Protective effects of diphenyl diselenide in a mouse model of brain toxicity

Chemico-Biological Interactions

Volumn 206, Issue 1, 2013, Pages 18-26

  Glaser, Viviane ^a   Moritz, Bettina ^a   Schmitz, Ariana ^a   Dafré, Alcir Luiz ^a   Nazari, Evelise Maria ^a   Rauh Müller, Yara Maria ^a   Feksa, Luciane ^b   Straliottoa, Marcos Raniel ^a   De Bem, Andreza Fabro ^a   Farina, Marcelo ^a   Da Rocha, João Batista Teixeira ^c   Latini, Alexandra ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b UNIVERSIDADE FEEVALE   (Brazil)

^c FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

Diphenyl diselenide; Methylmercury; Neurotoxicity; Oxidative stress; Respiratory chain complexes

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; DIPHENYL DISELENIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; LACTIC ACID; MITOCHONDRIAL COMPLEX II; MITOCHONDRIAL COMPLEX IV; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); THIOBARBITURIC ACID REACTIVE SUBSTANCE; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN TOXICITY; CELL VIABILITY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; ENZYME ACTIVITY; ENZYME RELEASE; LIPID PEROXIDATION; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS;

EID: 84984555573     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2013.08.002     Document Type: Article

References (72)

