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Volumn 8, Issue 6, 2016, Pages 1906-1916

Phylogenomic analysis of natural products biosynthetic gene clusters allows discovery of arseno-organic metabolites in model streptomycetes

Author keywords

Arseno organic metabolites; EvoMining; Natural products genome mining; Phylogenomics; Streptomyces

Indexed keywords

ANTIINFECTIVE AGENT;

EID: 84983243847     PISSN: None     EISSN: 17596653     Source Type: Journal    
DOI: 10.1093/gbe/evw125     Document Type: Article
Times cited : (86)

References (54)
  • 1
    • 0025183708 scopus 로고
    • Basic local alignment search tool
    • Altschul SF, et al. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403–410.
    • (1990) J. Mol. Biol. , vol.215 , pp. 403-410
    • Altschul, S.F.1
  • 2
    • 79955570812 scopus 로고    scopus 로고
    • Identification and quantification of arsenolipids using reversed-phase HPLC coupled simultaneously to high-resolution ICPMS and high-resolution electrospray SM without species-specific standards
    • Amayo KO, et al. 2011. Identification and quantification of arsenolipids using reversed-phase HPLC coupled simultaneously to high-resolution ICPMS and high-resolution electrospray SM without species-specific standards. Anal. Chem. 83:3589–3595.
    • (2011) Anal. Chem. , vol.83 , pp. 3589-3595
    • Amayo, K.O.1
  • 3
    • 40549120596 scopus 로고    scopus 로고
    • The RAST server: Rapid annotations using subsystems technology
    • Aziz RK, et al. 2008. The RAST Server: rapid annotations using subsystems technology. BMC Genomics 9:75.
    • (2008) BMC Genomics , vol.9 , pp. 75
    • Aziz, R.K.1
  • 4
    • 84895072793 scopus 로고    scopus 로고
    • Microbial genome mining for accelerated natural products discovery: Is a renaissance in the making?
    • Bachmann BO, Van Lanen SG, Baltz RH. 2014. Microbial genome mining for accelerated natural products discovery: is a renaissance in the making? J. Ind. Microbiol. Biotechnol. 41:175–184.
    • (2014) J. Ind. Microbiol. Biotechnol. , vol.41 , pp. 175-184
    • Bachmann, B.O.1    Van Lanen, S.G.2    Baltz, R.H.3
  • 5
    • 11444260150 scopus 로고    scopus 로고
    • Identification of a cluster of genes that directs Desferrioxamine biosynthesis in Streptomyces coelicolor M145
    • Barona-Gómez F, et al. 2004. Identification of a cluster of genes that directs Desferrioxamine biosynthesis in Streptomyces coelicolor M145. J. Am. Chem. Soc. 126:16282–16283.
    • (2004) J. Am. Chem. Soc. , vol.126 , pp. 16282-16283
    • Barona-Gómez, F.1
  • 6
    • 84856188450 scopus 로고    scopus 로고
    • What can genome-scale metabolic network reconstructions do for prokaryotic systematics?
    • Barona-Gómez F, Cruz-Morales P, Noda-García L. 2012. What can genome-scale metabolic network reconstructions do for prokaryotic systematics? Anton. Van Leeuwenhoek 101:35–43.
    • (2012) Anton. Van Leeuwenhoek , vol.101 , pp. 35-43
    • Barona-Gómez, F.1    Cruz-Morales, P.2    Noda-García, L.3
  • 7
    • 0037046560 scopus 로고    scopus 로고
    • Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
    • Bentley SD, et al. 2002. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 417:141–147.
    • (2002) Nature , vol.417 , pp. 141-147
    • Bentley, S.D.1
  • 8
    • 20444397992 scopus 로고    scopus 로고
    • Genome-scale analysis of Streptomyces coelicolor A3(2) metabolism
    • Borodina I, Krabben P, Nielsen J. 2005. Genome-scale analysis of Streptomyces coelicolor A3(2) metabolism. Genome Res. 15(6):820–829.
