Definition of a pool of epitopes that recapitulates the T cell reactivity against major house dust mite allergens

Clinical and Experimental Allergy

Volumn 45, Issue 10, 2015, Pages 1601-1612

  Hinz, D ^a   Oseroff, C ^a   Pham, J ^a   Sidney, J ^a   Peters, B ^a   Sette, A ^a  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

Author keywords

Dust mite allergy; Epitope identification; T cell reactivity

Indexed keywords

EPITOPE; GAMMA INTERFERON; HOUSE DUST ALLERGEN; IMMUNOGLOBULIN E ANTIBODY; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 5; ALLERGEN; PEPTIDE;

ADULT; AGED; ANTIBODY TITER; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DERMATOPHAGOIDES FARINAE; DERMATOPHAGOIDES PTERONYSSINUS; EX VIVO STUDY; FEMALE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; T LYMPHOCYTE; TH2 CELL; ANIMAL; ASTHMA; EPITOPE MAPPING; IMMUNOLOGY; PATHOLOGY; PYROGLYPHIDAE;

ALLERGENS; ANIMALS; ASTHMA; EPITOPE MAPPING; EPITOPES, T-LYMPHOCYTE; FEMALE; HUMANS; MALE; PEPTIDES; PYROGLYPHIDAE; T-LYMPHOCYTES;

EID: 84941634473     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/cea.12507     Document Type: Article

References (43)