1. A. Bock, K. Forchhammer, J. Heider, W. Leinfelder, G. Sawers, B. Veprek, and F. Zinoni Selenocysteine: the 21st amino acid Mol. Microbiol. 5 3 1991 515 520 (Pubitemid 21896072)
2. G. Mugesh, W.W. du Mont, and H. Sies Chemistry of biologically important synthetic organoselenium compounds Chem. Rev. 101 7 2001 2125 2179 (Pubitemid 35381674)
3. C.W. Nogueira, L.N. Rotta, M.L. Perry, D.O. Souza, and J.B. da Rocha Diphenyl diselenide and diphenyl ditelluride affect the rat glutamatergic system in vitro and in vivo Brain Res. 906 1-2 2001 157 163 (Pubitemid 32595550)
4. C.W. Nogueira, G. Zeni, and J.B. Rocha Organoselenium and organotellurium compounds: toxicology and pharmacology Chem. Rev. 104 12 2004 6255 6285 (Pubitemid 40025738)
5. A.S. de Freitas, V.R. Funck, S. Rotta Mdos, D. Bohrer, V. Morschbacher, R.L. Puntel, C.W. Nogueira, M. Farina, M. Aschner, and J.B. Rocha Diphenyl diselenide, a simple organoselenium compound, decreases methylmercury-induced cerebral, hepatic and renal oxidative stress and mercury deposition in adult mice Brain Res. Bull. 79 1 2009 77 84
6. L. Flohe, W.A. Gunzler, and H.H. Schock Glutathione peroxidase: a selenoenzyme FEBS Lett. 32 1 1973 132 134
7. A. Holmgren Thioredoxin and glutaredoxin systems J. Biol. Chem. 264 24 1989 13963 13966 (Pubitemid 19214215)
8. A.C. Bianco, D. Salvatore, B. Gereben, M.J. Berry, and P.R. Larsen Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases Endocr. Rev. 23 1 2002 38 89 (Pubitemid 34185306)
9. J. Panee, Z.R. Stoytcheva, W. Liu, and M.J. Berry Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification J. Biol. Chem. 282 33 2007 23759 23765 (Pubitemid 47327999)
10. A. Muller, E. Cadenas, P. Graf, and H. Sies A novel biologically active seleno-organic compound-I. Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (Ebselen) Biochem. Pharmacol. 33 20 1984 3235 3239 (Pubitemid 14023257)
11. L.L. Rupil, A.F. de Bem, and G.A. Roth Diphenyl diselenide-modulation of macrophage activation: down-regulation of classical and alternative activation markers Innate Immun. 18 4 2012 627 637
12. N.B. Barbosa, J.B. Rocha, D.C. Wondracek, J. Perottoni, G. Zeni, and C.W. Nogueira Diphenyl diselenide reduces temporarily hyperglycemia: possible relationship with oxidative stress Chem. Biol. Interact. 163 3 2006 230 238 (Pubitemid 44572228)
13. C. Luchese, R. Brandao, R. de Oliveira, C.W. Nogueira, and F.W. Santos Efficacy of diphenyl diselenide against cerebral and pulmonary damage induced by cadmium in mice Toxicol. Lett. 173 3 2007 181 190 (Pubitemid 47391551)
14. J.I. Rossato, L.A. Ketzer, F.B. Centuriao, S.J. Silva, D.S. Ludtke, G. Zeni, A.L. Braga, M.A. Rubin, and J.B. Rocha Antioxidant properties of new chalcogenides against lipid peroxidation in rat brain Neurochem. Res. 27 4 2002 297 303 (Pubitemid 34273571)
15. A.F. de Bem, M. Farina, L. Portella Rde, C.W. Nogueira, T.C. Dinis, J.A. Laranjinha, L.M. Almeida, and J.B. Rocha Diphenyl diselenide, a simple glutathione peroxidase mimetic, inhibits human LDL oxidation in vitro Atherosclerosis 201 1 2008 92 100
16. L.P. Borges, C.W. Nogueira, R.B. Panatieri, J.B. Rocha, and G. Zeni Acute liver damage induced by 2-nitropropane in rats: effect of diphenyl diselenide on antioxidant defenses Chem. Biol. Interact. 160 2 2006 99 107 (Pubitemid 43343914)
17. L. Savegnago, C.R. Jesse, L.G. Pinto, J.B. Rocha, D.A. Barancelli, C.W. Nogueira, and G. Zeni Diphenyl diselenide exerts antidepressant-like and anxiolytic-like effects in mice: involvement of l-arginine-nitric oxide-soluble guanylate cyclase pathway in its antidepressant-like action Pharmacol. Biochem. Behav. 88 4 2008 418 426 (Pubitemid 350266784)
18. L. Savegnago, L.G. Pinto, C.R. Jesse, D. Alves, J.B. Rocha, C.W. Nogueira, and G. Zeni Antinociceptive properties of diphenyl diselenide: evidences for the mechanism of action Eur. J. Pharmacol. 555 2-3 2007 129 138 (Pubitemid 46048799)