    • (2005) Genome Res , vol.15 , Issue.6 , pp. 820-829
    • Borodina, I.1    Krabben, P.2    Nielsen, J.3
  • 9
    • 56949085134 scopus 로고    scopus 로고
    • The origin and evolution of modern metabolism
    • Caetano-Anollés G, et al. 2009. The origin and evolution of modern metabolism. Int. J. Biochem. Cell Biol. 41:285–297.
    • (2009) Int. J. Biochem. Cell Biol. , vol.41 , pp. 285-297
    • Caetano-Anollés, G.1
  • 10
    • 84857188863 scopus 로고    scopus 로고
    • ArtemiS: An integrated platform for visualization and analysis of high-throughput sequence-based experimental data
    • Carver T, et al. 2012. Artemis: an integrated platform for visualization and analysis of high-throughput sequence-based experimental data. Bioinformatics 28(4):464–469.
    • (2012) Bioinformatics , vol.28 , Issue.4 , pp. 464-469
    • Carver, T.1
  • 11
    • 48449098635 scopus 로고    scopus 로고
    • Mining microbial genomes for new natural products and biosynthetic pathways
    • Challis G. 2008. Mining microbial genomes for new natural products and biosynthetic pathways. Microbiology (Reading, England) 154:1555–1569.
    • (2008) Microbiology (Reading, England) , vol.154 , pp. 1555-1569
    • Challis, G.1
  • 12
    • 84895075252 scopus 로고    scopus 로고
    • Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways
    • Challis GL. 2014. Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways. J. Ind. Microbiol. Biotechnol. 41:219–232.
    • (2014) J. Ind. Microbiol. Biotechnol. , vol.41 , pp. 219-232
    • Challis, G.L.1
  • 13
    • 0029027547 scopus 로고
    • Synthesis of 3-arsonopyruvate and its interaction with phosphoenolpyruvate mutase
    • Chawla S, et al. 1995. Synthesis of 3-arsonopyruvate and its interaction with phosphoenolpyruvate mutase. Biochem. J. 308(Pt 3):931–935.
    • (1995) Biochem. J. , vol.308 , pp. 931-935
    • Chawla, S.1
  • 14
    • 84904554933 scopus 로고    scopus 로고
    • Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters
    • Cimermancic P, et al. 2014. Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. Cell 158(2):412–412.
    • (2014) Cell , vol.158 , Issue.2 , pp. 412
    • Cimermancic, P.1
  • 15
    • 84876566794 scopus 로고    scopus 로고
    • ClusterMine360: A database of microbial PKS/NRPS biosynthesis
    • Conway K, Boddy C. 2013. ClusterMine360: a database of microbial PKS/NRPS biosynthesis. Nucleic Acids Res. 41:D402–D407.
    • (2013) Nucleic Acids Res , vol.41 , pp. D402-D407
    • Conway, K.1    Boddy, C.2
  • 16
    • 84891598612 scopus 로고    scopus 로고
    • The genome sequence of Streptomyces lividans 66 reveals a novel tRNA-dependent peptide biosynthetic system within a metal-related genomic island
    • Cruz-Morales P, et al. 2013. The genome sequence of Streptomyces lividans 66 reveals a novel tRNA-dependent peptide biosynthetic system within a metal-related genomic island. Genome Biol. Evol. 5:1165–1175.
    • (2013) Genome Biol. Evol. , vol.5 , pp. 1165-1175
    • Cruz-Morales, P.1
  • 17
    • 84895074954 scopus 로고    scopus 로고
    • Importance of microbial natural products and the need to revitalize their discovery
    • Demain AL. 2014. Importance of microbial natural products and the need to revitalize their discovery. J. Ind. Microbiol. Biotechnol. 41:185–201.
    • (2014) J. Ind. Microbiol. Biotechnol. , vol.41 , pp. 185-201
    • Demain, A.L.1
  • 18
    • 84893486177 scopus 로고    scopus 로고
    • Evolutionary concepts in natural products discovery: What actinomycetes have taught us
    • Diminic J, et al. 2014. Evolutionary concepts in natural products discovery: what actinomycetes have taught us. J. Ind. Microbiol. Biotechnol. 41(2):211–217.
