Screening of small-molecule inhibitors of protein-protein interaction with capillary electrophoresis frontal analysis

Analytical Chemistry

Volumn 88, Issue 16, 2016, Pages 8050-8057

  Xu, Mei ^a   Liu, Chao ^a   Zhou, Mi ^a   Li, Qing ^a   Wang, Renxiao ^a   Kang, Jingwu ^a,b  

^a SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

^b SHANGHAITECH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CAPILLARY ELECTROPHORESIS; CHEMICAL COMPOUNDS; COMPLEXATION; DISSOCIATION; LIGANDS; SCREENING; THROUGHPUT;

CAPILLARY ELECTROPHORESIS FRONTAL ANALYSIS; DISSOCIATION CONSTANT; EQUILIBRIUM CONCENTRATION; EXPERIMENTAL MODELING; INHIBITION CONSTANTS; PROTEIN-LIGAND COMPLEXES; PROTEIN-PROTEIN INTERACTIONS; SMALL MOLECULE INHIBITOR;

PROTEINS;

4-CARBOXYFLUORESCEIN; ANILINE DERIVATIVE; FLUORESCEIN DERIVATIVE; LIGAND; NAVITOCLAX; PROTEIN BCL X; PROTEIN BID; SULFONAMIDE; TRIPTERINE; TRITERPENE;

ANTAGONISTS AND INHIBITORS; APOPTOSIS; BINDING COMPETITION; CAPILLARY ELECTROPHORESIS; CHEMISTRY; DRUG EFFECT; HT-29 CELL LINE; HUMAN; KINETICS; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; PROCEDURES; PROTEIN DOMAIN;

ANILINE COMPOUNDS; APOPTOSIS; BCL-X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; BINDING, COMPETITIVE; ELECTROPHORESIS, CAPILLARY; FLUORESCEINS; HT29 CELLS; HUMANS; KINETICS; LIGANDS; PROTEIN INTERACTION DOMAINS AND MOTIFS; SMALL MOLECULE LIBRARIES; SULFONAMIDES; TRITERPENES;

EID: 84983319494     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/acs.analchem.6b01430     Document Type: Article

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