메뉴 건너뛰기




Volumn 26, Issue 12, 2015, Pages 1479-1490

Extra-virgin olive oil attenuates amyloid-β and tau pathologies in the brains of TgSwDI mice

Author keywords

Amyloid ; Blood brain barrier; Clearance; Extra virgin olive oil; Tau

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; EXTRA VIRGIN OLIVE OIL; TAU PROTEIN; AMYLOID; MAPT PROTEIN, MOUSE; OLIVE OIL;

EID: 84983158340     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2015.07.022     Document Type: Article
Times cited : (85)

References (62)
  • 1
    • 77951776829 scopus 로고    scopus 로고
    • Alzheimer's disease: strategies for disease modification
    • Citron M. Alzheimer's disease: strategies for disease modification. Nat Rev Drug Discov 2010, 9:387-398.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 387-398
    • Citron, M.1
  • 2
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: genes, proteins, and therapy
    • Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 2001, 81:741-766.
    • (2001) Physiol Rev , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 3
    • 67651180986 scopus 로고    scopus 로고
    • The amyloid hypothesis for Alzheimer's disease: a critical reappraisal
    • Hardy J. The amyloid hypothesis for Alzheimer's disease: a critical reappraisal. J Neurochem 2009, 110:1129-1134.
    • (2009) J Neurochem , vol.110 , pp. 1129-1134
    • Hardy, J.1
  • 4
    • 0042385119 scopus 로고    scopus 로고
    • Alterations in beta-amyloid production and deposition in brain regions of two transgenic models
    • Lehman E.J., Kulnane L.S., Lamb B.T. Alterations in beta-amyloid production and deposition in brain regions of two transgenic models. Neurobiol Aging 2003, 24:645-653.
    • (2003) Neurobiol Aging , vol.24 , pp. 645-653
    • Lehman, E.J.1    Kulnane, L.S.2    Lamb, B.T.3
  • 9
    • 0036849837 scopus 로고    scopus 로고
    • Major phenolic compounds in olive oil: metabolism and health effects
    • Tuck K.L., Hayball P.J. Major phenolic compounds in olive oil: metabolism and health effects. J Nutr Biochem 2002, 13:636-644.
    • (2002) J Nutr Biochem , vol.13 , pp. 636-644
    • Tuck, K.L.1    Hayball, P.J.2
  • 10
    • 33646445480 scopus 로고    scopus 로고
    • Daily consumption of a high-phenol extra-virgin olive oil reduces oxidative DNA damage in postmenopausal women
    • Salvini S., Sera F., Caruso D., Giovannelli L., Visioli F., Saieva C., et al. Daily consumption of a high-phenol extra-virgin olive oil reduces oxidative DNA damage in postmenopausal women. Br J Nutr 2006, 95:742-751.
    • (2006) Br J Nutr , vol.95 , pp. 742-751
    • Salvini, S.1    Sera, F.2    Caruso, D.3    Giovannelli, L.4    Visioli, F.5    Saieva, C.6
  • 11
    • 84912127755 scopus 로고    scopus 로고
    • Healthy eating: an NHS priority A sure way to improve health outcomes for NHS staff and the public
    • Malhotra A., Maruthappu M., Stephenson T. Healthy eating: an NHS priority A sure way to improve health outcomes for NHS staff and the public. Postgrad Med J 2014, 90:671-672.
    • (2014) Postgrad Med J , vol.90 , pp. 671-672
    • Malhotra, A.1    Maruthappu, M.2    Stephenson, T.3
  • 12
    • 68849109876 scopus 로고    scopus 로고
    • Extra virgin olive oil phenolics: absorption, metabolism, and biological activities in the GI tract
    • Corona G., Spencer J.P., Dessi M.A. Extra virgin olive oil phenolics: absorption, metabolism, and biological activities in the GI tract. Toxicol Ind Health 2009, 25:285-293.