    • (2014) J. Ind. Microbiol. Biotechnol. , vol.41 , Issue.2 , pp. 211-217
    • Diminic, J.1
  • 19
    • 3042666256 scopus 로고    scopus 로고
    • Muscle: Multiple sequence alignment with high accuracy and high throughput
    • Edgar RC. 2004. MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res. 32:1792–1797.
    • (2004) Nucleic Acids Res , vol.32 , pp. 1792-1797
    • Edgar, R.C.1
  • 20
    • 84868350970 scopus 로고    scopus 로고
    • The molecular basis of phosphate discrimination in arsenate-rich environments
    • Elias M, et al. 2012. The molecular basis of phosphate discrimination in arsenate-rich environments. Nature 491:134–137.
    • (2012) Nature , vol.491 , pp. 134-137
    • Elias, M.1
  • 21
    • 62349139062 scopus 로고    scopus 로고
    • A Darwinian view of metabolism: Molecular properties determine fitness
    • Firn R, Jones C. 2009. A Darwinian view of metabolism: molecular properties determine fitness. J. Exp. Bot. 60:719–726.
    • (2009) J. Exp. Bot. , vol.60 , pp. 719-726
    • Firn, R.1    Jones, C.2
  • 22
    • 0034923923 scopus 로고    scopus 로고
    • Divergent evolution of enzymatic function: Mechanistically diverse superfamilies and functionally distinct suprafa-milies
    • Gerlt JA, Babbitt PC. 2001. Divergent evolution of enzymatic function: mechanistically diverse superfamilies and functionally distinct suprafa-milies. Annu. Rev. Biochem. 70:209–246.
    • (2001) Annu. Rev. Biochem. , vol.70 , pp. 209-246
    • Gerlt, J.A.1    Babbitt, P.C.2
  • 23
    • 41049092908 scopus 로고    scopus 로고
    • Identification, characterization and potent anti-tumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand
    • Gourdeau H, et al. 2007. Identification, characterization and potent anti-tumor activity of ECO-4601, a novel peripheral benzodiazepine receptor ligand. Cancer Chemother. Pharmacol. 61:911–921.
    • (2007) Cancer Chemother. Pharmacol. , vol.61 , pp. 911-921
    • Gourdeau, H.1
  • 24
    • 0037452723 scopus 로고    scopus 로고
    • PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin
    • Gust B, et al. 2003. PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin. Proc. Natl. Acad. Sci. U S A. 100:1541–1546.
    • (2003) Proc. Natl. Acad. Sci. U S A. , vol.100 , pp. 1541-1546
    • Gust, B.1
  • 25
    • 84939493603 scopus 로고    scopus 로고
    • IMG-ABC: A knowledge base to fuel discovery of biosynthetic gene clusters and novel secondary metabolites
    • Hadjithomas M, et al. 2015. IMG-ABC: a knowledge base to fuel discovery of biosynthetic gene clusters and novel secondary metabolites. MBio 6(4):e00932.
    • (2015) MBio , vol.6 , Issue.4
    • Hadjithomas, M.1
  • 26
    • 84926205808 scopus 로고    scopus 로고
    • The re-emergence of natural products for drug discovery in the genomics era
    • Harvey A, Edrada-Ebel R, Quinn R. 2015. The re-emergence of natural products for drug discovery in the genomics era. Nat. Rev. Drug Discov. 14:111–129.
    • (2015) Nat. Rev. Drug Discov. , vol.14 , pp. 111-129
    • Harvey, A.1    Edrada-Ebel, R.2    Quinn, R.3
  • 27
    • 0036848817 scopus 로고    scopus 로고
    • Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor
    • Hojati Z, et al. 2002. Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor. Chem. Biol. 9(11):1175–1187.
