Diphenyl diselenide decreases serum levels of total cholesterol and tissue oxidative stress in cholesterol-fed rabbits

Basic and Clinical Pharmacology and Toxicology

Volumn 105, Issue 1, 2009, Pages 17-23

  De Bem, Andreza Fabro ^a   De Lima Portella, Rafael ^b   Colpo, Elisângela ^b   Duarte, Marta Maria Medeiros Frescura ^b   Frediane, Andressa ^b   Taube, Paulo Sergio ^b   Nogueira, Cristina Wayne ^b   Farina, Marcelo ^a   Da Silva, Edson Luiz ^a   Teixeira Rocha, João Batista ^b  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; DIPHENYL DISELENIDE; PORPHOBILINOGEN SYNTHASE; REACTIVE OXYGEN METABOLITE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOL GROUP;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD; BRAIN; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG LIVER LEVEL; EXPERIMENTAL RABBIT; HYPERCHOLESTEROLEMIA; LABORATORY; LIVER; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; THERAPY EFFECT; TREATMENT DURATION; TREATMENT RESPONSE;

ORYCTOLAGUS CUNICULUS;

EID: 84983723705     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2009.00414.x     Document Type: Article

References (40)

1. Penn MS, Chisolm GM. Oxidized lipoproteins, altered cell function and atherosclerosis. Atherosclerosis 1994 108 Suppl : S21 9.
2. Prasad K, Kalra J. Oxygen free radicals and hypercholesterolemic atherosclerosis: effect of vitamin E. Am Heart J 1993 125 : 958 73.
3. Sulyok S, Bar-Pollak Z, Feher E, Kemenes I, Kantor I, Feher J. Liver lipid peroxidation induced by cholesterol and its treatment with a dihydroquinoline type free radical scavenger in rabbits. Acta Physiol Hung 1984 64 : 437 42.
4. Wojcicki J, Rozewicka L, Barcew-Wiszniewska B, Samochowiec L, Juzwiak S, Kadlubowska D et al. Effect of selenium and vitamin E on the development of experimental atherosclerosis in rabbits. Atherosclerosis 1991 87 : 9 16.
5. Negis Y, Aytan N, Ozer N, Ogru E, Libinaki R, Gianello R et al. The effect of tocopheryl phosphates on atherosclerosis progression in rabbits fed with a high cholesterol diet. Arch Biochem Biophys 2006 450 : 63 6.
6. Jenner A, Ren M, Rajendran R, Ning P, Huat BT, Watt F et al. Zinc supplementation inhibits lipid peroxidation and the development of atherosclerosis in rabbits fed a high cholesterol diet. Free Radic Biol Med 2007 42 : 559 66.
7. Flohe L, Gunzler WA, Schock HH. Glutathione peroxidase: a selenoenzyme. FEBS Lett 1973 32 : 132 4.
8. Engman L, Cotgreave I, Angulo M, Taylor CW, Paine-Murrieta GD, Powis G. Diaryl chalcogenides as selective inhibitors of thioredoxin reductase and potential antitumor agents. Anticancer Res 1997 17 : 4599 605.
9. Navarro-Alarcon M, Lopez-Martinez MC. Essentiality of selenium in the human body: relationship with different diseases. Sci Total Environ 2000 249 : 347 71.
10. Rayman MP. The importance of selenium to human health. Lancet 2000 356 : 233 41.
11. El-Bayoumy K. The protective role of selenium on genetic damage and on cancer. Mutat Res 2001 475 : 123 39.
12. Huang K, Liu H, Chen Z, Xu H. Role of selenium in cytoprotection against cholesterol oxide-induced vascular damage in rats. Atherosclerosis 2002 162 : 137 44.
13. Dhingra S, Bansal MP. Hypercholesterolemia and apolipoprotein B expression: regulation by selenium status. Lipids Health Dis 2005 4 : 28.
14. Nogueira CW, Zeni G, Rocha JB. Organoselenium and organotellurium compounds: toxicology and pharmacology. Chem Rev 2004 104 : 6255 85.
15. Bem AF, Farina M, Portella RD, Nogueira C, Dinis T, Laranjinha JA et al. Diphenyl diselenide, a simple glutathione peroxidase mimetic, inhibits human LDL oxidation in vitro. Atherosclerosis 2008 201 : 92 100A.
16. Barbosa NB, Rocha JB, Wondracek DC, Perottoni J, Zeni G, Nogueira CW. Diphenyl diselenide reduces temporarily hyperglycemia: possible relationship with oxidative stress. Chem Biol Interact 2006 163 : 230 8.
17. Barbosa NB, Rocha JB, Soares JC, Wondracek DC, Gonçalves JF, Schetinger MR. Dietary diphenyl diselenide reduces the STZ-induced toxicity. Food Chem Toxicol 2008 46 : 186 94.