    • (2009) Toxicol Ind Health , vol.25 , pp. 285-293
    • Corona, G.1    Spencer, J.P.2    Dessi, M.A.3
  • 13
    • 20444476857 scopus 로고    scopus 로고
    • The phenolic compounds of olive oil: structure, biological activity and beneficial effects on human health
    • Tripoli E., Giammanco M., Tabacchi G., Di Majo D., Giammanco S., La Guardia M. The phenolic compounds of olive oil: structure, biological activity and beneficial effects on human health. Nutr Res Rev 2005, 18:98-112.
    • (2005) Nutr Res Rev , vol.18 , pp. 98-112
    • Tripoli, E.1    Giammanco, M.2    Tabacchi, G.3    Di Majo, D.4    Giammanco, S.5    La Guardia, M.6
  • 14
    • 77649223901 scopus 로고    scopus 로고
    • Biological activities of phenolic compounds present in virgin olive oil
    • Cicerale S., Lucas L., Keast R. Biological activities of phenolic compounds present in virgin olive oil. Int J Mol Sci 2010, 11:458-479.
    • (2010) Int J Mol Sci , vol.11 , pp. 458-479
    • Cicerale, S.1    Lucas, L.2    Keast, R.3
  • 15
    • 3142679377 scopus 로고    scopus 로고
    • Bioavailability and antioxidant effects of olive oil phenols in humans: a review
    • Vissers M.N., Zock P.L., Katan M.B. Bioavailability and antioxidant effects of olive oil phenols in humans: a review. Eur J Clin Nutr 2004, 58:955-965.
    • (2004) Eur J Clin Nutr , vol.58 , pp. 955-965
    • Vissers, M.N.1    Zock, P.L.2    Katan, M.B.3
  • 18
    • 77953613891 scopus 로고    scopus 로고
    • Effects of dietary extra-virgin olive oil on behaviour and brain biochemical parameters in ageing rats
    • Pitozzi V., Jacomelli M., Zaid M., Luceri C., Bigagli E., Lodovici M., et al. Effects of dietary extra-virgin olive oil on behaviour and brain biochemical parameters in ageing rats. Br J Nutr 2010, 103:1674-1683.
    • (2010) Br J Nutr , vol.103 , pp. 1674-1683
    • Pitozzi, V.1    Jacomelli, M.2    Zaid, M.3    Luceri, C.4    Bigagli, E.5    Lodovici, M.6
  • 19
    • 84872746217 scopus 로고    scopus 로고
    • Long-term dietary extra-virgin olive oil rich in polyphenols reverses age-related dysfunctions in motor coordination and contextual memory in mice: role of oxidative stress
    • Pitozzi V., Jacomelli M., Catelan D., Servili M., Taticchi A., Biggeri A., et al. Long-term dietary extra-virgin olive oil rich in polyphenols reverses age-related dysfunctions in motor coordination and contextual memory in mice: role of oxidative stress. Rejuvenation Res 2012, 15:601-612.
    • (2012) Rejuvenation Res , vol.15 , pp. 601-612
    • Pitozzi, V.1    Jacomelli, M.2    Catelan, D.3    Servili, M.4    Taticchi, A.5    Biggeri, A.6
  • 20
    • 84877120241 scopus 로고    scopus 로고
    • Olive-oil-derived oleocanthal enhances beta-amyloid clearance as a potential neuroprotective mechanism against Alzheimer's disease: in vitro and in vivo studies
    • Abuznait A.H., Qosa H., Busnena B.A., El Sayed K.A., Kaddoumi A. Olive-oil-derived oleocanthal enhances beta-amyloid clearance as a potential neuroprotective mechanism against Alzheimer's disease: in vitro and in vivo studies. ACS Chem Neurosci 2013, 4:973-982.
    • (2013) ACS Chem Neurosci , vol.4 , pp. 973-982
    • Abuznait, A.H.1    Qosa, H.2    Busnena, B.A.3    El Sayed, K.A.4    Kaddoumi, A.5
  • 21
    • 84881327671 scopus 로고    scopus 로고
    • The polyphenol oleuropein aglycone protects TgCRND8 mice against Ass plaque pathology
    • Grossi C., Rigacci S., Ambrosini S., Ed Dami T., Luccarini I., Traini C., et al. The polyphenol oleuropein aglycone protects TgCRND8 mice against Ass plaque pathology. PLoS One 2013, 8:e71702.
