Thrombin stimulates albumin transcytosis in lung microvascular endothelial cells via activation of acid sphingomyelinase

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 310, Issue 8, 2016, Pages L720-L732

  Kuebler, Wolfgang M ^a,b,c,d   Wittenberg, Claudia ^a   Lee, Warren L ^c,d   Reppien, Eike ^e   Goldenberg, Neil M ^c   Lindner, Karsten ^e   Gao, Yizhuo ^c   Winoto Morbach, Supandi ^f   Drab, Marek ^g   Mühlfeld, Christian ^h,i,j   Dombrowsky, Heike ^e   Ochs, Matthias ^h,i,j   Schütze, Stefan ^f   Uhlig, Stefan ^e,k  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b DEUTSCHES HERZZENTRUM BERLIN   (Germany)

^c ST MICHAEL'S HOSPITAL   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

^e RESEARCH CENTER BORSTEL   (Germany)

^f UNIVERSITY OF KIEL   (Germany)

^g INSTITUTE OF IMMUNOLOGY AND EXPERIMENTAL THERAPY   (Poland)

^h HANNOVER MEDICAL SCHOOL   (Germany)

ⁱ Member of the German Center for Lung Research   (Germany)

^j Excellence Cluster REBIRTH   (Germany)

^k RWTH AACHEN UNIVERSITY   (Germany)

more..

Author keywords

Acid sphingomyelinase; Acute lung injury; Caveolin 1; Ceramide; Transcytosis

Indexed keywords

ALBUMIN; CAVEOLIN 1; CERAMIDE; GOLD COMPLEX; MEMBRANE LIPID; SPHINGOMYELIN PHOSPHODIESTERASE; THROMBIN; ALBUMINOID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BOVINE; CAPILLARY ENDOTHELIAL CELL; CELL LYSATE; CELL MEMBRANE PERMEABILITY; CELL TRANSPORT; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME ACTIVATION; FLUORESCENCE IMAGING; HUMAN; HUMAN CELL; IMMUNOGOLD LABELING; IN VITRO STUDY; IN VIVO STUDY; ISOLATED LUNG; LIPID RAFT; LUNG ALVEOLUS CELL; LUNG ENDOTHELIUM; LUNG PERFUSION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PULMONARY ARTERY; RAT; TRANSCYTOSIS; WHOLE CELL; ANIMAL; CELL CULTURE; CYTOLOGY; ENDOTHELIUM CELL; ENZYMOLOGY; LUNG; MEMBRANE MICRODOMAIN; METABOLISM; MICROVASCULATURE; PHYSIOLOGY; PROTEIN TRANSPORT; SPRAGUE DAWLEY RAT; VASCULAR ENDOTHELIUM; VASCULARIZATION;

ALBUMINS; ANIMALS; CATTLE; CAVEOLIN 1; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; HUMANS; LUNG; MALE; MEMBRANE MICRODOMAINS; MICROVESSELS; PROTEIN TRANSPORT; RATS, SPRAGUE-DAWLEY; SPHINGOMYELIN PHOSPHODIESTERASE; THROMBIN; TRANSCYTOSIS;

EID: 84983742732     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00157.2015     Document Type: Article

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