Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P 2)-dependent oligomerization of fibroblast growth factor 2 (FGF2) triggers the formation of a lipidic membrane pore implicated in unconventional secretion

Journal of Biological Chemistry

Volumn 287, Issue 33, 2012, Pages 27659-27669

  Steringer, Julia P ^a   Bleicken, Stephanie ^b,c   Andreas, Helena ^a   Zacherl, Sonja ^a   Laussmann, Mareike ^a   Temmerman, Koen ^a,e   Contreras, F Xabier ^a   Bharat, Tanmay A M ^d   Lechner, Johannes ^a   Müller, Hans Michael ^a   Briggs, John A G ^d   García Sáez, Ana J ^b,c   Nickel, Walter ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b MAX PLANCK INSTITUTE FOR INTELLIGENT SYSTEMS   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^e EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOPLASMIC RETICULUM; EXTRACELLULAR SPACE; FIBROBLAST GROWTH FACTOR 2; LIPIDIC MEMBRANES; LIVING CELL; MEMBRANE TRANSLOCATION; MITOGENS; PHOSPHATIDYLINOSITOL 4; PHOSPHATIDYLINOSITOL 4 ,5-BISPHOSPHATE; PROTEIN TRANSLOCATION; SECRETORY PATHWAYS; TOROIDAL STRUCTURES; TUMOR-INDUCED ANGIOGENESIS; TYROSINE PHOSPHORYLATION;

AMINO ACIDS; OLIGOMERIZATION; OLIGOMERS; PHOSPHORYLATION; PHYSIOLOGY;

MEMBRANES;

FIBROBLAST GROWTH FACTOR 2; OLIGOMER; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; TYROSINE;

ARTICLE; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; LIPID MEMBRANE; MEMBRANE STRUCTURE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN TRANSPORT; UPREGULATION;

CELL MEMBRANE; FIBROBLAST GROWTH FACTOR 2; HUMANS; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTEIN TRANSPORT;

EID: 84864980066     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.381939     Document Type: Article

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