    • (2013) PLoS One , vol.8 , pp. e71702
    • Grossi, C.1    Rigacci, S.2    Ambrosini, S.3    Ed Dami, T.4    Luccarini, I.5    Traini, C.6
  • 23
    • 24344452961 scopus 로고    scopus 로고
    • Phytochemistry: ibuprofen-like activity in extra-virgin olive oil
    • Beauchamp G.K., Keast R.S., Morel D., Lin J., Pika J., Han Q., et al. Phytochemistry: ibuprofen-like activity in extra-virgin olive oil. Nature 2005, 437:45-46.
    • (2005) Nature , vol.437 , pp. 45-46
    • Beauchamp, G.K.1    Keast, R.S.2    Morel, D.3    Lin, J.4    Pika, J.5    Han, Q.6
  • 24
    • 2442594971 scopus 로고    scopus 로고
    • Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor
    • Davis J., Xu F., Deane R., Romanov G., Previti M.L., Zeigler K., et al. Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor. J Biol Chem 2004, 279:20296-20306.
    • (2004) J Biol Chem , vol.279 , pp. 20296-20306
    • Davis, J.1    Xu, F.2    Deane, R.3    Romanov, G.4    Previti, M.L.5    Zeigler, K.6
  • 25
    • 0026907151 scopus 로고
    • A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid
    • Mullan M., Crawford F., Axelman K., Houlden H., Lilius L., Winblad B., et al. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid. Nat Genet 1992, 1:345-347.
    • (1992) Nat Genet , vol.1 , pp. 345-347
    • Mullan, M.1    Crawford, F.2    Axelman, K.3    Houlden, H.4    Lilius, L.5    Winblad, B.6
  • 26
    • 0025296269 scopus 로고
    • Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type
    • Levy E., Carman M.D., Fernandez-Madrid I.J., Power M.D., Lieberburg I., van Duinen S.G., et al. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science 1990, 248:1124-1126.
    • (1990) Science , vol.248 , pp. 1124-1126
    • Levy, E.1    Carman, M.D.2    Fernandez-Madrid, I.J.3    Power, M.D.4    Lieberburg, I.5    van Duinen, S.G.6
  • 27
    • 0034982951 scopus 로고    scopus 로고
    • Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy
    • Grabowski T.J., Cho H.S., Vonsattel J.P., Rebeck G.W., Greenberg S.M. Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy. Ann Neurol 2001, 49:697-705.
    • (2001) Ann Neurol , vol.49 , pp. 697-705
    • Grabowski, T.J.1    Cho, H.S.2    Vonsattel, J.P.3    Rebeck, G.W.4    Greenberg, S.M.5
  • 28
    • 77956554222 scopus 로고    scopus 로고
    • Separation and identification of phenolic compounds of extra virgin olive oil from Olea europaea L. by HPLC-DAD-SPE-NMR/MS. Identification of a new diastereoisomer of the aldehydic form of oleuropein aglycone
    • Pérez-Trujillo M., Gómez-Caravaca A.M., Segura-Carretero A., Fernández-Gutiérrez A., Parella T. Separation and identification of phenolic compounds of extra virgin olive oil from Olea europaea L. by HPLC-DAD-SPE-NMR/MS. Identification of a new diastereoisomer of the aldehydic form of oleuropein aglycone. J Agric Food Chem 2010, 58:9129-9136.
    • (2010) J Agric Food Chem , vol.58 , pp. 9129-9136
    • Pérez-Trujillo, M.1    Gómez-Caravaca, A.M.2    Segura-Carretero, A.3    Fernández-Gutiérrez, A.4    Parella, T.5
  • 30
    • 84904480402 scopus 로고
    • Mixed oligomers and monomeric amyloid-beta disrupts endothelial cells integrity and reduces monomeric amyloid-beta transport across hCMEC/D3 cell line as an in vitro blood-brain barrier model
    • Qosa H., LeVine H., Keller J.N., Kaddoumi A. Mixed oligomers and monomeric amyloid-beta disrupts endothelial cells integrity and reduces monomeric amyloid-beta transport across hCMEC/D3 cell line as an in vitro blood-brain barrier model. Biochim Biophys Acta 1842, 2014:1806-1815.
