A balanced pyrimidine pool is required for optimal Chk1 activation to prevent ultrafine anaphase bridge formation

Journal of Cell Science

Volumn 129, Issue 16, 2016, Pages 3167-3177

  Gemble, Simon ^a,b,c   Buhagiar Labarchède, Géraldine ^a,b,c   Onclercq Delic, Rosine ^a,b,c   Biard, Denis ^d   Lambert, Sarah ^a,b,c   Amor Guéret, Mounira ^a,b,c  

^a INSTITUT CURIE   (France)

^b CNRS UMR3348   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d CEA DSV iMETI SEPIA   (France)

Author keywords

Chk1; Cytidine deaminase; Nucleotide pool; PARP 1; Ultrafine anaphase bridges

Indexed keywords

CHECKPOINT KINASE 1; CYTIDINE DEAMINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PYRIMIDINE; ATM PROTEIN; ATR PROTEIN, HUMAN; CHEK1 PROTEIN, HUMAN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PYRIMIDINE DERIVATIVE;

ANAPHASE; ARTICLE; CELL CYCLE CHECKPOINT; CELL LINE; CHROMOSOME SEGREGATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MITOSIS; PRIORITY JOURNAL; ULTRAFINE ANAPHASE BRIDGE; BIOLOGICAL MODEL; CELL CYCLE S PHASE; HELA CELL LINE; METABOLISM;

ANAPHASE; ATAXIA TELANGIECTASIA MUTATED PROTEINS; CELL CYCLE CHECKPOINTS; CHECKPOINT KINASE 1; CYTIDINE DEAMINASE; DNA DAMAGE; DNA REPLICATION; ENZYME ACTIVATION; HELA CELLS; HUMANS; MODELS, BIOLOGICAL; POLY(ADP-RIBOSE) POLYMERASES; PYRIMIDINES; S PHASE;

EID: 84983672132     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.187781     Document Type: Article

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