TNF α, PDGF, and TGF β synergistically induce synovial lining hyperplasia via inducible PI3Kδ

Modern Rheumatology

Volumn 25, Issue 1, 2015, Pages 72-78

  Shibuya, Hideyuki ^a   Yoshitomi, Hiroyuki ^a   Murata, Koichi ^a   Kobayashi, Shio ^a   Furu, Moritoshi ^a   Ishikawa, Masahiro ^a   Fujii, Takayuki ^a   Ito, Hiromu ^a   Matsuda, Shuichi ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Fibroblast like synoviocytes; PDGF; PI3K ; PI3K Akt pathway; TGF

Indexed keywords

CADHERIN; CADHERIN 11; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE B; SMALL INTERFERING RNA; STROMELYSIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; OSTEOBLAST CADHERIN; PHOSPHATIDYLINOSITOL 3 KINASE;

ARTICLE; CELL ISOLATION; CELL PROLIFERATION ASSAY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST CULTURE; GENE SILENCING; GENETIC TRANSFECTION; HISTOLOGY; HUMAN; HUMAN CELL; HYPERPLASIA; HYPERTROPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SYNOVIAL HYPERPLASIA; SYNOVIOCYTE; UPREGULATION; WESTERN BLOTTING; CELL CULTURE; DRUG EFFECTS; METABOLISM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; SYNOVIUM;

ARTHRITIS, RHEUMATOID; CADHERINS; CELLS, CULTURED; HUMANS; HYPERPLASIA; MATRIX METALLOPROTEINASE 3; PHOSPHATIDYLINOSITOL 3-KINASE; PLATELET-DERIVED GROWTH FACTOR; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SYNOVIAL MEMBRANE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84983392506     PISSN: 14397595     EISSN: 14397609     Source Type: Journal    
DOI: 10.3109/14397595.2014.900847     Document Type: Article

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