    • (1842) Biochim Biophys Acta , vol.2014 , pp. 1806-1815
    • Qosa, H.1    LeVine, H.2    Keller, J.N.3    Kaddoumi, A.4
  • 31
    • 80355132694 scopus 로고    scopus 로고
    • Detection of neuritic plaques in Alzheimer's disease mouse model
    • Ly P.T., Cai F., Song W. Detection of neuritic plaques in Alzheimer's disease mouse model. J Vis Exp 2011, 10.3791/2831.
    • (2011) J Vis Exp
    • Ly, P.T.1    Cai, F.2    Song, W.3
  • 32
    • 77957983425 scopus 로고    scopus 로고
    • Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2
    • Van Nostrand W.E., Xu F., Rozemuller A.J., Colton C.A. Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2. Stroke 2010, 41:S135-S138.
    • (2010) Stroke , vol.41 , pp. S135-S138
    • Van Nostrand, W.E.1    Xu, F.2    Rozemuller, A.J.3    Colton, C.A.4
  • 33
    • 84893833082 scopus 로고    scopus 로고
    • Differences in amyloid-beta clearance across mouse and human blood-brain barrier models: kinetic analysis and mechanistic modeling
    • Qosa H., Abuasal B.S., Romero I.A., Weksler B., Couraud P.O., Keller J.N., et al. Differences in amyloid-beta clearance across mouse and human blood-brain barrier models: kinetic analysis and mechanistic modeling. Neuropharmacology 2014, 79C:668-678.
    • (2014) Neuropharmacology , vol.79C , pp. 668-678
    • Qosa, H.1    Abuasal, B.S.2    Romero, I.A.3    Weksler, B.4    Couraud, P.O.5    Keller, J.N.6
  • 34
    • 35148859731 scopus 로고    scopus 로고
    • MDR1-P-glycoprotein (ABCB1) mediates transport of Alzheimer's amyloid-beta peptides - implications for the mechanisms of Abeta clearance at the blood-brain barrier
    • Kuhnke D., Jedlitschky G., Grube M., Krohn M., Jucker M., Mosyagin I., et al. MDR1-P-glycoprotein (ABCB1) mediates transport of Alzheimer's amyloid-beta peptides - implications for the mechanisms of Abeta clearance at the blood-brain barrier. Brain Pathol 2007, 17:347-353.
    • (2007) Brain Pathol , vol.17 , pp. 347-353
    • Kuhnke, D.1    Jedlitschky, G.2    Grube, M.3    Krohn, M.4    Jucker, M.5    Mosyagin, I.6
  • 35
    • 0034521392 scopus 로고    scopus 로고
    • Clearance of Alzheimer's amyloid-β(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
    • Shibata M., Yamada S., Kumar S.R., Calero M., Bading J., Frangione B., et al. Clearance of Alzheimer's amyloid-β(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J Clin Invest 2000, 106:1489-1499.
    • (2000) J Clin Invest , vol.106 , pp. 1489-1499
    • Shibata, M.1    Yamada, S.2    Kumar, S.R.3    Calero, M.4    Bading, J.5    Frangione, B.6
  • 36
    • 0033943469 scopus 로고    scopus 로고
    • Clearance of amyloid beta-peptide from brain: transport or metabolism?
    • Zlokovic B.V., Yamada S., Holtzman D., Ghiso J., Frangione B. Clearance of amyloid beta-peptide from brain: transport or metabolism?. Nat Med 2000, 6:718-719.
    • (2000) Nat Med , vol.6 , pp. 718-719
    • Zlokovic, B.V.1    Yamada, S.2    Holtzman, D.3    Ghiso, J.4    Frangione, B.5
  • 37
    • 84863895905 scopus 로고    scopus 로고
    • Enhanced brain amyloid-beta clearance by rifampicin and caffeine as a possible protective mechanism against Alzheimer's disease
    • Qosa H., Abuznait A.H., Hill R.A., Kaddoumi A. Enhanced brain amyloid-beta clearance by rifampicin and caffeine as a possible protective mechanism against Alzheimer's disease. J Alzheimers Dis 2012, 31:151-165.