    • (2002) Chem. Biol. , vol.9 , Issue.11 , pp. 1175-1187
    • Hojati, Z.1
  • 28
    • 84876517188 scopus 로고    scopus 로고
    • Dobiscuit: A database of secondary metabolite biosynthetic gene clusters
    • Ichikawa N, et al. 2013. DoBISCUIT: a database of secondary metabolite biosynthetic gene clusters. Nucleic Acids Res. 41:D408–D414.
    • (2013) Nucleic Acids Res , vol.41 , pp. D408-D414
    • Ichikawa, N.1
  • 29
    • 34447317247 scopus 로고    scopus 로고
    • Investigating the metabolic capabilities of Mycobacterium tuberculosis H37Rv using the in silico strain iNJ661 and proposing alternative drug targets
    • Jamshidi N, Palsson BØ. 2007. Investigating the metabolic capabilities of Mycobacterium tuberculosis H37Rv using the in silico strain iNJ661 and proposing alternative drug targets. BMC Syst. Biol. 8(1):26.
    • (2007) BMC Syst. Biol. , vol.8 , Issue.1 , pp. 26
    • Jamshidi, N.1    Palsson, B.O.2
  • 30
    • 24744433982 scopus 로고    scopus 로고
    • Evolutionary implications of bacterial polyketide synthases
    • Jenke-Kodama H, Sandmann A, Müller R, Dittmann E. 2005. Evolutionary implications of bacterial polyketide synthases. Mol. Biol. Evol. 22(10):2027–2039.
    • (2005) Mol. Biol. Evol. , vol.22 , Issue.10 , pp. 2027-2039
    • Jenke-Kodama, H.1    Sandmann, A.2    Müller, R.3    Dittmann, E.4
  • 31
    • 84895076771 scopus 로고    scopus 로고
    • Genomics-enabled discovery of phosphonate natural products and their biosynthetic pathways
    • Ju K-S, Doroghazi J, Metcalf W. 2013. Genomics-enabled discovery of phosphonate natural products and their biosynthetic pathways. J. Ind. Microbiol. Biotechnol. 41(2):345–356.
    • (2013) J. Ind. Microbiol. Biotechnol. , vol.41 , Issue.2 , pp. 345-356
    • Ju, K.-S.1    Doroghazi, J.2    Metcalf, W.3
  • 33
    • 58249089508 scopus 로고    scopus 로고
    • In silico genome-scale reconstruction and validation of the Corynebacterium glutamicum metabolic network
    • Kjeldsen KR, Nielsen J. 2009. In silico genome-scale reconstruction and validation of the Corynebacterium glutamicum metabolic network. Biotechnol. Bioeng. 102(2):583–597.
    • (2009) Biotechnol. Bioeng. , vol.102 , Issue.2 , pp. 583-597
    • Kjeldsen, K.R.1    Nielsen, J.2
  • 34
    • 27544477567 scopus 로고    scopus 로고
    • Discovery of a new peptide natural product by Streptomyces coelicolor genome mining
    • Lautru S, Deeth R, Bailey L, Challis G. 2005. Discovery of a new peptide natural product by Streptomyces coelicolor genome mining. Nat. Chem. Biol. 1:265–269.
    • (2005) Nat. Chem. Biol. , vol.1 , pp. 265-269
    • Lautru, S.1    Deeth, R.2    Bailey, L.3    Challis, G.4
  • 35
    • 84919683283 scopus 로고    scopus 로고
    • A systematic computational analysis of biosynthetic gene cluster evolution: Lessons for engineering biosynthesis
    • Medema MH, et al. 2015a. A systematic computational analysis of biosynthetic gene cluster evolution: lessons for engineering biosynthesis. PLoS Comput. Biol. 10(12):e1004016.
    • (2015) PLoS Comput. Biol. , vol.10 , Issue.12
    • Medema, M.H.1
  • 36
    • 84939557642 scopus 로고    scopus 로고
    • Minimum information about a biosynthetic gene cluster
    • Medema MH, et al. 2015b. Minimum information about a biosynthetic gene cluster. Nat. Chem. Biol. 11(9):625–631.