19. L. Savegnago, M. Trevisan, D. Alves, J.B. Rocha, C.W. Nogueira, and G. Zeni Antisecretory and antiulcer effects of diphenyl diselenide Environ. Toxicol. Pharmacol. 21 1 2006 86 92 (Pubitemid 41736079)
20. H.H. Draper, and M. Hadley Malondialdehyde determination as index of lipid peroxidation Methods Enzymol. 186 1990 421 431 (Pubitemid 20279983)
21. R.A. Floyd, and K. Hensley Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases Neurobiol. Aging 23 5 2002 795 807 (Pubitemid 35217704)
22. A.F. de Bem, R. de Lima Portella, M. Farina, J. Perottoni, M.W. Paixao, C.W. Nogueira, and J.B. Teixeira Rocha Low toxicity of diphenyl diselenide in rabbits: a long-term study Basic Clin. Pharmacol. Toxicol. 101 1 2007 47 55 (Pubitemid 46934649)
23. A.F. de Bem, R. de Lima Portella, J. Perottoni, E. Becker, D. Bohrer, M.W. Paixao, C.W. Nogueira, G. Zeni, and J.B. Rocha Changes in biochemical parameters in rabbits blood after oral exposure to diphenyl diselenide for long periods Chem. Biol. Interact. 162 1 2006 1 10 (Pubitemid 44080162)
24. F.C. Meotti, V.C. Borges, G. Zeni, J.B. Rocha, and C.W. Nogueira Potential renal and hepatic toxicity of diphenyl diselenide, diphenyl ditelluride and Ebselen for rats and mice Toxicol. Lett. 143 1 2003 9 16 (Pubitemid 36412167)
25. C.W. Nogueira, F.C. Meotti, E. Curte, C. Pilissao, G. Zeni, and J.B. Rocha Investigations into the potential neurotoxicity induced by diselenides in mice and rats Toxicology 183 1-3 2003 29 37 (Pubitemid 36005387)
26. I. Saito, T. Asano, K. Sano, K. Takakura, H. Abe, T. Yoshimoto, H. Kikuchi, T. Ohta, and S. Ishibashi Neuroprotective effect of an antioxidant, ebselen, in patients with delayed neurological deficits after aneurysmal subarachnoid hemorrhage Neurosurgery 42 2 1998 269 277 discussion 277-268
27. T. Yamaguchi, K. Sano, K. Takakura, I. Saito, Y. Shinohara, T. Asano, and H. Yasuhara Ebselen in acute ischemic stroke: a placebo-controlled, double-blind clinical trial. Ebselen Study Group Stroke 29 1 1998 12 17 (Pubitemid 28046934)
28. C.W. Nogueira, and J.B.T. Rocha Diphenyl diselenide a Janus-faced molecule J. Braz. Chem. Soc. 21 2010 2055 2071
29. V. Glaser, E.M. Nazari, Y.M. Muller, L. Feksa, C.M. Wannmacher, J.B. Rocha, A.F. de Bem, M. Farina, and A. Latini Effects of inorganic selenium administration in methylmercury-induced neurotoxicity in mouse cerebral cortex Int. J. Dev. Neurosci. 28 7 2010 631 637
30. C. Paulmier Selenoorganic functional groups 1986 Pergamon Press Oxford
31. J.L. Franco, A. Teixeira, F.C. Meotti, C.M. Ribas, J. Stringari, S.C. Garcia Pomblum, A.M. Moro, D. Bohrer, A.V. Bairros, A.L. Dafre, A.R. Santos, and M. Farina Cerebellar thiol status and motor deficit after lactational exposure to methylmercury Environ. Res. 102 1 2006 22 28 (Pubitemid 44080203)
32. J.L. Franco, T. Posser, P.R. Dunkley, P.W. Dickson, J.J. Mattos, R. Martins, A.C. Bainy, M.R. Marques, A.L. Dafre, and M. Farina Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase Free Radic. Biol. Med. 47 4 2009 449 457
33. M.E. Burger, R. Fachinetto, C. Wagner, J. Perottoni, R.P. Pereira, G. Zeni, and J.B. Rocha Effects of diphenyl-diselenide on orofacial dyskinesia model in rats Brain Res. Bull. 70 2 2006 165 170 (Pubitemid 43870399)
34. I. Yamamoto Studies on the behavior of mercury and selenium in blood of mice injected with those elements Hokkaido Igaku Zasshi 60 2 1985 227 240
35. A. Latini, C.G. da Silva, G.C. Ferreira, P.F. Schuck, K. Scussiato, J.J. Sarkis, C.S. Dutra Filho, A.T. Wyse, C.M. Wannmacher, and M. Wajner Mitochondrial energy metabolism is markedly impaired by d-2-hydroxyglutaric acid in rat tissues Mol. Genet. Metab. 86 1-2 2005 188 199 (Pubitemid 41412175)