    • (2012) J Alzheimers Dis , vol.31 , pp. 151-165
    • Qosa, H.1    Abuznait, A.H.2    Hill, R.A.3    Kaddoumi, A.4
  • 38
    • 84857010356 scopus 로고    scopus 로고
    • Assessing burrowing, nest construction, and hoarding in mice
    • Deacon R. Assessing burrowing, nest construction, and hoarding in mice. J Vis Exp 2012, 10.3791/2607.
    • (2012) J Vis Exp
    • Deacon, R.1
  • 39
    • 33947621993 scopus 로고    scopus 로고
    • Assessing nest building in mice
    • Deacon R.M. Assessing nest building in mice. Nat Protoc 2006, 1:1117-1119.
    • (2006) Nat Protoc , vol.1 , pp. 1117-1119
    • Deacon, R.M.1
  • 40
    • 17744376173 scopus 로고    scopus 로고
    • A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis
    • Chawla A., Boisvert W.A., Lee C.H., Laffitte B.A., Barak Y., Joseph S.B., et al. A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol Cell 2001, 7:161-171.
    • (2001) Mol Cell , vol.7 , pp. 161-171
    • Chawla, A.1    Boisvert, W.A.2    Lee, C.H.3    Laffitte, B.A.4    Barak, Y.5    Joseph, S.B.6
  • 41
    • 78049278719 scopus 로고    scopus 로고
    • Retinoid X receptors: common heterodimerization partners with distinct functions
    • Lefebvre P., Benomar Y., Staels B. Retinoid X receptors: common heterodimerization partners with distinct functions. Trends Endocrinol Metab 2010, 21:676-683.
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 676-683
    • Lefebvre, P.1    Benomar, Y.2    Staels, B.3
  • 42
    • 33845533439 scopus 로고    scopus 로고
    • Mediterranean diet, Alzheimer disease, and vascular mediation
    • Scarmeas N., Stern Y., Mayeux R., Luchsinger J.A. Mediterranean diet, Alzheimer disease, and vascular mediation. Arch Neurol 2006, 63:1709-1717.
    • (2006) Arch Neurol , vol.63 , pp. 1709-1717
    • Scarmeas, N.1    Stern, Y.2    Mayeux, R.3    Luchsinger, J.A.4
  • 43
    • 79952499466 scopus 로고    scopus 로고
    • Mediterranean diet and magnetic resonance imaging-assessed cerebrovascular disease
    • Scarmeas N., Luchsinger J.A., Stern Y., Gu Y., He J., DeCarli C., et al. Mediterranean diet and magnetic resonance imaging-assessed cerebrovascular disease. Ann Neurol 2011, 69:257-268.
    • (2011) Ann Neurol , vol.69 , pp. 257-268
    • Scarmeas, N.1    Luchsinger, J.A.2    Stern, Y.3    Gu, Y.4    He, J.5    DeCarli, C.6
  • 44
    • 77950952757 scopus 로고    scopus 로고
    • Olive oil and health: summary of the II international conference on olive oil and health consensus report, Jaen and Cordoba (Spain) 2008
    • Lopez-Miranda J., Perez-Jimenez F., Ros E., De Caterina R., Badimon L., Covas M.I., et al. Olive oil and health: summary of the II international conference on olive oil and health consensus report, Jaen and Cordoba (Spain) 2008. Nutr Metab Cardiovasc Dis 2010, 20:284-294.
    • (2010) Nutr Metab Cardiovasc Dis , vol.20 , pp. 284-294
    • Lopez-Miranda, J.1    Perez-Jimenez, F.2    Ros, E.3    De Caterina, R.4    Badimon, L.5    Covas, M.I.6
  • 45
    • 79961003604 scopus 로고    scopus 로고
    • New insights on the interaction mechanism between tau protein and oleocanthal, an extra-virgin olive-oil bioactive component
    • Monti M.C., Margarucci L., Tosco A., Riccio R., Casapullo A. New insights on the interaction mechanism between tau protein and oleocanthal, an extra-virgin olive-oil bioactive component. Food Funct 2011, 2:423-428.
