Ceramide alters endothelial cell permeability by a nonapoptotic mechanism

British Journal of Pharmacology

Volumn 145, Issue 1, 2005, Pages 132-140

  Lindner, Karsten ^a   Uhlig, Ulrike ^a   Uhlig, Stefan ^a  

^a RESEARCH CENTER BORSTEL   (Germany)

Author keywords

Ceramide; Edema; Endothelial permeability; Human microvascular endothelial cells; Nonapoptotic; Ser Thr kinase; Sphingosine 1 phosphate

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; CASPASE 8; CERAMIDE; CERAMIDE DERIVATIVE; DIHYDROCERAMIDE; ISOENZYME; K 252A; K 252B; L 108; LACTATE DEHYDROGENASE; PHOSPHOLIPASE C INHIBITOR; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; SINGLE STRANDED DNA; SPHINGOSINE 1 PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BLOOD VESSEL PERMEABILITY; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; COW; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; LUNG EDEMA; LUNG ENDOTHELIUM; MONOLAYER CULTURE; NONHUMAN; PRIORITY JOURNAL; SECOND MESSENGER;

ANIMALS; APOPTOSIS; CATTLE; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; CERAMIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; LYSOPHOSPHOLIPIDS; NECROSIS; SPHINGOSINE;

EID: 18744369317     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706173     Document Type: Article

References (37)

