A human blood-brain barrier transcytosis assay reveals antibody transcytosis influenced by pH-dependent receptor binding

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Sade, Hadassah ^a   Baumgartner, Claudia ^a   Hugenmatter, Adrian ^b   Moessner, Ekkehard ^b   Freskgård, Per Ola ^c   Niewoehner, Jens ^a  

^a LMR Penzberg   (Germany)

^b Roche Pharma Research and Early Development   (Switzerland)

^c Pharma Research and Development   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

RECEPTOR ANTIBODY; SOMATOMEDIN C RECEPTOR; SOMATOMEDIN C RECEPTOR ANTIBODY; TRANSFERRIN; TRANSFERRIN RECEPTOR; TRANSFERRIN RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY AFFINITY; ANTIBODY DETECTION; ARTICLE; BIODEGRADATION; BLOOD BRAIN BARRIER; BRAIN CELL; CELL ASSAY; CELL COMPARTMENTALIZATION; CELL IMMORTALIZATION; CELL VACUOLE; CONTROLLED STUDY; ENDOSOME; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROVASCULAR ENDOTHELIAL CELL; PH; QUANTITATIVE ANALYSIS; RECEPTOR AFFINITY; RECEPTOR BINDING; TRANSCYTOSIS;

ANTIBODIES; ANTIGENS, CD; BLOOD-BRAIN BARRIER; CELL LINE; HUMANS; HYDROGEN-ION CONCENTRATION; RECEPTOR, IGF TYPE 1; RECEPTORS, TRANSFERRIN; TRANSCYTOSIS;

EID: 84899710959     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096340     Document Type: Article

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