    • (2011) Food Funct , vol.2 , pp. 423-428
    • Monti, M.C.1    Margarucci, L.2    Tosco, A.3    Riccio, R.4    Casapullo, A.5
  • 46
    • 0032700863 scopus 로고    scopus 로고
    • Extra-virgin olive oil increases the resistance of LDL to oxidation more than refined olive oil in free-living men with peripheral vascular disease
    • Ramirez-Tortosa M.C., Urbano G., López-Jurado M., Nestares T., Gomez M.C., Mir A., et al. Extra-virgin olive oil increases the resistance of LDL to oxidation more than refined olive oil in free-living men with peripheral vascular disease. J Nutr 1999, 129:2177-2183.
    • (1999) J Nutr , vol.129 , pp. 2177-2183
    • Ramirez-Tortosa, M.C.1    Urbano, G.2    López-Jurado, M.3    Nestares, T.4    Gomez, M.C.5    Mir, A.6
  • 47
    • 77249122543 scopus 로고    scopus 로고
    • Elevated circulating LDL phenol levels in men who consumed virgin rather than refined olive oil are associated with less oxidation of plasma LDL
    • de la Torre-Carbot K., Chávez-Servín J.L., Jaúregui O., Castellote A.I., Lamuela-Raventós R.M., Nurmi T., et al. Elevated circulating LDL phenol levels in men who consumed virgin rather than refined olive oil are associated with less oxidation of plasma LDL. J Nutr 2010, 140:501-508.
    • (2010) J Nutr , vol.140 , pp. 501-508
    • de la Torre-Carbot, K.1    Chávez-Servín, J.L.2    Jaúregui, O.3    Castellote, A.I.4    Lamuela-Raventós, R.M.5    Nurmi, T.6
  • 48
    • 70349241517 scopus 로고    scopus 로고
    • Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal
    • Pitt J., Roth W., Lacor P., Smith A.B., Blankenship M., Velasco P., et al. Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal. Toxicol Appl Pharmacol 2009, 240:189-197.
    • (2009) Toxicol Appl Pharmacol , vol.240 , pp. 189-197
    • Pitt, J.1    Roth, W.2    Lacor, P.3    Smith, A.B.4    Blankenship, M.5    Velasco, P.6
  • 49
    • 0032837741 scopus 로고    scopus 로고
    • The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging
    • Wang J., Dickson D.W., Trojanowski J.Q., Lee V.M. The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging. Exp Neurol 1999, 158:328-337.
    • (1999) Exp Neurol , vol.158 , pp. 328-337
    • Wang, J.1    Dickson, D.W.2    Trojanowski, J.Q.3    Lee, V.M.4
  • 50
    • 0027518937 scopus 로고
    • Alzheimer's disease-like dystrophic neurites characteristically associated with senile plaques are not found within other neurodegenerative diseases unless amyloid beta-protein deposition is present
    • Benzing W.C., Mufson E.J., Armstrong D.M. Alzheimer's disease-like dystrophic neurites characteristically associated with senile plaques are not found within other neurodegenerative diseases unless amyloid beta-protein deposition is present. Brain Res 1993, 606:10-18.
    • (1993) Brain Res , vol.606 , pp. 10-18
    • Benzing, W.C.1    Mufson, E.J.2    Armstrong, D.M.3
  • 51
    • 67249087641 scopus 로고    scopus 로고
    • Soluble oligomers of amyloid beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake
    • Li S., Hong S., Shepardson N.E., Walsh D.M., Shankar G.M., Selkoe D. Soluble oligomers of amyloid beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron 2009, 62:788-801.
