Investigations into the potential neurotoxicity induced by diselenides in mice and rats

Toxicology

Volumn 183, Issue 1-3, 2003, Pages 29-37

  Nogueira, C W ^a   Meotti, F C ^a   Curte, E ^a   Pilissao C ^a   Zeni, G ^a   Rocha, J B T ^a  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

Diselenides; Glutamatergic and GABAergic systems; Seizures; Selenium

Indexed keywords

ALIPHATIC COMPOUND; ANTICONVULSIVE AGENT; ANTIOXIDANT; AROMATIC COMPOUND; ATROPINE; CARBAMAZEPINE; CHLORAL HYDRATE; CHOLINERGIC RECEPTOR BLOCKING AGENT; DIAZEPAM; DIPHENYL DISELENIDE; DIPROPYL DISELENIDE; DIZOCILPINE; EBSELEN; GLUTAMIC ACID; GUANOSINE; GUANOSINE PHOSPHATE; GUANOSINE TRIPHOSPHATE; MAGNESIUM SULFATE; MEPHENESIN; MUSCIMOL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROTRANSMITTER; PHENOBARBITAL; SELENIDE; SODIUM CHANNEL BLOCKING AGENT; TRITIUM; UNCLASSIFIED DRUG; VALPROIC ACID;

ALLOSTERISM; AMINO ACID TRANSPORT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN SYNAPTOSOME; CHEMICAL STRUCTURE; CONTROLLED STUDY; DEATH; DOSE RESPONSE; DRUG EFFECT; GABAERGIC SYSTEM; LATENT PERIOD; MALE; MORTALITY; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE; SPECIES DIFFERENCE; TREATMENT OUTCOME;

ANIMALIA; MAMMALIA;

EID: 84984578367     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00423-7     Document Type: Article

References (41)