36. S.F. Llesuy, J. Milei, H. Molina, A. Boveris, and S. Milei Comparison of lipid peroxidation and myocardial damage induced by adriamycin and 4'-epiadriamycin in mice Tumori 71 3 1985 241 249 (Pubitemid 15007582)
37. B. Gonzalez-Flecha, and A. Boveris Mitochondrial sites of hydrogen peroxide production in reperfused rat kidney cortex Biochim. Biophys. Acta 1243 3 1995 361 366
38. A.Q. dos Santos, P. Nardin, C. Funchal, L.M. de Almeida, M.C. Jacques-Silva, S.T. Wofchuk, C.A. Goncalves, and C. Gottfried Resveratrol increases glutamate uptake and glutamine synthetase activity in C6 glioma cells Arch. Biochem. Biophys. 453 2 2006 161 167 (Pubitemid 44344218)
39. T. Mosmann Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J. Immunol. Methods 65 1-2 1983 55 63 (Pubitemid 14203433)
40. A.R. Sigwalt, H. Budde, I. Helmich, V. Glaser, K. Ghisoni, S. Lanza, E.L. Cadore, F.L. Lhullier, A.F. de Bem, A. Hohl, F.J. de Matos, P.A. de Oliveira, R.D. Prediger, L.G. Guglielmo, and A. Latini Molecular aspects involved in swimming exercise training reducing anhedonia in a rat model of depression Neuroscience 192 2011 661 674
41. 2 generation in isolated mitochondria J. Bioenerg. Biomembr. 34 3 2002 227 233 (Pubitemid 34847805)
42. A. Cassina, and R. Radi Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transport Arch. Biochem. Biophys. 328 2 1996 309 316 (Pubitemid 26160113)
43. J.C. Fischer, W. Ruitenbeek, J.A. Berden, J.M. Trijbels, J.H. Veerkamp, A.M. Stadhouders, R.C. Sengers, and A.J. Janssen Differential investigation of the capacity of succinate oxidation in human skeletal muscle Clin. Chim. Acta 153 1 1985 23 36
44. P. Rustin, J. Lebidois, D. Chretien, T. Bourgeron, J.F. Piechaud, A. Rotig, A. Munnich, and D. Sidi Endomyocardial biopsies for early detection of mitochondrial disorders in hypertrophic cardiomyopathies J. Pediatr. 124 2 1994 224 228 (Pubitemid 24057788)
45. I. Carlberg, and B. Mannervik Glutathione reductase Methods Enzymol. 113 1985 484 490 (Pubitemid 16195819)
46. A. Wendel Glutathione peroxidase Methods Enzymol. 77 1981 325 333
47. A. Latini, G.C. Ferreira, K. Scussiato, P.F. Schuck, A.F. Solano, C.S. Dutra-Filho, C.R. Vargas, and M. Wajner Induction of oxidative stress by chronic and acute glutaric acid administration to rats Cell. Mol. Neurobiol. 27 4 2007 423 438 (Pubitemid 46763889)
48. H. Esterbauer, and K.H. Cheeseman Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal Methods Enzymol. 186 1990 407 421 (Pubitemid 20279982)
49. G. Danscher Autometallography. A new technique for light and electron microscopic visualization of metals in biological tissues (gold, silver, metal sulphides and metal selenides) Histochemistry 81 4 1984 331 335 (Pubitemid 15205064)
50. R.H. Hfreere, and E.R. Weibel Stereologic techniques in microscopy J. R. Microsc. Soc. 87 1 1967 25 34
51. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
52. J.P. Kinsella, S.R. Neish, D.D. Ivy, E. Shaffer, and S.H. Abman Clinical responses to prolonged treatment of persistent pulmonary hypertension of the newborn with low doses of inhaled nitric oxide J. Pediatr. 123 1 1993 103 108 (Pubitemid 23185210)
53. A.F. de Bem, L. Portella Rde, E. Colpo, M.M. Duarte, A. Frediane, P.S. Taube, C.W. Nogueira, M. Farina, E.L. da Silva, and J.B. Teixeira Rocha Diphenyl diselenide decreases serum levels of total cholesterol and tissue oxidative stress in cholesterol-fed rabbits Basic Clin. Pharmacol. Toxicol. 105 1 2009 17 23
54. N.B. Barbosa, J.B. Rocha, J.C. Soares, D.C. Wondracek, J.F. Goncalves, M.R. Schetinger, and C.W. Nogueira Dietary diphenyl diselenide reduces the STZ-induced toxicity Food Chem. Toxicol. 46 1 2008 186 194 (Pubitemid 350245555)
55. T. Takeuchi Pathology of Minamata disease. With special reference to its pathogenesis Acta Pathol. Jpn. 32 Suppl. 1 1982 73 99
56. K. Eto Pathology of Minamata disease Toxicol. Pathol. 25 6 1997 614 623 (Pubitemid 28027786)
