Sequence conservation predicts T cell reactivity against ragweed allergens

Clinical and Experimental Allergy

Volumn 46, Issue 9, 2016, Pages 1194-1205

  Pham, J ^a   Oseroff, C ^a   Hinz, D ^a   Sidney, J ^a   Paul, S ^a   Greenbaum, J ^a   Vita, R ^a   Phillips, E ^b,c   Mallal, S ^b,c   Peters, B ^a   Sette, A ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b MURDOCH UNIVERSITY   (Australia)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

allergens; ragweed; T cell epitopes

Indexed keywords

EPITOPE; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 5; RAGWEED ANTIGEN; RAGWEED POLLEN EXTRACT;

ADULT; ALLERGENICITY; AMBROSIA ARTEMISIIFOLIA; ARTICLE; CELLULAR IMMUNITY; CONSERVED SEQUENCE; CYTOKINE RELEASE; FEMALE; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; IN VITRO STUDY; MALE; PEPTIDE SYNTHESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; POLLEN ALLERGY; PRIORITY JOURNAL; RAGWEED ALLERGY; SEROLOGY; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

EID: 84984607926     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/cea.12772     Document Type: Article

References (38)

1. Pichler U, Hauser M, Wolf M et al. Pectate lyase pollen allergens: sensitization profiles and cross-reactivity pattern. PLoS ONE 2015; 10:e0120038.
2. Laaidi M, Laaidi K, Besancenot JP, Thibaudon M. Ragweed in France: an invasive plant and its allergenic pollen. Ann Allergy Asthma Immunol 2003; 91:195–201.
3. Dechamp C. [Ambrosia pollinosis]. Rev Mal Respir 2013; 30:316–27.
4. Hamaoui-Laguel L, Vautard R, Liu L et al. Effects of climate change and seed dispersal on airborne ragweed pollen loads in Europe. Nat Clim Chang 2015; 5:766–71.
5. El-Qutob D. Vaccine development and new attempts of treatment for ragweed allergy. Ther Adv Vaccines 2015; 3:41–7.
6. King TP, Norman PS, Tao N. Chemical modifications of the major allergen of ragweed pollen, antigen E. Immunochemistry 1974; 11:83–92.
7. Adolphson C, Goodfriend L, Gleich GJ. Reactivity of ragweed allergens with IgE antibodies. Analyses by leukocyte histamine release and the radioallergosorbent test and determination of cross-reactivity. J Allergy Clin Immunol 1978; 62:197–210.
8. Jahn-Schmid B, Hauser M, Wopfner N et al. Humoral and cellular cross-reactivity between Amb a 1, the major ragweed pollen allergen, and its mugwort homolog Art v 6. J Immunol 2012; 188:1559–67.
9. Ghosh B, Perry MP, Rafnar T, Marsh DG. Cloning and expression of immunologically active recombinant Amb a V allergen of short ragweed (Ambrosia artemisiifolia) pollen. J Immunol 1993; 150:5391–9.
10. Roebber M, Hussain R, Klapper DG, Marsh DG. Isolation and properties of a new short ragweed pollen allergen, Ra6. J Immunol 1983; 131:706–11.
11. Bouley J, Groeme R, Le Mignon M et al. Identification of the cysteine protease Amb a 11 as a novel major allergen from short ragweed. J Allergy Clin Immunol 2015; 136:1055–64.
12. Bordas-Le Floch V, Le Mignon M, Bouley J et al. Identification of novel short ragweed pollen allergens using combined transcriptomic and immunoproteomic approaches. PLoS ONE 2015; 10:e0136258.
13. Jahn-Schmid B, Wopfner N, Hubinger G et al. The T-cell response to Amb a 1 is characterized by 3 dominant epitopes and multiple MHC restriction elements. J Allergy Clin Immunol 2010; 126:1068–71, 71.e1–2.
14. Rothbard JB, Lechler RI, Howland K et al. Structural model of HLA-DR1 restricted T cell antigen recognition. Cell 1988; 52:515–23.
15. Oseroff C, Sidney J, Tripple V et al. Analysis of T cell responses to the major allergens from German cockroach: epitope specificity and relationship to IgE production. J Immunol 2012; 189:679–88.
16. Wopfner N, Jahn-Schmid B, Schmidt G et al. The alpha and beta subchain of Amb a 1, the major ragweed-pollen allergen show divergent reactivity at the IgE and T-cell level. Mol Immunol 2009; 46:2090–7.