    • (2015) Nat. Chem. Biol. , vol.11 , Issue.9 , pp. 625-631
    • Medema, M.H.1
  • 37
    • 84939536885 scopus 로고    scopus 로고
    • Computational approaches to natural product discovery
    • Medema MH, Fischbach MA. 2015. Computational approaches to natural product discovery. Nat. Chem. Biol. 11(9):639–648.
    • (2015) Nat. Chem. Biol. , vol.11 , Issue.9 , pp. 639-648
    • Medema, M.H.1    Fischbach, M.A.2
  • 38
    • 67650743221 scopus 로고    scopus 로고
    • Biosynthesis of phosphonic and phos-phinic acid natural products
    • Metcalf W, van der Donk W. 2009. Biosynthesis of phosphonic and phos-phinic acid natural products. Biochemistry 78:65–94.
    • (2009) Biochemistry , vol.78 , pp. 65-94
    • Metcalf, W.1    Van Der Donk, W.2
  • 39
    • 70350722394 scopus 로고    scopus 로고
    • Genomic basis for natural product biosynthetic diversity in the actinomycetes
    • Nett M, Ikeda H, Moore BS. 2009. Genomic basis for natural product biosynthetic diversity in the actinomycetes. Nat. Prod. Rep. 26:1362–1384.
    • (2009) Nat. Prod. Rep. , vol.26 , pp. 1362-1384
    • Nett, M.1    Ikeda, H.2    Moore, B.S.3
  • 40
    • 0030035418 scopus 로고    scopus 로고
    • A set of ordered cosmids and a detailed genetic and physical map for the 8 Mb Streptomyces coelicolor A3(2) chromosome
    • Redenbach M, et al. 1996. A set of ordered cosmids and a detailed genetic and physical map for the 8 Mb Streptomyces coelicolor A3(2) chromosome. Mol. Microbiol. 21:77–96.
    • (1996) Mol. Microbiol. , vol.21 , pp. 77-96
    • Redenbach, M.1
  • 41
    • 84860109324 scopus 로고    scopus 로고
    • MrBayes 3.2: Efficient Bayesian phylogenetic inference and model choice across a large model space
    • Ronquist F, et al. 2012. MrBayes 3.2: efficient Bayesian phylogenetic inference and model choice across a large model space. Syst. Biol. 61:539–542.
    • (2012) Syst. Biol. , vol.61 , pp. 539-542
    • Ronquist, F.1
  • 42
    • 84958119312 scopus 로고    scopus 로고
    • Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery
    • Rudolf JD, Yan X, Shen B. 2015. Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery. J. Ind. Microbiol. Biotechnol. 43(2–3):261–276.
    • (2015) J. Ind. Microbiol. Biotechnol. , vol.43 , Issue.2-3 , pp. 261-276
    • Rudolf, J.D.1    Yan, X.2    Shen, B.3
  • 43
    • 77955301196 scopus 로고    scopus 로고
    • Biochemical and genetic insights into asukamycin biosynthesis
    • Rui Z, et al. 2010. Biochemical and genetic insights into asukamycin biosynthesis. J. Biol. Chem. 285:24915–24924.
    • (2010) J. Biol. Chem. , vol.285 , pp. 24915-24924
    • Rui, Z.1
  • 44
    • 33644846857 scopus 로고    scopus 로고
    • Small molecules: The missing link in the central dogma
    • Schreiber S. 2005. Small molecules: the missing link in the central dogma. Nan. Chem. Biol. 1:64–66.
    • (2005) Nan. Chem. Biol. , vol.1 , pp. 64-66
    • Schreiber, S.1
  • 45
    • 84913534816 scopus 로고    scopus 로고
    • Enediynes: Exploration of microbial genomics to discover new anticancer drug leads
    • Shen B, et al. 2015. Enediynes: exploration of microbial genomics to discover new anticancer drug leads. Bioorg. Med. Chem. Lett. 25(1):9–15.
