Increased Th2 activity and diminished skin barrier function cooperate in allergic skin inflammation

European Journal of Immunology

Volumn 46, Issue 11, 2016, Pages 2609-2613

  Sehra, Sarita ^a   Krishnamurthy, Purna ^a   Koh, Byunghee ^a   Zhou, Hong Ming ^a   Seymour, Lee ^a   Akhtar, Nahid ^a   Travers, Jeffrey B ^a,b   Turner, Matthew J ^a   Kaplan, Mark H ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WRIGHT STATE UNIVERSITY   (United States)

Author keywords

Allergic skin inflammation; Atopic dermatitis; Genetic lesions; Stat6; Th2 response

Indexed keywords

STAT6 PROTEIN; FGFR1 PROTEIN, MOUSE; FIBROBLAST GROWTH FACTOR RECEPTOR 1; MEMBRANE PROTEIN; STAT6 PROTEIN, MOUSE; TMEM79 PROTEIN, MOUSE;

ALLELE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATOPIC DERMATITIS; CONTROLLED STUDY; DERMIS; GENE MUTATION; HISTOPATHOLOGY; INFLAMMATORY INFILTRATE; MATING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN ALLERGY; SKIN DEFECT; SKIN FUNCTION; TH2 CELL; TRANSGENIC MOUSE; ANIMAL; DISEASE MODEL; GENETICS; HUMAN; IMMUNOLOGY; PATHOLOGY; PATHOPHYSIOLOGY; PERMEABILITY; SKIN;

ANIMALS; DERMATITIS, ATOPIC; DISEASE MODELS, ANIMAL; HUMANS; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; PERMEABILITY; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; SKIN; STAT6 TRANSCRIPTION FACTOR; TH2 CELLS;

EID: 84983685064     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201646421     Document Type: Article

References (20)

1. Leung, D. Y. and Guttman-Yassky, E., Deciphering the complexities of atopic dermatitis: shifting paradigms in treatment approaches. J. Allergy Clin. Immunol. 2014. 134: 769–779.
2. Guttman-Yassky, E., Nograles, K. E. and Krueger, J. G., Contrasting pathogenesis of atopic dermatitis and psoriasis–part I: clinical and pathologic concepts. J. Allergy Clin. Immunol. 2011. 127: 1110–1118.
3. Guttman-Yassky, E., Nograles, K. E. and Krueger, J. G., Contrasting pathogenesis of atopic dermatitis and psoriasis–part II: immune cell subsets and therapeutic concepts. J. Allergy Clin. Immunol. 2011. 127: 1420–1432.
4. Gittler, J. K., Krueger, J. G. and Guttman-Yassky, E., Atopic dermatitis results in intrinsic barrier and immune abnormalities: implications for contact dermatitis. J. Allergy Clin. Immunol. 2013. 131: 300–313.
5. Irvine, A. D., McLean, W. H. and Leung, D. Y., Filaggrin mutations associated with skin and allergic diseases. N. Engl. J. Med. 2011. 365: 1315–1327.
6. Palmer, C. N., Irvine, A. D., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Lee, S. P., Goudie, D. R. et al., Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat. Genet. 2006. 38: 441–446.
7. Sandilands, A., Terron-Kwiatkowski, A., Hull, P. R., O'Regan, G. M., Clayton, T. H., Watson, R. M., Carrick, T. et al., Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema. Nat. Genet. 2007. 39: 650–654.
8. Fallon, P. G., Sasaki, T., Sandilands, A., Campbell, L. E., Saunders, S. P., Mangan, N. E., Callanan, J. J. et al., A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming. Nat. Genet. 2009. 41: 602–608.
9. Presland, R. B., Boggess, D., Lewis, S. P., Hull, C., Fleckman, P. and Sundberg, J. P., Loss of normal profilaggrin and filaggrin in flaky tail (ft/ft) mice: an animal model for the filaggrin-deficient skin disease ichthyosis vulgaris. J. Invest Dermatol. 2000. 115: 1072–1081.
10. Sasaki, T., Shiohama, A., Kubo, A., Kawasaki, H., Ishida-Yamamoto, A., Yamada, T. et al., A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis. J. Allergy Clin. Immunol. 2013. 132: 1111–1120 e1114.
11. Saunders, S. P., Goh, C. S., Brown, S. J., Palmer, C. N., Porter, R. M., Cole, C., Campbell, L. E. et al., Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects. J. Allergy Clin. Immunol. 2013. 132: 1121–1129.
12. Oyoshi, M. K., Murphy, G. F. and Geha, R. S., Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen. J. Allergy Clin. Immunol. 2009. 124: 485–493, 493 e481.
13. Saunders, S. P., Moran, T., Floudas, A., Wurlod, F., Kaszlikowska, A., Salimi, M., Quinn, E. M. et al., Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity. J. Allergy Clin. Immunol. 2016. 137: 482–491.
14. Sehra, S., Yao, Y., Howell, M. D., Nguyen, E. T., Kansas, G. S., Leung, D. Y., Travers, J. B. et al., IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation. J. Immunol. 2010. 184: 3186–3190.
15. Bruns, H. A., Schindler, U. and Kaplan, M. H., Expression of a constitutively active stat6 in vivo alters lymphocyte homeostasis with distinct effects in T and B cells. J. Immunol. 2003. 170: 3478–3487.
16. Sehra, S., Bruns, H. A., Ahyi, A. N., Nguyen, E. T., Schmidt, N. W., Michels, E. G., von Bulow, G. U. et al., IL-4 Is a critical determinant in the generation of allergic inflammation initiated by a constitutively active Stat6. J. Immunol. 2008. 180: 3551–3559.
17. Sehra, S., Serezani, A. P., Ocana, J. A., Travers, J. B. and Kaplan, M. H., Mast cells regulate epidermal barrier function and the development of allergic skin inflammation. J. Invest Derm. 2016. In press.
18. Howell, M. D., Kim, B. E., Gao, P., Grant, A. V., Boguniewicz, M., Debenedetto, A., Schneider, L. et al., Cytokine modulation of atopic dermatitis filaggrin skin expression. J. Allergy Clin. Immunol. 2007. 120: 150–155.
19. Sehra, S., Serezani, A. P., Ocana, J. A., Travers, J. B. and Kaplan, M. H., Mast cells regulate epidermal barrier function and the development of allergic skin inflammation. J. Invest Dermatol. 2016. 136: 1429–1437.
20. Beck, L. A., Thaci, D., Hamilton, J. D., Graham, N. M., Bieber, T., Rocklin, R., Ming, J. E. et al., Dupilumab treatment in adults with moderate-to-severe atopic dermatitis. N. Engl. J. Med. 2014. 371: 130–139.