18. Rossato JI, Ketzer LA, Centuriao FB, Silva SJ, Ludtke DS, Zeni G et al. Antioxidant properties of new chalcogenides against lipid peroxidation in rat brain. Neurochem Res 2002 27 : 297 303. (Pubitemid 34273571)
19. Meotti FC, Stangherlin EC, Zeni G, Nogueira CW, Rocha JB. Protective role of aryl and alkyl diselenides on lipid peroxidation. Environ Res 2004 94 : 276 82.
20. Posser T, Moretto MB, Dafre AL, Farina M, da Rocha JB, Nogueira CW et al. Antioxidant effect of diphenyl diselenide against sodium nitroprusside (SNP) induced lipid peroxidation in human platelets and erythrocyte membranes: an in vitro evaluation. Chem Biol Interact 2006 164 : 126 35.
21. Bem AF, de Lima Portella R, Perottoni J, Becker E, Bohrer D, Paixao MW et al. Changes in biochemical parameters in rabbits blood after oral exposure to diphenyl diselenide for long periods. Chem Biol Interact 2006 162 : 1 10. (Pubitemid 44080162)
22. Bem AF, Portella RL, Farina M, Perottoni J, Paixao MW, Nogueira CW et al. Low toxicity of diphenyl diselenide in rabbits: a long-term study. Basic Clin Pharmacol Toxicol 2007 101 : 47 55 (Pubitemid 46934649)
23. Nogueira CW, Quinhones EB, Jung EA, Zeni G, Rocha JB. Anti-inflammatory and antinociceptive activity of diphenyl diselenide. Inflamm Res 2003 52 : 56 63. (Pubitemid 36286702)
24. Paulmier C. Selenium reagents and intermediates. Organic Synthesis Pergamon, Oxford. 1986.
25. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951 193 : 265 75.
26. Sassa S. δ-aminolevulinic acid dehydratase assay. Enzyme 1982 28 : 133 45.
27. Ellman GL. Tissue sulfhydryl groups. Arch Biochem Biophys 1959 82 : 70 7.
28. Bonini MG, Rota C, Tomasi A, Mason RP. The oxidation of 2′,7′-dichlorofluorescin to reactive oxygen species: a self-fulfilling prophesy? Free Radic Biol Med 2006 40 : 968 75.
29. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979 95 : 351 8.
30. Jacques-Silva MC, Nogueira CW, Broch LC, Flores EM, Rocha JB. Diphenyl diselenide and ascorbic acid changes deposition of selenium and ascorbic acid in liver and brain of mice. Pharmacol Toxicol 2001 88 : 119 25.
31. Puntel RL, Roos DH, Paixao MW, Braga AL, Zeni G, Nogueira CW et al. Oxalate modulates thiobarbituric acid reactive species (TBARS) production in supernatants of homogenates from rat brain, liver and kidney: effect of diphenyl diselenide and diphenyl ditelluride. Chem Biol Interact 2007 165 : 87 98. (Pubitemid 46072794)
32. Ghisleni G, Porciuncula LO, Cimarosti H, Batista TRJ, Salbego CG, Souza DO. Diphenyl diselenide protects rat hippocampal slices submitted to oxygen-glucose deprivation and diminishes inducible nitric oxide synthase immunocontent. Brain Res 2003 986 : 196 9.
33. Burger M, Fachinetto R, Calegari L, Paixao MW, Braga AL, Rocha JB. Effects of age on reserpine-induced orofacial dyskinesia and possible protection of diphenyl diselenide. Brain Res Bull 2004 64 : 339 45.
34. Mahfouz MM, Kummerow FA. Cholesterol-rich diets have different effects on lipid peroxidation, cholesterol oxides, and antioxidant enzymes in rats and rabbits. J Nutr Biochem 2000 11 : 293 302. (Pubitemid 30392416)
35. Bolayirli IM, Aslan M, Balci H, Altug T, Hacibekiroglu M, Seven A. Effects of atorvastatin therapy on hypercholesterolemic rabbits with respect to oxidative stress, nitric oxide pathway and homocysteine. Life Sci 2007 81 : 121 7.
36. Harrison D, Griendling KK, Landmesser U, Hornig B, Drexler H. Role of oxidative stress in atherosclerosis. Am J Cardiol 2003 91 : 7A 11A. (Pubitemid 36351457)
37. Draper HH, Hadley M. A review of recent studies on the metabolism of exogenous and endogenous malondialdehyde. Xenobiotica 1990 20 : 901 7.
38. Perottoni J, Lobato LP, Silveira A, Rocha JB, Emanuelli T. Effects of mercury and selenite on delta-aminolevulinate dehydratase activity and on selected oxidative stress parameters in rats. Environ Res 2004 95 : 166 73.
39. Barnard GF, Itoh R, Hohberger LH, Shemin D. Mechanism of porphobilinogen synthase. Possible role of essential thiol groups. J Biol Chem 1977 252 : 8965 74.
40. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev 2008 16 (2 CD007176.