    • (2015) Bioorg. Med. Chem. Lett. , vol.25 , Issue.1 , pp. 9-15
    • Shen, B.1
  • 46
    • 79951832427 scopus 로고    scopus 로고
    • The biosynthetic genes for prenylated phenazines are located at two different chromosomal loci of Streptomyces cinnamonensis DSM 1042
    • Seeger K, et al. 2011. The biosynthetic genes for prenylated phenazines are located at two different chromosomal loci of Streptomyces cinnamonensis DSM 1042. Microb. Biotechnol. 4:252–262.
    • (2011) Microb. Biotechnol. , vol.4 , pp. 252-262
    • Seeger, K.1
  • 47
    • 79951622275 scopus 로고    scopus 로고
    • Arsenate replacing phosphate: Alternative life chemistries and ion promiscuity
    • Tawfik D, Viola R. 2011. Arsenate replacing phosphate: alternative life chemistries and ion promiscuity. Biochemistry 50:1128–1134.
    • (2011) Biochemistry , vol.50 , pp. 1128-1134
    • Tawfik, D.1    Viola, R.2
  • 48
    • 84933500464 scopus 로고    scopus 로고
    • Natural products in soil microbe interactions and evolution
    • Traxler MF, Kolter R. 2015. Natural products in soil microbe interactions and evolution. Nat. Prod. Rep. 32(7):956–970.
    • (2015) Nat. Prod. Rep. , vol.32 , Issue.7 , pp. 956-970
    • Traxler, M.F.1    Kolter, R.2
  • 49
    • 34447302758 scopus 로고    scopus 로고
    • Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica
    • Udwary D, et al. 2007. Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica. Proc. Natl. Acad. Sci. U S A. 104:10376–10381.
    • (2007) Proc. Natl. Acad. Sci. U S A. , vol.104 , pp. 10376-10381
    • Udwary, D.1
  • 50
    • 0026656738 scopus 로고
    • Secondary metabolism, inventive evolution and biochemical diversity – A review
    • Vining LC. 1992. Secondary metabolism, inventive evolution and biochemical diversity – a review. Gene 115:135–140.
    • (1992) Gene , vol.115 , pp. 135-140
    • Vining, L.C.1
  • 51
    • 33646584815 scopus 로고    scopus 로고
    • ArsRBOCT arsenic resistance system encoded by linear plasmid pHZ227 in Streptomyces sp. Strain FR-008
    • Wang L, et al. 2006. arsRBOCT arsenic resistance system encoded by linear plasmid pHZ227 in Streptomyces sp. strain FR-008. Appl. Environ. Microbiol. 72:3738–3742.
    • (2006) Appl. Environ. Microbiol. , vol.72 , pp. 3738-3742
    • Wang, L.1
  • 52
    • 65449188232 scopus 로고    scopus 로고
    • Jalview Version 2 – A multiple sequence alignment editor and analysis workbench
    • Waterhouse AM, et al. 2009. Jalview Version 2 – a multiple sequence alignment editor and analysis workbench. Bioinformatics (Oxford, England) 25:1189–1191.
    • (2009) Bioinformatics (Oxford, England) , vol.25 , pp. 1189-1191
    • Waterhouse, A.M.1
  • 53
    • 84979859096 scopus 로고    scopus 로고
    • AntiSMASH 3.0 – A comprehensive resource for the genome mining of biosynthetic gene clusters
    • Weber T, et al. 2015. antiSMASH 3.0 – a comprehensive resource for the genome mining of biosynthetic gene clusters. Nucleic Acids Res. 43(W1):W237–W243.
    • (2015) Nucleic Acids Res , vol.43 , Issue.W1 , pp. W237-W243
    • Weber, T.1
  • 54
    • 33646595699 scopus 로고    scopus 로고
    • Phosphate analogues as probes of the catalytic mechanisms of MurA and AroA, two carboxyvinyl transferases
    • Zhang F, Berti PJ. 2006. Phosphate analogues as probes of the catalytic mechanisms of MurA and AroA, two carboxyvinyl transferases. Biochemistry 45:6027–6037.
    • (2006) Biochemistry , vol.45 , pp. 6027-6037
    • Zhang, F.1    Berti, P.J.2


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