuta, Giuseppe ^a   Wegehingel, Sabine ^a   Sehr, Peter ^b   Ller, Hans Michael Mü ^a   Dimou, Eleni ^a   Steringer, Julia P ^a   Grotwinkel, Mareike ^a   Hentze, Nikolai ^c   Mayer, Matthias P ^c   Will, David W ^b   Uhrig, Ulrike ^b   Lewis, Joe D ^b   Nickel, Walter ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c GERMAN CANCER RESEARCH CENTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL CULTURE; CELL MEMBRANES; ENZYME ACTIVITY; ENZYMES; FIBROBLASTS; MOLECULES; PHYSIOLOGY; TUMORS;

BIOCHEMICAL CHARACTERIZATION; DIFFERENT SUBSTRATES; DIRECT INTERACTIONS; FIBROBLAST GROWTH FACTOR 2; HEPARAN SULFATE PROTEOGLYCANS; SMALL MOLECULE INHIBITOR; TUMOR-INDUCED ANGIOGENESIS; TYROSINE PHOSPHORYLATION;

PHOSPHORYLATION;

FIBROBLAST GROWTH FACTOR 2; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; SMALL INTERFERING RNA; TEC KINASE; UNCLASSIFIED DRUG; PROTEIN TYROSINE KINASE; TEC PROTEIN-TYROSINE KINASE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; DRUG RESEARCH; DRUG SPECIFICITY; DRUG TARGETING; ENZYME SUBSTRATE; IN VITRO STUDY; METASTASIS INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RNA INTERFERENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CHO CELL LINE; CRICETULUS; DRUG EFFECTS; GENETICS; HAMSTER; HUMAN; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN MULTIMERIZATION; SECRETION (PROCESS);

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; FIBROBLAST GROWTH FACTOR 2; HUMANS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN MULTIMERIZATION; PROTEIN-TYROSINE KINASES; RNA INTERFERENCE;

EID: 84984690321     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.729384     Document Type: Article

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