57. D. Hunter, and D.S. Russell Focal cerebellar and cerebellar atrophy in a human subject due to organic mercury compounds J. Neurol. Neurosurg. Psychiatry 17 4 1954 235 241
58. B.H. Choi, L.W. Lapham, L. Amin-Zaki, and T. Saleem Abnormal neuronal migration, deranged cerebral cortical organization, and diffuse white matter astrocytosis of human fetal brain: a major effect of methylmercury poisoning in utero J. Neuropathol. Exp. Neurol. 37 6 1978 719 733 (Pubitemid 9080082)
59. K. Eto, Y. Takizawa, H. Akagi, K. Haraguchi, S. Asano, N. Takahata, and H. Tokunaga Differential diagnosis between organic and inorganic mercury poisoning in human cases-the pathologic point of view Toxicol. Pathol. 27 6 1999 664 671
60. A.S. de Freitas, A. de Souza Prestes, C. Wagner, J. Haigert Sudati, D. Alves, L. Oliveira Porciúncula, I.J. Kade, and J.B. Rocha Reduction of diphenyl diselenide and analogs by mammalian thioredoxin reductase is independent of their gluthathione peroxidase-like activity: a possible novel pathway for their antioxidant activity Molecules 15 2010 7699 76714
61. A.S. de Freitas, C. Wagner, J. Haigert Sudati, D. Alves, L. Oliveira Porciúncula, I.J. Kade, and J.B. Rocha Diphenyl diselenide and analogs are substrates of cerebral rat thioredoxin reductase: a pathway for their neuroprotective effects Molecules 15 2010 7699 76714
62. A.S. de Freitas, and J.B. Rocha Diphenyl diselenide and analogs are substrates of cerebral rat thioredoxin reductase: a pathway for their neuroprotective effects Neurosci. Lett. 503 1 2011 1 5
63. M.C. Newland, M.N. Reed, A. LeBlanc, and W.D. Donlin Brain and blood mercury and selenium after chronic and developmental exposure to methylmercury Neurotoxicology 27 5 2006 710 720
64. S.C. Fang Interaction of selenium and mercury in the rat Chem. Biol. Interact. 17 1 1977 25 40 (Pubitemid 8119863)
65. A. Naganuma, and N. Imura Changes in distribution of mercury and selenium in soluble fractions of rabbit tissues after simultaneous administration Pharmacol. Biochem. Behav. 13 4 1980 537 544 (Pubitemid 10024771)
66. F.W. Santos, G. Zeni, J.B. Rocha, S.N. Weis, J.M. Fachinetto, A.M. Favero, and C.W. Nogueira Diphenyl diselenide reverses cadmium-induced oxidative damage on mice tissues Chem. Biol. Interact. 151 3 2005 159 165 (Pubitemid 40279060)
67. A. Latini, A.F. Bem, R. Raisman-Vozari, and C. Tasca Mechanisms of neurodegeneration in Parkinson's disease: mitochondrial dysfunction, oxidative stress and glutamatergic excitotoxicity Aderbal S. Aguiar Jr. Rui D.S. Prediger, Frontiers in Parkinson s Disease 2011 Nova Science Publishers Inc. New York 51 92
68. A.F. Bem, B. Fiuza, P. Calcerrada, P.M. Brito, G. Peluffo, T.C. Dinis, M. Trujillo, J.B. Rocha, R. Radi, and L.M. Almeida Protective effect of diphenyl diselenide against peroxynitrite-mediated endothelial cell death: a comparison with ebselen Nitric Oxide 31 2013 20 30
69. J. Faff, and A. Frankiewicz-Jozko Effect of ubiquinone on exercise-induced lipid peroxidation in rat tissues Eur. J. Appl. Physiol. Occup. Physiol. 75 5 1997 413 417 (Pubitemid 27234888)
70. V. Glaser, G. Leipnitz, M.R. Straliotto, J. Oliveira, V.V. dos Santos, C.M. Wannmacher, A.F. de Bem, J.B. Rocha, M. Farina, and A. Latini Oxidative stress-mediated inhibition of brain creatine kinase activity by methylmercury Neurotoxicology 31 5 2010 454 460
71. S. Araragi, M. Kondoh, M. Kawase, S. Saito, M. Higashimoto, and M. Sato Mercuric chloride induces apoptosis via a mitochondrial-dependent pathway in human leukemia cells Toxicology 184 1 2003 1 9 (Pubitemid 36009304)
72. N. Mori, A. Yasutake, and K. Hirayama Comparative study of activities in reactive oxygen species production/defense system in mitochondria of rat brain and liver, and their susceptibility to methylmercury toxicity Arch. Toxicol. 81 11 2007 769 776 (Pubitemid 350043640)