    • (2009) Neuron , vol.62 , pp. 788-801
    • Li, S.1    Hong, S.2    Shepardson, N.E.3    Walsh, D.M.4    Shankar, G.M.5    Selkoe, D.6
  • 52
    • 68849119806 scopus 로고    scopus 로고
    • Mediterranean diet and late-life cognitive impairment: a taste of benefit
    • Knopman D.S. Mediterranean diet and late-life cognitive impairment: a taste of benefit. JAMA 2009, 302:686-687.
    • (2009) JAMA , vol.302 , pp. 686-687
    • Knopman, D.S.1
  • 54
    • 67349142021 scopus 로고    scopus 로고
    • Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease
    • Bell R.D., Zlokovic B.V. Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol 2009, 118:103-113.
    • (2009) Acta Neuropathol , vol.118 , pp. 103-113
    • Bell, R.D.1    Zlokovic, B.V.2
  • 55
    • 4043061467 scopus 로고    scopus 로고
    • LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms
    • Deane R., Wu Z., Sagare A., Davis J., Du Yan S., Hamm K., et al. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron 2004, 43:333-344.
    • (2004) Neuron , vol.43 , pp. 333-344
    • Deane, R.1    Wu, Z.2    Sagare, A.3    Davis, J.4    Du Yan, S.5    Hamm, K.6
  • 56
    • 33748753481 scopus 로고    scopus 로고
    • Clearance of amyloid-beta in Alzheimer's disease: progress, problems and perspectives
    • Wang Y.J., Zhou H.D., Zhou X.F. Clearance of amyloid-beta in Alzheimer's disease: progress, problems and perspectives. Drug Discov Today 2006, 11:931-938.
    • (2006) Drug Discov Today , vol.11 , pp. 931-938
    • Wang, Y.J.1    Zhou, H.D.2    Zhou, X.F.3
  • 57
    • 84864806543 scopus 로고    scopus 로고
    • Apolipoprotein E, amyloid-β clearance and therapeutic opportunities in Alzheimer's disease
    • Kline A. Apolipoprotein E, amyloid-β clearance and therapeutic opportunities in Alzheimer's disease. Alzheimers Res Ther 2012, 4:32.
    • (2012) Alzheimers Res Ther , vol.4 , pp. 32
    • Kline, A.1
  • 59
    • 84862777666 scopus 로고    scopus 로고
    • ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models
    • Cramer P.E., Cirrito J.R., Wesson D.W., Lee C.Y., Karlo J.C., Zinn A.E., et al. ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models. Science 2012, 335:1503-1506.
    • (2012) Science , vol.335 , pp. 1503-1506
    • Cramer, P.E.1    Cirrito, J.R.2    Wesson, D.W.3    Lee, C.Y.4    Karlo, J.C.5    Zinn, A.E.6
  • 60
    • 84904694734 scopus 로고    scopus 로고
    • Alzheimer's disease: relevant molecular and physiopathological events affecting amyloid-beta brain balance and the putative role of PPARs
    • Zolezzi J.M., Bastias-Candia S., Santos M.J., Inestrosa N.C. Alzheimer's disease: relevant molecular and physiopathological events affecting amyloid-beta brain balance and the putative role of PPARs. Front Aging Neurosci 2014, 6:176.
    • (2014) Front Aging Neurosci , vol.6 , pp. 176
    • Zolezzi, J.M.1    Bastias-Candia, S.2    Santos, M.J.3    Inestrosa, N.C.4
  • 61
    • 4043167747 scopus 로고    scopus 로고
    • Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
    • Oddo S., Billings L., Kesslak J.P., Cribbs D.H., LaFerla F.M. Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron 2004, 43:321-332.
    • (2004) Neuron , vol.43 , pp. 321-332
    • Oddo, S.1    Billings, L.2    Kesslak, J.P.3    Cribbs, D.H.4    LaFerla, F.M.5
  • 62
    • 62649114953 scopus 로고    scopus 로고
    • Burrowing: a sensitive behavioural assay, tested in five species of laboratory rodents
    • Deacon R.M. Burrowing: a sensitive behavioural assay, tested in five species of laboratory rodents. Behav Brain Res 2009, 200:128-133.
    • (2009) Behav Brain Res , vol.200 , pp. 128-133
    • Deacon, R.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.