1. Andersson G., Brattsand R., Hallberg A. Diaryl tellurides as inhibitors of lipid peroxidation in biological and chemical systems. Free Rad. Res. 20:1994;401-410.
2. Barbosa N.B., Rocha J.B.T., Zeni G., Emanuelli T., Beque M.C., Braga A.L. Effect of organic forms of selenium on δ-aminolevulinate dehydratase from liver, kidney and brain of adult rats. Toxicol. Appl. Pharmacol. 149:1998;243-253.
3. Behne D., Kyriakopoulos A. Identification of type I iodothyronine 5′-deiodinase as a selenoenzyme. Biochem. Biophys. Res. Commun. 173:1990;1143-1149.
4. Bolzan, R.C., Folmer, V., Farina, M., Zeni, G., Nogueira, C.W., Rocha, J.B.T., Emanuelli, T. 2002. δ-Aminolevulinate dehydratase inhibition by phenyl selenoacetylene: effect of reaction with hydrogen peroxide. Pharmacol. Toxicol. 90, 214-219.
5. Bradford M.M. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-254.
6. Caldwell J. The current status of attempts to predict species differences in drug metabolism. Drug Metab. Rev. 12:1981;221-237.
7. Caldwell J. Conjugation reactions in foreign compound metabolism: definition, consequences and species variations. Drug Metab. Rev. 13:1982;745-777.
8. Ellman G.L. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7:1961;88-95.
9. Engman L. Expedient synthesis of Ebselen and related compounds. J. Org. Chem. 54:1989;2964-2966.
10. Farina M., Folmer V., Bolzan R.C., Andrade L.H., Zeni G., Braga A.L., Rocha J.B.T. Selenoxides inhibit δ-aminolevulinate acid dehydratase. Toxicol. Lett. 119:2001;27-37.
11. Farina, M., Barbosa, N.B., Nogueira, C.W., Folmer, V., Andrade, L.H., Zeni, G., Braga, A.L., Rocha, J.B.T. 2002. Reaction of diphenyl diselenide with peroxide and inhibition of aminolevulinate dehydratase from rat liver and cucumber leaves. Braz. J. Medi. Biol. Res. 35, 623-631.
12. Gordon A.A., Haves R.C. Cholinesterases in the blood of man. J. Biol. Chem. 133:1939;375-389.
13. Hodgson E., Levi P. Absorption and distribution. Riviere J.E. Introduction to Biochemical Toxicology. Second ed. 1994;11-48 Appleton & Lange, Norwalk, Connecticut, USA.
14. Hucker H.B. Species differences in drug metabolism. Annu. Rev. Pharmacol. 10:1970;99-117.
15. Jacques-Silva M.C., Nogueira C.W., Broch L.C., Rocha J.B.T. Diphenyl diselenide and ascorbic acid changes deposition of selenium and ascorbic acid in brain of mice. Pharmacol. Toxicol. 88:2001;119-125.
16. Kohl B.K., Dannhardt G. The NMDA receptor complex: a promising target for novel antiepileptic strategies. Curr. Med. Chem. 8:2001;1275-1289.
17. Lara D.R., Schmidt A.P., Frizzo M.E.S., Burgos J.S., Ramirez G.I., Souza D.O. Effect of orally administered guanosine on seizures and death induced by glutamatergic agents. Brain Res. 912:2001;176-180.
18. Lipton S.A., Rosenberg P.A. Mechanisms of disease. Excitatory amino acids as a final common pathway for neurological disorders. N. Eng. J. Med. 330:1994;613-622.
19. Litchfield J.T., Wilcoxon F. A simplified method of evaluating dose-effect experiments. JPET. 96:1949;99-113.
20. Maciel N., Bolzan R.C., Braga A.L., Rocha J.B.T. Diphenyl diselenide and diphenyl ditelluride differentially affects aminolevulinate dehydratase from liver, kidney and brain of mice. J. Biochem. Mol. Toxicol. 14:2000;310-319.
21. Müller A., Gabriel H., Sies H. A novel biologically active selenoorganic compound protective glutathione-dependent effect of PZ 51 (Ebselen) against ADP-Fe-induced lipid peroxidation in isolated hepatocytes. Biochem. Pharmacol. 34:1985;1185-1189.
22. Nogueira C.W., Soares F.A., Bolzan R., Jacques-Silva M.C., Souza D.O., Rocha J.B.T. Investigations into the mechanism of 2,3-dimercaptopropanol neurotoxicity. Neurochem. Res. 12:2000;1553-1558.
23. Nogueira, C.W., Maciel, E.M., Zeni, G., Graça, D., Rocha, J.B.T., 2001a. Biochemical toxicology of simple diorganoyl chalcogenides. ECSOC Electronic Conference on Synthetic Organic Chemistry, http://www.mdpi.net/ecsoc-5/d0013 .
24. Nogueira C.W., Rotta L.N., Perry M.L., Souza D.O., Rocha J.B.T. Diphenyl diselenide and diphenyl ditelluride affect the rat glutamatergic system in vitro and in vivo. Brain Res. 906:2001;157-163514.
25. Nogueira C.W., Rotta L.N., Zeni G., Souza D.O., Rocha J.B.T. Exposure to Ebselen changes glutamate uptake and release by rat brain synaptosomes. Neurochem. Res. 27:2002;283-288.
26. Painter E.P. The chemistry and toxicity of selenium compounds, with special reference to the selenium problem. Chem. Rev. 1941;179-213.
27. Parnham M.J., Graf E. Pharmacology of synthetic organic selenium compounds. Prog. Drug Res. 36:1991;1-47.
28. Paulmier C. Selenoorganic functional groups. Paulmier C. Selenium Reagents and Intermediates in Organic Synthesis. First ed:1986;25-51 Pergamon Press, Oxford, England.
29. Penrith M.L. Acute selenium toxicosis as a cause of paralysis in pigs. J. S. Afr. Vet. Assoc. 66:1995;47-48.
30. Price D.L. New order from neurological disorders. Nature. 399:1999;A3-A5.
31. Rocha J.B.T., Mello C.F., Sarkis J.J., Dias R.D. Undernutrition during the preweaning period changes calcium ATPase and ADPase activities of synaptosomal fractions of weanling rats. Br. J. Nutr. 63:1990;273-283.
32. Rocha J.B.T., Emanuelli T., Pereira M.E. Effects of early undernutrition on kinetic parameters of brain acetylcholinesterase from adult rats. Acta Neurobiol. Exp. 53:1993;431-437.
33. Rossato J.I., Zeni G., Mello C.F., Rubin M.A., Rocha J.B.T. Ebselen blocks the quinolinic acid-induced production of thiobarbituric acid reactive species but does not prevent the behavioral alterations produced by intrastriatal quinolinic acid administration in rat. Neurosci. Lett. 318:2002a;137-140.
34. Rossato J.I., Ketzer L.A., Centurião F.B., Silva S.J.N., Lüdtke D.S., Zeni G., Braga A.L., Rubin M.A., Rocha J.B.T. Antioxidant properties of new chalcogenides against lipid peroxidation in rat brain. Neurochem. Res. 27:2002b;297-303.
35. Saito L., Asano T., Sano K., Takakura K., Abe H., Yoshimoto T., Kikichi H., Ohta T., Ishibashi S. Neuroprotective effect of an antioxidant, ebselen, in patients with delayed neurological deficits after aneurysmal subarachnoid hemorrhage. Neurosurgery. 42:1998;269-278.
36. Spallholz J.E. On the nature of selenium toxicity and carcinostatic activity. Free Rad. Biol. Med. 17:1993;45-64.
37. Timbrell J. Factors affecting toxic responses: disposition. Timbrell J. Principles of Biochemical Toxicology. Third ed:2000;25-62 Taylor & Francis Ltd, Philadelphia, USA.
38. Ursini F., Heim S., Kiess M., Maiorino M., Roveri A., Wissing J., Flohé L. Dual function of the selenoprotein PHGPx during sperm maturation. Science. 285:1990;1393-1396.
39. Wilson S.R., Zucker P.A., Huang R.C., Spector A. Development of synthetic compounds with glutathione peroxidase activity. J. Am. Chem. Soc. 111:1989;5936-5939.
40. Wingler K., Brigelius-Flohé R. Gastrointestinal glutathione peroxidase. Biofactors. 10:1999;245-249.
41. Yamaguchi T., Sano K., Takakura K., Saito I., Shinohara Y., Asano T., Yasuhara H. Ebselen in acute ischemic stroke. A placebo-controlled, double-blind clinical trial. Stroke. 29:1998;12-17.