The T-cell response to Amb a 1 is characterized by 3 dominant epitopes and multiple MHC restriction elements

Journal of Allergy and Clinical Immunology

Volumn 126, Issue 5, 2010, Pages

  Jahn Schmid, Beatrice ^a   Wopfner, Nicole ^b   Hubinger, Gudrun ^b   Asero, Riccardo ^c   Ebner, Christof ^d   Ferreira, Fatima ^b   Bohle, Barbara ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF SALZBURG   (Austria)

^c CLINICA SAN CARLO   (Italy)

^d Allergie Ambulatorium Rennweg Vienna   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

AMB A 1 ANTIGEN; EPITOPE; RAGWEED ANTIGEN; UNCLASSIFIED DRUG;

ALLERGENICITY; AMINO ACID SEQUENCE; ANTIGEN RECOGNITION; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; HUMAN; IMMUNE RESPONSE; LETTER; MAJOR HISTOCOMPATIBILITY COMPLEX; POLLEN ALLERGY; PRIORITY JOURNAL; RAGWEED; T LYMPHOCYTE;

EID: 78049458151     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2010.05.038     Document Type: Article

References (12)

1. G.J. Burbach, L.M. Heinzerling, C. Rohnelt, K.C. Bergmann, H. Behrendt, and T. Zuberbier Ragweed sensitization in Europe - GA(2)LEN study suggests increasing prevalence Allergy 64 2009 664 665
2. T.P. King, P.S. Norman, and L.M. Lichtenstein Isolation and characterization of allergens from ragweed pollen. IV Biochemistry 6 1967 1992 2000
3. P.S. Creticos, J.T. Schroeder, R.G. Hamilton, S.L. Balcer-Whaley, A.P. Khattignavong, and R. Lindblad Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis N Engl J Med 355 2006 1445 1455
4. J.F. Bond, R.D. Garman, K.M. Keating, T.J. Briner, T. Rafnar, and D.G. Klapper Multiple Amb a I allergens demonstrate specific reactivity with IgE and T cells from ragweed-allergic patients J Immunol 146 1991 3380 3385
5. Kuo MC, Garman R, Greensten J, Evans S, Amsberry K, Shaked Z. T cell epitopes of the major allergens from Ambrosia artemisifolia. Patent WO 96/13589; 1996.
6. T. Rafnar, I.J. Griffith, M.C. Kuo, J.F. Bond, B.L. Rogers, and D.G. Klapper Cloning of Amb a I (antigen E), the major allergen family of short ragweed pollen J Biol Chem 266 1991 1229 1236
7. N. Wopfner, B. Jahn-Schmid, G. Schmidt, T. Christ, G. Hubinger, and P. Briza The alpha and beta subchain of Amb a 1, the major ragweed-pollen allergen show divergent reactivity at the IgE and T-cell level Mol Immunol 46 2009 2090 2097
8. S.K. Huang, P. Zwollo, and D.G. Marsh Class II major histocompatibility complex restriction of human T cell responses to short ragweed allergen, Amb a V Eur J Immunol 21 1991 1469 1473
9. R. Asero, N. Wopfner, P. Gruber, G. Gadermaier, and F. Ferreira Artemisia and Ambrosia hypersensitivity: co-sensitization or co-recognition? Clin Exp Allergy 36 2006 658 665
10. T.P. King, P.S. Norman, and J.T. Connell Isolation and characterization of allergens from ragweed pollen Ii. Biochemistry 3 1964 458 468
11. N. Wopfner, B. Jahn-Schmid, G. Schmidt, T. Christ, G. Hubinger, and P. Briza The alpha and beta subchain of Amb a 1, the major ragweed-pollen allergen show divergent reactivity at the IgE and T-cell level Mol Immunol 46 2009 2090 2097
12. B. Jahn-Schmid, P. Kelemen, M. Himly, B. Bohle, G. Fischer, and F. Ferreira The T cell response to Art v 1, the major mugwort pollen allergen, is dominated by one epitope J Immunol 169 2002 6005 6011