1. Platts-Mills TA, Thomas WR, Aalberse RC, Vervloet D, Champman MD. Dust mite allergens and asthma: report of a second international workshop. J Allergy Clin Immunol 1992; 89:1046-60.
2. Platts-Mills TA, Vervloet D, Thomas WR, Aalberse RC, Chapman MD. Indoor allergens and asthma: report of the Third International Workshop. J Allergy Clin Immunol 1997; 100:S2-24.
3. Salo PM, Arbes SJ Jr, Crockett PW, Thorne PS, Cohn RD, Zeldin DC. Exposure to multiple indoor allergens in US homes and its relationship to asthma. J Allergy Clin Immunol 2008; 121:678-84 e2.
4. Voorhorst R. House dust mite and house dust allergy. Ann Allergy 1977; 38:71.
5. Chapman MD, Pomes A, Breiteneder H, Ferreira F. Nomenclature and structural biology of allergens. J Allergy Clin Immunol 2007; 119:414-20.
6. Pomes A. Allergen structures and biologic functions: the cutting edge of allergy research. Curr Allergy Asthma Rep 2008; 8:425-32.
7. Tovey ER, Chapman MD, Platts-Mills TA. Mite faeces are a major source of house dust allergens. Nature 1981; 289:592-3.
8. Thomas WR, Smith WA, Hales BJ. The allergenic specificities of the house dust mite. Chang Gung Med J 2004; 27:563-9.
9. Ando T, Ino Y, Haida M et al. Isolation of cysteine protease in the crude mite extract, Dermatophagoides farinae. Int Arch Allergy Appl Immunol 1991; 96:199-205.
10. Stewart GA, Lake FR, Thompson PJ. Faecally derived hydrolytic enzymes from Dermatophagoides pteronyssinus: physicochemical characterisation of potential allergens. Int Arch Allergy Appl Immunol 1991; 95:248-56.
11. Weghofer M, Grote M, Resch Y et al. Identification of Der p 23, a peritrophin-like protein, as a new major Dermatophagoides pteronyssinus allergen associated with the peritrophic matrix of mite fecal pellets. J Immunol 2013; 190:3059-67.
12. Mudde GC, Hansel TT, von Reijsen FC, Osterhoff BF, Bruijnzeel-Koomen CA. IgE: an immunoglobulin specialized in antigen capture? Immunol Today 1990; 11:440-3.
13. Larche M, Akdis CA, Valenta R. Immunological mechanisms of allergen-specific immunotherapy. Nat Rev Immunol 2006; 6:761-71.
14. Lebman DA, Coffman RL. Interleukin 4 causes isotype switching to IgE in T cell-stimulated clonal B cell cultures. J Exp Med 1988; 168:853-62.
15. Gauchat JF, Lebman DA, Coffman RL, Gascan H, de Vries JE. Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production. J Exp Med 1990; 172:463-73.
16. Punnonen J, Aversa G, Cocks BG, de Vries JE. Role of interleukin-4 and interleukin-13 in synthesis of IgE and expression of CD23 by human B cells. Allergy 1994; 49:576-86.
17. Yssel H, Johnson KE, Schneider PV et al. T cell activation-inducing epitopes of the house dust mite allergen Der p I. Proliferation and lymphokine production patterns by Der p I-specific CD4+ T cell clones. J Immunol 1992; 148:738-45.
18. Okano M, Nagano T, Nakada M et al. Epitope analysis of HLA-DR-restricted helper T-cell responses to Der p II, a major allergen molecule of Dermatophagoides pteronyssinus. Allergy 1996; 51:29-35.
19. Verhoef A, Higgins JA, Thorpe CJ et al. Clonal analysis of the atopic immune response to the group 2 allergen of Dermatophagoides spp.: identification of HLA-DR and -DQ restricted T cell epitopes. Int Immunol 1993; 5:1589-97.
20. Joost van Neerven R, van t'Hof W, Ringrose JH et al. T cell epitopes of house dust mite major allergen Der p II. J Immunol 1993; 151:2326-35.
21. Bonvalet M, Wambre E, Moussu H et al. Comparison between major histocompatibility complex class II tetramer staining and surface expression of activation markers for the detection of allergen-specific CD4(+) T cells. Clin Exp Allergy 2011; 41:821-9.
22. Wambre E, Bonvalet M, Bodo VB et al. Distinct characteristics of seasonal (Bet v 1) vs. perennial (Der p 1/Der p 2) allergen-specific CD4(+) T cell responses. Clin Exp Allergy 2011; 41:192-203.
23. Crack LR, Chan HW, McPherson T, Ogg GS. Identification of an immunodominant region of the major house dust mite allergen Der p 2 presented by common human leucocyte antigen alleles. Clin Exp Dermatol 2012; 37:266-76.
24. Akdis M, Verhagen J, Taylor A et al. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med 2004; 199:1567-75.
25. Oseroff C, Sidney J, Kotturi MF et al. Molecular determinants of T cell epitope recognition to the common Timothy grass allergen. J Immunol 2010; 185:943-55.
26. Moutaftsi M, Peters B, Pasquetto V et al. A consensus epitope prediction approach identifies the breadth of murine T(CD8+)-cell responses to vaccinia virus. Nat Biotechnol 2006; 24:817-9.
27. Oseroff C, Peters B, Pasquetto V et al. Dissociation between epitope hierarchy and immunoprevalence in CD8 responses to vaccinia virus western reserve. J Immunol 2008; 180:7193-202.
28. Arlehamn CS, Sidney J, Henderson R et al. Dissecting mechanisms of immunodominance to the common tuberculosis antigens ESAT-6, CFP10, Rv2031c (hspX), Rv2654c (TB7.7), and Rv1038c (EsxJ). J Immunol 2012; 188:5020-31.
29. Weiskopf D, Yauch LE, Angelo MA et al. Insights into HLA-restricted T cell responses in a novel mouse model of dengue virus infection point toward new implications for vaccine design. J Immunol 2011; 187:4268-79.
30. Wambre E, Van Overtvelt L, Maillere B et al. Single cell assessment of allergen-specific T cell responses with MHC class II peptide tetramers: methodological aspects. Int Arch Allergy Immunol 2008; 146:99-112.
31. Vita R, Overton JA, Greenbaum JA et al. The immune epitope database (IEDB) 3.0. Nucleic Acids Res 2015; 43: D405-D412.
32. Chua KY, Stewart GA, Thomas WR et al. Sequence analysis of cDNA coding for a major house dust mite allergen, Der p 1. Homology with cysteine proteases. J Exp Med 1988; 167:175-82.
33. Dilworth RJ, Chua KY, Thomas WR. Sequence analysis of cDNA coding for a major house dust mite allergen, Der f I. Clin Exp Allergy 1991; 21:25-32.
34. Oseroff C, Sidney J, Tripple V et al. Analysis of T cell responses to the major allergens from German cockroach: epitope specificity and relationship to IgE production. J Immunol 2012; 189:679-88.
35. Oseroff C, Sidney J, Vita R et al. T cell responses to known allergen proteins are differently polarized and account for a variable fraction of total response to allergen extracts. J Immunol 2012; 189:1800-11.
36. Hales BJ, Thomas WR. T-cell sensitization to epitopes from the house dust mites Dermatophagoides pteronyssinus and Euroglyphus maynei. Clin Exp Allergy 1997; 27:868-75.
37. O'Brien RM, Thomas WR, Tait BD. An immunogenetic analysis of T-cell reactive regions on the major allergen from the house dust mite, Der p I, with recombinant truncated fragments. J Allergy Clin Immunol 1994; 93:628-34.
38. O'Hehir RE, Verhoef A, Panagiotopoulou E et al. Analysis of human T cell responses to the group II allergen of Dermatophagoides species: localization of major antigenic sites. J Allergy Clin Immunol 1993; 92:105-13.
39. Schulten V, Tripple V, Sidney J et al. Association between specific timothy grass antigens and changes in TH1- and TH2-cell responses following specific immunotherapy. J Allergy Clin Immunol 2014; 134:1076-83.
40. Michaud B, Gouvis-Echraghi R, Candon S et al. Quantification of circulating house dust mite-specific IL-4- and IL-13-secreting T cells correlates with rhinitis severity in asthmatic children and varies with the seasons. Clin Exp Allergy 2014; 44:222-30.
41. Pacciani V, Corrente S, Gregori S et al. Correlation of Der p 2 T-cell responses with clinical characteristics of children allergic to house dust mite. Ann Allergy Asthma Immunol 2012; 109:442-7.
42. Focke M, Marth K, Valenta R. Molecular composition and biological activity of commercial birch pollen allergen extracts. Eur J Clin Invest 2009; 39:429-36.
43. Esch RE. Allergen source materials and quality control of allergenic extracts. Methods 1997; 13:2-13.