Microsecond Molecular Dynamics Simulations of Influenza Neuraminidase Suggest a Mechanism for the Increased Virulence of Stalk-Deletion Mutants

Journal of Physical Chemistry B

Volumn 120, Issue 33, 2016, Pages 8590-8599

  Durrant, Jacob D ^a   Bush, Robin M ^b   Amaro, Rommie E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPID BILAYERS; PROTEINS;

COMPLEX MIXTURE; DELETION MUTANTS; ENZYMATIC ACTIVITIES; MODELING AND SIMULATING; MOLECULAR DYNAMICS SIMULATIONS; SIALYLATED OLIGOSACCHARIDES; STRUCTURE BASED DRUG DESIGNS; SURFACE PROTEINS;

MOLECULAR DYNAMICS;

N ACETYLNEURAMINIC ACID; NA PROTEIN, INFLUENZA A VIRUS; SIALIDASE; VIRAL PROTEIN;

BINDING SITE; CHEMISTRY; GENE DELETION; GENETICS; INFLUENZA A VIRUS (H1N1); LIPID BILAYER; METABOLISM; MOLECULAR DYNAMICS; MOLECULAR MODEL; PATHOGENICITY; PHYSIOLOGY; PRINCIPAL COMPONENT ANALYSIS; PROTEIN DOMAIN; PROTEIN SECONDARY STRUCTURE; TIME FACTOR; VIRULENCE;

BINDING SITES; INFLUENZA A VIRUS, H1N1 SUBTYPE; LIPID BILAYERS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; N-ACETYLNEURAMINIC ACID; NEURAMINIDASE; PRINCIPAL COMPONENT ANALYSIS; PROTEIN DOMAINS; PROTEIN STRUCTURE, SECONDARY; SEQUENCE DELETION; TIME FACTORS; VIRAL PROTEINS; VIRULENCE;

EID: 84984614373     PISSN: 15206106     EISSN: 15205207     Source Type: Journal    
DOI: 10.1021/acs.jpcb.6b02655     Document Type: Article

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