17. Ghiani A, Aina R, Asero R, Bellotto E, Citterio S. Ragweed pollen collected along high-traffic roads shows a higher allergenicity than pollen sampled in vegetated areas. Allergy 2012; 67:887–94.
18. Schulten V, Tripple V, Aasbjerg K et al. Distinct modulation of allergic T cell responses by subcutaneous vs. sublingual allergen-specific immunotherapy. Clin Exp Allergy 2016; 46:439–48.
19. Schulten V, Tripple V, Sidney J et al. Association between specific timothy grass antigens and changes in TH1- and TH2-cell responses following specific immunotherapy. J Allergy Clin Immunol 2014; 134:1076–83.
20. Wambre E. Effect of allergen-specific immunotherapy on CD4 + T cells. Curr Opin Allergy Clin Immunol 2015; 15:581–7.
21. Karp CL. Guilt by intimate association: what makes an allergen an allergen? J Allergy Clin Immunol 2010; 125:955–60; quiz 61–2.
22. Radauer C, Nandy A, Ferreira F et al. Update of the WHO/IUIS allergen nomenclature database based on analysis of allergen sequences. Allergy 2014; 69:413–9.
23. Mari A, Rasi C, Palazzo P, Scala E. Allergen databases: current status and perspectives. Curr Allergy Asthma Rep 2009; 9:376–83.
24. Weiskopf D, Bangs DJ, Sidney J et al. Dengue virus infection elicits highly polarized CX3CR1 + cytotoxic CD4 + T cells associated with protective immunity. Proc Natl Acad Sci USA 2015; 112:E4256–63.
25. Lindestam Arlehamn CS, Paul S, Mele F et al. Immunological consequences of intragenus conservation of Mycobacterium tuberculosis T-cell epitopes. Proc Natl Acad Sci USA 2015; 112:E147–55.
26. Chiu C, McCausland M, Sidney J et al. Broadly reactive human CD8 T cells that recognize an epitope conserved between VZV, HSV and EBV. PLoS Pathog 2014; 10:e1004008.
27. Westernberg L, Schulten V, Greenbaum JA et al. T-cell epitope conservation across allergen species is a major determinant of immunogenicity. J Allergy Clin Immunol 2016; Feb 13. pii: S0091-6749(16)00083-X. doi: 10.1016/j.jaci.2015.11.034. [Epub ahead of print].
28. Asero R, Bellotto E, Ghiani A, Aina R, Villalta D, Citterio S. Concomitant sensitization to ragweed and mugwort pollen: who is who in clinical allergy? Ann Allergy Asthma Immunol 2014; 113:307–13.
29. Oseroff C, Sidney J, Kotturi MF et al. Molecular determinants of T cell epitope recognition to the common Timothy grass allergen. J Immunol 2010; 185:943–55.
30. Moutaftsi M, Peters B, Pasquetto V et al. A consensus epitope prediction approach identifies the breadth of murine T(CD8 +)-cell responses to vaccinia virus. Nat Biotechnol 2006; 24:817–9.
31. Erlich RL, Jia X, Anderson S et al. Next-generation sequencing for HLA typing of class I loci. BMC Genom 2011; 12:1–13.
32. Robinson J, Halliwell JA, Hayhurst JD, Flicek P, Parham P, Marsh Steven GE. The IPD and IMGT/HLA database: allele variant databases. Nucleic Acids Res 2015; 43:D423–31.
33. Paul S, Dillon MB, Lindestam Arlehamn CS et al. A population response analysis approach to assign class II HLA-epitope restrictions. J immunol 2015; 194:6164–76.
34. Schulten V, Greenbaum JA, Hauser M et al. Previously undescribed grass pollen antigens are the major inducers of T helper 2 cytokine-producing T cells in allergic individuals. Proc Natl Acad Sci USA 2013; 110:3459–64.
35. Grabherr MG, Haas BJ, Yassour M, et al. Full-length transcriptome assembly from RNA-seq data without a reference genome. Nat Biotechnol 2011; 29:644–52.
36. Hinz D, Oseroff C, Pham J, Sidney J, Peters B, Sette A. Definition of a pool of epitopes that recapitulates the T cell reactivity against major house dust mite allergens. Clin Exp Allergy 2015; 45:1601–12.
37. Dillon MB, Schulten V, Oseroff C et al. Different Bla-g T cell antigens dominate responses in asthma versus rhinitis subjects. Clin Exp Allergy 2015; 45:1856–67.
38. Goodfriend L, Choudhury AM, Klapper DG et al. Ra5G, a homologue of Ra5 in giant ragweed pollen: isolation, HLA-DR-associated activity and amino acid sequence. Mol Immunol 1985; 22:899–906.