1. BAIN, J., MCLAUCHLAN, H., ELLIOTT, M. & COHEN, P. (2003). The specificities of protein kinase inhibitors: an update. Biochem. J., 371, 199-204.
2. CASTILLO, S.S. & TEEGARDEN, D. (2003). Sphingosine-1-phosphate inhibition of apoptosis requires mitogen-activated protein kinase phosphatase-1 in mouse fibroblast C3H10T 1/2 cells. J. Nutr., 133, 3343-3349.
3. DUDEK, S.M. & GARCIA, J.G.N. (2001). Cytoskeletal regulation of pulmonary vascular permeability. J. Appl. Physiol., 91, 1487-1500.
4. ESCARGUEIL-BLANC, I., ANDRIEU-ABADIE, N., CASPAR-BAUGUIL, S., BROSSMER, R., LEVADE, T., NEGRE-SALVAYRE, A. & SALVAYRE, R. (1998). Apoptosis and activation of the sphingomyelin-ceramide pathway induced by oxidized low density lipoproteins are not causally related in ECV-304 endothelial cells. J. Biol. Chem., 273, 27389-27395.
5. FRANKFURT, O.S. & KRISHAN, A. (2001). Enzyme-linked immunosorbent assay (ELISA) for the specific detection of apoptotic cells and its application to rapid drug screening. J. Immunol. Methods, 253, 133-144.
6. GARCIA, J.G., LIU, F., VERIN, A.D., BIRUKOVA, A., DECHERT, M.A., GERTHOFFER, W.T., BAMBERG, J.R. & ENGLISH, D. (2001). Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. J. Clin. Invest., 108, 689-701.
7. GARCIA, J.G.N., SIFLINGER-BIRNBOIM, A., BIZIOS, R., DELVECCHIO, P.J., FENTON, J.W. & MALIK, A.B. (1986). Thrombin-induced increase in albumin permeability across the endothelium. J. Cell. Physiol., 128, 96-104.
8. GOGGEL, R., WINOTO-MORBACH, S., VIELHABER, G., IMAI, Y., LINDNER, K., BRADE, L., BRADE, H., EHLERS, S., SLUTSKY, A.S., SCHÜTZE, S., GULBINS, E. & UHLIG, S. (2004). PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. Nat. Med, 10, 155-160.
9. HAIMOVITZ-FRIEDMAN, A., CORDON-CARDO, C., BAYOUMY, S., GARZOTTO, M., MCLOUGHLIN, M., GALLILY, R., EDWARDS, C.K., SCHUCHMAN, E.H., FUKS, Z. & KOLESNICK, R. (1997). Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation. J. Exp. Med., 189, 1831-1841.
10. 2+/calmodulin- dependent protein kinase II by K252a and its derivative, KT5926. Biochem. Biophys. Res. Commun., 181, 423-429.
11. HIDAKA, H., INAGAKI, M., KAWAMOTO, S. & SASAKI, Y. (1984). Isoquinoline-sulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry (Mosc), 23, 5036-5041.
12. HISANO, N., YATOMI, Y., SATOH, K., AKIMOTO, S., MITSUMATA, M., FUJINO, M.A. & OZAKI, Y. (1999). Induction and suppression of endothelial cell apoptosis by sphingolipids: a possible in vitro model for cell-cell interactions between platelets and endothelial cells. Blood, 93, 4293-4299.
13. HOWE, C.J., LAHAIR, M.M., MAXWELL, J.A., LEE, J.T., ROBINSON, P.J., RODRIGUEZ-MORA, O., MCCUBREY, J.A. & FRANKLIN, R.A. (2002). Participation of the calcium/calmodulin-dependent kinases in hydrogen peroxide-induced IκB phosphorylation in human T lymphocytes. J. Biol. Chem., 277, 30469-30476.
14. HUWILER, A., KOLTER, T., PFEILSCHIFTER, J. & SANDHOFF, K. (2000). Physiology and pathophysiology of sphingolipid metabolism and signaling. Biochim. Biophys. Acta, 1485, 63-99.
15. ITO, M. (2003). Insulin or bFGF and C2 ceramide increase newborn rat retinal ganglion cell survival rate. Biochem. Biophys. Res. Commun., 301, 564-571.
16. KASE, H., IWAHASHI, K., NAKANISHI, S., MATSUDA, Y., YAMADA, K., TAKAHASHI, M., MURAKATA, C., SATO, A. & KANEKO, M. (1987). K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochem. Biophys. Res. Commun., 142, 436-440.
17. KOLESNICK, R. (2002). The therapeutic potential of modulating the ceramide/sphingomyelin pathway. J. Clin. Invest., 110, 3-8.
18. KOLESNICK, R. & FUKS, Z. (2003). Radiation and ceramide-induced apoptosis. Oncogene, 22, 5897-5906.
19. LAPOSATA, M., DOVNARSKY, O.K. & SHIN, H.S. (1983). Thrombin-induced gap formation in confluent endothelial cell monolayers in vitro. Blood, 62, 549-556.
20. LEGRAND, C., BOUR, J.M., JACOB, C., CAPIAUMONT, J., MARTIAL, A., MARC, A., WUDTKE, M., KRETZMER, G., DEMANGEL, C. & DUVAL, D. (1992). Lactate dehydrogenase (LDH) activity of the cultured eukaryotic cells as marker of the number of dead cells in the medium. J. Biotechnol., 25, 231-243.
21. LIU, D., JIANG, H. & GRANGE, R.W. (2005). Genistein activates the 3′, 5′-cyclic adenosine monophosphate signaling pathway in vascular endothelial cells and protects endothelial barrier function. Endocrinology, 146, 1312-1320.
22. MADGE, L.A., SIERRA-HONIGMANN, M.R. & POBER, J.S. (1999). Apoptosis-inducing agents cause rapid shedding of tumor necrosis factor receptor 1 (TNFR1). A nonpharmacological explanation for inhibition of TNF-mediated activation. J. Biol. Chem., 274, 13643-13649.
23. MALLAMPALLI, R.K., PETERSON, E.J., BRENT CARTER, A., SALOME, R.G., MATHUR, S.N. & KORETZKY, O.A. (1999). TNF-α increases ceramide without inducing apoptosis in alveolar type II epithelial cells. Am. J. Respir. Cell. Mol. Biol., 20, L481-L490.
24. MOHRI, T., KAMESHITA, I., SUZUKI, S., HIOKI, K., TOKUNAGA, R. & TAKATANI, S. (1998). Rapid adhesion and spread of non-adherent colon cancer Colo201 cells induced by the protein kinase inhibitors, K252a and KT5720 and suppression of the adhesion by the immunosuppressants FK506 and cyclosporin A. Cell Struct. Funct., 23, 255-264.
25. MOSMANN, T. (1983). Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65, 55-63.
26. PETRACHE, I., VERIN, A.D., CROW, M.T., BIRUKOVA, A., LIU, F. & GARCIA, J.G. (2001). Differential effect of MLC kinase in TNF-α-induced endothelial cell apoptosis and barrier dysfunction. Am. J. Physiol. Lung Cell. Mol. Physiol., 280, L1168-L1178.
27. PHILLIPS, P.O., LUM, H., MALIK, A.B. & TSAN, M.F. (1989). Phallacidin prevents thrombin-induced increases in endothelial permeability to albumin. Am. J. Physiol., 257, C562-C567.
28. POWIS, G., SEEWALD, M.J., GRATAS, C., MELDER, D., RIEBOW, J. & MODEST, E.J. (1992). Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues. Cancer Res., 52, 2835-2840.
29. RABIET, M.J., PLANTIER, J.L., RIVAL, Y., GENOUX, Y., LAMPUGNANI, M.G. & DEJANA, E. (1996). Thrombin-induced increase in endothelial permeability is associated with changes in cell-to-cell junction organization. Arterioscler. Thromb. Vasc. Biol., 16, 488-496.
30. SAITOH, M., ISHIKAWA, T., MATSUSHIMA, S., NAKA, M. & HIDAKA, H. (1987). Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase. J. Biol. Chem., 262, 7796-7801.
31. SANCHEZ, T., ESTRADA-HERNANDEZ, T., PAIK, J.H., WU, M.T., VENKATARAMAN, K., BRINKMANN, V., CLAFFEY, K. & HLA, T. (2003). Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability. J. Biol. Chem., 278, 47281-47290.
32. SCHAPHORST, K.L., CHIANG, E., JACOBS, K.N., ZAIMAN, A., NATARAJAN, V., WIGLEY, F. & GARCIA, J.G. (2003). Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products. Am. J. Physiol. Lung Cell. Mol. Physiol., 285, L258-L267.
33. SLOWIK, M.R., DE LUCA, L.G., MIN, W. & POBER, J.S. (1996). Ceramide is not a signal for tumor necrosis factor-induced gene expression but does cause programmed cell death in human vascular endothelial cells. Circ. Res., 79, 736-747.
34. 2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature, 306, 67-69.
35. TIRUPPATHI, C., NAQVI, T., SANDOVAL, R., MEHTA, D. & MALIK, A.B. (2001). Synergistic effects of tumor necrosis factor-α and thrombin in increasing endothelial permeability. Am. J. Physiol. Lung Cell. Mol. Physiol., 281, L958-L968.
36. VOURET-CRAVIARI, V., BOURCIER, C., BOULTER, E. & OBBERGHEN-SCHILLING, E. (2002). Distinct signals via Rho GTPases and Src drive shape changes by thrombin and sphingosine-1-phosphate in endothelial ceils. J. Cell Sci., 115, 2475-2484.
37. YAMADA, K., IWAHASHI, K. & KASE, H. (1987). K252a, a new inhibitor of protein kinase C concomitantly inhibits 40K protein phosphorylation and serotonin secretion in a phorbol ester-stimulated platelets. Biochem. Biophys. Res. Commun., 144, 35-40.