Formation of disulfide bridges drives oligomerization, membrane pore formation, and translocation of fibroblast growth factor 2 to cell surfaces

Journal of Biological Chemistry

Volumn 290, Issue 14, 2015, Pages 8925-8937

  Müller, Hans Michael ^a   Steringer, Julia P ^a   Wegehingel, Sabine ^a   Bleicken, Stephanie ^b,c   Münster, Maximilian ^a   Dimou, Eleni ^a   Unger, Sebastian ^a   Weidmann, Georg ^a   Andreas, Helena ^a   García Sáez, Ana J ^b,c   Wild, Klemens ^a   Sinning, Irmgard ^a   Nickel, Walter ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c MAX PLANCK INSTITUTE FOR INTELLIGENT SYSTEMS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL CULTURE; CELL MEMBRANES; COVALENT BONDS; FIBROBLASTS; OLIGOMERIZATION; OLIGOMERS; PEPTIDES; PHYSIOLOGY; PROTEINS;

CHEMICAL ALKYLATION; ENDOPLASMIC RETICULUM; FIBROBLAST GROWTH FACTOR 2; MEMBRANE INSERTION; PHOSPHATIDYLINOSITOL 4; SIGNALING MOLECULES; TUMOR-INDUCED ANGIOGENESIS; TYROSINE PHOSPHORYLATION;

MEMBRANES;

CYSTEINE; DISULFIDE; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR 4; HYBRID PROTEIN; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; SIGNAL PEPTIDE;

AMINO ACID SUBSTITUTION; ARTICLE; CELL SURFACE; CHANNEL GATING; CONTROLLED STUDY; CYTOKINE RELEASE; DISULFIDE BOND; ENDOPLASMIC RETICULUM; GOLGI MEMBRANE; MOLECULAR INTERACTION; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN LOCALIZATION; PROTEIN STABILITY; RESIDUE ANALYSIS; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; SURFACE PROPERTY; AMINO ACID SEQUENCE; ANIMAL; CELL MEMBRANE; CHEMISTRY; CHO CELL LINE; CRICETULUS; HAMSTER; METABOLISM; MOLECULAR GENETICS; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERIZATION; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; CELL MEMBRANE; CHO CELLS; CRICETINAE; CRICETULUS; DISULFIDES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FIBROBLAST GROWTH FACTOR 2; MOLECULAR SEQUENCE DATA; POLYMERIZATION; PROTEIN SORTING SIGNALS; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84926500199     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.622456     Document Type: Article

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